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Journal : International Journal of Health, Medicine, and Sports

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Phytochemical Screening, Antioxidant Test and Antimicrobial Test of Streptococcus Mutans and Candida Albicans from Extracts of Ultrasound Assisted Extraction of Red Betel Leaves (Piper Ornatum N. E. Br) Djarot, Prasetyorini; Utami, Novi Fajar; Mahyun, Siti; Annisa, Julmudia Nurul; Mutmaiah, Siti Nafsiatul
International Journal of Health, Medicine, and Sports Vol. 3 No. 1 (2025): International Journal of Health, Medicine, and Sports
Publisher : Corespub

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46336/ijhms.v3i1.175

Abstract

Red betel (Piper ornatum) is an ornamental plant with potential antibacterial and antioxidant properties due to its bioactive compounds, including alkaloids, flavonoids, steroids, triterpenoids, saponins, and tannins. This study aimed to determine the relationship between flavonoid content, antioxidant activity, and antimicrobial activity in red betel leaves. Ultrasound-Assisted Extraction (UAE) was employed using three solvents of varying polarity: n-hexane (non-polar), ethyl acetate (semi-polar), and ethanol (polar). Total flavonoid content was determined spectrophotometrically based on flavonoids' ability to form complexes with AlCl3. Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Antibacterial and antifungal properties were evaluated through Minimum Inhibitory Concentration (MIC) and Zone of Inhibition (ZOI) tests. MIC was determined using the agar dilution method, while ZOI was measured using the disc diffusion method. Results showed that the 96% ethanol extract yielded the highest flavonoid content (4.748%) and the strongest antioxidant activity (IC50 = 47.185 ppm, classified as very strong). The n-hexane extract at 25% concentration exhibited the best antibacterial activity against Streptococcus mutans (ZOI = 17.43 mm), while the 96% ethanol extract at 25% concentration demonstrated the highest antifungal activity against Candida albicans (ZOI = 17.02 mm). In conclusion, red betel leaf extracts show promising potential as strong antioxidants and antimicrobial agents against C. albicans and S. mutans.
Co-Authors . Yulianita, . Achmad, Dinar Munggaran Adnan, Vanya Nafiza Putri Akhmad Endang Zainal Hasan Alfi Syari Sukarya Anggita Rahmadini Anisa Hidayatul Amini Annisa, Julmudia Nurul Apriansyah, Rafli Berna Elya Bina Lohita Sari Cantika Zaddana D Prasetyorini Deden Ardiansyah Diana Amaliasari Dinar Munggaran Achmad Djarot, Prasetyorini Durrotun Nafisah Abd.Nf E Mulyati Effendi Eka Novia Indriyani Elly Sukmanasa Eneng Tita Tosida Esti Pratiwi Esti Pratiwi Evi Indah Wigati Fajriati, Annisa Fitri Atika suri Fitria Dewi Sulistiyono Florensia Ndole Mbete Fredi Andria Hayun Hayun, Hayun Hermawati, Ema Ike Yulia Wiendarlina Kusmardi Kusmardi Mahyun, Siti Mahyuni, Siti Mona . Mutmaiah, Siti Nafsiatul Nhestricia, Nhadira Nissa, Trisni Fatwatun Novi Novitasari Oom Komala Prihastuti Harsani Putra, Agita Detia Putri Dwi Antini Rikkit Riswana, Dea Putri Rizqi Aulia Rahmah Roni Jayawinangun S Sabila Sara Nurmala Saraswati Darmawan Sely Meidi Nurdayanty Siti Mariyam Rosdiana Siti Maysaroh Siti Warnasih Siti Warnasih Sri Maryanti Sri Maryanti Sri Wardatun Srinarayani, Kadek suri, Fitri Atika Sutanto Sutanto Syamsu Nur, Syamsu Tien Tisya Tri Retno Handayani, Marybet Trisni Fatwatun Nissa Usep Suhendar usep suhendar Usep Suhendar Utami, Munifa Putri Widya fitriyani Wigati, Evi Indah Yelni Rahmawati Yuli Wahyuni Yuli Wahyuni Yulianita Zaldy Rusli