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Wahyu Setia Budi
Department Of Physics, Faculty Of Science And Mathematics, Diponegoro University
Astronomy Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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PENENTUAN AKUMULASI RADIOFARMAKA Tc99m MDP PADA SPINE DAN STERNUM SAAT PEMERIKSAAN BONE SCAN PASIEN KANKER PAYUDARA Arifah, Dwi Intan; Setiabudi, Wahyu
BERKALA FISIKA Vol 24, No 4 (2021): Berkala Fisika
Publisher : BERKALA FISIKA

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Abstract

Based on data from Indonesian Health Ministry, breast cancer is the type of cancer with the highest prevalence in Indonesia amounted to 0.5% in 2013. This study aims to determine the accumulation of  activity  Tc99m  Methylene  Diphosponate  (MDP)  on  the  bone  around  the  breast,  spine  and sternum. This study was conducted on 30 patients undergoing the bone scan using in vivo nuclear medicine technique. The study was conducted using Tc99m obtained from elution of Mo99 generator and mixed with MDP. Bone scan was performed by injecting Tc99m MDP intravenously into the patients arm as much 15.84 – 21.95 mCi. Furthermore, the anterior posterior planar imaging in whole of body at 4 hours after injection of the patient by using a gamma camera. Then, using region of interest (ROI), the accumulative of activity on bone can be measured. A range of values based on the activity of bone metastasis can be seen from the percentage uptake of lesions found on the spine  and  sternum.  Based  on  the  existence  of  lesions,  there  were  12  patients  had  lesions  in  the spine only, 9 patients had lesions in the sternum only, 7 patients had lesions on both of them and there are 16 patients who have not lesions in both.
Identifikasi Kalsium dan Magnesium dalam Obat Menggunakan LIPS (Laser-Induced Plasma Spectroscopy) Heri Sugito; Ali Khumaeni; Wahyu Setia Budi; Asep Yoyo Wardaya
Cendekia Journal of Pharmacy Vol 4, No 1 (2020): Cendekia Journal of Pharmacy
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v4i1.78

Abstract

Identifikasi kandungan zat makro pada obat-obatan kimia sangat diperlukan untuk tujuan perlindungan kesehatan masyarakat. Dalam penelitian ini, identifikasi magnesium (Mg) dalam produk farmasi dilakukan menggunakan LIPS (Laser-Induced Plasma Spectroscopy). Laser yang digunakan pada penelitian adalah laser Nd: YAG dan laser CO2. sampel yang digunakan adalah tablet suplemen. Sinar laser diarahkan dan difokuskan oleh lensa cembung pada sampel. Berkas plasma diinduksikan pada permukaan sampel. Spectrum emisi yang tajam dan berintensitas tinggi yang terdeteksi menggunakan laser Nd:YAG menunjukkan adanya kandungan Kalsium (Ca) dan Magnesium (Mg) pada sampel. Hasil yang diperoleh kemudian dibandingan dengan pengujian sampel menggunakan laser CO2. Diperoleh hasil intensitas spectrum Mg jauh lebih tinggi menggunakan laser CO2.
Uji Diagnostik Pemeriksaan Tulang Osteolitik Berbasis Intensitas Citra Digital Susilo Susilo; Maesadji Tjokro Nagoro; Kusminarto Kusminarto; Wahyu Setia Budi
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 1 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Diagnostic test of osteolytic bone examination based on digital image intensityBackground: The visual examination of bone radiographs using digital computed radiography (CR) is an examination for the diagnosis of bone-metastatic cancer. The subjectivity of interpretation of bone radiographs may lead to doctor’s doubt in making decision to treatment patients with bone-metastatic cancer. Software Matlab-based computer application program makes a standard method to organize the results of bone radiographs. The objective of this study is to develop a software based on Matlab to analyze the diagnostic values, and to determine the optimal of cut off point to diagnose of osteolytic bone.Method: The researches data are collected from Department of Radiology of three hospitals i.e. Dr. Kariadi Hospital Semarang, Dr. Sardjito Hospital and Bethesda Hospital Yogyakarta. This research was carried out during four month from April to August 2009. Radiographs of osteolytic bone interpreted by radiologist were compared with PA examination result of the osteolytic bone which were viewed as the gold standard. The steps in this study i.e. patients are classified as a normal or osteolytic bone patients based on the cut off point that had been determined, calculate the value of the diagnostic test using 2x2 tables, determined the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), and determined the optimal of cut off point.Result: The results of study show that the diagnostic test for osteolytic bone by using Matlab-based software has sensitivity of 0.88, specificity of 0.891, positive expected value of 0.897, negative expected value of 0.950 and the cut off point at 0.93, while, the value of area under the curve (AUC) is 94% (95% CI: 89.7%-98.3%), and the accuracy is 0.881 for the case of osteolytic bone.Conclusion: Matlab-based software being used for diagnosing osteolytic bone has relatively high sensitivity and specificity.Keywords: Digital image, bone metastases, osteolytic, optimum cut off point ABSTRAKLatar belakang: Pemeriksaan radiograf tulang secara visual menggunakan sistem radiografi digital CR (computed radiography) merupakan pemeriksaan untuk diagnosis kanker metastasis tulang. Subyektivitas interpretasi radiograf tulang dapat menyebabkan keraguan dokter dalam mengambil keputusan untuk pengobatan pasien dengan kanker tulang metastatik. Software berbasis program aplikasi computer Matlab membuat suatu metode standard untuk mengorganisasikan hasil radiograf tulang. Tujuan penelitianadalah mengembangkan software berbasis Matlab untuk menganalisis nilai-nilai diagnostik, cut off point optimal dan akurasi pemeriksaan pada diagnosis tulang osteolitik.Metode: Data penelitian diambil di bagian radiologi dari tiga rumah sakit, yaitu RSUP Dr. Kariadi Semarang, RSUP Dr. Sardjito dan Rumah Sakit Bethesda Yogyakarta. Penelitian dilakukan selama empat bulan dari April sampai Agustus 2009. Radiograf tulang  osteolitik yang diinterpretasikan oleh radiolog ini dibandingkan dengan hasil pemeriksaan PA tulang osteolitik yang dianggap sebagai gold standard. Langkah yang dilakukan dalam penelitian ini adalah pasien diklasifikasikan sebagai pasien tulang normal dan pasien osteolitik berdasar cut off point yang telah ditetapkan, menghitung nilai uji diagnostik menggunakan tabel 2x2, menghitung luasan di bawah kurva (AUC) dengan cara receiver operating characteristic (ROC), serta menetapkan cut off point optimal.Hasil: Hasil penelitian menunjukkan bahwa uji diagnostik tulang osteolitik menggunakan software berbasis Matlab memiliki sensitivitas 0,875, spesifisitas 0,891, nilai dugapositif 0,897, nilai duga negatif 0,950 dan cut off point 0,93. Nilai luasan di bawah kurva (AUC) ROC adalah sebesar 94%
Uji Diagnostik Pemeriksaan Osteosklerotik Tulang dengan Sistem Radiografi Digital Susilo Susilo; Maesadji Tjokro Nagoro; Kusminarto Kusminarto; Wahyu Setia Budi
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACTDiagnostic test of bone osteosclerotics examination using digital radiography systemBackground: The interpretation of a conventional röntgen images have a high degree of subjectivity due to the limitation of humansight. The computationally detection help establish the accuracy of diagnosis of the radiologist. According to our knowledge, there has not been previous research on this issue in Indonesia. The research was aimed to examine a Matlab based software to determine the diagnostic value in the diagnosis of osteosclerotic bone.Methods: This study was a diagnostic test which was conducted in Radiology Department of Dr. Kariadi Hospital Semarang, Dr.Sardjito Hospital Yogyakarta and Bethesda Hospital Yogyakarta, April to August 2009. The radiographs of bone osteosclerotic resulted from computed radiography (CR) test results were taken consecutively, interpreted by a radiologist which was supported by the Anatomical Pathology Laboratory examination as a gold standard. Afterwards these steps were done respectively: classify patients as a normal or osteosclerotic patients based on the cut off point that was determined, calculate the value of the diagnostic by analysis of 2x2 tables, determine the area under the curve (AUC) by the procedure of receiver operating characteristic (ROC), anddetermine the optimal of COP (cut off point) using ROC procedure.Results: From the results of diagnostic tests of bone radiographs these following parameter values was obtained: AUC value of 97.6% (95% CI: 94.4%-100%), the optimal cut off point for bone oseosclerotic COP ≥1.05 with a sensitivity value of 93.0% and a specificity of 89.1%. Suitability kappa value of 0.818 K (95% CI: 0.757 to 0.879).Conclusion: The radiographic examination of the results of CR using Matlab-based software can be used to diagnose boneosteosclerotic with high sensitivity and specificity.Keywords: Bone osteosclerotic, röntgen images, optimal of COP, Matlab softwareABSTRAKLatar belakang: Pembacaan foto röntgen secara konvensional memiliki tingkat subyektivitas tinggi karena keterbatasan indrapenglihatan manusia. Pendeteksian secara terkomputasi membantu menegakkan diagnosis para radiolog. Sebagaimana diketahui, belum ada penelitian sebelumnya mengenai masalah ini di Indonesia. Penelitian ini bertujuan menguji perangkat lunak berbasis Matlab untuk menentukan nilai diagnostik pada diagnosis tulang osteosklerotik.Metode: Penelitian ini adalah uji diagnostik yang dilakukan di Bagian Radiologi RSUP Dr. Kariadi Semarang, RSUP Dr. SardjitoYogyakarta dan Rumah Sakit Bethesda Yogyakarta, April-Agustus 2009. Radiograf osteosklerotik tulang hasil pemeriksaan CR (computed radiography) diambil untuk sampel secara konsekutif, kemudian diperiksa oleh radiolog yang didukung oleh pemeriksaan Laboratorium Patologi Anatomi sebagai baku emas. Tahapan yang dilakukan berturut-turut adalah: mengelompokkan pasien sebagai osteosklerotik dan normal berdasar titik potong yang ditentukan, menghitung nilai diagnostik dengan tabel analisis 2x2, menentukan AUC (area under the curve) dengan prosedur ROC (receiver operating characteristic), dan menentukan COP (cut off point) optimal dengan prosedur ROC.Hasil: Hasil uji diagnostik radiograf tulang diperoleh nilai-nilai parameter sebagai berikut: nilai AUC adalah sebesar 97,6% (IK 95%: 94,4%-100%), titik potong optimal untuk osteosklerotik tulang COP ≥1,05 dengan nilai sensitivitas sebesar 93,0% dan spesifisitas sebesar 89,1%. Nilai kesesuaian kappa K sebesar 0,818 (IK 95%: 0,757-0,879).Simpulan: Pemeriksaan radiografi hasil CR menggunakanperangkat lunak berbasis Matlab dapat digunakan untukmendiagnosis osteosklerotik tulang dengan sensitivitas danspesifisitas tinggi
PERBANDINGAN NILAI DENSITAS CITRA MENGGUNAKAN GRID BERGERAK (MOVING GRID) POSISI HORISONTAL DAN VERTIKAL Supriyati Supriyati; Wahyu Setia Budi; Heri Sutanto
Youngster Physics Journal Vol 2, No 3 (2013): Youngster Physics Journal Juli 2013
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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Abstract

In making radiographs  often differences exposure  factors used when using  moving  of horizontal and vertical. This study aims to determine the comparative value of the density of the resulting image when using a moving grid of horizontal and vertical position. So that research results can be applied in an effort to improve the quality of the radiograph. The study begins with the initial  test  without the grid to determine   density value, the second initial test using a moving grid both  horizontally  and vertically without  the  use  of material / objects.  Research   continued with three  aluminum thickness variation are  1 mm, 3 mm and 5 mm. Then using acrylic  material three thickness   variation are 1 cm,  2 cm and 3 cm. Results of image density measured using a densitometer.Results are then analyzed the data.  The  results  of research  show   value  of   the   image   using  horizontal    grid  density has    smaller  values  than    the  vertical    but   still within the   range  of  values density using   vertical   grid.  Thus   it can    be  said    that    the   image  density  values using  moving    grid   horizontal   position   is  not different with    density  of  the image using a vertical grid at the same exposure factors.Keywords: radiograph,  moving grid,  density,  comparison value
Laju paparan dan dosis radiasi dari pasien terapi kelainan kelenjar tiroid dengan pemberian radiofarmaka Iodium-131 Ahmad Mutohar; Wahyu Setiabudi; Rini Shintawati
Youngster Physics Journal Vol 6, No 1 (2017): Youngster Physics Journal Januari 2017
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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Research about exposure and dose rate from patients with thyroid gland disorders therapy who received radiopharmaceutical Iodine-131 is done by direct measurement using a survey meter. In this study, the exposure rate collected from 37 patients who received doses of radiopharmaceutical therapy with activity ≤ 30 mCi and 13 patients who received doses of radiopharmaceutical therapy with activity> 30 mCi. Exposure rate of each patient was subsequently changed in the form of the dose rate. The results obtained that all patients who received a dose of a radiopharmaceutical with activity ≤ 30 mCi, produce dose rate below the maximum extent permitted to leave the hospital.  While patients who received doses with activity > 30 mCi, produce a dose rate above generate maximum extent permitted to leave the hospital. Besides that, the research also analyzed the reduction of dose rate from each patient. A decrease of dose rate (within 1 hour after administration of radiopharmaceutical) is affected by the excretion rate and rate of uptake of iodine in the blood.  Specially, patient who received a dose with activity > 30 mCi, efective half-life value is determined from a decrease of the dose rate each patient. The results obtained that effective half-life of I-131 in the body of every patient in the range of 6 to 14 hours. Patient H had the shortest effective half-life and patient M has longest effective half-life. The difference of effective half-life of I-131 affected by  biological elimination/ biological half-life of each patients.Keywords: Exposure rate, dose rate, Iodine-13 therapy patients, effective half-life
EVALUASI METODE PERHITUNGAN KETEBALAN PERISAI PADA RUANG DIGITAL RADIOGRAFI Wulandhari Wulandhari; Wahyu Setia Budi; Agung Dwiyanto
Youngster Physics Journal Vol 4, No 1 (2015): Youngster Physics Journal Januari 2015
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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This research would discuss about the methods to determine shielding thickness for X-Ray of digital radiography room published by BIR (British Institute of Radiology), NCRP (National Council on Radiation Protection), KEMENKES No.1014/Menkes/SK/XI/2008 and Perka BAPETEN No. 4 (2013). Each method assume different considerations so evaluation is needed in terms of it’s ability to control external radiation exposure.                Shielding thickness based on NCRP and BIR need data such as space map area of the other side operation X-Ray, shift workers, total number of patient, and distance of primary and secondary radiation to the point of occupation, all of data collected based on survey before experiment. Then shielding thickness calculated  based on the dose rate inside and outside room be used as a comparation.                 The result  of primary Pb shielding thickness by NCRP 49 is 1,00  mm, NCRP 147 is 0,469 mm and BIR is amount of 0,650 mm. The secondary Pb thickness shielding by NCRP 49 is 0,500 mm, NCRP 147 is 0,170 mm and BIR is amount of 0,00980 mm. Shielding thickenss based on dose rate, for primary Pb shielding thickness is  0,898 mm and secondary Pb shielding thickness is 0,987 mm respectivelly. The result of shielding thickness based on NCRP 49 method is closer with the result by shielding thickness was based on dose rate. Keywords: NCRP 49, NCRP 147, BIR, Shielding Thickness, Dose Rate.
Penentuan karakteristik cacahan pada counter dengan menggunakan sumber standar 152Eu, 60Co dan 137Cs Hendrika Liana Sari; Wahyu Setia Budi
Youngster Physics Journal Vol 6, No 2 (2017): Youngster Physics Journal April 2017
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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Abstract

The determination count of caracteristics on a counter using the standard source 152Eu, 60Co and 137Cs. The calibration in Counter A due measurement activity source of  Europium-152 (152Eu), Cobalt-60 (60Co) and Cesium-137 (137Cs), because Cesium has one peak of energy. From the calculation on obtained efficiency the average of a sistem when using counter DIN711 is 0,0237±0,0028 and efficiency the average for each Counter A is 0,0243±0,0029. Of the value of activity between the two source measurable by both counter can be seen that counter DIN711 having results activity that were more accessible activity on certificates. To deviation of 19,71 % in counter DIN711 and 19,92 % in counter a.But counter a has deviation of 0.45 % of the measurement result of counter DIN711.Keywords: Spektrometer Nuklir, Counter, Calibration Spektrometer, Uji Banding, Calibration Linierityes, Stabilitas Test
DISTRIBUSI FLUKS NEUTRON SEBAGAI FUNGSI BURN-UP BAHAN BAKAR PADA REAKTOR KARTINI Fatkhiyatul Athiqoh; Wahyu Setia Budi; Choirul Anam; Tri Wulan Tjiptono
Youngster Physics Journal Vol 3, No 2 (2014): Youngster Physics Journal April 2014
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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The effective multiplication factor (keff) and the flux distribution in the Kartini reactor which used Uranium Zirconium Hydride (UZrH) as fuel, pure water (H2O) as moderators and cooland has been analyzed using Monte Carlo simulation. The flux distribution analyzed by splitting core reactor become 5 rings (B, C, D, E and F). The effective multiplication factor (keff) and flux distribution calculated by MCNP 4C with burn-up variation 0%, 2,5%, 5%, 7,5%, 10%, 12,5%, 15%. The result shows that the critical condition obtained from burn-up rate 0% up to 5%. The highest value of flux distribution in the middle, at ring B and the value gets smaller towards to edge of reactor core.Keywords : flux distribution, keff, MCNP, Kartini reactor
ANALISIS PERBANDINGAN PARAMETER DAN PROFIL DOSIS MENGGUNAKAN PHANTOM STANDAR DAN TIDAK STANDAR Nora Fajria; Wahyu Setia Budi; Zaenal Arifin
Youngster Physics Journal Vol 3, No 4 (2014): Youngster Physics Journal Oktober 2014
Publisher : Jurusan Fisika, Fakultas Sains dan Matematika, Universitas Diponegoro

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A study has been conducted to analyze the dose parameters are CTDI100, CTDIw, CTDIvol, DLP and dose profiles by using standard phantom (150 mm) and non-standard phantom (300 mm). This research utilized an abdomen phantom, CT Dose Profiler and software Ocean. Exposure factors in this study in accordance with the conditions of the abdomen routinely performed at the Hospital of the tube voltage 120 kV, current 350 mA, collimation 40 mm, and pitch 1.375. The detector is placed in the center of the phantom and scanning with variation of scan-length 150 mm and 200 mm in the standard phantom (150 mm) and the variation of the scan-length 150 mm, 200 mm, 300 mm in non-standard phantom (300 mm). The result obtained is the parameter dose values in the non-standard phantom (300 mm) are higher than standard phantom (150 mm). At a scan length of 150 mm, the difference in value is 4.825% CTDI100, CTDIw 4.858%, 4.823% CTDIvol, and DLP 4.820%. Meanwhile, the difference in the value of the parameter dose at the scan length of 200 mm is CTDI100 3.477%, 3.494% CTDIw, CTDIvol 3.510%, and DLP 3.512%. The resulting dose profile has similar peak-dose value but have a different width so that the dose profile in non- standard phantom (300 mm) is wider and having higher FWHM value than the standard phantom (150 mm) because non-standard phantom has longer scan length that lead to excessively scattered radiation.Keywords: CT Dose Profiler, dose profiles, scan length, standard phantom, non- standard phantom, CTDI100, CTDIw, CTDIvol, DLP, FWHM.
Co-Authors Ade Ika Susan Afgani, Jundi Jundullah Agung Dwiyanto Agus Subagio Ahmad Mutohar Ainul Ibnu Khotob Alan Tanjung Aji Prastowo Alfian Rizani Ali Khumaeni Anis Nila Kusuma Anugrah Ariyani S. Arif Fahmi Arifah, Dwi Intan Asep Yoyo Wardaya Astrihasna Shafa Bambang Haris Suhartono, Bambang Haris Choirul Anam Choirul Anam AM Diponegoro Chorirul Anam Dewandaru, Ardian Dewantoro, Fajar Dewantoro, Fajar Dhahryan Dhahryan Dini Desita Dwi Siwi Retnoningsih Eddy Prianto Eko Hidayanto Erni Setyowati Fadil Nazir Fajar Arianto Fatkhiyatul Athiqoh G. B. Suparta Gagoek Hardiman Gagoek Hardiman Gani Gunawan Gani Gunawan Hamdani, Muhammad Alif Iza Handayani, Liska Tri Harianja, Bernard Hendri Widiyandari Hendrika Liana Sari Heri Sugito Heri Sutanto Hidayatullah, Aydymas Davansyah I Wayan Ari Makmur Ismail Ismail Istifadatun Ni’amah Juhroh, Aminatul Jundi Jundullah Afgani K Sofjan Firdausi K. Sofjan Firdausi Kaka, Susanti Radi Kesawa Sudarsih Ketut Sofjan Firdausi, Ketut Sofjan Khomilia, Crysant Ayu Sufi Kusminarto Kusminarto Kusminarto Kusminarto Kusminarto Kusminarto Kusworo Adi Liska Tri Handayani Maesadji Tjokro Nagoro Maesadji Tjokro Nagoro Maliki Maliki Maria Carizza Pandora Raharjo Masrokan Masrokan Masrokan, Masrokan Michelson Fahrurazi Much Azam Muhamad Adi Muharam Budi Laksono, Muharam Budi Nora Fajria Nur Dwi Prasetyo Pandora Raharjo, Maria Carizza Parsaoran Siahaan Prasetyo Basuki Pratama, Arthana Setia Priyono, Setyo Purwanto Purwanto Rahmawati, Fatimah Dwi Redemtus Heru Tjahjana Rini Shintawati Rozanah Rozanah Rusmaharani, Diyah Sihotang, Pandapotan Sri Haryanti Sugiarto, Oki Suhardi Suhardi Sunarsih Sunarsih Supriyati Supriyati Suryono Suryono Susanti, Audry Nadifa Susila Wardaya, Susila Susilo Susilo Susilo Susilo Susilo Susilo Sutiah Sutiah Sutiyowati Sutiyowati, Sutiyowati Sutrati Melissa Malik Syamsiar, Syamsiar Taqwim S, M Ainut Titi Purwati Tri Wulan Tjiptono Tri Wulan Tjiptono Very Richardina Vitria, Yati Weirna Yusanti Wibowo, Danang Rujito Widiastuti, Ratih Wulandhari Wulandhari Zaenal Arifin