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FORMULASI GEL KOMBINASI EKSTRAK KERING LIDAH BUAYA (Aloe vera. (L) brum. f.) DAN EKSTRAK KENTAL DAUN SIRIH MERAH (Piper crocatum ruiz & pav) UNTUK ANTIBAKTERI PENYEBAB JERAWAT . Suhaimi; Teti Indrawati; Shirly Kumala
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Ekstrak kering lidah buaya dan ekstrak kental daun sirih merah mengandung senyawa alkaloid, flavonoid, tanin, saponin dan fenol yang mempunyai aktivitas sebagai antibakteri penyebab jerawat. Penelitian ini bertujuan untuk memformulasi sediaan gel antibakteri penyebab jerawat kombinasi ekstrak lidah buaya dan ekstrak kental daun sirih merah yang stabil secara fisik, kimia dan mikrobiologi serta memiliki efektivitasnya. Formulasi gel kombinasi esktrak kering lidah buaya dan ekstrak kental dan sirih merah sebanyak 4 formula menggunakan gelling agent, carbophol serta bahan tambahan lainnya. Sediaan yang dihasilkan dievaluasi dan diuji aktivitasnya. Evaluasi sediaan meliputi pemeriksaan organoleptis, homogenitas, uji kemampuan menyebar, viskositas, sifar alir, pH dan uji mikrobiologi. Uji aktivitas meliputi pertumbuhan terhadap bakteri Propionibacterium acnes dan Staphylococcus aureus. Hasil evaluasi didapatkan formula terbaik yaitu formula 1 yang mengandung 1,56 % kombinasi ekstrak kering lidah buaya dan ekstrak kental daun sirih merah kemudian di uji stabilitas pada suhu kamar (25-30oC) dan suhu 60oC selama 3 minggu. Hasil uji stabilitas menunjukan tidak ada perbedaan yang signifikan selama penyimpanan.

UJI AKTIVITAS PENYUBUR RAMBUT GEL KOMBINASI EKSTRAK AIR TEH HIJAU DAN HERBA PEGAGAN Lela Sulastri; Teti Indrawati; Shely Taurhesia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 4 No 1 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Rambut sehat mempunyai siklus pertumbuhan rambut yang panjang dan kelembaban yang cukup dimana pertumbuhan rambut terjadi karena sel-sel daerah matriks atau umbi rambut secara terus menerus membelah. Bahan alam yang diperkirakan berpotensi dalam pertumbuhan rambut adalah daun teh hijau (Camellia sinensis (L) OK) dan herba pegagan (Centella asiatica (L) Urban). Dalam penelitian ini ekstrak air daun teh hijau 5% dan herba pegagan 2,5% diformulasikan dalam sediaan gel penyubur rambut dengan gelling agent carbophol 940 0,5%, 1% dan 1,5 %. Penelitian ini bertujuan mengetahui apakah ekstrak air daun teh hijau 5% dan herba pegagan 2,5% dapat diformulasikan menjadi sediaan gel dan apakah gel yang mengandung kombinasi ekstrak tersebut mempunyai aktivitas sebagai penyubur rambut dan formula manakah yang memiliki aktivitas penyubur rambut yang paling optimum. Uji aktivitas penyubur rambut meliputi laju pertumbuhan rambut, percepatan pertumbuhan rambut dan bobot rambut. Hasil penelitian menunjukkan Campuran ekstrak air daun teh hijau 5 % dan ekstrak air herba pegagan 2,5% dengan gelling agent carbophol 940 0,5%, 1% dan 1,5% dapat dibuat menjadi sediaan gel yang baik, dan yang memiliki aktifitas optimum adalah gel penyubur rambut yang menggunakan gelling agent carbophol 0,5 % dengan karakteristik warna coklat, aroma yang khas, homogen, nilai konsistensi 585,886 dyne/cm2, viskositas 90.333 cps, sifat aliran plastis tikstropik, pH 5,56 , laju pertumbuhan 1,804 cm dalam 28 hari percepatan pertumbuhan rambut 0,1201 cm/hari dan bobot rambut 0,0858 gram dalam 28 hari.

Formulasi Gel Pengelupas Sel Kulit Mati yang Mengandung Sari Buah Nanas (Ananas comosus L) antara 17 sampai 78% TETI INDRAWATI; FINA ZISSAKINA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.764 KB)

The juice of Ananas comosus L. contains bromelain which has been known to defoliate dead skin cells. Investigation on five gel formulations containing 17%, 33%, 50%, 67% and 78% of the juice of Ananas comosus L with 4% of HPMC as gelling agent, have been carried out. The stability of all formula were examined by the accelerated test method at room temperature and 40 oC for 6 weeks. Parameters observed were organoleptic, homogeneity, syneresis, viscosity, flow behavior, spreading ability, and pH. Results indicated that the higher the juice concentration in the gel would reduce the gel stability progressively. Gel formula using 4% of HPMC containing 17% or 33% of Ananas comosus juice can be produced while maintaining good physical stability for 6 weeks. The products were pale yellow to yellow in color, homogeneous, and have viscosity of 13000-45800 cps, pH 4.0-4.9, pseudo plastic flow, and spreading ability of 2732.58 to 4534.16 mm².

Pengembangan Pewarna Rambut dari Ekstrak Kental Gambir (Uncaria gambir Roxb.) dalam Sediaan Setengah Padat LATIRAH LATIRAH; TETI INDRAWATI; ANNY VICTOR PURBA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Gambier (Uncaria gambir Roxb.) is one of the alternatives used as a natural colouring agent in foods and drinks. The aim of this research was to develop extract gambier as a hair dye. Gambier extract was obtained by macerated with water in base condition (pH 8-10). The resulting extract was evaluated for hair adhesion, organoleptic, physical, chemical and irritation test to rabbit’s skin. Viscous gambier extract has 0HUE value of 338.73 ± 0.116 (purple), can be processed into permanent hair colour cream with 0HUE value of 42.167 ± 0.231 (red), pH 8, ammoniac odor, produce red yellowish hair with 0HUE value of 53.43 ± 0.060, fulfil requitment for microbiology, not iritant to rabbit's skin has density of 0.903 0.006 g/L and viscosity of 13,100 ± 0.000 cP.

UJI AKTIVITAS KOMBINASI EKSTRAK KERING LIDAH BUAYA (Aloe vera. (L) brum. f.) DAN EKSTRAK KENTAL DAUN SIRIH MERAH (Piper crocatum ruiz & pav) UNTUK ANTIBAKTERI PENYEBAB JERAWAT Suhaimi Suhaimi; Teti Indrawati; Shirly Kumala
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Ekstrak kering lidah buaya dan ekstrak kental daun sirih merah mengandung senyawa alkaloid, flavonoid, tanin, saponin dan fenol yang mempunyai aktivitas sebagai antibakteri penyebab jerawat. Penelitian ini bertujuanUntuk menentukan konsentrasi ekstrak kering lidah buaya (Aloe vera (L) brum f), untuk menentukan ekstrak kental daun sirih merah (Piper crotacum ruiz dan pav) mempunyai daya hambat ter terhadap bakteri Propionibacterium acnes dan Staphylococcus aureus penyebab jerawat dan untuk menentukan konsentrasi kombinasi ekstrak kering lidah buaya (Aloe vera (L) brum f) dan ekstrak kental daun sirih merah (Piper crotacum ruiz dan pav)mempunyai daya hambat terterhadap bakteri Propionibacterium acnes dan Staphylococcus aureus penyebab jerawat.Tahap-tahap penelitian yaitu determinasi tanaman lidah buaya dan daun sirih merah, pembuatan ekstrak, pemeriksaan ekstrak meliputi organoleptik, pH, uji skrining fitokimia serta pengujian aktivitas masing-masing ekstrak kering lidah buaya dengan konsentrasi 10%, 15%, 20%, 25%, 30% dan 35%, ekstrak kental daun sirih merah dengan konsentrasi 25%, 12,5%, 7,16%, 3,13%, 1,78% dan 0,78% serta kombinasi ekstrak kering lidah buaya dan ekstrak kental daun sirih merah dengan konsentrasi 50%, 25%, 12,5%, 7,16%, 3,13%, dan 1,56 terhadap bakteri Propionibacterium acnes dan Staphylococcus aureus. Kombinasi ekstrak kering lidah buaya dan ekstrak kental daun sirih merah memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus pada konsentrasi 1,56 % dan Propionibacterium acne pada konsentrasi 3,13 Kata kunci : Lidah buaya, daun sirih merah, Propionibacterium acnes, Staphylococcus aureus. ABSTRACT Dried aloe vera extract and thick red betel leaf extract contains alkaloid compounds, flavonoids, tannins, saponins and phenols that have activity as an antibacterial cause of acne. The aim of this study was to determine the concentration of Aloe vera (L) brum f) extract, to determine the thick red betel leaf extract (Piper crotacum ruiz and pav) to have the inhibitory effect against the bacteria Propionibacterium acnes and Staphylococcus aureus causes acne and to determine the concentration of Aloe vera (L) brum f) and red thick betel leaf extract (Piper crotacum ruiz and pav) have inhibitory effect on bacteria Propionibacterium acnes and Staphylococcus aureus cause acne. The research stages are the determination of aloe vera and red betel leaf, extract preparation, extract examination including organoleptic, pH, phytochemical screening test and activity test of dry aloe vera extract with concentration 10%, 15%, 20%, 25% , 30% and 35%, thick red betel leaf extract with concentration of 25%, 12.5%, 7.16%, 3.13%, 1.78% and 0.78%, and combination of aloe vera extract and viscous extract red betel leaves with concentrations of 50%, 25%, 12.5%, 7.16%, 3.13%, and 1.56 against the bacteria Propionibacterium acnes and Staphylococcus aureus. The combination of dry extract of aloe vera and thick red betel leaf extract have antibacterial activity against Staphylococcus aureus bacteria at concentration 1.56% and Propionibacterium acne at concentration 3,13 %. Keywords: aloe vera, red betel leaf extract, Propionibacterium acnes, Staphylococcus aureus

Pengembangan Sediaan Gel Antijerawat Kombinasi Ekstrak Herba Meniran (Phylanthus niruri L) dan Ekstrak Daun Sirsak (Annoni muricata L) Dimas Adrianto; Shirly Kumala; Teti Indrawati
Jurnal sosial dan sains Vol. 1 No. 11 (2021): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Jerawat (Acne vulgaris) merupakan penyakit inflamasi kronik yang terjadi pada unit pilosebaseus. Infeksi dapat disebabkan oleh Propionibacterium acne dan Staphylococcus aureus. Daun sirsak dan Herba meniran diketahui dapat menghambat pertumbuhan jerawat dan mampu membunuh bakteri. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan gel kombinasi kedua ekstrak dalam menghambat pertumbuhan bakteri penyebab jerawat (Propionibacterium acne dan Staphylococcus aureus), melakukan analisa parameter fisik, kimia dan stabilitas sediaan pada suhu dan waktu penyimpanan, serta uji iritasi akut dermal terhadap kelinci. Masing-masing ekstrak dilakukan uji aktivitas antibakteri terhadap bakteri uji dengan metode difusi cakram dengan konsentrasi 50%; 25%; 12,5%; 6,25%; 3,0%; 1,5%; 0,75%, kontrol positif (klindamisin) dan kontrol negatif (DMSO). Selanjutnya dilakukan pengukuran zona hambat dan penetapan konsentrasi zona hambat minimum dari kedua ekstrak. Kombinasi ekstrak diformulasi dalam sediaan gel dengan eksipien Na-CMC, Gliserin, Propilenglikol, Phenoxyetanol, dan Aquadest. Uji aktivitas antibakteri sediaan gel menggunakan metode cakram dengan kontrol positif gel mediklin. Evaluasi sediaan gel meliputi parameter fisik, kimia dan mikrobiologi. Hasil penelitian menunjukkan bahwa sediaan gel kombinasi herba meniran dan daun sirsak memiliki aktivitas terhadap bakteri P. acne dan S. aureus pada konsentrasi 4,5% dan 3,0% termasuk kategori kuat. Formula gel dapat memenuhi parameter fisik dan kimia serta stabil terhadap suhu 4oC, 27oC, 40oC dan waktu penyimpanan selama 12 minggu. Hasil indeks iritasi primer diperoleh sebesar 0,40 (kategori respon sangat ringan).

ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.) Aprilia Fatma Ely; Shelly Taurhesia; Teti Indrawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.809

Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity and good physical stability. This study included an experimental research. The research population was in the form of antibacterial compounds in face toner. The sample was green tea kombucha, which showed antibacterial activity at a concentration of 50% with an 18 mm Diameter of Inhibition Zone (DIZ). And the best formula is F1 with 0.84 mm DIZ, has a pH of 4 which is safe for the skin, clear solution, has clean power, it is also stable during storage at 30o and 40oC, but it has a rather disagreeable scent of toner. Keywords: Acne, Antibacterial, Green Tea Leaves Kombucha, Face Tone

FORMULASI GEL KOMBINASI EKSTRAK KERING LIDAH BUAYA (Aloe vera. (L) brum. f.) DAN EKSTRAK KENTAL DAUN SIRIH MERAH (Piper crocatum ruiz & pav) UNTUK ANTIBAKTERI PENYEBAB JERAWAT . Suhaimi; Teti Indrawati; Shirly Kumala
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v3i2.67

Ekstrak kering lidah buaya dan ekstrak kental daun sirih merah mengandung senyawa alkaloid, flavonoid, tanin, saponin dan fenol yang mempunyai aktivitas sebagai antibakteri penyebab jerawat. Penelitian ini bertujuan untuk memformulasi sediaan gel antibakteri penyebab jerawat kombinasi ekstrak lidah buaya dan ekstrak kental daun sirih merah yang stabil secara fisik, kimia dan mikrobiologi serta memiliki efektivitasnya. Formulasi gel kombinasi esktrak kering lidah buaya dan ekstrak kental dan sirih merah sebanyak 4 formula menggunakan gelling agent, carbophol serta bahan tambahan lainnya. Sediaan yang dihasilkan dievaluasi dan diuji aktivitasnya. Evaluasi sediaan meliputi pemeriksaan organoleptis, homogenitas, uji kemampuan menyebar, viskositas, sifar alir, pH dan uji mikrobiologi. Uji aktivitas meliputi pertumbuhan terhadap bakteri Propionibacterium acnes dan Staphylococcus aureus. Hasil evaluasi didapatkan formula terbaik yaitu formula 1 yang mengandung 1,56 % kombinasi ekstrak kering lidah buaya dan ekstrak kental daun sirih merah kemudian di uji stabilitas pada suhu kamar (25-30oC) dan suhu 60oC selama 3 minggu. Hasil uji stabilitas menunjukan tidak ada perbedaan yang signifikan selama penyimpanan.

ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.) Aprilia Fatma Ely; Shelly Taurhesia; Teti Indrawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.809

Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity and good physical stability. This study included an experimental research. The research population was in the form of antibacterial compounds in face toner. The sample was green tea kombucha, which showed antibacterial activity at a concentration of 50% with an 18 mm Diameter of Inhibition Zone (DIZ). And the best formula is F1 with 0.84 mm DIZ, has a pH of 4 which is safe for the skin, clear solution, has clean power, it is also stable during storage at 30o and 40oC, but it has a rather disagreeable scent of toner. Keywords: Acne, Antibacterial, Green Tea Leaves Kombucha, Face Tone

Review: Pemanfaatan Nanosains dan Nanoteknologi untuk Meningkatkan Efektivitas Obat Indrawati, Teti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 2 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i2.1682

Science and nanotechnology in the pharmaceutical field, among others, are used to increase drug effectiveness and optimal safety. The research was conducted using the review method with the aim of this study to obtain information about the utilization of nanoscience and nanotechnology which can be used as reference material for development in the pharmaceutical field. Nano-drug delivery system technology is carried out by developing materials used both from natural origin, synthetic, and semi-synthetic as well as developing drug delivery systems. Nano-drug delivery system technology or known as smart drugs promises a very bright future through various modifications of drug dosage forms developed from conventional dosage forms to dosage forms with drug delivery systems with controlled drug release. Nano-drugs with nano-delivery systems can be made using carriers in the form of natural polymers, or synthetic ones that can be biodegradable or non-biodegradable. Efficient therapy using nanotechnology is carried out in order to increase the safety level of the drug, as well as the ability of the drug to reach its target with minimal side effects. There are three ways to do this: increasing the solubility and bioavailability of drugs, creating new dosage forms, and using better routes of administration. Nanotechnology has great potential in contributing to the national economy and the nation's competitiveness, although much needs to be done to transform scientific and technological excellence into the economic field.

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