Article Per Year (5 Year)
p-Index From 2021 - 2026
3.143
P-Index
This Author published in this journals
All Journal International Journal of Integrated Health Sciences Journal of the Medical Sciences (Berkala Ilmu Kedokteran) THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST BIOEDUSCIENCE Jurnal SOLMA Jurnal Ilmu Kedokteran dan Kesehatan Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Abdi: Media Pengabdian Kepada Masyarakat Muhammadiyah Medical Journal Indonesian Journal of Biomedicine and Clinical Sciences Sanus Medical Journal
Permata Sari, Shinta Dewi
Faculty Of Medicine, Universitas Muhammadiyah Prof. DR. HAMKA
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 18 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 18 Documents
Search

 1   2 
Drug Alternative Approach Through Comparative Study of Antibacterial Effect of Curcumin and Andrographolide Against Salmonella enterica serovar Typhimurium Kirani, Elisa Safa; Sari, Shinta Dewi Permata; Kurnia, Achdi; Rahmadi, Agus
Muhammadiyah Medical Journal Vol 5, No 2 (2024): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.5.2.122-129

Abstract

Background: Salmonella typhimurium is a pathogen that causes gastroenteritis with a broad host range. Several studies reported antimicrobial resistance against S. Typhimurium. The inappropriate use of antibiotics exacerbates the issue of drug resistance. Indonesian natural products, curcumin, a polyphenol derived from turmeric, and andrographolide from Andrographis paniculata, have shown antibacterial activity due to their various health benefits. These natural products are potential candidates for alternative therapy in S. Typhimurium infection to evade antibiotic resistance. Purposes: This study aims to compare the effectiveness of the antibacterial activity of curcumin and andrographolide against S. Typhimurium. Methods: This study design was true experimental. The curcumin (500 μg/mL, 1000 μg/mL, 5000 μg/mL) and andrographolide (10 μg/mL, 100 μg/mL, 1000 μg/mL) were tested for their antibacterial effects against S. Typhimurium using the Kirby-Bauer diffusion method. Chloramphenicol was used as a positive control, and DMSO was used as a negative control. Inhibition zone bacteria with curcumin treatment compared to andrographolide treatment to assess the effectiveness of the antibacterial activity. Results: Various concentrations of curcumin and andrographolide inhibit the growth of S. Typhimurium bacteria. The highest average of S. Typhimurium inhibition zone was 9 mm and 9.67 mm, with doses of 500 μg/mL curcumin and 1000 μg/mL andrographolide. The andrographolide inhibition zone is larger than curcumin at 1000 µg/mL. These findings showed the potential of andrographolide as a natural antibacterial agent against S. Typhimurium. However, chloramphenicol inhibition zone is still highest between andrographolide and curcumin group doses. Conclusion: Andrographolide has a more effective antibacterial effect against S. Typhimurium than curcumin at 1000 µg/mL based on inhibition zone diameter results. However, chloramphenicol is still more effective as an antibacterial agent against S. Typhimurium.
UPAYA PENINGKATAN PEMAHAMAN PENCEGAHAN INFEKSI : PADA GURU DAN WALI MURID SD MUHAMMADIYAH 3 KOTA TANGERANG Pudyastuti, Erlina; Permata Sari, Shinta Dewi; Ardhya Yahya, Teuku Jilan; Tasbita, Kayla Taza
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol. 10 No. 2 (2025): JURNAL ABDI : Media Pengabdian Kepada masyarakat
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/abdi.v10i2.35975

Abstract

Drastic climate change and poor air quality in several large cities contribute to the incidence of infectious diseases, especially ARIs. Preventing infection can be done to break the chain of spread of ARI, especially in children. Parents and teachers play a vital role in preventing childhood ARI. Therefore, it is necessary to increase the knowledge of infection prevention among parents and teachers. This community service activity was conducted by educating teachers and parents of students at SD Muhammadiyah 3 and SMK Muhammadiyah on infection prevention. The knowledge of the participants was evaluated by pre-test and post-test. The average score from pre-test to post-test showed an increase of 28%. Therefore, it can be concluded that there is an increase in knowledge after the training so that teachers and parents can play an active role in preventing and breaking the chain of transmission of infectious diseases in the school environment. Keywords: acute respiratory infection, education, infectious disease, air quality
Computational study of active compounds of Citrullus lanatus Linn peel extract as potential antidiabetics Sari, Shinta Dewi Permata; Budiman, Muhamad Arif; Ningsih, Sri Suciati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.14518

Abstract

Diabetes mellitus (DM) is one of the metabolic diseases that have emerged as a global health problem. Type 2 diabetes mellitus (T2DM), which affect 90-95% of DM, is caused by reduced insulin sensitivity and insulin resistance in peripheral tissues. Oral antidiabetics have resulted side effects, prompting an investigation for a natural-based antidiabetic agent as an alternative treatment. Using network pharmacology, we investigated the mechanism of phytochemical substances of Citrulus lanatus Linn. peel extract and their interactions with target proteins in the DM pathogenesis pathway. Cytoscape 3.6.1 software has created a network of extract compound-protein targets. Investigation of protein interaction, target gene function enrichment, and signal pathway performed via DAVID, STRING database, and the KEGG pathway database. The computational study identified 90 target proteins associated with T2DM based on protein-protein interactions. In addition, Cytoscape analysis and DAVID enrichment revealed the network of extract compound's target and generated proteins such as INS, TNF-α, IL-6, and AKT2. The KEGG pathway analysis presented the crucial role of insulin resistance and AGE-RAGE signaling pathways. This pathway correlated with lower glucose activity in obesity and hyperglycemia. It indicates that the active constituents of C. lanatus Linn peel extract can lower blood sugar levels by interacting with selected proteins. This study's findings will be carried out in further research of in vitro trials.
Synergistic Anti-inflammatory Activity of Tinospora crispa L. and Zingiber officinale: A BSA Assay Study Dewi, Sari Puspita; Kurnia, Achdi; Permata Sari, Shinta Dewi; Budiman, Muhamad Arif
Sanus Medical Journal Vol. 7 No. 1 (2025)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v7i1.20514

Abstract

Ginger rhizome (Zingiber officinale) and Tinospora crispa L. (Tinospora crispa L.) extracts contain various active compounds that have the potential to be anti-inflammatory agents. This study aims to evaluate the anti-inflammatory activity of ginger rhizome and Tinospora crispa L. leaf extracts, both singly and in combination, using the BSA test method. Extraction was carried out using the maceration method with 70% ethanol solvent. Anti-inflammatory activity tests were carried out in vitro at 75, 100, and 150 μg/mL concentrations by measuring the extract's ability to prevent heat-induced BSA denaturation. The yield of Tinospora crispa L. extract reached 41.39% and that of ginger extract 25.63%. The combination of 150 μg/mL extracts showed the highest anti- inflammatory activity (96.82%) of all the extract test samples. In comparison, the lowest anti-inflammatory activity was found in 75 μg/mL ginger extract, at 89.21%. Statistical tests showed a significant difference between the 75 μg/mL ginger extract and the 150 μg/mL combination (p=0.047). The combination of ginger and Tinospora crispa extract has the potential to be developed as a natural anti-inflammatory agent.
Growth Inhibition Effect of Syzygium aromaticum Ethanol Extract on Methicillin-Resistant Staphylococcus aureus Kamila, Tsabita Rana; Syahniar, Rike; Indriyani, Indriyani; Sari, Shinta Dewi Permata
Muhammadiyah Medical Journal Vol. 6 No. 2 (2025): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.6.2.68-79

Abstract

Background: MRSA is the leading cause of death caused by antimicrobial resistance. The distribution of MRSA occurs globally, and the incidence rate is around 30 per 100,000 people per year. Cloves had antimicrobial properties that were tested in both resistant and susceptible clones. Purpose: To determine the growth inhibition effect of clove flower ethanol extract on the growth of Methicillin-Susceptible Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA). Methods: This research uses an experimental design. Clove extract will be analyzed using gas mass chromatography-spectrometry (GC-MS). MSSA isolate was taken from S.aureus ATCC 25913, and MRSA  was taken from nasal swabs. The concentrations of the ethanol extract of cloves used are 20%, 40%, 60%, 80%, and 100%. All ethanol extract concentrations from cloves will be tested using the Kirby-Bauer disc diffusion technique. The magnitude of the barrier zone determines the antibacterial properties. Results: The results of the GC-MS analysis showed three main antibacterial compounds, including eugenol, phenol, and caryophyllene. The average inhibitory zones of the antibacterial test at concentrations of 20%, 40%, 60%, 80%, and 100% clove flower ethanol extract against MSSA were 16 mm, 16.33 mm, 17.67 mm, 18.33 mm, and 18.33 mm, respectively. The results of the average calculation of the inhibition zone in MRSA according to each concentration of clove flower ethanol extract were 11 mm, 12 mm, 13 mm, 14.33 mm, and 15.67 mm. Conclusion: Cloves have antibacterial properties, as confirmed by studies showing a zero zone in the MSSA and MRSA antibacterial sensitivity test, with the best concentration being 100% ethanol extract. The study's results show that the antibacterial effect of cloves affects MSSA more than MRSA.
Sedative Effects of Intraperitoneal Diazepam in Mice Vania, Marsha; Sari, Shinta Dewi Permata; Siswitono, Bambang; Stujanna, Endin Nokik
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital.Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and diazepam group. Two tests were performed on these group: the traction Test and the Fireplace Test. Pupillary diameter was also observed.Results: A significant difference based on the Kruskal - Wallis statistical test was observed between the positive control and the diazepam group (<0.05) in the traction test, which was also true for the fireplaced test (p<0.05). The pupillary diameter in the test animals in the positive control and diazepam group was not statistically significant (p>0.05).Conclusion: Diazepam has a better sedative effect than Phenobarbital. The sedative effect produced by Diazepam is stronger, with faster onset and longer half-life than the Phenobarbital the positive control. However, different test methods and comparisons should be sought to support this conclusion.
Gambaran Duplex Sonography Plak Arteri Karotis Pada Pasien Stroke Iskemik Hakim, Syiffa Rellya; Fredy, Felix Chikita; Sari, Dewi Novita; Sari, Shinta Dewi Permata
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 12 (2025): Volume 12 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i12.20941

Abstract

Stroke iskemik, sering dikaitkan dengan plak aterosklerotik di arteri karotis. Evaluasi plak arteri karotis yang akurat sangat penting untuk diagnosis dan penanganan stroke iskemik yang tepat waktu. Sonografi dupleks, modalitas pencitraan non-invasif, telah muncul sebagai alat yang berharga dalam menilai plak arteri karotis dan potensinya untuk menyebabkan kejadian emboli. Penelitiian ini bertujuan untuk memberikan gambaran Plak arteri karotis pada pasien stroke iskemik dengan bantuan duplex sonography. Penelitian ini menggunakan desain studi kasus dan pemeriksaan non-invasif dengan sonografi dupleks. Penelitian ini dilakukan di RSUD Cibinong, Bogor, dan melibatkan dua kasus yang didiagnosis stroke iskemik yang memiliki plak pada arteri karotisnya. Visualisasi sonografi dupleks B-Mode karotis pada Kasus 1 menunjukkan plak stabil pada bifurkasi dekstra, dengan IMT 2 mm. Di sisi lain, Kasus 2 menunjukkan adanya plak tidak stabil pada bifurkasi dekstra dan sinistra, dengan IMT 2 mm. Pada kasus 2 terdapat riwayat hipertensi dan kebiasaan merokok berat. Kedua faktor risiko tersebut memungkinkan pasien memiliki plak tidak stabil. Kedua pasien sama-sama memiliki plak, namun kedua plak tersebut belum menimbulkan stenosis. Kedua pasien memiliki jenis plak yang berbeda; kasus 1 memiliki plak yang stabil, sedangkan kasus 2 memiliki plak yang tidak stabil. Lokasi plak pada kedua pasien ditemukan di arteri bifurkasi. Sonografi dupleks merupakan alat yang andal untuk menilai plak karotis pada pasien dengan stroke iskemik karena bersifat non-invasif, hemat biaya, dan mudah dilakukan.
The Spectrum of Severity: Clinical and Hematological Markers in Jakarta’s COVID-19 Patients Listiyaningsih, Erlin; Sari, Shinta Dewi Permata; Martalena, Dewi; Sukarya, Wawang
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/660

Abstract

Jakarta, a densely populated megacity with high hybrid immunity, presents a unique epidemiological landscape for COVID-19. Understanding the clinical and hematological markers in this context is vital for improving clinical management. This study aims to analyze the clinical and hematological profiles of COVID-19 patients in Jakarta to identify markers associated with disease severity. This cross-sectional study analyzed secondary data from 100 confirmed COVID-19 patients (26 mild, 54 moderate, 20 severe) at two Jakarta hospitals. ANOVA and Kruskal-Wallis tests were employed to compare variables across severity groups, while categorical variables were analyzed using Chi-square tests. Significant associations with increasing severity were found for higher HR and RR. Among hematological parameters, basophil levels decreased significantly with higher severity. Although not statistically significant, trends of decreasing lymphocytes and platelets, alongside increasing blood glucose and neutrophils, were observed. Diabetes was the most prevalent comorbidity in severe cases. In conclusion, HR, RR, and basophils roles as significant markers of COVID-19 severity in our population. Trends in lymphocyte, thrombocyte, blood glucose, and diabetes prevalence, align with known patterns of severe disease with insignificant statistically, due to sample size limitations.
Co-Authors Alfina Septiasari Ardhya Yahya, Teuku Jilan Asysyifa, Nurul Budiman, Muhamad Arif Claudia, Regita Almira Dewi Martalena Dewi Martalena Dewi Martalena Dewi Novita Sari Endin Nokik Stujanna ERLIN LISTIYANINGSIH Erlin Listiyaningsih Erlin Listiyaningsih Fredy, Felix Chikita Gitrif Qonsolanisota Hakim, Syiffa Rellya Indriyani Indriyani Irena Ujianti Kamila, Tsabita Rana Kirani, Elisa Safa Kurnia, Achdi Mawanti, Wening Tri Muhamad Arif Budiman Pudyastuti, Erlina Rahmadi, Agus Rido Dawami Rike Syahniar Rini Latifah Rizkyana Avissa Rizkyana Avissa Rizkyana Avissa Roito Elmina Gogo Harahap Safitri, Yolanda Sari Puspita Dewi, Sari Puspita Siswitono, Bambang Sri Suciati Ningsih Sri Suciati Ningsih Stujanna, Endin Nokik Sukarya, Wawang Tasbita, Kayla Taza Tasya Alleandra Vania, Marsha Wawang S Sukarya Wawang S. Sukarya Wening Tri Mawanti Wening Tri Mawanti