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Diet sebagai Faktor Risiko Timbulnya Adenoma Kolorektal dan Kanker Karsinoma Dini: A Systematic Review Yuliastuti, Maria Eka; Rahmiwati, Anita; Ocktariyana, Ocktariyana; Zulkarnain, Zulkarnain; Flora, Rostika
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 14 No 2 (2024): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: April 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v14i2.1887

Secara global, prevalensi kanker kolorektal pada orang dewasa berusia 50 tahun ke bawah meningkat. Salah satu faktor risiko yang dapat dimodifikasi adalah diet. Tujuan penelitian ini adalah untuk meninjau data yang berkaitan dengan hubungan antara makanan dan risiko dewasa muda adenoma kolorektal onset dini dan kanker kolorektal onset dini (EOCRC). Pencarian komprehensif dilakukan melalui PUBMED, Web of Science, dan Embase untuk menemukan studi yang melihat asupan makanan sebagai faktor risiko untuk karsinoma kolonrektal onset dini dan EOCRC. Karena penelitian sangat berbeda satu sama lain, hasilnya disintesis secara naratif. Dari 413 artikel yang diidentifikasi sampai 10 artikel yang dipilih mulai dari tahun 2014 rampai 2023.Temuan penelitian menunjukkan bahwa berbagai praktik makan bisa menjadi faktor risiko. atau melindungi terhadap adenoma dan kanker kolorektal dengan awal yang awal. Investigasi selanjutnya adalah berkonsentrasi pada studi kohort prospektif ekstensif yang menggabungkan periode tindak lanjut yang diperpanjang untuk memvalidasi temuan yang dilaporkan dan menyelidiki lebih lanjut jika variasi dalam kualitas makanan terkait dengan kejadian EOCRC.

ANALISIS KEMURNIAN EKSTRAKSI ASAM RIBONUKLEAT PADA SAMPEL DARAH MENSTRUASI Ocktariyana, Ocktariyana; Lestari, Dian; Asmarinah, Asmarinah
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 17 No 2 (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v17i2.1392

Latar Belakang: Asam nukleat mengandung materi genetik dan berfungsi untuk mengatur perkembangan biologis seluruh bentuk kehidupan secara seluler. Asam nukleat yang paling umum adalah Asam deoksiribonukleat (ADN) dan Asam ribonukleat (ARN). Untuk mengeluarkan ARN dari dalam intisel maka diperlukan suatu teknik isolasi. Suatu ekstraksi asam nukleat dikatakan baik jika dari prosedur yang dilakukan bisa didapatkan asam nukleat yang murni dan utuh. Penelitian ini bertujuan untuk mengetahui bagaimana tingkat kemurnian ekstrak asam nukleat dari sampel darah menstruasi menggunakan teknik isolasi asam nukleat. Metode: Sampel darah menstruasi dikumpulkan dengan cara ditampung pada kertas saring yang di desain khusus. Sampel akan diekstraksi menggunakan Quick-ARN Miniprep Plus Kit R1058 Zymo Research untuk isolasi ARN, selanjutnya diukur tingkat kemurnian dengan menggunakan alat nanodrop berdasarkan prinsip spektrofotometri. Data diolah secara statistic dengan menggunakan analisis deskripsi dalam disajikan dalam bentu distribusi frekuensi dan nilai rerata. Hasil: pada penelitian ini diperoleh bahwa rerata tangka kemurnian ARN sampel darah menstruasi yang ditampung pada kertas saring pada Panjang gelombang A260 / A280 adalah 2,07, dan Panjang gelombang A260 / A230 adalah 2,1. Kesimpulan: Isolasi ARN pada sampel darah menstruasi yang ditampung di kertas saring memiliki tingkat kemurnian yang optimal.

PENGARUH PEMBERIAN EKSTRAK ISOFLAVON TEMPE TERHADAP TINGKAT STRESS OKSIDATIF PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus novergicus) SETELAH DIINDUKSI DENGAN DOSIS TOKSIK PARASETAMOL Taswin, Muhamad; Astuti, Ratnaningsih Dewi; Marlina, Dewi; Ocktariyana, Ocktariyana; Agustianingsih, Ade
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 17 No 2 (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v17i2.1513

ABSTRACT Background: As a producing country and at the same time the largest consumer of tempeh in the world, Indonesia has become the largest soybean market in Asia. As much as 50% of soybean consumption in Indonesia is done in the form of tempeh. Tempe is a potential food ingredient as a hepatoprotector. The content of isoflavones in tempeh has been shown to protect rat liver function under stress conditions. Isoflavones contained in tempeh have activity as antioxidants, which can prevent oxidation reactions from occurring by working as reducing agents and protecting cell membranes from oxidation, as well as counteracting free radicals by stopping chain reactions and protecting cells from DNA activation so as to reduce cell damage. This situation has prompted the authors to investigate the effect of the isoflavone extract of tempeh on the histochemistry and histopathology of the livers of male white Wistar rats (Rattus novergicus) after being induced by toxic doses of Paracetamol. Methods: This study was an experimental study using the Randomized Posttest Only Control Group Design to determine the level of oxidative stress after administration of tempeh isoflavone extract to male white rats (Rattus novergicus) induced with a toxic dose of paracetamol. 5 groups, namely group 1 was given tempe extract 160 mg/kgBB, group 2 was given tempe extract 320 mg/kgBB, group 3 was given tempe extract 640 mg/kgBB, group 5 was given distilled water and group 6 was given 1% NaCMC solution. Each rat was treated for 14 days. On day 12, 13 and 14 rats were given paracetamol at a dose of 900 mg/kg BW in 1% NaCMC. And on the 15th day, rat blood serum was examined for levels of SGOT, SGPT and MDA. Results: It was found that tempeh at a dose of 640 mg/kgBW could significantly reduce SGOT, SGPT and MDA levels (p<0.05) compared to other doses as well as distilled water and 1% NaCMC. Conclusion: So it can be concluded that tempeh can be an alternative source of antioxidants that can protect liver cells from the effects of substances that can damage the liver. Keywords: Tempe, SGOT, SGPT, MDA

The Effect of EGFR DNA Methylation on the Incident of Endometriosis Anisah Nida'ul Haq; Ocktariyana Ocktariyana; Zen Hafy; Irsan Saleh
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.274

Endometriosis is a gynecological condition characterized by the development of endometrial tissue outside the uterus, often leading to pain and infertility. We explore the relationship between endometriosis and the effects of DNA methylation on the Epidermal Growth Factor Receptor (EGFR) gene. DNA methylation, an epigenetic mechanism, involves adding a methyl group to cytosine bases followed by guanine in CpG islands, thereby influencing gene expression through hypermethylation or hypomethylation. In endometriosis, methylation patterns on specific genes can lead to transcriptional changes, impacting inflammatory processes and hormonal functions, such as estrogen, that support the growth of ectopic tissue. Variations in the EGFR gene's DNA methylation are linked to elevated cellular activity and expression, which aids in the pathophysiology of endometriosis. These findings highlight the potential of DNA methylation as a therapeutic target in treating endometriosis, offering hope for improved patient outcomes.

Effectiveness of Phoenix Dactylifera and Oxytocin Massage on Prolactin Levels in Breastfeeding Mothers in Palembang City Aprilina, Aprilina; Ocktariyana, Ocktariyana; Lestari, Dian
EMBRIO: Jurnal Kebidanan Vol 16 No 2 (2024): EMBRIO: Jurnal Kebidanan (NOVEMBER)
Publisher : Program Studi S1 Kebidanan - Fakultas Ilmu Kesehatan Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/embrio.v16i2.9787

Exclusive breastfeeding is essential in the growth and development of babies and improves maternal health. Exclusive breastfeeding can reduce infant mortality rates; of the 3 thousand infant deaths in Indonesia, 10 million deaths of children aged less than 5 years in the world each year can be prevented by exclusive breastfeeding. The hormones that play a role in breastfeeding mothers are prolactin and oxytocin. The research aimed to look at the effectiveness of oxytocin massage and Phoenix dactylifera in increasing the levels of the hormone prolactin in breastfeeding mothers. The research was a Quasi Experiment with a Post Test only design, a sample of 30 people divided into three groups. Phoenix Dactylifera intervention, oxytocin massage intervention, and control without treatment. The research was conducted at TPMB Palembang city. Analysis using the Shapiro-Wilks test for data homogeneity using Levene's test (pmore than 0.05) and the One Way ANOVA test compared the means of the three groups. The results showed no significant differences between the three groups where the ρ value was more than 0.05. The conclusion is that there is nothing more effective in increasing prolactin hormone levels than giving Phoenix dactylifera and oxytocin massage because it is thought to be caused by many influencing factors, including age, education, nutritional intake, and maternal parity.

Optimalisasi Petugas Kesehatan dan Kader Posyandu untuk Pengendalian Kekurangan Energi Kronik (KEK) pada Ibu Hamil di Desa Limbang Mulia Ocktariyana, Ocktariyana; Aprilina, Aprilina; Muzakar, Muzakar; Listrianah, Listrianah
Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS) Vol 7 No 1 (2025): Jurnal Pengabdian Kepada Masyarakat (ABDIKEMAS
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Politeknik Kesehatatan Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/j.abdikemas.v7i1.2814

Chronic energy deficiency (CED) is the most common nutritional disorder in pregnant women. In 2022, the incidence of CED in pregnant women in Limbang Mulia Village was 15 out of 435 pregnant women. The working area of the Limbang Mulia Health Center in 2021 was reported to have 12 integrated health posts spread across 10 villages with a full strata purnama. Integrated health posts carry out 5 complete basic service programs, namely KIA, KB, immunization, nutrition and diarrhea prevention. This activity aims to optimize the role of integrated health post cadres in controlling CED in pregnant women so that it can reduce the incidence of stunting. The implementation of this activity is carried out by identifying, collecting and conducting training for integrated health post cadres. In the form of providing counseling on pregnancy health as an effort to prevent CED so that it can prevent stunting in children. The results achieved in this counseling and training activity were an increase in the knowledge of integrated health post cadres. Increasing the role of cadres and the community in efforts to control stunting and reduce the incidence of CED in pregnant women. Keywords: Cadres, Posyandu, Chronic energy deficiency (KEK), pregnant women Abstrak Kekurangan energi kronik (KEK) merupakan gangguan gizi yang paling umum terjadi pada ibu hamil. Pada tahun 2022 angka kejadian KEK pada ibu hamil di Desa Limbang Mulia sebanyak 15 ibu hamil dari 435 ibu hamil. Wilayah kerja Puskesmas Limbang Mulia tahun 2021 dilaporkan ada 12 jumlah posyandu yang tersebar di 10 desa dengan strata purnama. Posyandu melakukan 5 program pelayanan dasar lengkap, yaitu KIA, KB, imunisasi, gizi serta pencegahan diare. Kegiatan ini bertujuan untuk mengoptimalkan peran kader posyandu dalam pengendalian KEK pada ibu hamil sehingga dapat menurunkan akan kejadian stunting. Pelaksanaan kegiatan ini dilakukan dengan mengidentifikasi, menghimpun dan melakukan pelatihan kepada kader posyandu. Berupa memberikan penyuluhan tentang kesehatan masa kehamilan sebagai upaya pencegahan KEK sehingga dapat mencegah stunting pada anak. Hasil yang dicapai dalam kegiatan penyuluhan dan pelatihan ini adalah terjadi peningkatan pengetahuan kader Posyandu. Meningkatnya peran serta kader dan masyarakat dalam upaya pengendalian stunting dan menurunnya angka kejadian KEK pada ibu hamil. Kata kunci: Kader, Posyandu, Kekurangan energi kronis (KEK), ibu hamil

Pendampingan dan Pelatihan Senam Kombinasi Abdominal Stretching Exercise pada Remaja Putri yang Mengalami Dismenorea Sumastri, Heni; Ocktariyana, Ocktariyana; Septeria, Indah Puji; Astuti, Ratnaningsih Dewi
Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS) Vol 4 No 2 (2022): Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS)
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Politeknik Kesehatatan Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/j.abdikemas.v4i2.1472

Abdominal stretching exercise merupakan latihan peregangan otot perut dan dapat digunakan untuk mengurangi rasa nyeri pada menstruasi. Berdasarkan studi pendahuluan di SMA Kota Palembang didapatkan bahwa masih banyak siswi yang mengalami nyeri haid (dismenore) dan pada saat mengalami nyeri haid beberapa siswi meminta izin pulang ke rumah dan akhirnya tidak dapat mengikuti proses pembelajaran di sekolah. Tujuan dari kegiatan Pengabdian kepada masyarakat ini untuk membantu Remaja Putri mengatasi nyeri haid dengan melakukan senam kombinasi dismenore dan abdominal stretching exercise. Metode dalam kegiatan ini dengan Pelatihan dan Pendidikan kesehatan. Hasil yang didapat pada kegiatan pengabdian kepada masyarakat ini adalah duta abdominal stretching exercise mampu mempraktikkan kembali senam kombinasi abdominal stretching exercise dengan benar. Selain itu, siswi yang mengalami dismenore mampu mengatasi keluhan nyeri selama menstruasi yang cara melakukan senam kombinasi abdominal stretching exercise. Kami menyarankan bahwa kegiatan ini sebaiknya dilakukan secara terus menerus dan berkesimbungan oleh pihak Mitra sehingga tingkat pada remaja putri dapat mengatasi dismenorea dengan cara senam kombinasi Abdominal Stretching Exercise. Senam ini dapat dilakukan pada siswa SMA dengan keluhan nyeri haid secara teratur sesuai dengan standar operasional protokol (SOP) dan video senam dismenorre. Kata kunci: Abdominal stretching exercise. Dismenore, Pelatihan, Senam, Siswa.

Risk Factors for Iron Deficiency Anemia Among Adolescents in Developing Countries: Study Literature Review Ocktariyana, Ocktariyana; Flora, Rostika; Yuliastuti, Maria Eka; Zulkarnain, Zulkarnain; Lasepha, Ani
Indonesian Journal of Global Health Research Vol 6 No 3 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i3.3163

Adolescents experience physiological and psychological growth to establish the basis for maturity. The biological well-being of adolescents requires improved nutrition. Intake of foods rich in micronutrients such as iron, zinc, and vitamin A, which are relevant to supporting biological metamorphosis in adolescents, can influence growth and well-being. The aim of this study is to holistically identify the main risk factors affecting adolescents that contribute to anemia in developing country developing.A systematic review was conducted following the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The current review defines adolescents as individuals ranging in age from 10 to 19 years. A total of 2,252 articles were retrieved from the database, of which 618 duplicates were removed and 1,492 records were issued after filtering by title and abstract. 142 articles were fully assessed for notability, and 127 articles were also excluded based on inclusion and exclusion criteria. Finally, 15 studies were included in the systematic review. The review showed that food intake practices, parasite infections, menstruation, the increasing age of adolescent girls, and the low educational status of guardians are the main risk factors for iron deficiency anemia among adolescents in most developing countries.

Analysis of risk factors for gestational hypertension and preeclampsia: Literature review Hayati, Thursina Vera; Zulkarnain, M.; Flora, Rostika; Fajar, Nur Alam; Rahmiwati, Anita; Ocktariyana, Ocktariyana; Ariana, Rika
Science Midwifery Vol 12 No 1 (2024): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i1.1415

Based on Disability Adjusted Life Years (DALYs), there are four main disease burdens, namely ischemic heart disease, cerebrovascular disease (including stroke and hypertension), diabetes and tuberculosis infectious disease. Gestational hypertension is very closely related to CVD (cardiovascular disease) with the potential for preeclampsia to have an impact on premature birth or small babies for the gestational age, stillbirths, low birth weight babies, etc. The research objective was to analyze the risk factors for gestational hypertension and preeclampsia. Methods: This study is a literature review based on the PRISMA guidelines. using electronic databases namely Google scholar, Sciencedirect and Pubmed with a period from 2017 to 2022 with the keywords "Hypertension, risk factors, high risk pregnancy". Results: The prevalence of hypertension and pre-eclampsia varies between countries. In Bangladesh, the prevalence of pre-eclampsia: 14.4%, without history of hypertension, 5.4% prevalence of pre-eclampsia with chronic hypertension, the same as Ethiopia. The incidence of gestational hypertension is 6%, in Ireland, gestational hypertension is 5.9% and 4.6% of pre-eclampsia. In France hypertension was 7.4% and pre-eclampsia was 2.0%, gestational hypertension was 4.2%, HELLP syndrome was 10.4%. Hypertension is associated with risk factors for pregnancy, lifestyle and sociodemographic factors. Conclusion: Prevention, timely diagnosis and prompt management of hypertension in pregnancy should be intensified so as to reduce morbidity and severity of adverse birth outcomes

Analysis of risk factors for gestational hypertension and preeclampsia: Literature review Hayati, Thursina Vera; M. Zulkarnain, M. Zulkarnain; Flora, Rostika; Fajar, Nur Alam; Rahmiwati, Anita; Ocktariyana, Ocktariyana; Ariana, Rika
Science Midwifery Vol 12 No 2 (2024): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i2.1531

Based on Disability Adjusted Life Years (DALYs), there are four main disease burdens, namely ischemic heart disease, cerebrovascular disease (including stroke and hypertension), diabetes and tuberculosis infectious disease. Gestational hypertension is very closely related to CVD (cardiovascular disease) with the potential for preeclampsia to have an impact on premature birth or small babies for the gestational age, stillbirths, low birth weight babies, etc. The research objective was to analyze the risk factors for gestational hypertension and preeclampsia. Methods: This study is a literature review based on the PRISMA guidelines. using electronic databases namely Google scholar, Sciencedirect and Pubmed with a period from 2017 to 2022 with the keywords "Hypertension, risk factors, high risk pregnancy". Results: The prevalence of hypertension and pre-eclampsia varies between countries. In Bangladesh, the prevalence of pre-eclampsia: 14.4%, without history of hypertension, 5.4% prevalence of pre-eclampsia with chronic hypertension, the same as Ethiopia. The incidence of gestational hypertension is 6%, in Ireland, gestational hypertension is 5.9% and 4.6% of pre-eclampsia. In France hypertension was 7.4% and pre-eclampsia was 2.0%, gestational hypertension was 4.2%, HELLP syndrome was 10.4%. Hypertension is associated with risk factors for pregnancy, lifestyle and sociodemographic factors. Conclusion: Prevention, timely diagnosis and prompt management of hypertension in pregnancy should be intensified so as to reduce morbidity and severity of adverse birth outcomes.

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