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All Journal JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Syntax Literate: Jurnal Ilmiah Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Prima Medika Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) International Journal Of Science, Technology & Management (IJSTM) Jurnal EduHealth Journal of Health Research Science Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP) Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences.
Wienaldi, Wienaldi
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Bakteri Endofit Pinang Sebagai Penghasil Antioksidan dan Inhibitor α-Glukosidase Balkis, Tiara; Fachrial , Edy; Wienaldi, Wienaldi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1090

Abstract

Introduction: Diabetes mellitus is a chronic metabolic disorder with a high global prevalence and serious complications. The prediabetes stage is a critical target for prevention, often managed with α-glucosidase inhibitors. However, synthetic drugs such as acarbose are frequently associated with gastrointestinal side effects, highlighting the need for safer alternatives. Endophytic microbes from medicinal plants, including areca nut (Areca catechu), have the potential to produce bioactive compounds with antioxidant and antidiabetic activities. Objective: This study aimed to explore endophytic bacteria from fresh areca nut seeds as a source of metabolites with antioxidant and α-glucosidase inhibitory activity. Methods: Fresh areca nut seeds were sterilized using the surface sterilization method, followed by endophytic bacterial isolation and Gram staining. Cultures were fermented in Nutrient Broth, and supernatants were obtained by centrifugation. Antioxidant activity was assessed using the DPPH method, while α-glucosidase inhibition was tested in vitro with p-nitrophenyl α-D-glucopyranoside as substrate. Acarbose served as the positive control. Results: Seven Gram-negative, rod-shaped endophytic isolates (BP1-BP7) were obtained. Isolate BP1 exhibited the highest antioxidant activity with 45.7% inhibition. Furthermore, the BP1 supernatant demonstrated potent α-glucosidase inhibitory activity up to 93,6%, comparable to that of acarbose (91%). Conclusion: Endophytic bacteria from areca nut seeds possess dual bioactivity as antioxidants and α-glucosidase inhibitors, suggesting their potential as sustainable alternative antidiabetic agents worthy of further investigation.
Hubungan Kualitas Tidur dengan Indeks Massa Tubuh (IMT) di Fakultas Kedokteran Universitas Prima Indonesia Angkatan Tahun 2022 Mahani, Yensielia; Wienaldi, Wienaldi; Fachrial, Edy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62564

Abstract

Kualitas tidur yang buruk dapat memengaruhi keseimbangan metabolik tubuh dan berdampak pada perubahan Indeks Massa Tubuh (IMT). Mahasiswa kedokteran merupakan kelompok yang rentan mengalami gangguan tidur akibat beban akademik yang tinggi dan pola hidup tidak teratur. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas tidur dengan Indeks Massa Tubuh (IMT) pada mahasiswa Fakultas Kedokteran Universitas Prima Indonesia angkatan tahun 2022. Jenis penelitian ini adalah kuantitatif dengan metode analitik cross-sectional. Data dikumpulkan melalui kuesioner Pittsburgh Sleep Quality Index (PSQI) untuk menilai kualitas tidur serta pengukuran berat dan tinggi badan untuk menentukan IMT. Jumlah sampel sebanyak 178 mahasiswa yang dipilih dengan metode total sampling. Analisis data dilakukan menggunakan uji Chi-Square dan uji Cramer’s V dengan bantuan program SPSS. Hasil penelitian menunjukkan bahwa 94 responden (52,8%) memiliki kualitas tidur baik dan 84 responden (47,2%) memiliki kualitas tidur buruk. Mayoritas responden memiliki IMT normal sebanyak 113 orang (63,5%), sedangkan 29 orang (16,3%) tergolong obesitas. Uji Chi-Square menghasilkan nilai p < 0,001 yang menunjukkan adanya hubungan signifikan antara kualitas tidur dengan IMT, dengan kekuatan hubungan sedang (Cramer’s V = 0,492). Kesimpulan penelitian ini adalah semakin buruk kualitas tidur seseorang, semakin tinggi kecenderungan mengalami peningkatan IMT.
The Effect of Laughter Therapy, a Low-Salt Diet, Exercise, and Physical Activity on Reducing Blood Pressure in Elderly Patients at the Sei Kepayang Timur Community Health Center, Asahan Regency RAngelin Purba, Rona; Wahyuni Nasution, Sri; Wienaldi, Wienaldi
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.502

Abstract

Hypertension is a common health problem among the elderly and carries a risk of increasing cardiovascular complications. Non-pharmacological efforts such as laughter therapy, a low-salt diet, exercise, and physical activity are important strategies in controlling blood pressure. This study aims to analyze the effectiveness of laughter therapy, a low-salt diet, exercise, and physical activity on reducing blood pressure in elderly patients at the Sei Kepayang Timur Community Health Center in Asahan Regency. The study used a quasi-experimental design with a pre-test and post-test control group approach. The number of respondents was 60 elderly people who were divided equally into an intervention group of 30 people and a control group of 30 people. Data were analyzed using comparative statistical tests (paired t-test and chi-square test) with a significance level of p < 0.05. The results showed that in the intervention group, there was a decrease in mean systolic blood pressure from 150.2 mmHg to 135.4 mmHg, with a difference of 14.8 mmHg (p = 0.000), and a decrease in diastolic blood pressure from 93.2 mmHg to 84.4 mmHg, with a difference of 8.8 mmHg (p= 0.000). Other interventions, including a low-fat diet, exercise, and physical activity, were also shown to be effective in reducing both systolic and diastolic blood pressure. In conclusion, laughter therapy, a low-salt diet, exercise, and physical activity are effective in reducing blood pressure in the elderly. Based on these study results, the elderly are advised to regularly engage in laughter therapy, maintain a low-salt diet, and increase physical activity and exercise. Health institutions need to integrate this non-pharmacological intervention program into promotive and preventive services. Future research is expected to examine long-term effectiveness and expand the sample size.
Application Of Consumption Method With Eoq, Mmsl Forecasting And Abc-Ven Analysis In Pharmaceutical Briefing Management In Hospitals General Royal Prima Marelan Afni Kartika, Ajeng; Girsang, Ermi; Wienaldi, Wienaldi; Novalinda Ginting, Chrismis
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.850

Abstract

Hospitals should plan for drug needs using accountable methods to avoid empty drugs. Good drug planning can improve pharmaceutical stock control in hospitals. The purpose of this study was to find out about the application of consumption methods with EOQ, MMSL and ABC-VEN forecasting in the management of pharmaceutical supplies in hospitals. This study used retrospective mix-method data, quantitative data and qualitative primary data. The research was conducted at RSU Royal Prima Marelan. The results showed that drug supply control using the EOQ method of getting drugs reordered: cefixime 200MG ordered at 447, ondacetron 4MG 740, gabapentin 300MG 706, ranitidine 25MG 1467, novorapid flexpen / 5" 42. In the SS method, the number of drugs available at delivery, cefixime 200MG should be 627 drugs at the time of shipment, ondacetron 4MG should be 522, gabapentin 300MG should be 470, ranitidine 25MG should be 940, and novorapid flexpen/5" should be 26. In the ROP method the drug was reordered at cefixime 200MG it was reordered when the stock was 447 and the quantity ordered was 12027, ondacetron 4MG 740 and 10000, gabapentin 300MG 706 and 9020, ranitidine 25MG 1467 and 18040, novorapid flexpen 42 and 502. In the ABC method, group A as many as 59 types 70.59% with a total investment of 70.59% drug use and an investment value of IDR 606,511,106, group B 64 drug investment 20.33% investment 20.33% drug use investment 174,722,327, group C 146 types (9.08%) investment 9.08% drug use and investment 78,028,263.
Quality Analysis Of Nursing Services Towards Internal Disease Inpatient Satisfaction At The Prima Indonesia Royal Hospital During The Covid-19 Pandemic Of 2021 Jonathan Samuel Gultom, Andre; Wienaldi, Wienaldi; Sari Mutia, Maya; Napiah Nasution, Ali
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.04 KB) | DOI: 10.51601/ijhp.v3i1.138

Abstract

The Covid-19 pandemic has caused a decrease in the number of patient visits and changes in service procedures for patients being treated to prevent transmission of Covid-19. This has an impact on decreasing patient satisfaction with service quality which includes physical evidence, reliability, responsiveness, assurance, and empathy. The purpose of this study was to analyze the quality of nursing services on the satisfaction of internal medicine inpatients during the Covid-19 pandemic. This research is a quantitative analytic study with a crosssectional approach. The research was conducted at the Royal Prima Hospital, Medan. Theresearch population was 285 people, the sample obtained was 166 people. Sampling by purposive sampling. Data analysis was univariate, bivariate with a chi-square test, and multivariate with multiple logistic regression at a 95% confidence level (α = 0.05). The results showed that the quality of nursing services affected the satisfaction of inpatients for internal medicine at the Royal Prima Hospital Medan during the Covid pandemic including physical evidence (p = 0.000), and reliability (p = 0.008), responsiveness (p = 0.001), and assurance. (p=0.000). While the factor that has no effect is empathy (p = 0.959). The physical evidencevariable (tangibles) is the most dominant variable affecting the satisfaction of internal medicine inpatients during the Covid-19 pandemic with a value of Exp(B)/OR = 13,773. Patients who stated good physical evidence had a 13.7 times higher chance of being satisfied than patients who stated poor physical evidence
A microbiological analysis of coliform bacteria in street food around Universitas Prima Indonesia, Medan Davin, Radhitya Qowiyyul; Fachrial, Edy; Wienaldi, Wienaldi
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.8083

Abstract

Background: Street foods, particularly fried snacks, are highly popular among university students due to their convenience and affordability. However, the safety of such foods is a public health concern, as they are susceptible to contamination by coliform bacteria, which can cause gastrointestinal illnesses such as diarrhea. This study aimed to analyze the total coliform bacteria in fried snacks sold around the Universitas Prima Indonesia campus area in Medan as an indicator of food safety. Methods: This descriptive laboratory study analyzed fried snack samples of two types (rissole and filled tofu) collected from six street vendors on Jalan Ayahanda, Medan. Samples were obtained using a simple random sampling technique, resulting in a total of 12 samples. The presence of coliform bacteria was determined using the Most Probable Number (MPN) method with a 3-3-3 tube series, which included a presumptive test using Lactose Broth (LB) medium. Data were analyzed descriptively by comparing results with the standard set by the Indonesian Ministry of Health Regulation No. 2 of 2023 (maximum permissible limit <3.6 MPN/gram). Results: All 12 samples tested negative in the presumptive test, indicated by the absence of gas bubbles in the Durham tubes after 48 hours of incubation. The MPN value for all samples was <3 MPN/gram, confirming they met the required safety standard (<3.6 MPN/gram). Conclusion: Fried snacks sold around the Universitas Prima Indonesia campus were free from coliform bacterial contamination and are considered safe for consumption based on current regulations. Factors such as the high-temperature deep-frying process (>150°C) and adequately maintained vendor sanitation practices likely contributed to the absence of contamination.
Co-Authors Adrian Adrian Afni Kartika, Ajeng Angnes, Odri Aulia, Hilda Rafni Balkis, Tiara Br. Sitorus, Irma Yeni Chailur, Muhammad Chandra, Dody Cristoffel, Abraham Darmadi, Suhartina Davin, Radhitya Qowiyyul Edy Fachrial Elisabeth Elisabeth Fioni, Fioni Ginting, Chrismis Novalinda Girsang, Ermi Harta Winata, Jaya Hati Harefa, Lurusan Jonathan Samuel Gultom, Andre Lestari Nasution, Sri Mahani, Yensielia Manalu, Angelia Tesalonika Mawarni Marthin Simbolon, Boyke Napiah Nasution, Ali Nazar Syahputri, Iskandar Oetari, Widyaningsih Pardianto, Gede Purba, Greace Hasianna RAngelin Purba, Rona Riza Al Djoefri, Mohamad Santy Deasy Siregar Sari Mutia, Maya Selviana Barus, Shella Sidabutar, Mitra Juniaty Sinurat, Buenita Siregar, Hernita Sitompul, Fernades Sri Lestari Ramadhani Nasution Suandy, Suandy Suhartina Suhartina, Suhartina Wahyuni Nasution, Sri Widhiasi, Lia Kristiani Willim, Devannie Alberta