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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Heca Journal of Applied Sciences Malacca Pharmaceutics Indonesian Journal of Case Reports Journal of Innovative and Creativity
Earlia, Nanda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Dermatological Presentations in Systemic Lupus Erythematosus: A Comprehensive Case Study Earlia, Nanda; Salim, Fitria; Hidayati, Arie; Pradistha, Aldilla; Ibrahim, Teuku Maulana Malik; Azzahra, Shelda Syifa; Maulidina, Rizka Yuliani
Indonesian Journal of Case Reports Vol. 2 No. 2 (2024): December 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i2.188

Abstract

Lupus erythematosus (LE) is an inflammatory autoimmune disease with a broad clinical spectrum of multi-organ inflammation and can be life-threatening. Manifestations of LE can occur confined to the skin (cutaneous lupus erythematosus, CLE) or systemic involving several organs such as the kidneys, heart, and lungs (systemic lupus erythematosus, SLE). We report a female, 27-year-old with complaints of black spots on her back, stomach area, hands, and feet. The patient feels that the spots increase when doing activities outside the home. Patients also complain of fever, pain when swallowing, joint pain, fatigue, and hair loss. Dermatological status in the abdominal, posterior thoracic, and extremities regions shows the presence of macules accompanied by hyperpigmented patches with unclear borders, irregular edges, gutta-plaque size, multiple numbers, and atypical arrangement and configuration. In the ANA profile examination, the native SS-A antigen (60 kDa) +++ results were strongly positive. The examination results concluded CLE type Subacute CLE (SCLE). The patient was given Calcium Carbonate capsules, Folic Acid tablets, and Methylprednisolone tablets. Topical medications include tretinoin 0.25% cream, momethasone 0.1% cream, Desoximethasone 0.25% cream, clobetasol propional 0.05% cream, and must use Sunscreen morning and evening. After 2 weeks, the patient showed good results. The black spots are starting to fade. Other complaints, such as fever, fatigue, and pain when swallowing, have decreased. Cutaneous lupus can be a challenge to treat because the symptoms are varied and complex. Management of CLE aims to eliminate symptoms and signs of the disease, prevent damage from occurring, minimize side effects of drugs, and improve quality of life.
Skin Changes in Iatrogenic Cushing’s Syndrome: A Detailed Case Analysis Earlia, Nanda; Maulida, Mimi; Vella, Vella; Pradistha, Aldilla; Wisesa, Wizurai; Razaq, Abdur; Ikram, Tubagus Pasca Faiz; Rahmatillah, Muhammad Zahrul; Farsa, Bianda Sabrina; Alghani, Fajri
Indonesian Journal of Case Reports Vol. 2 No. 2 (2024): December 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i2.243

Abstract

Cushing's syndrome can lead to various skin complications. Iatrogenic Cushing's syndrome is a condition caused by excessive exogenous glucocorticoid exposure. This case report presents a patient with a history of Cushing's syndrome and long-term corticosteroid use who developed multiple skin manifestations. A 20-year-old male presented with erythematous purulent lesions on the face, neck, chest, and back. Concurrently, the patient developed purplish-red striae on the chest, abdomen, arms, and legs. Physical examination revealed erythematous nodules and pustules, along with atrophic striae. Laboratory tests showed leukocytosis with a left shift and hypokalemia. Radiological investigations revealed lumbar spondylosis and cardiomegaly. The patient was treated with a combination therapy, including topical and systemic medications, and showed significant improvement in skin lesions. This case highlights the importance of a comprehensive evaluation for patients presenting with unusual skin lesions. A thorough history, physical examination, and laboratory investigations are crucial to identify underlying conditions and initiate appropriate treatment.
Formulation and Antibacterial Activity of Averrhoa bilimbi L. Fruits Extract in Vegetable Oil-Based Liquid Hand Soap Hayati, Rima; Sari, Amelia; Hanum, Faridah; Nabilah, Nada; Earlia, Nanda; Lukitaningsih, Endang
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.35

Abstract

The main method of preventing infections is good hand cleanliness. Bilimbi (Averrhoa bilimbi) fruits contains flavonoids, which have been tested for antibacterial activity. Polar chemicals like flavonoids are often extracted using ethanol as a solvent.  Therefore, this study aimed to formulate an ethanol extract of A. bilimbi fruits in the form of hand soap. This formulation used vegetable oils such as olive oil, coconut oil, and castor oil, which are high in fatty acids to maintain healthy skin. Antibacterial activity was carried out against Staphylococcus aureus and Escherichia coli. The extract was prepared by maceration for 5 days using an ethanol solvent. Liquid soap contained A. bilimbi fruit extracts at 5% (F1) and 10% (F2). The F1 and F2 organoleptic tests showed the preparation as a thick liquid with a distinctive coconut oil aroma, light brown (F1) and brown (F2) color. pH values of 5.8 (F1) and 5.6 (F2). Foam height stability was 71.5% (F1) and 73.1% (F2). The specific gravity for the two formulas was 1.02 g/mL. The viscosity of F1 and F2 was 137.6 cP and 163.5 cP, respectively. Inhibition power against S. aureus using the agar diffusion method by measuring the diameter of the inhibition zone showed strong (F1) and very strong (F2) categories The inhibition against S. aureus showed strong (F1) and very strong (F2) categories. While F1 has no inhibitory power against E. coli, F2 showed inhibition in the strong category. Based on our research, it can be concluded that A. bilimbi fruit extract can produce good hand soap and have bacteria-inhibiting activity. However, further formula development is still needed to obtain preparations that meet all the requirements and stability tests.
Psoriasis severity assessment: Optimizing diagnostic models with deep learning Maulana, Aga; Noviandy, Teuku R.; Suhendra, Rivansyah; Earlia, Nanda; Prakoeswa, Cita RS.; Kairupan, Tara S.; Idroes, Ghifari M.; Subianto, Muhammad; Idroes, Rinaldi
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1512

Abstract

Psoriasis is a chronic skin condition with challenges in the accurate assessment of its severity due to subtle differences between severity levels. The aim of this study was to evaluate deep learning models for automated classification of psoriasis severity. A dataset containing 1,546 clinical images was subjected to pre-processing techniques, including cropping and applying noise reduction through median filtering. The dataset was categorized into four severity classes: none, mild, moderate, and severe, based on the Psoriasis Area and Severity Index (PASI). It was split into 1,082 images for training (70%) and 463 images for validation and testing (30%). Five modified deep convolutional neural networks (DCNN) were evaluated, including ResNet50, VGGNet19, MobileNetV3, MnasNet, and EfficientNetB0. The data were validated based on accuracy, precision, sensitivity, specificity, and F1-score, which were weighted to reflect class representation; Pairwise McNemar's test, Cochran's Q test, Cohen’s Kappa, and Post-hoc test were performed on the model performance, where overall accuracy and balanced accuracy were determined. Findings revealed that among the five deep learning models, ResNet50 emerged as the optimum model with an accuracy of 92.50% (95%CI: 91.2–93.8%). The precision, sensitivity, specificity, and F1-score of this model were found to be 93.10%, 92.50%, 97.37%, and 92.68%, respectively. In conclusion, ResNet50 has the potential to provide consistent and objective assessments of psoriasis severity, which could aid dermatologists in timely diagnoses and treatment planning. Further clinical validation and model refinement remain required.
Ekstravasasi Kemoterapi Akibat Cisplatin Dan 5-Fluorourasil : Laporan Kasus Lestari, Wahyu; Hajar, Sitti; Earlia, Nanda; Fitria, Fitria
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.418

Abstract

   Ekstravasasi kemoterapi adalah infiltrasi terapi antikanker sistemik yang tidak disengaja ke dalam jaringan subkutan atau subdermal di sekitar lokasi injeksi. Manifestasi klinis dapat terjadi segera atau beberapa waktu setelah pemberian obat kemoterapi. Secara klinis terjadi iritasi pembuluh darah, iskemik vaskular, dan akhirnya menyebabkan nekrosis pada kulit. Dilaporkan adanya kasus ekstravasasi akibat kemoterapi dengan cisplatin dan 5-fluorourasil (5-FU). Keluhan yang dialami adalah bercak merah disertai dengan bintik merah yang nyeri pada beberapa bagian tubuh setelah mendapat kemoterapi yang diinjeksikan pada lengan bawah kanan. Lesi kulit muncul setelah beberapa hari mendapat obat kemoterapi. Secara klinis terlihat papul eritema pada pipi kanan, leher kiri dan kanan, dan plak eritema linier dengan ukuran bervariasi, dan papul eritema yang tersebar di sekitarnya. Pasien diberi terapi dengan kortikosteroid potensi sedang selama 1 minggu dan tampak lesi mengalami perbaikan. Terapi spesifik untuk kasus ekstravasasi akibat kemoterapi belum ada, yang paling utama penentuan lokasi, kanula dan prosedur penyuntikan secara tepat sehingga risiko terjadinya ekstravasasi dapat dicegah. 
PERAN ANTIOKSIDAN PADA MELASMA Sari, Ninda; Earlia, Nanda; Maulida, Mimi
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.479

Abstract

   Melasma adalah kelainan hipermelanotik didapat, biasanya terjadi pada perempuan dengan jenis kulit yang lebih gelap. Sejumlah faktor pemicu melasma antara lain genetik, pajanan sinar ultraviolet (UV), dan hormon seks perempuan. Patofisiologi melasma tidak terbatas pada melanosit; penelitian saat ini menunjukkan bahwa keratinosit, sel mast, regulasi gen yang menyimpang, neovaskularisasi, dan gangguan membran basal saling barkaitan. Sinar UV sebagai agen utama diyakini memicu reactive oxygen species (ROS) melalui stimulus melanogenesis dan mengaktifkan oksida nitrat terinduksi. Melasma sulit diobati dan cenderung kambuh setelah pengobatan karena patofisiologinya yang kompleks. Antioksidan telah digunakan dalam pengobatan melasma untuk mengurangi melanogenesis akibat sinar UV, karena fungsinya sebagai penetral dan penghambat pembentukan ROS. 
Coexistence of Psoriasis Vulgaris and Systemic Lupus Erythematosus: A Rare Clinical Case Earlia, Nanda; Zulfan, Zulfan; Pradistha, Aldilla; Asrizal, Cynthia Wahyu; Yoo, Soo-Ji; Wisesa, Wizurai; Abdurrazaq, Abdurrazaq; Ikram, Tubagus Pasca Faiz; Ismida, Fitri Dewi; Murtadha, Raihan; Zuhra, Sofi Alfia; Ramadhani, Cut Sukma
Indonesian Journal of Case Reports Vol. 3 No. 1 (2025): June 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i1.278

Abstract

Psoriasis vulgaris is a chronic skin inflammation characterized by the appearance of clearly limited erythematous plaques, along with rough, thick, and silvery-white scales. Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease with diverse clinical manifestations and can involve one or more organs. This case report presents a patient with Psoriasis Vulgaris with SLE. A 47-year-old woman presented with erythematous plaque lesions with thick scales and some hyperpigmentation, numerous, plaque-sized lesions with regional distribution on the scalp, right and left cubital areas, gluteal, left tibia, and yellow unguium dyschromia was seen on the distal lateral aspect, solitary on the right 3rd digit. Histopathological examination found typical Psoriasis Vulgaris. The patient was diagnosed with Psoriasis Vulgaris. In 2022, the patient was diagnosed with SLE and received Hydroxychloroquine sulfate therapy. The patient was treated with a combination therapy including methotrexate (MTX) and topical medications. This case highlights the importance of comprehensive evaluation for Psoriasis Vulgaris therapy with a previous history of SLE and the choice of treatment in patients with the coexistence of PV and SLE.
Dermagistry: Sistem Registri Penyakit Dermato Alergo-Imunologi : Dermagistry: Dermatology Allergy-Immunology Disease Registry System Earlia, Nanda; Hidayati, Arie; Bulqiah, Mikyala; Agustyananda, Dedi
Journal of Medical Science Vol 6 No 2 (2025): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v6i2.224

Abstract

Penyakit dermato alergo imunologi merupakan penyakit kulit yang ditandai dengan keterlibatan sistem imunitas. Penyakit ini merupakan penyakit kulit dan kelamin yang cukup banyak diderita oleh pasien dan mendominasi keluhan penyakit kulit pada umumnya. Saat ini, kebutuhan akan data sangat penting. Data penting digunakan untuk keperluan klinis, penemuan obat hingga untuk data epidemiologi sehingga dibutuhkan suatu sistem registri.  Disease Registry System (DRS) adalah sistem dengan standar data tentang populasi pasien yang telah ditentukan sebelumnya berdasarkan penyakit atau kondisi yang sama yang dikumpulkan, dianalisis, dan dilaporkan secara berkelanjutan. Tujuan penelitian ini adalah untuk terciptanya sistem registri penyakit dermato alergo imunologi berbasis web-aplikasi. Penelitian ini observasional analitik dengan desain kohort prospektif dengan penggunaan teknologi sistem registri (WebApp). Telah berhasil dibuat portal Web-Aplikasi Sistem Registri Dermato Alergo-Imunologi telah selesai dan dapat digunakan dengan nama “Dermagistry (https://dermagistry.id/). Melalui portal ini diharapkan data pasien dapat disimpan dengan baik dan dapat dimanfaatkan untuk data baik untuk penelitian dan pelayanan.
Scabies with Predilection Athypical in Elderly Patients : A Case Report Zulfan, Zulfan; Earlia, Nanda; Fitria, Fitria; Lestari, Wahyu; Zakaria, Sri Rezeki
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Scabies is an infectious skin disease caused by Sarcoptes scabiei infestation that is often found in vulnerable populations such as the elderly. In the elderly, clinical manifestations are often atypical and do not follow classic predilection patterns, which can cause delays in diagnosis and therapy. A 69-year-old woman presented with chronic itching of the perianal area since the last two months accompanied by skin thickening and rough surface. Physical examination showed papules confluent into erythematous plaques with lichenification in the perianal region. KOH skin scraping examination confirmed the presence of Sarcoptes scabiei mites. The patient was diagnosed with scabies with chronic lichen simplex due to repeated scratching. Therapy was given in the form of 5% permethrin cream, oral antihistamines (cetirizine), and topical corticosteroids to reduce inflammation, along with hygiene education and simultaneous treatment of family members. Scabies in the elderly may show atypical predilections, including the buttocks, face, or scalp areas. Decreased cellular immunity, physiological skin changes and comorbid factors influence susceptibility and clinical manifestations. Late diagnosis risks increasing the parasite burden and triggering complications. This case emphasizes the importance of clinical vigilance against atypical manifestations of scabies in the elderly. Early diagnosis, laboratory confirmation, and comprehensive management including patient and family education play an important role in preventing complications and recurrences
Co-Authors . Zulfan Abdurrazaq Abdurrazaq, Abdurrazaq Agustyananda, Dedi Alghani, Fajri Amelia Sari Asnawi, Vella asrizal, cynthia wahyu Athira, Athira Azzahra, Shelda Syifa Badiri, Istanul Bulqiah, Mikyala Dinillah, Teuku Muhammad Muizzy Doris , Ezigbo E. Dwiyana, Reiva F. Elfa Wirdani Fitri Endang Lukitaningsih Farsa, Bianda Sabrina Fitria Fitria Gondokaryono, Srie P. Handriani, Risna Hanum, Faridah Hayati, Rima hidayati, Arie Hizir Sofyan Husdayanti, Noviana Ibrahim, Teuku Maulana Malik Idroes, Ghazi M. Idroes, Ghifari M. Ikram, Tubagus Pasca Faiz Ismida, Fitri Dewi Kairupan, Tara S. Liana, Mahda Rizki Maghfirah, Karamina Maulana, Aga Maulida, Mimi Maulidina, Rizka Yuliani Menul Ayu Umborowati, Menul Ayu Mikyal Bulqiah, Mikyal Muhammad Subianto Murtadha, Raihan Nabilah, Nada Niode, Nurdjannah Jane Noviandy, Teuku R. NUR FAJRINA Nurdjannah J. Niode Pradistha , Aldilla Pradistha, Aldilla Prakoeswa, Cita RS. Rahmatillah, Muhammad Zahrul Ramadhani, Cut Sukma Razaq, Abdur Reno Keumalazia Kamarlis Rinaldi Idroes Salim, Fitria Sari, Ninda Sasmita, Novi Reandy SITTI HAJAR Suhendra, Rivansyah Sulamsih Sri Budini, Sulamsih Sri Suryadi Suryadi Tasrif, Aqil Yuniawan Teuku Rizky Noviandy Vella Vella, Vella Vemulen, Dara Avinda Wahyu Lestari Wisesa, Wizurai Yoo, Soo-Ji Zakaria, Sri Rezeki Zuhra, Sofi Alfia