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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Wiyata : Penelitian Sains dan Kesehatan JMM (Jurnal Masyarakat Mandiri) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Farmasi Higea Jurnal Dunia Farmasi JURNAL GIZI DAN KESEHATAN Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) PROFICIO: Jurnal Pengabdian Masyarakat Al-Khidmah Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Prosiding SIMKESNAS Parapemikir Jurnal Ilmiah Farmasi Jurnal Ayurveda Medistra Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Ikifa
Reubun, Yonathan Tri Atmodjo
Program Studi Sarjana Farmasi, Sekolah Tinggi Ilmu Kesehatan Medistra Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pemberdayaan Masyarakat dalam Pencegahan TBC dan Hipertensi Melalui Edukasi dan Inovasi Produk Kesehatan Tradisional Nisa, Hainun; Marbun, Vermona; Tri Atmodjo Reubun, Yonathan; Ratnah, I; Siregar, Renince; Nuryanti, Lisna; Izwardy, Doddy; Aisyah, Aisyah; Saeful Rahma, Icha; Safira, Bela; Fatimah, Dewi; Aindra, Dinda; Fitriana Febriyanti, Eka; Adi Saputra, Fajar; Rey Safana, Fia; Manda Pika, Indriani; Maknun, Lu luul; Azizah, Nadiyatul; Kamelia, Rika; Apryanti, Selvy; Trilestari, Yulmuhti
Al-Khidmah Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2025): SEPTEMBER-DESEMBER
Publisher : Institute for Research and Community Service (LPPM) of the Islamic University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56013/jak.v5i3.4642

Abstract

The high prevalence of tuberculosis (TB) and hypertension in Sepanjang Jaya Village, Bekasi, coupled with limited access to health information, prompted the implementation of this community service program. The aim was to improve health literacy, promote the consumption of nutrient-rich local functional foods, and encourage physical activity. A community-based approach was employed, actively involving participants from the initial assessment to implementation and evaluation stages. The activities included: a pre-test and baseline health screening, interactive health education sessions, demonstrations of pumpkin pudding and roselle-ginger tea preparation, group hypertension exercise, a post-test, data analysis, and both formative and summative evaluations. The results indicated a significant improvement in participants’ knowledge scores (from 10–22 to 35–45) and an increase in the proportion of participants with normal blood pressure (from 29% to 69%). However, 74% of participants still exhibited above-normal blood glucose levels. Most participants (92.5%) reported that the program was beneficial and expressed commitment to applying the knowledge gained. In conclusion, participatory community-based health education combined with local functional food utilization proved effective in enhancing health literacy and improving blood pressure control, while sustained support is required for optimal blood glucose management.
Analisis kuersetin pada ekstrak benalu teh (Scurrula oortiana Dans.) secara kuantitatif Silvyana, Annysa Ellycornia; Reubun, Yonathan Tri Atmodjo; Warti, Lia; Simangunsong, Lidia Octaviani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.575

Abstract

Indonesia has a variety of plants that are useful as medicine. One is the Tea Mistletoe plant (Scurrula oortiana Dans.). This plant contains flavonoid compounds that are effective as antioxidants, especially in the form of quercetin. Quercetin in the tea mistletoe plant can prevent cell damage caused by free radicals, where cells need this antioxidant to avoid the harmful effects of excessive reactive oxygen species (ROS) production and prevent damage to immune cells. This study aims to analyze the levels of quercetin in Tea Mistletoe extract using quantitative analysis methods such as thin-layer chromatography and UV-Vis spectrophotometry. Tea Mistletoe powder was extracted by maceration with 96% ethanol solvent and then concentrated using a rotary evaporator and water bath. The thick extract obtained was then tested for phytochemical screening and specific and non-specific parameters. Analysis of flavonoid quercetin compounds was carried out using a thin layer chromatography method using a mobile phase of a mixture of chloroform, ethyl acetate, and n-butanol with a ratio of 5:4:1 and a stationary phase of Silica Gel GF₂₅₄. Determination of flavonoid levels was carried out using UV-Vis spectrophotometry at a wavelength of 428 nm. The results of this study indicate that the Mistletoe Tea plant contains flavonoids, alkaloids, steroids, tannins, saponins, phenolics, and glycosides. All test parameters meet the specified requirements. The thin layer chromatography test showed the Rf value of the Mistletoe Tea extract of 0.78. The linearity test showed a correlation value (r) = 0.9988 with a total flavonoid compound content of 372.250 mg QE/g extract, or a percentage of 37.225%.
Perbandingan Ekstrak Empat Bahan Alam Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Fathimatus Safra; Aliyah Zahra; Mutiara Ratna Riris; Rahmalia Putri Khayla; Yonathan Tri Atmodjo Reubun
Jurnal Farmasi IKIFA Vol. 4 No. 1 (2025): JURNAL FARMASI IKIFA VOL.4 NO.1 APRIL TAHUN 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Staphylococcus aureus is part of the normal flora of the human body and can be found in the oral cavity (both in individuals who use orthodontic equipment), skin, respiratory tract, and digestive tract, as well as in the air and surrounding environment. The mechanism of action of antibacterial compounds includes blocking cell wall formation and affecting integrity. The ability of bacterial cell walls, inhibition of enzyme activity, and failure to combine nucleic acids and proteins are some of the antibacterial mechanisms of lime leaves extracted using essential oil, which have anti-bacterial activity with a minimum bactericidal concentration (KBM) against Staphylococcus aureus of 0.625% v/v and Escherichia coli of 1.25% v/v. Red betel leaf extract at a concentration of 60% showed an inhibitory zone for Staphylococcus aureus bacteria with an average inhibitory zone diameter of 7.96 mm against Staphylococcus aureus with a significant value (P<0.05). The anti-bacterial activity of papaya leaf ethanol extract and this phytochemical test showed that the average diameter of the inhibition zone was 8.24 mm at a concentration of 80%, followed by 8.1 mm at a concentration of 60%, 6.7 mm at a concentration of 40%, 4.96 mm at a concentration of 20%, and 3.92 mm at a concentration of 10%.
IMPLEMENTASI FARMASI SOSIAL UNTUK MENINGKATKAN KESADARAN KESEHATAN MASYARAKAT DI DESA DANGDEUR Annysa Ellycornia Silvyana; Muhammad Hafis Fahreza; Yonathan Tri Atmodjo Reubun; Lia Warti; Muchammad Reza Ghozaly; Hilma Fathiah
JMM (Jurnal Masyarakat Mandiri) Vol 10, No 3 (2026): Juni
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v10i3.39379

Abstract

Abstrak: Penyakit tidak menular seperti diabetes melitus, hipertensi, dan asam urat masih menjadi masalah kesehatan utama di Indonesia, terutama akibat pola hidup tidak sehat, rendahnya literasi kesehatan, serta minimnya penerapan Perilaku Hidup Bersih dan Sehat (PHBS). Desa Dangdeur merupakan salah satu wilayah dengan tingkat kesadaran kesehatan rendah dan pemanfaatan Tanaman Obat Keluarga (TOGA) yang belum optimal. Pengabdian ini bertujuan meningkatkan kesadaran dan kemandirian masyarakat melalui Praktik Farmasi Sosial (PFS). Kegiatan dilaksanakan selama 14 hari oleh mahasiswa Universitas Esa Unggul dengan metode edukatif dan partisipatif berupa penyuluhan penyakit tidak menular, pemeriksaan kesehatan, edukasi PHBS di sekolah dasar, penanaman TOGA, serta penyuluhan minuman herbal. Hasil pre-test dan post-test menunjukkan peningkatan pemahaman signifikan, yaitu diabetes dan asam urat dari 50% menjadi 90%, serta hipertensi dari 40% menjadi 87,5%. Program ini terbukti efektif meningkatkan literasi kesehatan, mendorong pemanfaatan sumber daya lokal, serta memperkuat kebersamaan masyarakat dalam mewujudkan pola hidup sehat berkelanjutan.Abstract: Non-communicable diseases such as diabetes mellitus, hypertension, and gout are still major health problems in Indonesia, mainly due to unhealthy lifestyles, low health literacy, and lack of implementation of Clean and Healthy Living Behavior (PHBS). Dangdeur Village is one of the areas with a low level of health awareness and non-optimal utilization of Family Medicinal Plants (TOGA). This research aims to increase community awareness and independence through Social Pharmacy Practice (PFS). Activities were carried out for 14 days by Esa Unggul University students with educational and participatory methods in the form of counseling on non-communicable diseases, health checks, PHBS education in elementary schools, planting TOGA, and counseling on herbal drinks. The pre-test and post-test results showed a significant increase in understanding, namely diabetes and gout from 50% to 90%, and hypertension from 62.5% to 93.7%. This program proved effective in improving health literacy, encouraging the use of local resources, and strengthening community togetherness in realizing a sustainable healthy lifestyle.
- TINJAUAN LITERATUR PARAMETER SPESIFIK DAN NON-SPESIFIK PADA SIMPLISIA DAN EKSTRAK BUNGA SEBAGAI BAHAN BAKU HERBAL TERSTANDAR Maria Indriati Ose; Lulu Hikmah Fauziah; Mahardika Shaib Prayoga; Cesarianti Puteri Dwi Hatmoko; Yonathan Tri Atmodjo Reubun
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.139

Abstract

Flowers are a source of secondary metabolites that can be used as raw materials for herbal medicines. The standardization of crude drug materials and flower extracts using specific and non-specific parameters is essential to ensure their quality, safety, and efficacy. This study aims to review the specific and non-specific parameters of ten types of flowers, namely gemitir, soka, rosella, clove, kecombrang, tapak darah, pucuk merah, telang, matahari, and kembang bulan. The analyzed parameters include organoleptic properties, water and ethanol extract yields, phytochemical tests, identification of active compounds via TLC and GC-MS, as well as moisture content, ash content, and percentage of damage due to heating. The results showed that seven flowers (gemitir, rosela, kecombrang, tapak darah, pucuk merah, matahari, and kembang bulan) met most of the quality parameters. Moisture content was generally <10%, but the cengkeh flower had high moisture content (18.9%) and the kembang bulan flower had a drying loss exceeding the limit (13.64%). The highest water-soluble extract content was found in gemitir (37.34%) and tapak darah (30.2%), while soka (20.7%) and telang (8.5%) were below the standard. All flowers contain flavonoids, with the best identification of active compounds found in rosella (quercetin 7.02%) and moonflower (GC-MS results). Overall, most flowers can be used as standardized herbal raw materials, but soka, clove, and telang flowers still require improvements in the processing.
Literature Review: Studi Komparatif Parameter Standarisasi Spesifik dan Non-Spesifik Simplisia Buah Unggulan Indonesia Siti Haura Khairunnisa; Albertrysia Richzchika Yolanurnazwa; Neng Nely Widianti Rahma; Perdi ansyah; Yonathan Tri Atmodjo Reubun
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.140

Abstract

As a megabiodiversity country, Indonesia possesses a wealth of local fruits with extensive pharmacologicalpotential; however, systematic comparative studies of standardization parameters for fruit crude drugs remainvery limited. This literature review aims to compile a comparative study of specific and non-specificstandardization parameters for ten leading Indonesian fruit crude drugs based on scientific literature and toevaluate their compliance with the Indonesian Herbal Pharmacopoeia (FHI). A systematic literature search wasconducted via Google Scholar using the keywords “standardization of fruit crude drugs,” “specific and non-specific parameters,” and “characterization of crude drugs.” A total of 9 journal articles and 1 thesis publishedbetween 2017 and 2025 met the inclusion criteria and were analyzed comparatively. The study covered tentypes of fruit, namely green apples, hiyung chili peppers, yellow squash, red pomegranates, ceremai, belimbingwuluh, asam gelugur, lime, limpasu, and selutui puka. Specific parameters revealed characteristic organolepticvariations as well as significant differences in water-soluble extract content (3.6–65.57%) and ethanol-solubleextract content (3.9–70.50%). Non-specific parameters identified three critical safety issues: the acid-insolubleash content (KATLA) of green apples exceeded the Indonesian Food and Drug Administration (BPOM RI) limit(6.95%); Cadmium contamination in Hiyung chili peppers exceeded the maximum limit (4.00 mg/kg vs. 0.3mg/kg); and the KATLA content in Ceremai (1.50–1.59%) exceeded BPOM RI requirements. None of the crudedrugs or extracts comprehensively met all FHI requirements. Standardization of extraction procedures, morecomprehensive parameter testing, and the development of specific FHI monographs for undocumentedIndonesian fruit crude drugs are required.Keywords: Standardization of fruit crude extracts, specific parameters, non-specific parameters, characterization of crude extracts.
Sizka Irdianti Literature Review: Standardization of the Quality of Medicinal Plants and Leaf Extracts Based on Specific and Non-Specific Parameters Sizka Irdianti; Alifah Salsabila; Vina Vina; Syifa Aulia Putri; Yonathan Tri Atmodjo Reubun
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.142

Abstract

Medicinal plants have long been used by the Indonesian people, passed down through generations, in various forms of traditional preparations. Leaves are one of the most commonly used parts of plants as raw materials for herbal medicines because they are rich in secondary metabolites such as flavonoids, alkaloids, tannins, and saponins. To ensure the quality, safety, and efficacy of traditional medicinal raw materials, a standardization process is required that adheres to the Indonesian Herbal Pharmacopoeia (FHI) and the Indonesian Materia Medica (MMI) through testing of specific and non-specific parameters. This literature review aims to compare and analyze the results of specific and non-specific parameter tests of ten types of crude drug materials and leaf extracts from medicinal plants, namely Kersen leaves (Muntingia calabura L.), Kawau leaves (Millettia sericea), Avocado leaves (Persea americana Mill.), Moringa leaves (Moringa oleifera), Lotus Leaf (Nelumbium nelumbo D.), Senggani Leaf (Melastoma malabathricum L.), Matoa Leaf (Pometia pinnata JR & G.Forst), Bidara Leaf (Ziziphus nummularia), Gatal Leaf (Laportea decumana (Roxb.) Wedd), and Dandang Gendis Leaf (Clinacanthus nutans). A literature search was conducted via the Google Scholar database using the keywords “Leaf Extract,” “Specific,” and “Non-Specific,” with the criterion that journals were published between 2018 and 2025. The review results indicate that most specific parameters—including organoleptic properties, phytochemical screening, and water-soluble and ethanol-soluble extract content—met the established standards. Meanwhile, for non-specific parameters—including moisture content, drying loss, total ash content, acid-insoluble ash content, heavy metal contamination, and microbial contamination—most results met the requirements, although some parameters in certain plants still exceeded the specified limits. This review provides a comprehensive overview of the standard quality ranges for medicinal plants and serves as a reference for the development of standardized herbal medicines in Indonesia.
Literature Review: Evaluation of Spesific and Non-Spesific Parameters in the Quality Assessment of Rhizome Simplicia Mars Jenita Grace Santy Indah Purba; Sofi Khoerunnisa; Dini Dwi Oktaviani; Caecilia Sukma Larasati; Yonathan Tri Atmodjo Reubun
Jurnal Ayurveda Medistra Vol 8 No 1 (2026): Jurnal Ayurveda Medistra: Jurnal Ilmiah Kesehatan
Publisher : STIKes Medistra Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51690/medistra-jurnal123.v8i1.144

Abstract

Rhizomes are the underground stems of plants and are widely used as crude drug materials in the Indonesian traditional medicine industry because they contain various beneficial bioactive compounds. Rhizome crude drugs must meet quality standards that can be measured through two groups of parameters—specific and non-specific parameters—to ensure the safety, efficacy, and consistency of these raw materials. This study is a literature review that involves the collection and analysis of secondary data from ten scientific articles obtained through Google Scholar. This study focuses on the evaluation of specific parameters, namely organoleptic properties, water-soluble and ethanol-soluble extract content, as well as phytochemical profiles, and non-specific parameters such as drying loss, moisture content, total ash content, acid-insoluble ash content, and heavy metal content in ten types of rhizome crude drugs: red galangal, yellow turmeric, ginger, red ginger, kencur, purun danau, black temu, temu kunci, mango temu, and wundu watu. Analysis results indicate that Temu Kunci (Kaempferia pandurata Roxb.) has the best overall quality, followed by Red Ginger and Kencur, which each meet all established standards. Conversely, Black Temu and Mango Temu showed non-compliance with non-specific parameters, particularly regarding ash content and moisture content, indicating a need to improve post-harvest processing. Lake Purun requires special attention due to its high heavy metal content, which impacts the aquatic ecosystem in the lake. Standardizing both specific and non-specific parameters is a crucial step to ensure the quality and safety of rhizome crude drugs as raw materials for traditional medicine in Indonesia. Keywords: Herbal Rhizomes, Specific Parameters, Non-Specific Parameters
Co-Authors Adi Saputra, Fajar adinda tri octaviani Aindra, Dinda Aisyah Aisyah Albertrysia Richzchika Yolanurnazwa Alifah Salsabila Aliyah Zahra Anggelina Aprilia Pangalila Anna Yuliana, Anna Annysa Ellycornia Annysa Ellycornia Silvyana Annysa Ellycornia Silvyana Apryanti, Selvy Azizah, Nadiyatul Batubara, Kevin Septiyanto Bunga, Dinda Nur Fajri Hidayati Caecilia Sukma Larasati Cesarianti Puteri Dwi Hatmoko Choirunnisa Iskandar Dewi Fatimah Dini Dwi Oktaviani Doddy Izwardy, Doddy Fathimatus Safra Fitriana Febriyanti, Eka Herdini Herdini Hilma Fathiah I Ratnah Iskandar, Choirunnisa Kamelia, Rika Kevin Septiyanto Batubara Khayla, Rahmalia Putri Lia Warti Lia Warti Lia Warti Lisna Nuryanti Lulu Hikmah Fauziah Mahardika Shaib Prayoga Maknun, Lu luul Manda Pika, Indriani Marbun, Vermona Maria Indriati Ose Mars Jenita Grace Santy Indah Purba Muchammad Reza Ghozaly Muhaereni, Desweri Muhammad Hafis Fahreza Mutiara Ratna Riris Neng Nely Widianti Rahma Nisa, Hainun Nunung Nurhayati Octaviani, Adinda Tri Octaviani, Lidia Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Perdi ansyah Rahayu, Feronika Evma Rahmalia Putri Khayla Ratnah, I Rey Safana, Fia Saeful Rahma, Icha Safira, Bela Shirly Kumala Shirly Kumala Shirly Kumala Simangunsong, Lidia Octaviani Siregar, Renince Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siti Haura Khairunnisa Sizka Irdianti Sofi Khoerunnisa Suripah Suripah Syifa Aulia Putri Trilestari, Yulmuhti Vina Vina Warti, Lia Zahra, Aliyah