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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JMM (Jurnal Masyarakat Mandiri) JURNAL FARMASIMED (JFM) Majalah Farmasetika Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Journal of Fundamental and Applied Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan dr. Soebandi Prosiding Seminar Nasional Unimus Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JPEMAS: Jurnal Pengabdian Kepada Masyarakat Journal of Community Research and Engagement
Fransisca Dita Mayangsari
Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Lamongan, Jawa Timur, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Evaluation of Skin Irritation Level and Effectiveness of Foot Sleeping Mask Containing Tengkawang Fat in Nanostructured Lipid Carriers System Fidayanti, Ayu; Mayangsari, Fransisca Dita; Pratiwi, Elasari Dwi
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2608

Abstract

One of the export commodities from the Non-Timber Forest Products (NTFP) group is tengkawang fruit. This fruit can be processed into fat which has properties similar to cocoa butter. The advantage of this fat compared to cocoa butter is that the price is relatively cheaper. However, the use of tengkawang fat in cosmetics is not widely known. Therefore, researchers are interested in developing cosmetic products based on tengkawang fat to treat xerosis of the feet. To increase occlusivity, tengkawang fat is formulated into an NLC (Nanostructured Lipid Carriers) system. In this research, a foot sleeping mask product was made containing NLC tengkawang fat with the addition of gel (to improve viscosity) and sweet orange oil (to improve aroma). The aim of this research was to determine the irritation skin level and effectiveness of moisturizing the skin of the soles of the feet from a foot sleeping mask containing NLC tengkawang fat. The results of the physical characteristics test show that the foot sleeping mask made meets the desired specifications. The results of skin irritation tests with 35 panelists showed that there was no redness or edema on the panelists' skin during 24, 48 and 72 hours of observation. The results of the moisture effectiveness test showed that the average moisture content of the soles of the panelists' feet on day 0 was 34.531%, while on day 28 (4 weeks) it was 42.815%. There was an increase in humidity of 8.284% during 4 weeks of use. The conclusion of this research is that a foot sleeping mask containing Tengkawang fat NLC can increase the moisture of the skin of the soles of the feet by 8.284% during 4 weeks of use.
Comparison of Continuous Percolation and Ultrasound-Assisted Extraction (UAE) Methods on Total Phenolic Content of 70% Ethanol Extract of Purslane (Portulaca oleracea L.) Aditya Sindu Sakti; Fransisca Dita Mayangsari; Sri Bintang Sahara Mahaputra Kusuma Negara; Elasari Dwi Pratiwi; Sandrawati
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/dxzsgc71

Abstract

Background: Portulaca oleracea L., commonly known as Krokot, is rich in phenolic compounds with notable pharmacological benefits. Optimizing extraction methods is critical to maximize its bioactive potential. Objective: This study aimed to compare the efficiency of Continuous Percolation (CP) and Ultrasound-Assisted Extraction (UAE) in obtaining total phenolic content (TPC) from 70% ethanol extract of P. oleracea. Methods: Dried powdered P. oleracea was subjected to CP and UAE using a 1:10 (w/v) plant-to-solvent ratio. Qualitative screening with FeCl₃ confirmed the presence of phenolics. TPC was quantified using the Folin–Ciocalteu method, expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis included normality testing, Levene’s test, and the Mann–Whitney U test. Results: UAE yielded significantly higher TPC (420.04 ± 0.40 mg GAE/g) compared to CP (354.30 ± 0.00 mg GAE/g; p = 0.034), although CP produced a higher extract mass. Statistical results confirmed the superiority of UAE in selectively extracting phenolic constituents. Conclusion: UAE is more effective than CP in extracting phenolic compounds from P. oleracea, likely due to enhanced cavitation-induced mass transfer. This method is recommended for maximizing phenolic recovery in plant-based extractions, especially for thermolabile compounds.
Nanostructured Lipid Carrier (NLC) Based Gel as Patchouli Oil Delivery : Physical Characteristic and In Vivo Skin Irritation Test Mayangsari, Fransisca Dita; Aditya Sindu Sakti; Merry Anggelya Mentari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vc33d509

Abstract

Patchouli oil (PO) contained patchoulol, which has antioxidant activity, making it a valuable ingredient in anti-aging products. However, this oil is volatile and chemically unstable. Therefore, it needs to be formulated into a Nanostructured Lipid Carriers based gel (NBG). This study aims to observe the effect of PO’s concentration on the physical characteristics and skin irritation of NBG preparations. NBG consists of 50% NLC and 50% gel. There are three formulas observed in this study, namely NBG-0 (0% PO), NBG-2 (2% PO), NBG-4 (4% PO). NLC prepared using the High Shear Homogenization method. Based on the physical characteristics test, it is known that all formulas have differences in the aroma aspect, where NBG-0 odorless, while NBG-2 and NBG-4 have a patchouli scent. All formula do not have differences in color and consistency. All formula have a pH in the range of 5.92 - 6.21. Statistically, increasing the concentration of PO decreases the pH of NBG. The three formulas have a viscosity in the range of 4.493 - 9.880 cP. Statistically, viscosity of NBG increasased by increasing concentration of PO. Based on in vivo skin irritation tests using white mice, it is known that all formulas have the same IIP (Primary Irritation Index) value. Based on the study, it can be concluded that the concentration of PO (0%, 2%, 4%) affects the aroma, pH and viscosity aspects but does not affect the color and consistency of NBG. Increasing the PO concentration in NBG up to 4% did not cause skin irritation.
Co-Authors ABDUL ROKHMAN Adhimi, Cici Sayyidatul Adinda Rakhmawati Aditya Sindu Sakti Afrianti, Diah Laili Dwi Anugrahayu Harsart, Yully Arrofiqi, Mochammad Rasyad Arrohmah, Nabilah Asyalafia Aula Nurwanda, Friska Selsabillah Azmy, Dymas Zahruddin Azwar Mirza Al Fath Diah Laili Dwi Afrianti Dianda Aryntya Firia Ferlania Dwi Pratiwi, Elasari Dymas Zahruddin Azmy Elasari Dwi Pratiwi ELASARI DWI PRATIWI, ELASARI DWI Emilia Rahmawati Fadhilah, Indi Ulul Faricha Maf'ula Fidayanti, Ayu Habibatur Rohmah Hilda Rohadatul Aliyah I Ketut Suada Imtiyaaz, Moh Thaariq Zelda Indi Ulul Fadhilah Khusnul Khotimah khusnul khotimah Kumala Sari, Diah Indah Kusumo, Djati Wulan Lailiyah, Qurrotul Melinda, Sinta Oktavia Merry Anggelya Mentari MIFTAKHUL JANNAH Muhammad Arendra Ardiansyah Muhammad Nurul Fadel Noorma Rosita Nurin, Eka Filza Primanitha Ria Utami Primanitha Ria Utami Putri Gita Ayu Safitri PUTRI WULANDARI Rakhmawati, Adinda Rizka Amalia Fachriani Rohmah, Habibatur Sakti, Aditya Sindu Sandrawati Sari, Diah Indah Kumala Setianingsih, Elfrida Rosselly Siti Mutamimah, Siti Sri Bintang Sahara Mahaputra Kusuma Negara Sri Bintang Sahara Mahaputra Kusumanegara Tristiana Erawati Uswatun Khasanah Utami, Primanitha Ria Widji Soeratri Yulia Retno Agustin Zahro Aisyi Khaddah Zuhri, Mukhammad Syaifuddin Zurotul Muarifah