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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedical Journal of Indonesia Jurnal Pemberdayaan Masyarakat Madani (JPMM) Journal of Islamic Medicine Jurnal Medika Malahayati Fullerene Journal of Chemistry JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Farmasi Malahayati (JPFM) Majalah Farmasetika Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Pharmacoscript Jurnal Farmagazine Jurnal Ilmiah Wahana Pendidikan Journal of Biobased Chemicals (JOBC) Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Cosmetics Pharmacon: Jurnal Farmasi Indonesia JOURNAL OF Pharmacy and Tropical Issues
Angga Saputra Yasir
Institut Teknologi Sumatera
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ANALYSIS OF SKIN CONDITIONS IN EARLY ADULT CONSUMERS USING A SKIN ANALYZER: : IMPLICATIONS FOR COSMETIC PRODUCT FORMULATION Suryaneta, Suryaneta; Yasir, Angga Saputra; Muhtar, Wafiq Azizah; Sholeha, Aida Febina; Ambarita, Petrus Alvin Peter; Noviantoro, Tri
Indonesian Journal of Cosmetics Vol. 2 No. 1 (2024): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v2i1.1795

Abstract

This study aimed to analyze the skin characteristics of early adult consumers using data collected from a skin analyzer and explore the implications for cosmetic product formulation. The research sample consisted of 73 participants, with the majority aged between 17 and 20 years. The measured skin parameters included moisture, pores, melanin, acne (acne), wrinkles, and sensitivity. Data were analyzed using descriptive statistics and consumer segmentation techniques. The findings revealed that the early adult consumers in the sample generally exhibited low skin moisture levels (56.2%), enlarged skin pores (mean of 3.90 out of 5), fair skin pigmentation (69.9% with a melanin value of 1), severe acne severity (56.2% with an acne value of 5), minimal wrinkling (53.4% with a wrinkle value of 1), and high skin sensitivity (38.4% with a sensitivity value of 5). Based on consumer segmentation, formulation recommendations were provided for groups with dry and sensitive skin, severe acne and enlarged pores, and normal-to-oily skin with minimal wrinkle concerns. These findings highlight the need for targeted cosmetic formulations to address the specific skin concerns faced by early adult consumers. Although limitations such as a relatively small sample size and a focus on objective measurements existed, this study provides valuable insights for data-driven cosmetic product development. Further studies are recommended to investigate lifestyle and environmental factors, incorporate subjective data, and explore inter-group differences within the early adult consumer population. This research demonstrates the importance of evidence-based skin data analysis in informing cosmetic formulation strategies. By understanding and catering to the unique needs of early adult consumers, the cosmetic industry can develop more effective and satisfying products, driving market growth within this critical consumer demographic. A data-driven approach to cosmetic product development will become increasingly crucial in adapting to evolving consumer needs and preferences.
Optimization of Formula and In Vitro Activity Testing of O/W Lotion Cosmetic Formulations Containing Ethanol Extract of Cat's Whiskers Leaves (Orthosiphon aristatus) as Sunscreen Yasir, Angga Saputra; Suryaneta, Suryaneta; Putri, Tikarahayu; Saputra, Iwan; Handayani, Kiki; Zulaicha, Annisaa; Sari, Indah Puspita; Nurhayati, Veni; Sholeha, Aida
Indonesian Journal of Cosmetics Vol. 2 No. 1 (2024): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v2i1.1809

Abstract

Exposure to ultraviolet (UV) radiation from sunlight can induce erythema, sunburn, and skin sensitivity, culminating in dermal damage. The application of sunscreen mitigates potential skin harm resulting from solar radiation. This investigation aims to ascertain the optimal formulation for lotion preparations incorporating Orthosiphon aristatus leaf extract and evaluate the sunscreen efficacy of said formulations through in vitro testing. Extraction procedures involved ethanol maceration, followed by phytochemical characterization of the resultant extract. Formulation of the extract into oil-in-water (O/W) lotion preparations was executed, with optimization conducted utilizing the Simplex Lattice Design (SLD) method, incorporating varied concentrations of stearic acid, cetyl alcohol, and olive oil to assess their impact on lotion viscosity, spreadability, and adhesion. Subsequent evaluation encompassed in vitro assessment of sunscreen activity for both the lotion and extract. Findings revealed the presence of flavonoids, saponins, and tannins in the extract. Optimal lotion formulation, determined via the SLD method, yielded concentrations of 2.00, 4.22, and 8.78 for stearic acid, cetyl alcohol, and olive oil, respectively. Formulation optimization was guided by minimizing viscosity while maximizing spreadability and adhesion. Confirmation studies underscored the predictive capacity of the SLD method in determining viscosity, spreadability, and adhesion of the cat's whiskers leaf extract lotion. SPF values for the extract and lotion were recorded as 33.63 ± 0.963 and 2.54 ± 0.001, respectively, at a concentration of 30,000 ppm.
Community Empowerment through Pala Waste Utilization: Ecoenzymes, Syrup, and Candied Nutmeg in Paya Village, Pesawaran District Yasir, Angga Saputra; Suryaneta, Suryaneta; Sari, Indah Puspita; Putri, Tikarahayu; Handayani, Kiki Yuli
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 9 (2023): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i9.431

Abstract

This community engagement initiative unfolds in Paya Village, located in the Padang Cermin Subdistrict, Lampung Province, Indonesia. With a population of 1,190 individuals distributed across four hamlets, the village predominantly thrives on daily labor and agriculture, with nutmeg as a prominent crop. Organic waste generated from nutmeg fruit, particularly the husks and flesh, has been largely underutilized. This initiative, led by the PKK group, endeavors to empower the community, enhance household incomes, and address the issue of organic waste accumulation by converting nutmeg waste into value-added products. The program focuses on creating eco-enzymes, nutmeg syrup, and candied nutmeg. Capacity-building activities are central to this initiative, involving workshops, training, and educational programs. Regular evaluations highlight the program’s success in enhancing participants’ knowledge and awareness of nutmeg products.
Irritation, Hedonic, and Antioxidant Activity Testing of Sunkist Orange Peel (Citrus sinensis (L.) Osbeck) Peel-Off Gel Mask Formulation Nofita, Nofita; Sofyan, Shefira; Saputra Yasir, Angga
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.3130

Abstract

Sunkist orange peel is a rich source of antioxidants beneficial for skin protection, making it a promising ingredient in cosmetic products like peel-off gel masks. This study investigated the sensory profile, primary irritation index (PII), and antioxidant activity of peel-off gel mask formulations containing Sunkist orange peel extract (Citrus sinensis (L.) Osbeck). The extract was obtained through maceration using 96% ethanol, with a mean yield of 9.95 ± 1,2 %. Phytochemical analysis identified the presence of polyphenols, tannins, and flavonoids. The extract was incorporated into peel-off gel mask formulations and evaluated for quality parameters (organoleptic properties, pH, viscosity, and drying speed), sensory characteristics, PII, and antioxidant activity using the DPPH method. All formulations fulfilled the required quality standards. Sensory evaluation indicated that Formula III (FIII) was the most favored by respondents across all stages of application (before, during, and after use). The irritation index test on 25 volunteers revealed no irritation, with PII values ranging from 0 to 0.4, classifying the preparations as non-irritating. Antioxidant evaluation showed that the peel-off gel with 2% extract exhibited an IC-50 value of 23.38 ppm, categorizing it as a very strong antioxidant. These findings highlight the potential of Sunkist orange peel extract in peel-off gel masks, combining excellent antioxidant properties with favorable sensory and safety profiles. Further optimization may enhance its application in skincare products.
Uji Aktivitas Anti Penuaan Kulit Sediaan Emulgel Minyak Nilam (Pogostemon cablin Benth) Yasir, Angga Saputra; Nofita, Nofita; Br barus, Emia Athena
Jurnal Medika Malahayati Vol 9, No 1 (2025): Volume 9 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v9i1.18799

Abstract

Nilam atau dilem wangi (Jawa) merupakan tanaman perdu (herba), tanaman ini berbau harum dengan batang hampir seluruhnya berbentuk segi empat. Penelitian ini bertujuan untuk mengetahui apakah sediaan emulgel minyak nilam memiliki efektivitas sebagai anti penuaan kulit. Hasil uji organoleptis sediaan berwarna putih dan berbau khas basis untuk formulasi F0 dan K+, berwarna kekuningan dan berbau khas minyak nilam untuk formulasi F1. Hasil uji pH didapatkan dalam rentang 4,73 – 3,95. Hasil uji viskositas dalam rentang 8725 – 5778 cP. Hasil uji daya sebar dalam rentang 6,68 – 5,26 cm. Hasil uji daya lekat dalam rentang 1,68 – 1,01 detik. Hasil statistik parameter fisik menunjukkan adanya perbedaan signifikan selama penyimpanan selama 28 hari untuk ketiga formulasi yang ditandai dengan p-value < 0,05. Hasil uji iritasi tidak menunjukkan tanda-tanda reaksi iritasi. Hasil uji hedonik didapatkan K+ sebagai formulasi paling disukai. Hasil uji anti penuaan kulit dihitung dengan rumus persen, hasil dalam rentang 106,25 –(- 67,56) untuk parameter hidrasi, 110 – (- 68,08) untuk parameter elastisitas, 85,71 – (- 800) untuk parameter pori dan 88,8 – (- 433,3) untuk parameter kerutan. Selanjutnya uji statistik Kruskal Walli untuk menunjukkan tidak ada perbedaan signifikan terhadap semua perlakuan baik hidrasi, elastisits, pori dan kerutan pada formulasi F0, F1, K+ maupun tanpa sediaan yang ditandai dengan p-value > 0,05.
STUDI IN SILICO INTERAKSI MOLEKULER SENYAWA AKTIF PALA (Myristica Fragrans Houtt.) DENGAN CASPASE-1 SEBAGAI TARGET ANTI-INFLAMASI PADA JERAWAT Yasir, Angga
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 7 No. 1 (2025): Publikasi Penelitian Kimia dan Terapannya 2025
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v7i1.4991

Abstract

Jerawat merupakan kondisi dermatologis yang memerlukan penanganan efektif karena dapat mempengaruhi kualitas hidup penderita. Penelitian ini bertujuan untuk mengevaluasi interaksi molekuler senyawa aktif pala (Myristica fragrans Houtt.) dengan caspase-1 sebagai target anti-inflamasi pada jerawat menggunakan pendekatan in silico. Studi dilakukan menggunakan metode molecular docking terhadap metabolit utama pala meliputi miristisin, lignan, α-pinene, β-pinen, dan sabinen dengan protein target caspase-1 (PDB: 1BMQ). Hasil analisis menunjukkan bahwa lignan memiliki afinitas pengikatan tertinggi (-6.00 kcal/mol) dibandingkan dengan ligan alami (-5.00 kcal/mol). Analisis interaksi molekuler mengungkapkan bahwa lignan membentuk ikatan yang lebih kompleks meliputi ikatan hidrogen konvensional dengan HIS B:342 dan ARG B:383, interaksi π-anion dengan ASP B:381, π-cation dengan ARG B:352, serta interaksi π-sigma dan π-alkyl dengan VAL B:348 dan PHE B:377. Pola interaksi lignan berbeda dengan ligan alami yang didominasi oleh ikatan hidrogen dan interaksi elektrostatik. Hasil penelitian ini memberikan landasan ilmiah potensi senyawa pala, khususnya lignan, sebagai inhibitor caspase-1 yang dapat dikembangkan sebagai agen anti-inflamasi dalam pengobatan jerawat.
RASIONALITAS PENGGUNAAN OBAT PADA PASIEN REMATOID ARTHRITIS DI RUANG PENYAKIT DALAM RSUD SUKADANA KABUPATEN LAMPUNG TIMUR TAHUN 2019 Saputri, Gusti Ayu Rai; Yasir, Angga Saputra; Sandika, Agung Ngurah Feri
JOURNAL OF Pharmacy and Tropical Issues Vol. 1 No. 2 (2021): December Edition 2021
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v1i2.108

Abstract

Aberg, J. A., Lacy, C. F., Amstrong, L. L., Goldman, M. P., & Lance, L. L. (2015). Drug information handbook. Lexi-Comp for the American Pharmacist Association. Anggriani, A., Lisni, I., & Faujiah, D. S. R. (2016). Analisis masalah terkait obat pada pasien lanjut usia penderita osteoartritis di poli ortopedi di salah satu rumah sakit di bandung. Kartika: Jurnal Ilmiah Farmasi, 4(2), 13-20. Azizah, N., & Sutrisna, E. M. (2019). Evaluasi Rasionalitas Penggunaan Obat Pada Pasien Rheumatoid Arthritis Di Instalasi Rawat Jalan Rsud Dr. Moewardi Surakarta Tahun 2018 (Doctoral dissertation, Universitas Muhammadiyah Surakarta). Dransfield, M. T., Voelker, H., Bhatt, S. P., Brenner, K., Casaburi, R., Come, C. E., ... & Connett, J. E. (2019). Metoprolol for the prevention of acute exacerbations of COPD. New England Journal of Medicine, 381(24), 2304-2314. Husna, U. Y., & Karuniawati, H. (2017). Evaluasi Terapi Oains Dan Dmard Pada Pasien Rheumatoid Arthritis Di Instalasi Rawat Jalan RSUP Dr. Soeradji Tirtonegoro Klaten Tahun 2015-2016 (Doctoral dissertation, Universitas Muhammadiyah Surakarta). Ismayanti, N., & Solikhah, S. (2012). Hubungan antara pola konsumsi dan aktivitas fisik dengan status gizi pada Lansia di Panti Sosial Tresna Werdha Unit Abiyoso Yogyakarta. Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Universitas Ahmad Daulan, 6(3), 24972. Katzung, B. G., Masters, S. B., & Trevor, A. J. (Eds.). (2015). Basic & clinical pharmacology. Koromat, F. K. (2019). Faktor dominan yang berhubungan dengan kekambuhan penyakit rematik pada lansia di puskesmas kebonsari kota surabaya (Doctoral dissertation, Universitas Merdeka). Mawarni, D. (2016). Hubungan Nyeri Reumatoid Artritis Dengan Aktivitas Fisik Sehari-Hari Pada Lansia Di Panti Sosial Tresna Werdha Teratai Km 6 Palembang (Doctoral dissertation, Universitas Katolik Musi Charitas). Muslim, A. T. N. (2017). Identifikasi drug related problems potensial kategori ketidaktepatan dosis dan adverse drug reactions pada pasien osteoartritis rawat jalan di RSUD Jombang periode 2016 (Doctoral dissertation, Universitas Islam Negeri Maulana Malik Ibrahim). Prahastiawan, B., & Suryani, M. (2016). PENERAPAN KESELAMATAN PASIEN DALAM PEMBERIAN OBAT OLEH PERAWAT DI RSJD PROPINSI JAWA TENGAH. Karya Ilmiah. Primadi, F., & Maliya, A. (2018). Gambaran aktivitas fisik pada lansia yang menderita rematik di desa sendang, donorojo, pacitan (Doctoral dissertation, Universitas Muhammadiyah Surakarta). Purwoastuti, E. (2015). Waspadai Gangguan Rematik. Kanisius. Yogyakarta. Rekomendasi Perhimpunan Reumatologi Indonesia. (2014). Diagnnosis dan Pengelolaan Artritis Reumatiod. Jakarta: Perhimpunan Reumatologi Indonesia, 1-18. Diakses dari: https://reumatologi.or.id/wp-content/uploads/2020/10/Rekomendasi_Reumatoid_Artritis_2014.pdf SARI, F. N. (2019). Asuhan Keperawatan Gerontik Dengan Gangguan Nyeri Akut Pada Kasus Rheumatoid Arthritis Terhadap Tn. S Di wilayah Kerja Puskesmas Kotabumi II Kabupaten Lampung Utara, Tanggal 13-15 mei 2019 (Doctoral dissertation, Poltekkes Tanjungkarang). Srivastava, S. B., Fluegel, N., & Mansukhani, R. P. (2019). Pharmacologic Management of Rheumatoid Arthritis. Orthopaedic Nursing, 38(6), 390-395. Setiawati, S., Alwi, S., Sudoyo, A. W., Simadibrata, M. K., Setiyohadi, B., & Syam, A. F. (2015). Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi VI. Jakarta: Interna Publishing.   Syamsuddin, S., & Zulkifli, A. (2021). THE FAKTOR RISIKO KEJADIAN PENYAKIT REUMATIK DI WILAYAH KERJA PUSKESMAS MAWASANGKA KABUPATEN BUTON TENGAH TAHUN 2019. Indonesian Journal of Health and Medical, 1(2), 348-357. Trilia, T., & Yellisni, I. (2015). PENGETAHUAN DAN SIKAP LANSIA TENTANG REMATIK DI PANTI SOSIAL TRESNA WERDHA TERATAI PALEMBANG. Masker Medika, 3(1), 12-21. Wakhidah, S. U. N. (2019). ASUHAN KEPERAWATAN LANSIA PENDERITA RHEUMATOID ARTHRITIS DENGAN MASALAH KEPERAWATAN HAMBATAN MOBILITAS FISIK Di Puskesmas Siman Kabupaten Ponorogo (Doctoral dissertation, Universitas Muhammadiyah Ponorogo).
STABILITY AND IRRITATION TESTING USING THE PATCH TEST METHOD OF A COMBINATION GEL FORMULATION CONTAINING ALOE VERA AND BASIL LEAF EXTRACTS Yasir, Angga Saputra; Suryaneta, Suryaneta; Handayani, Kiki Yuli; Satria, Bagus
Indonesian Journal of Cosmetics Vol. 1 No. 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v1i1.1638

Abstract

Aloe vera and basil leaves have been recognized for their anti-inflammatory and antibacterial properties. Combining these extracts into a gel formulation offers convenience in application. However, research concerning potential irritations associated with its use remains limited. This study aims to assess irritation in humans resulting from the application of a gel formulation containing basil and aloe vera extracts using patch testing. The gel formulation is prepared with a 2% concentration of the extracts, with a 1:1 ratio of basil to aloe vera extracts. Optimization is achieved by varying carbopol concentrations and the final pH of the gel formulation. The parameters used for determining the optimal formula include organoleptic characteristics, viscosity, spreadability, adhesiveness, and pH of the formulation. The optimal formula is subsequently subjected to stability testing over four weeks and irritation testing using patch methods. A total of 25 volunteers are involved in the irritation testing. Observations are made up to 72 hours after the removal of the formulation to ensure the absence of delayed irritation effects. Aloe vera and basil extractions using ethanol as a solvent yield sequential yields of 1.7% and 3%, respectively. Quality evaluation for Formulations I (FI), II (FII), and III (FIII) includes spreadability, adhesiveness, and viscosity, as follows: (4.1 cm; 5.4 seconds; 5504 mPa.s); (6.5 cm; 4.1 seconds; 3480 mPa.s); and (5.2 cm; 4.2 seconds; 6340 mPa.s), respectively. FII is selected as the optimal formula because it exhibits wider spreadability and lower viscosity compared to FI and FIII (P <0.05). Stability testing for FII shows that the formula remains stable during storage for all quality testing parameters (P > 0.05). The Primary Irritation Index (PII) for FII has a value of 0.0216, indicating that it does not cause irritation during patch testing.
Evaluation of Nutmeg Extract as a Natural Anti-Acne Agent Against P. acnest Sari, Indah; Angga Saputra Yasir; Indarto I; Sinta Bella Triyanti; Aida Febina Sholeha; Veni Putri Nurhayati
Journal of Biobased Chemicals Vol. 5 No. 1 (2025): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v5i1.5590

Abstract

Acne vulgaris is a common inflammatory skin disorder primarily caused by the proliferation of Propionibacterium acnes. In response to increasing demand for natural and safer therapeutic alternatives, this study investigated the phytochemical composition, total flavonoid content, and antibacterial activity of the ethanolic extract of Myristica fragrans flesh. Phytochemical screening revealed the presence of flavonoids, terpenoids, tannins, saponins, and alkaloids—classes of compounds widely recognized for their antimicrobial properties. The total flavonoid content (TFC), determined using the aluminum chloride colorimetric method, was found to be 0.1582 ± 0.0044 mg quercetin equivalents per gram of dry extract. Antibacterial assays using the disc diffusion method demonstrated dose-dependent inhibition of both Staphylococcus aureus and P. acnes, with greater efficacy observed against P. acnes. These results suggest that nutmeg flesh extract possesses significant antibacterial potential, particularly as a candidate for anti-acne cosmetic formulations. Moreover, this study highlights the underexplored value of nutmeg flesh—a byproduct of spice processing—as a sustainable source of bioactive compounds for skincare applications.
IN VITRO AND MOLECULAR DOCKING ANALYSIS OF NUTMEG EXTRACT ANTIBACTERIAL ACTIVITY AGAINST Propionibacterium acnes Angga Saputra, Yasir; Indah Puspita, Sari; Veni Putri, Nurhayati; Aida Febina, Sholeha
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2107

Abstract

This study investigated the antibacterial activity of nutmeg (Myristica fragrans Houtt.) extract against Propionibacterium acnes  through in vitro and molecular docking approaches. The nutmeg flesh was extracted using ultrasonication with 96% ethanol, yielding 8.21% extract. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and steroids. The antibacterial activity was evaluated using the microdilution method, determining Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values of 0.5% and 1%, respectively. Molecular docking analysis was performed to understand the interaction between nutmeg's bioactive compounds and three essential Propionibacterium Acnes proteins: Sialidase (7LBV), lipase (5H6G), and Penicillin-Binding Protein 2 (3UPO). Among the tested compounds, myristicin showed the strongest binding affinity with 7LBV (-6.8 kcal/mol), while lignan exhibited notable interactions with 3UPO (-6.6 kcal/mol) and 5H6G (-5.9 kcal/mol). The molecular interactions were primarily stabilized through hydrophobic interactions and hydrogen bonding with specific amino acid residues. These findings suggest that nutmeg extract possesses significant antibacterial activity against Propionibacterium Acnes, potentially mediated through multiple molecular targets, supporting its development as a natural anti-acne ingredient.
Co-Authors Abdul Hamid Al Fikri Achmad Gus Fahmi Ade Maria Ulfa Ade Maria Ulfa Ade Maria Ulfa Agesta Yesti Renita Aida Febina Sholeha Aida Febina, Sholeha Ambarita, Petrus Alvin Peter Angin, Martinus Perangin Br Barus, Emia Athena Chusairil Pasa Entin Sari Fachry Abda El Rahman Ghifari, M Alvien Gusti Ayu Rai Saputri Handayani, Kiki Yuli Helisya Putri Herawati, Nenti Hermawan, Dessy Indah Puspita Sari Indah Puspita Sari, Indah Puspita Indah Puspita, Sari Indarto I Iwan Syahjoko Saputra Jayanti, Merly Kiki Handayani Lintang Buwana Wijaya Made Wike Wiranti Maria Ulfa, Ade Martianus Perangin Angin MARTIANUS PERANGIN ANGIN Merly Jayanti Mochammad Imron Awalludin Muhtar, Wafiq Azizah Ni Wayan Wulantika Niken Feladita Nofita Nofita Nofita, Nofita Noviantoro, Tri Nurhayati, Veni Putri, Tikarahayu Raihannisa, Cantika Raysa Rara Rista Putri Rery Tri Berliyanti Robiyun, Robiyun RR. Ella Evrita Hestiandari Sandika, Agung Ngurah Feri Saputri, Gusti Ayu Rai Selvi Marcellia Sholeha, Aida Sholeha, Aida Febina Sinta Bella Triyanti Siti Zulaicha, Annisaa Sofyan, Shefira Suryaneta Syahjoko, Iwan Tika Rahayu Putri Tutik Tutik Umu Wafika Veni Putri Nurhayati Veni Putri, Nurhayati Widianti, Reika Aqni Yohan Alfianys Yudhi Chandra Zulaicha, Annisaa