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All Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Farmanesia Journal of Innovative and Creativity Jurnal ABDIMAS MUTIARA JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
Chandra, Devina
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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PEMBUATAN TABLET EKSTRAK ETANOL SELEDRI (Apium graveolens L.) MENGGUNAKAN VARIASI UKURAN PARTIKEL GRANUL Chandra, Devina; Manik, Tumpak Rudi Aman; Frida Lina Br Tarigan
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 1 No. 1 (2019): JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

Latar belakang : Salah satu tumbuhan yang sering digunakan dalam pengobatan tradisional atau herbal adalah seledri ( Apium graveolens L), seledri mempunyai berbagai khasiat salah satunya adalah sebagai anti hipertensi, yang beredar dipasaran dalam bentuk sediaan kapsul dari ekstrak seledri. Peneliti ingin membuat sediaan tablet yang komponennya ekstrak. Tujuan : Untuk mengetahui pengaruh perbedaan ukuran partikel granul terhadap hasil evaluasi sediaan tablet ekstrak seledri ( Apium graveolens L.). Metode : Simplisia seledri dibuat menggunakan metode maserasi dengan etanol 96% sampai diperoleh ekstrak kental. Diencerkan dengan penambahan amilum manihot 1:3, pembuatan serbuk tablet dibuat dalam bentuk granul dengan berbagai variasi ukuran partikel dengan ukuran mesh nomor 20 dan mesh nomor 10 dan bahan pengikat yang berbeda yaitu amilum manihot dan gelatin. Hasil granul yang diuji preformulasi meliputi uji sudut diam granul, waktu alir, indeks tap. Tablet dicetak dan evaluasi keseragaman bobot, uji kekerasan fisik, uji friabilitas, uji waktu hancur. Hasil : Hasil yang diperoleh semua formula dengan variasi ukuran partikel granul dapat dicetak menjadi tablet dengan metode granulasi basah, dan Keempat formula memenuhi persyaratan tablet yang meliputi uji keseragaman bobot, uji kekerasan, uji friabilitas, uji waktu hancur. Pada uji evaluasi tablet formula 4 ( menggunakan mesh no 10 dengan bahan pengikat Gelatin) merupakan tablet terbaik dengan uji kekerasan dan uji friabilitas lebih baik dari formula lainnya. Kesimpulan: Ekstrak daun seledri dengan variasi ukuran partikel granul dapat dibuat menjadi sediaan tablet, dan perbedaan ukuran partkel granul mempengaruhi sifat fisik granul dan juga mempengaruhi hasil uji tablet ekstrak seledri( Apium graveolens L.) .
FORMULASI NANOKRIM EKSTRAK DAUN KATUK (Sauropus androgynus L.Merr.) SEBAGAI PELEMBAB KULIT Chandra, Devina; Rohana Sinaga, Taruli; Rudi Aman Manik, Tumpak; Kristiani Aruan, Tina
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 3 No. 1 (2021): JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Katuk (Sauropus androgynus (L.) Merr.) leaves have benefits for the human body to protect cell structure and work up vitamin C activity. Cream is a semi-solid preparation which contain one or more dissolved medicinal ingredients in a suitable base material and containing not less than 60% water. Nanocream has an easy, comfortable diffusion on the skin area and increases the absorption of active substances on the skin. This research aims to formulate 3% katuk leaf extract as a skin moisturizer in the form of nanocream preparations with a comparison using blanks (without extract) and Citra brand products. This research was conducted by using an experimental method. The research steps are plant identification, simplicity characterization, screening test, the sample was extracted by maceration for 5 × 24 hours using 80% ethanol solvent then the filtrate was evaporated by a vacuum rotary evaporator at approximately 500C for ±5 hours until a thick extract of katuk leaves was produced. The thick extracts of katuk leaves and blanks (without extract) were formulated in Nanocream preparation by using a high-shear emulsification method (high-shear stirring) using a mixer for 8 hours. Then the organoleptic test, homogeneity test, emulsion test, pH test, viscosity test, irritation test by using 6 volunteers with an age range of 20-30 years and humidity test by using 9 volunteers using a skin analyzer from before use to after use for 4 week. The results of the katuk leaf extract nanocream and blank nanocream (without extract) obtained were homogeneous, remained stable, the emulsion type was o/w, the irritation test did not cause skin irritation and the results of the moisture test were the preparation without extract (blank) from 21.3% to 40.1%, the preparation of katuk leaf extract 3% from 21.3% to 40.8% , and stock image products from 22.6% to 38.9%. The results of the analysis showed that the use of katuk leaf extract nanocream gave changes to dry skin conditions for the better and faster increase in water content in the skin so as to obtain a moisturizing effect on the skin.
FORMULASI SEDIAAN FACIAL WASH GEL EKSTRAK ETANOL DAUN AFRIKA (Vernonia amygdalina Del) SEBAGAI PELEMBAB Chandra, Devina; Lifiani, Rialita; Bemby Sinaga, Arman; Wilson Sembiring, Antonius
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 3 No. 1 (2021): JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Abstract

African leaves (Vernonia amygdalina Del) contain flavonoids that can provide antioxidant effectiveness fromflavonoids and also contain vitamins C and E. And its function is to neutralize free radicals. The purpose of this study was to formulate facial wash gel preparations from African leaf extract, as well as to identify and test the safety, quality, and benefits of the formulation preparations. This research method was carried out experimentally. African leaf ethanol extract was obtained by maceration using 96% ethanol extract which was then concentrated with a rotary evaporator at a temperature of 40oC, then formulated in facial wash gel preparations with concentrations of 1% (Formula 1), 3% (Formula 2), and 6% (Formula 3). Evaluation of facial wash gel preparations included organoleptic examination, pH test, homogeneity, stability, viscosity, spreadability, and foaming power. Irritation test and effectiveness test using a skin analyzer on the volunteer's facial skin, the parameters measured included water content and pore size, the treatment was carried out for 4 weeks. The results of this study indicate that the evaluation of facial wash gel preparations is well formulated and stable, African leaf extract is formulated as a facial wash gel that can provide effectiveness on the volunteer's facial skin, namely increasing moisture on the skin and decreasing pore size on the volunteer's facial skin for 4 weeks of use.
Variation of HPMC gelling agent concentrations in ethanol extract based setting spray of Goji Berry (Lycium barbarum L.) as a Moisturizer Chandra, Devina; Suryani, Monica; Simarmata, Yettrie; Napitupulu, Muhammad Irianto; Siburian, Erwina
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.6864

Abstract

The natural properties of the skin, which are constantly exposed to Ultraviolet (UV) rays and free radicals, can lead to various skin problems such as rashes, spots, and dryness. Natural antioxidants can provide moisturizing and brightening effects on the skin. One type of plant that contains natural antioxidants is goji berry (Lycium barbarum L.), which will be formulated into a gel-based setting spray with variations in the concentration of the HPMC gelling agent used as a moisturizer. This study aims to determine the effective concentration variations of the HPMC gelling agent that can be formulated into a gel setting spray preparation. This research used an experimental method consisting of sample collection, plant identification, sample processing, extract preparation, characterization tests, phytochemical screening, and formulation of the gel setting spray with variations of gelling agent concentrations of 0.1%, 0.2%, 0.3%, 0.4%, and 0.5%. The formulated products were then evaluated for quality, and moisturizing effectiveness. The results showed that the gel setting spray preparations were dark brown in color, had a characteristic fragrance, were homogeneous, and had a spreadability of 6.8533 to 5.6400 cm, viscosity ranging from 35,000 to 95,000 cPs, and pH values between 5.6500 and 3.7233. Moisture effectiveness on the skin increased over 4 weeks, ranging from 37.2% to 55.6%. In conclusion, variations in the concentration of HPMC gelling agent can be successfully formulated into a gel setting spray, and goji berry (Lycium barbarum L.) extract can be used as a moisturizer that meets the required physicochemical quality standards for a good gel setting spray preparation.
Formulasi dan Evaluasi Sediaan Body Scrub dari Ekstrak Etanol Daun Alpukat (Persea Americana Mill) Kombinasi Beras Ketan Putih (Oryza Sativa l Var Glutinous) Sebagai Pelembab Kulit Mairani, Fridelly; Izzani, Alya; Suryani, Monica; Chandra, Devina
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7141

Abstract

Masyarakat sekarang sangat mendambakan kecantikan yang alami salah satunya dengan memiliki kulit yang bersih dan lembab. Untuk mendapaktkan kulit yang sehat,bersih dan lembab masyarakat dapat menggunakan sediaan kosmetik Body scrub yang berasal dari bahan alam maupun sintetis. Body scrub dapat membantu menutrisi kulit dengan tambahan bahan-bahan yang diperoleh dari alam seperti tumbuh-tumbuhan. Salah satu kandungan kimia yang terdapat pada daun alpukat yaitu Quersetin tersebut dapat didefinisikan sebagai senyawa kelompok flavonol terbesar dan termasuk senyawa flavonoid yang paling efektif untuk dapat melembabkan kulit dan juga sebagai antioksidan yang dapat menangkal radikal bebas. Penelitian ini bertujuan untuk membuat sediaan Body scrub dari ekstrak etanol daun alpukat yang dapat melembabkan kulit. Metode yang digunakan dalam penelitian ini yaitu metode eksperimental. Pembuatan ekstrak etanol daun alpukat dengan cara ekstraksi metode maerasi dan menggunakan pelarut etanol 96%. Konsentrasi kandungan daun alpukat yang terkandung bervariasi yaitu, 3%, 5% dan 7%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun alpukat dapat diformulasikan kedalam sediaan Body scrub yang dapat melembabkan kulit, dan sediaan tersebut homogen, sediaan yang stabil uji pH yang dihasilkan 5,12-6,00. Sediaan Body scrub tidak menimbulkan iritasi pada kulit uji viskositas yang dihasilkan 2.573-3.334 cPs uji daya sebar rentan 5,76-5,93 cm uji tipe emulsi menunjkkan tipe M/A uji daya lekat yang dihasilkan 44-61 detik. Pada uji kelembaban konsentrasi 3%,5% dan 7% dapat melembabkan kulit, semakin tinggi konsentrasi ekstrak daun alpukat, semakin tinggi tingkat kelembaban yang di peroleh. Sediaan Body scrub F3 dengan konsentrasi 7% yang paling disukai (sangat suka) dikarenakan lebih dapat melembabkan kulit. Secara keseluruhan dapat disimpulkan bahwa ekstrak etanol daun alpukat dapat diformulasikan kedalam sediaan Body scrub dan memiliki kemampuan melembabkan kulit.
Co-Authors Aman Manik, Tumpak Rudi Anggraini, May Annisazikra, Cut Ariani, Ananda Bemby Sinaga, Arman Berutu, Nesli y.f Fitri, Raissa Fitria Frida Lina Br Tarigan Frida Lina Tarigan, Frida Lina Fridelly Mairani Apt Izzani, Alya Kristiani Aruan, Tina Lifiani, Rialita Manik, Tumpak Rudi Aman Marbu, Eva Diansari Monica Suryani Nanda, Farahlina Napitupulu, Muhammad irianto Pasaribu, Yusuf Gunawan Priltiu, Natanael Priltiu Priltius, Natanael Purba, Sondang Rohana Sinaga, Taruli Rudi Aman Manik, Tumpak Siburian, Erwina Silitonga, Evawani Martalena Silitonga, Maringan Simarmata, Yettrie Sitanggang, Berton Siti Maimunah Siti Nurbaya Sitorus, Panal Sri Wahyuni Suharyanisa Supartiningsih - - Tampubolon, Manuppak Irianto Tandiono, Steven Thaib, Cut Masyithah Wilson Sembiring, Antonius Zebua, Besti Eynzel