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Norhayati
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Religion Arts Humanities Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : MPI (Media Pharmaceutica Indonesiana)

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Pharmacokinetics and Toxicity Prediction of Lansium domesticum Corr. Rizaldi, Gusti; Norhayati
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6416

Abstract

A wide range of compounds has been isolated from Lansium domesticum Corr. Secondary metabolites are commonly utilised as valuable resources for potential drug for research and development. An exemplary drug candidate must possess efficacy against the therapeutic target, safety, and favourable pharmacokinetic characteristics. The objective of this study was to determine the pharmacokinetic characteristics and toxicity potentials of 23 compounds derived from Lansium domesticum Corr. utilising the pKCSM online tool and the drug-likeness using swissADME online tool. Based on pKCSM prediction, compounds 14 (methyl angolensate) and 22 (7,14(27)-Onoceradiene-3,21-dione) from Lansium domesticum Corr. are identified as having favourable pharmacokinetic properties and are not expected to exhibit mutagenic or hepatotoxic effects. The LD50 values for compounds 14 and 22 were 2.983 and 1.813 (mol/kg), respectively, indicating their lethal dosages. In conclusion, only compound 14 that also met all the Lipinski’s Rule of Five.
Co-Authors Abdurahman Abdurrahman Agung Prabowo Agustina, Fitria Sanova Ahmad Syauqi Fuady ANIDA Ariza, A. Firsa Bayu Pratama Nugroho Catharina Elmayantie Catharina Elmayantie, Catharina Chandra, M. Andi Diki Hidayat Elvine Ivana Kabuhung Haris, Ferdiyani Ichsan, Mochammad Ika Safitri Windiarti Irawan, Angga Jayanti, Elfa Muhammad Agus Syamsur Rijal Noorwina, Syifa Nuntufa Nur Mashani Mustafidah Nurul Amalia Putra, Christia Rahmah, Helena Rizaldi, Gusti Rosmiati Rusida, Esty Restiana Sam'ani Santoso Pakpahan, Herman Sherly Jayanti Sitanggang, Fransiska Sulistyowati Suparno Toyyibah, Wardah Ula, Ummi Mauliatul Warni Yusuf, Helmy