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All Journal Jurnal Farmanesia Journal of Innovative and Creativity Jurnal ABDIMAS MUTIARA Jurnal Medika STIKes Kesehatan Baru
Marpaung, Jon Kenedy
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Chemistry Computer Science & IT Education Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Social Sciences Other

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Journal : Journal of Innovative and Creativity

 1 
Effectiveness Test Of Green Betel Leaf Ethanol Extract Gel Preparation (Piper Betle L.) Against Pseudomonas Aeruginosa Bacteria Hutauruk, Dumartina; Marpaung, Jon Kenedy; Nurmela, Nuranti; Ginting, Jansen Asriel
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2056

Abstract

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium commonly associated with nosocomial infections, particularly in immunocompromised patients. Inappropriate use of antibiotics can lead to resistance, highlighting the need for safer and more effective alternative treatments. Green betel leaf (Piper betle L.) contains active compounds such as flavonoids, tannins, and saponins that exhibit antibacterial properties. This study aims to evaluate the effectiveness of an ethanol extract gel formulation of green betel leaves against the growth of Pseudomonas aeruginosa. The methods included ethanol extraction of betel leaves through maceration, formulation of gels with varying extract concentrations, and antibacterial activity testing using the disk diffusion method. The results showed that the ethanol extract gel was able to inhibit the growth of P. aeruginosa, with inhibition zones increasing along with higher extract concentrations. In conclusion, the ethanol extract gel of green betel leaves has potential as a natural antibacterial agent against Pseudomonas aeruginosa.
Antibacterial Activity Test Of Ethanolic Extract Patch Preparations From Noni Leaves (Morinda Citrifolia L.) Using The Zone Of Inhibition Against Staphylococcus Aureus And Staphylococcus Epidermidis Bacteria Musyaawarah, Yanti; Suharyanisa, Suharyanisa; Marpaung, Jon Kenedy; Marpaung, Aditiya Baginda
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2060

Abstract

Wounds occur when there is damage or loss of body tissue due to factors that interfere with the body's protective system and cause infection caused by Staphylococcus aureus and Staphylococcus epidermidis.Noni leaf (Morinda citrifolia L.) has strong potential as an antibacterial, so researchers are interested in formulating ethanol extract of noni leaf (EEDM) into a patch preparation. Objective: Knowing that EEDM can be formulated as a patch preparation, as well as knowing its antibacterial activity. Methods: Four formulas were made with variations in extract concentration, namely F0 (blank); FI : 5%; FII: 10%; and FIII: 15%. Antibacterial testing using disc paper diffusion method. Results: A clear patch preparation was produced in F0, while in FI, FII and FIII the gel was blackish green with a distinctive smell of EEDM. The results of the antibacterial activity test against Staphylococcus aureus in each formula are FI: 2.58 mm; FII: 2.35 mm; FIII: 2.41 mm, while against Staphylococcus epidermidis, FI: 1.46; FII: 2.28; FIII: 3.33. Conclusion: EEDM can be formulated into patch preparations. The antibacterial potential of the three formulas is in the weak category.
Co-Authors Adiansyah Adiansyah, Adiansyah Ahmad ghazali, Ahmad Ayu, Herti Dicky Yuswardi Wiratma Eka Margareta Sinaga Eriwaty Silalahi, Yosy Cinthya Fitri, Nadiatul Ginting, Jansen Asriel Girsang, Febriyantu Harefa, Karnerius Harun, Fatur Rahman Hutajulu, Johansen Hutauruk, Dumartina Komsary, Pauline Manik, Maria Partiwi Manurung, Kesaktian Marbun, Eva Diansari Mardianis, Mardianis Marpaung, Aditiya Baginda Munthe, Bernadetta R. Musyaawarah, Yanti Nasution, Pandapotan Nelson Simanjuntak Nurmela, Nuranti Purba, Yuni Kristina Purwandari, Vivi Silitonga, Maringan Simanjuntak, Amsal Wahyu Maralus Simbolon, Lampita Putri Sinarsi, Sinarsi Sipayung, Inri Priskila Sitanggang, Rolastri Siti Maimunah Siti Nurbaya Sitorus, Carlos Salinas Sitorus, Panal Sofwan, Ahmad Gazali Suharyanisa Suhendri, Martin Supartiningsih Supartiningsih - - Syahfitri, Novita Thaib, Cut Masyithah Tiara Pratiwi, Tiara Turnip, Icha Wahyuni Vevariantina, Ayu Yanti, Roma Devina Yosy Cinthya Eriwaty Silalahi Yudhistira Yudhistira Zai, Andi Kristian Faatulo Zuhairiah Nasution, Zuhairiah