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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Wiyata : Penelitian Sains dan Kesehatan JMM (Jurnal Masyarakat Mandiri) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Farmasi Higea Jurnal Dunia Farmasi JURNAL GIZI DAN KESEHATAN Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) PROFICIO: Jurnal Pengabdian Masyarakat Al-Khidmah Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Prosiding SIMKESNAS Parapemikir Jurnal Ilmiah Farmasi Jurnal Ayurveda Medistra Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Ikifa
Reubun, Yonathan Tri Atmodjo
Program Studi Sarjana Farmasi, Sekolah Tinggi Ilmu Kesehatan Medistra Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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SOURSLEPINE SEBAGAI UPAYA PENURUNAN KADAR ASAM URAT PADA MASYARAKAT RT004/RW003 KELURAHAN SEPANJANG JAYA Bunga, Dinda Nur Fajri Hidayati; Reubun, Yonathan Tri Atmodjo; Nisa, Hainun; Siregar, Renince; I Ratnah; Octaviani, Lidia
PROFICIO Vol. 6 No. 1 (2025): PROFICIO : Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v6i1.4032

Abstract

Masalah kesehatan terkait metabolisme dan penyakit kronis seperti asam urat, kolesterol tinggi, hipertensi, dan diabetes melitus dapat diatasi dengan meningkatkan prevalensi gaya hidup tidak sehat dan pola makan yang buruk. metode non farmakologis atau dengan cara praktik pengobatan tradisional telah mengidentifikasi sejumlah bahan alami yang memiliki potensi terapeutik untuk mengatasi AKHD. Di antara bahan-bahan tersebut, buah nanas (Ananas comosus (L.) Merr.) dan daun sirsak (Annona muricata L.) muncul sebagai bahan yang alami serta menjanjikan dalam mengelola dan mengurangi risiko kondisi kesehatan AKHD. Penelitian ini bertujuan untuk memberikan wawasan tentang bagaimana kombinasi bahan alami ini dapat dimanfaatkan dalam menurunkan asam urat, kolesterol, hipertensi, serta diabetes dan sebagai bagian dari strategi kesehatan holistik. Metode yang digunakan adalah pengabdian kepada masyarakat. Penyakit Tidak Menular (PTM) seperti asam urat, kolesterol tinggi, hipertensi, dan diabetes melitus merupakan masalah kesehatan serius yang dapat dikelola melalui kombinasi gaya hidup sehat dan penggunaan bahan alami seperti nanas dan daun sirsak. Kombinasi ini terbukti efektif dalam mengurangi risiko dan mengelola gejala penyakit-penyakit tersebut.
Freezed Drying of Kelor Leaves Extract (Moringa oleifera Lam.) Yonathan Tri Atmodjo Reubun; Shirly Kumala; Siswa Setyahadi; Partomuan Simanjuntak
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i4.427

Abstract

Moringa oleifera Lam. is a plant that is widely used by people in Indonesia because it is believed to be one of the medicinal plants for various diseases such as diabetes, diuretics, and has the potential to prevent Alzheimer's disease. The purpose of this research is to obtain kelor leaves extract which is more stable in storage and durable, namely by using the freeze drying method, which in this method aims to remove the moisture content in an ingredient or extract. The initial stage of making the extract begins with the extraction of kelor leaves using the maceration method using ethanol as a solvent. The results of maceration are collected and concentrated using a rotary evaporator until a thick extract is obtained and followed by freeze drying which aims to obtain a thick, stable extract. The results showed that 467.12g of kelor leaves extract from 1,000g simplicia was obtained where the yield obtained was 46.71%. the extract yield after freeze drying was 286.03g. After that the extract was tested for phytochemical screening where the results showed that the Moringa leaf extract contained alkaloids, saponins, tannins, phenolics, flavonoids, glycosides, and steroids.
EVALUASI SEDIAAN SABUN MANDI CAIR EKSTRAK ETANOL DAUN JAMBU BOL (Syizigium malaccense L.) Reubun, Yonathan Tri Atmodjo; Batubara, Kevin Septiyanto
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p55-60

Abstract

Bath soap is a skin care cosmetic product that can moisturize and protect the skin from sunlight and dirt that comes from outside. Of the various forms of soap preparations on the market, one type of soap that is currently being produced is in liquid dosage form because its use is more practical and the form is more attractive than other forms of soap. The use of natural ingredients as bath soap has been widely used in several soap products, one of the plants that can be used as an active ingredient in liquid soap is guava leaves. The purpose of this study was to determine the antioxidant activity of the ethanol extract of guava leaves (Syizigium malaccense L.) in liquid body soap preparations. The method used in this study was extraction using 96% ethanol solvent and the formulation of liquid bath soap was carried out, after which tests were carried out which included organoleptic tests, foam height tests, specific gravity tests, stability tests, and antioxidant activity tests. The results showed that the ethanol extract liquid bath soap of guava leaves is brown in color, liquid in shape, has a characteristic odor, and has a smooth texture. The foam height test result was 2 cm, the specific gravity test result was 1.020 g/mL and the antioxidant activity test result for the guava bol ethanol extract liquid bath soap was 9.6898. The conclusion of this study is that guava leaf extract can be used as a liquid bath soap preparation and has a good inhibitory concentration based on the results.
Pengujian Toksisitas Akut Pada Obat Bahan Alam Reubun, Yonathan Tri Atmodjo
Jurnal Ayurveda Medistra Vol 2 No 2 (2020): Jurnal Ayurveda Medistra
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v2i2.29

Abstract

Toxicity tests need to be carried out on a drug product to be marketed. This initial test (screening test) is very important pharmacologically and toxicologically because it will be used for consideration of determining the dosage, the time span of administration and its application. Herbal medicine is a preparation of traditional medicine which until now its use is still needed by people in Indonesia. The toxicity testing method was chosen based on the Organization for Economic Co-operation and Development (OECD) guidelines. This method is a standard method that is recognized by many countries. Europe which is a member of the OECD. The main strengths of this method are the small amount of rodents used and the relatively fast testing time based on 3R principles. in a journal review, LD50 results were obtained in various plants, namely 0.2g / kg BW, 2g / kg BW, 3.91 g / kgBW, 3.91 g / kgBB, 4.9g / kgBW, 5g / kg BW, 16g / kg BW, and 22.41 g / kg BW. The conclusion from this test is the value of the toxic dose of herbal medicine is> 50-300 mg / kg bw as stated in Annex 2c: OECD / OCE.
UJI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK BENALU TEH (Scurrula oortiana Dans.) Reubun, Yonathan Tri Atmodjo
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.5977

Abstract

The tea mistletoe plant (Scurrula oortiana Dans.) has been widely used by the community in treating diseases both modernly and traditionally. Mistletoe tea is also known to have pharmacological effects so it can be used in various diseases such as hypertension, gout, and prevention of Alzheimer's disease. The aim of this research was to determine the specific and non-specific parameter tests of mistletoe tea extract which were extracted using 96% ethanol, then carried out phytochemical screening tests, macroscopic and microscopic tests as well as testing specific and non-specific parameters. Based on the research results, it was found that the yield of mistletoe tea extract was 37.237%, specific and non-specific parameter testing showed that the drying loss value was 4,32%, the water content was 4,94%, the ethanol soluble extract content was 59,20%. Based on the test results, the ethanol extract of mistletoe tea meets the specific and non-specific parameter tests
POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12, No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Abstract

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.
UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK KULIT BUAH ALPUKAT (Persea americana Mill) TERHADAP BAKTERI PENYEBAB JERAWAT Silvyana, Annysa Ellycornia; Warti, Lia; Nurhayati, Nunung; Atmodjo Reubun, Yonathan Tri; Yuliana, Anna; Iskandar, Choirunnisa; Suripah, Suripah; Zahra, Aliyah; Khayla, Rahmalia Putri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12, No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.917

Abstract

Latar belakang: Kandungan flavonoid, fenol, steroid, dan alkaloid pada kulit buah alpukat (Persea americana Mill) yang berpotensi sebagai antibakteri penyebab jerawat. Jerawat umumnya terjadi pada remaja dan muncul di wajah, bahu, dada, serta punggung atas. Penyebab utamanya adalah bakteri S. Epidermidis, S. aureus dan P. acnes. Tujuan: Untuk menentukan konsentrasi optimal ekstrak kulit alpukat sebagai antibakteri terhadap S. Epidermidis, S. aureus dan P. acnes menggunakan metode KHM dan KBM, serta melakukan uji parameter spesifik dan nonspesifik. Metode: Metode ini menentukan Konsentrasi Hambat Minimum menggunakan microplate 96-well dengan Nutrient Broth untuk S. epidermidis dan S. aureus, serta Brain Heart Infusion Broth untuk P. acnes. Campuran diinkubasi pada 37°C (aerob 24 jam untuk S. epidermidis dan S. aureus; anaerob 72 jam untuk P. acnes), lalu diamati kekeruhannya. Konsentrasi Bunuh Minimum ditentukan dari sampel KHM tidak keruh, dengan inkubasi ulang untuk melihat konsentrasi terendah yang membunuh 99,9% bakteri. Hasil: Penelitian menunjukkan bahwa ekstrak kulit buah alpukat)  dapat menghambat pertumbuhan bakteri S. aureus pada konsentrasi 25.000 ppm, terdapat aktivitas antibakteri S. epidermidis pada konsentrasi 25.000 ppm, dan pada bakteri P. acnes  aktivitas antibakteri terjadi pada konsentrasi 50.000 ppm. Simpulan: Ekstrak kulit buah alpukat memiliki aktivitas antibakteri penyebab jerawat.
UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK KULIT BUAH ALPUKAT (Persea americana Mill) TERHADAP BAKTERI PENYEBAB JERAWAT Silvyana, Annysa Ellycornia; Warti, Lia; Nurhayati, Nunung; Atmodjo Reubun, Yonathan Tri; Yuliana, Anna; Iskandar, Choirunnisa; Suripah, Suripah; Zahra, Aliyah; Khayla, Rahmalia Putri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.917

Abstract

Latar belakang: Kandungan flavonoid, fenol, steroid, dan alkaloid pada kulit buah alpukat (Persea americana Mill) yang berpotensi sebagai antibakteri penyebab jerawat. Jerawat umumnya terjadi pada remaja dan muncul di wajah, bahu, dada, serta punggung atas. Penyebab utamanya adalah bakteri S. Epidermidis, S. aureus dan P. acnes. Tujuan: Untuk menentukan konsentrasi optimal ekstrak kulit alpukat sebagai antibakteri terhadap S. Epidermidis, S. aureus dan P. acnes menggunakan metode KHM dan KBM, serta melakukan uji parameter spesifik dan nonspesifik. Metode: Metode ini menentukan Konsentrasi Hambat Minimum menggunakan microplate 96-well dengan Nutrient Broth untuk S. epidermidis dan S. aureus, serta Brain Heart Infusion Broth untuk P. acnes. Campuran diinkubasi pada 37°C (aerob 24 jam untuk S. epidermidis dan S. aureus; anaerob 72 jam untuk P. acnes), lalu diamati kekeruhannya. Konsentrasi Bunuh Minimum ditentukan dari sampel KHM tidak keruh, dengan inkubasi ulang untuk melihat konsentrasi terendah yang membunuh 99,9% bakteri. Hasil: Penelitian menunjukkan bahwa ekstrak kulit buah alpukat)  dapat menghambat pertumbuhan bakteri S. aureus pada konsentrasi 25.000 ppm, terdapat aktivitas antibakteri S. epidermidis pada konsentrasi 25.000 ppm, dan pada bakteri P. acnes  aktivitas antibakteri terjadi pada konsentrasi 50.000 ppm. Simpulan: Ekstrak kulit buah alpukat memiliki aktivitas antibakteri penyebab jerawat.
POTENSI EKSTRAK BENALU TEH (Scurrula oortiana Dans.) TERHADAP BAKTERI PENYEBAB JERAWAT Staphylococcus epidermidis DAN Staphylococcus aureus Reubun, Yonathan Tri Atmodjo; Silvyana, Annysa Ellycornia; Warti, Lia; Octaviani, Adinda Tri
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 12 No 1 (2025)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v12i1.919

Abstract

Acne is a disease in which there is a buildup of skin oil glands which results in clogged skin pores, causing excess fat deposits. Bacteria such as Staphylococcus epidermidis and Staphylococcus aureus are the main factors in the emergence of this acne disease. The use of natural medicine can be used to test the inhibitory activity of both bacteria, one of which is tea mistletoe. The purpose of this study was to obtain the inhibitory activity of bacteria such as Staphylococcus epidermidis and Staphylococcus aureus from tea mistletoe extract using the liquid dilution method, namely MIC and MBC. The concentrations used consisted of 100000ppm, 50000 ppm, 25000ppm, 12500 ppm, 6250ppm, and 3125ppm. The MIC method is based on the turbidity or clarity of the test solution, while the MBC is based on the concentration of the extract in the media used. The results of the study showed that tea mistletoe extract has the potential to inhibit at 50,000ppm and above on both bacteria with the MIC method and kill at a concentration of 50,000ppm on S.aureus bacteria and 25,000ppm on S.epidermidis. The conclusion of this study is that tea mistletoe extract has the potential to inhibit and kill S.epidermidis and S.aureus bacteria at a concentration of 50,000ppm on the MIC and 25,000ppm on the MBC method.
A review: Utilization of Herbal Medicines in Alzheimer's Disease from Three Plants in Indonesia Reubun, Yonathan Tri Atmodjo
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.4197

Abstract

Alzheimer's disease is a disease in which brain damage is characterized by a decrease in attention, memory, and personality. Personality changes often occur when sufferers become less spontaneous, more apathetic, and withdrawn from their environment. The use of chemical drugs derived from the synthesis of natural drugs is approved for clinical use for Alzheimer's patients. Synthesis from natural materials is carried out because of the many chemical compounds contained in plants which have various biological and pharmacological effects. As for the use of natural medicines that are efficacious as antioxidants, anticoagulants, and anti-inflammatories, they are targets in the prevention of Alzheimer's disease where from these effects they can inhibit the acetylcholinesterase enzyme that plays a role in neurotransmitter damage. This journal review aims to maximize the use of natural medicines that have antioxidant effects from plants such as turmeric (Curcuma longa L.), gotu kola (Centella asiatica L.) and Kelor leaves (Moringa oleifera Lam.) so that these three plants are expected to have an effect. potential in the prevention of Alzheimer's disease which will be discussed extensively.
Co-Authors Adi Saputra, Fajar adinda tri octaviani Aindra, Dinda Aisyah Aisyah Albertrysia Richzchika Yolanurnazwa Alifah Salsabila Aliyah Zahra Anggelina Aprilia Pangalila Anna Yuliana, Anna Annysa Ellycornia Silvyana Annysa Ellycornia Silvyana Apryanti, Selvy Azizah, Nadiyatul Batubara, Kevin Septiyanto Bunga, Dinda Nur Fajri Hidayati Caecilia Sukma Larasati Cesarianti Puteri Dwi Hatmoko Choirunnisa Iskandar Dewi Fatimah Dini Dwi Oktaviani Doddy Izwardy, Doddy Fathimatus Safra Fitriana Febriyanti, Eka Herdini Herdini Hilma Fathiah I Ratnah Iskandar, Choirunnisa Kamelia, Rika Kevin Septiyanto Batubara Khayla, Rahmalia Putri Lia Warti Lia Warti Lisna Nuryanti Lulu Hikmah Fauziah Mahardika Shaib Prayoga Maknun, Lu luul Manda Pika, Indriani Marbun, Vermona Maria Indriati Ose Mars Jenita Grace Santy Indah Purba Muchammad Reza Ghozaly Muhaereni, Desweri Muhammad Hafis Fahreza Mutiara Ratna Riris Neng Nely Widianti Rahma Nisa, Hainun Nunung Nurhayati Octaviani, Adinda Tri Octaviani, Lidia Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Perdi ansyah Rahayu, Feronika Evma Rahmalia Putri Khayla Ratnah, I Rey Safana, Fia Saeful Rahma, Icha Safira, Bela Shirly Kumala Shirly Kumala Shirly Kumala Simangunsong, Lidia Octaviani Siregar, Renince Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siti Haura Khairunnisa Sizka Irdianti Sofi Khoerunnisa Suripah Suripah Syifa Aulia Putri Trilestari, Yulmuhti Vina Vina Warti, Lia Zahra, Aliyah