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All Journal Jurnal Veteriner Jurnal Natur Indonesia Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Journal of Nutraceuticals and Herbal Medicine Molekul: Jurnal Ilmiah Kimia Pharmacy Reports Welfare: Jurnal Pengabdian Masyarakat
Hanif Nasiatul Baroroh
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats Baroroh, Hanif Nasiatul; Lesty, Rupa; Utami, Esti Dyah; Zulkepli, Nur Ayunie
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5789

Abstract

Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.
Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera Rachmani, Eka Prasasti Nur; Baroroh, Hanif Nasiatul; Rehana, Rehana; Rahmawati, Novia Ayu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5929

Abstract

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties. Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC). Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method. Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%. Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.
The effectiveness of N-acetylcysteine in alleviating clinical Symptoms of COVID-19 hospitalized patients at Santa Elisabeth Purwokerto General Hospital, Indonesia Ekowati, Heny; Nadzif, Faradina Qorina; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Baroroh, Hanif Nasiatul
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.7548

Abstract

Background: COVID-19 has been associated with increased innate immune system activation, leading to increased mucus production, inflammation, and tissue damage. N-Acetylcystysteine (NAC), an antioxidant and mucolytic, has demonstrated potential as a COVID-19 therapy. Objective: The purpose of this study was to evaluate the effectiveness of NAC on the clinical symptoms of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital in Indonesia. Methods: An observational analytical study design was employed, with data collected from the medical records of hospitalized COVID-19 patients at Santa Elisabeth Purwokerto General Hospital over the period of July 2020 to July 2021. The study included 209 patients who met the eligibility criteria. Results: The results indicated that the use of NAC affected the clinical symptoms of cough, oxygen saturation (SPO2), and respiratory rate in patients with mild and moderate degrees of COVID-19 patients (p<0.05). However, it was found not to affect patients with severe degrees of the disease (p>0.05). Conclusion: This study suggests that NAC may be a useful treatment option for patients with mild and moderate COVID-19. Further research is needed to confirm these findings and determine their effectiveness in severe cases.
Evaluation of natural compounds as VEGFR-2 inhibitors for breast cancer therapy: insights from molecular docking and drug-likeness analysis Aprilia, Vika; Sarmoko; Fareza, Muhamad Salman; Baroroh, Hanif Nasiatul; Choironi, Nur Amalia
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.82

Abstract

Breast cancer remains one of the most common cancers worldwide, with VEGFR-2 (KDR) playing a key role in tumor angiogenesis. Inhibiting VEGFR-2 is a promising therapeutic strategy. Natural compounds are increasingly studied for their potential to inhibit VEGFR-2. This study aims to assess the binding affinity of 11 natural compounds (andrographolide, alpha-mangostin, pinostrobin, pinocembrin, ethyl-p-methoxycinnamate (EPMS), xanthorrhizol, galangin, gamma-mangostin, curcumin, cinnamaldehyde, and alashanoid B) to the VEGFR-2 protein through molecular docking and Lipinski's rule analysis, identifying promising candidates for breast cancer treatment. Molecular docking simulations were performed for 11 compounds and sunitinib as a control, with binding energies and interactions analyzed. The compounds were also evaluated for drug-likeness using Lipinski’s rule of five. Curcumin showed the highest binding affinity to VEGFR-2 with a binding energy of -9.9 kcal/mol, surpassing sunitinib (-9.4 kcal/mol). Key interactions were observed with active site residues Cys919 and Asp1046. All tested compounds met the criteria for oral bioavailability per Lipinski’s rules. Curcumin demonstrates potential as a VEGFR-2 inhibitor due to its favorable binding affinity and drug-like properties. Enhancing curcumin’s bioavailability is recommended for effective therapeutic application.
Therapeutic Effects of Methylprednisolone on Clinical Symptoms in COVID-19 Patients at Dr. R. Goeteng Taroenadibrata Hospital Baroroh, Hanif Nasiatul; Hana, Rifa Khairunnisa; Ekowati, Heny
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.1

Abstract

COVID-19 is a respiratory syndrome disease in humans caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until now, treatment for COVID-19 has not been found. This study aimed to observed a therapeutic effect of methylprednisolone in COVID-19 patients. Medical records of COVID-19 patients at Dr. R. Goeteng Taroenadibrata Purbalingga Hospital were collected retrospectively as part of this descriptive observational study from October 2020 to September 2021. Utilizing the Wilcoxon and Sign Test, a statistical analysis was conducted to determine the therapeutic effect of methylprednisolone on variables such as temperature, respiratory rate, oxygen saturation, cough, and shortness of breath. A total of 132 patients met the inclusion criteria, with 87 patients in mild severity, 22 patients with moderate severity, and 23 patients with severe severity. The clinical symptoms of cough, dyspnea, RR values, and SpO2 improved when methylprednisolone was given to mild COVID-19 patients receiving treatment at RSUD Dr. R. Goeteng Taroenadibrata Purbalingga. Additionally, clinical symptoms related to cough, SpO2, and temperature parameters improved in patients with moderate severity; in contrast, breathlessness, respiratory distress, SpO2, and temperature parameters improved in patients with severe severity. In conclusion, Goeteng Taroenadibrata Hospital COVID-19 patients report improved clinical symptoms when receiving methylprednisolone.
Immunostimulatory Effects of Zingiber ottensii Rhizome Extract on Mouse Lymphocytes and Peritoneal Macrophages Baroroh, Hanif Nasiatul; Warsinah, Warsinah; Suryoputri, Masita Wulandari; Ekowati, Heny
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95105

Abstract

Zingiber ottensii (bangle hantu) is a member of the Zingiberaceae family, known for its pharmacological effects. Several studies have demonstrated immunomodulatory potential of Zingiberaceae rhizomes, including Zingiber officinale, Zingiber zerumbet, and Zingiber cassumunar. This study aimed to evaluate the immunomodulatory effects of Z. ottensii extract on mouse peritoneal macrophages and lymphocytes. The extract was prepared using a maceration method with 96% ethanol (1:6) and the extract compound was observed by phytochemical screening with thin layer chromatography (TLC). Phagocytotic macrophage activity was quantified using a phagocytotic assay, which use mouse peritoneal macrophages. Lymphocyte proliferation was assessed with the MTT assay and absorbance measured at 595 nm. TLC results, showed that Z. ottensii extract tested positive for flavonoids and terpenoids. The Z. ottensii extract stimulated macrophage phagocytosis activity, significantly increasing the phagocytotic index at 25 and 50 µg/mL concentrations compared to the control. Additionally, significant lymphocyte proliferation was observed with the treatment of the extract. The Z. ottensii extract may be developed for adjuvant therapy to enhance the immune responses, offering a promising natural approach to immunomodulation.
Optimalisasi Peran Sekolah dan Keluarga dalam Menumbuhkan Kesadaran Pengelolaan Sampah pada Anak Usia Dini Wasito, Hendri; Nuryanti, Nuryanti; Baroroh, Hanif Nasiatul; Utami, Vitis Vini Fera Ratna; Sholihat, Nia Kurnia; Hasan, Nahrul; Wahyudi, Ari; Sari, Suci Wulan
Welfare : Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2025): Welfare : June 2025
Publisher : Fakultas Ekonomi dan Bisnis Islam, IAIN Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/welfare.v3i2.2215

Abstract

Waste management remains a critical issue in schools due to low awareness of clean living and limited knowledge. This community service aimed to foster early waste awareness at Azalia Integrated Islamic Kindergarten using a Participatory Action Research (PAR) approach. Activities included initial observation, game-based education, teacher-parent training, improved educational tools, and mentoring. Evaluations through pre- and post-tests showed significant improvement in both student and parent understanding of waste sorting. The program cultivated a collective awareness of waste management and is expected to continue as part of a clean and healthy life.
Co-Authors . Harwoko ANISYAH ACHMAD Aprilia, Vika ARI WAHYUDI Diah Ayu Wulandari Diah Ayu Wulandari, Diah Ayu Eka Prasasti Nur Rachmani Endriastuti, Nialiana Endah Eni Sumarni Esti Dyah Utami Esti Dyah Utami Fareza, Muhamad Salman H. Harwoko Hana, Rifa Khairunnisa Harwoko, H. Hasan, Nahrul HENDRI WASITO Heny Ekowati HENY EKOWATI Ika Mustikaningtias Laksmi Maharani Laksmi Maharani Lesty, Rupa Loekas Soesanto MUSTIKANINGTIAS, IKA Nadzif, Faradina Qorina Nia Kurnia Sholihat, Nia Kurnia Noor Farid Nur Amalia Choirani Nur Amalia Choironi Nuryanti Nuryanti Rahmawati, Novia Ayu Rehana, Rehana Rizky Farihah Sari, Suci Wulan Sarmoko Sarmoko SOETOMO, SUNARTO Sunarto Sunarto Suryoputri, Masita Wulandari Utami, Vitis Vini Fera Ratna Warsinah Warsinah Zulkepli, Nur Ayunie