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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Jurnal Kebidanan Dan Kesehatan Tradisional Jurnal Kimia Mulawarman Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Jurnal Farmasi Sains dan Komunitas Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Jurnal Teknik Kimia Best Journal (Biology Education, Sains and Technology) Jurnal Ners Jurnal Abdi Insani Sriwijaya Journal of Ophthalmology Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Proceedings National Conference Sisi Indonesia Global Medical and Health Communication
Fatmawati
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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SPECIFIC ROLE OF IL-1Β IN URIC ACID-RELATED INFLAMMATION : A NARRATIVE REVIEW Rona Hawa Kamilah; Salni; Ziske Maritska; Fatmawati
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 11 No. 2 (2024): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v11i2.396

Abstract

Inflammatory conditions in hyperuricemia are caused by monosodium urate crystals that induce the release of IL-1β, marking a crucial milestone in the pathogenesis of hyperuricemia. Several studies have linked the relationship between serum uric acid levels and the release of IL-1β. IL-1β plays a key role in the pathogenesis of gout. The IL-1β signaling is currently considered an initiating event that triggers uric acid inflammation and promotes the recruitment of a large number of neutrophils to the inflammatory site. Neutrophil activation caused by crystals results in the inhibition of apoptosis, degranulation, the release of reactive oxygen species (ROS), TNF-α, IL-1β, and PGE2, as well as the formation of extracellular neutrophil tissue, further reinforcing the inflammatory process. Recent research indicates that hyperuricemia patients have significantly higher levels of IL-1β. Other studies suggest that elevated IL-1β levels correlate with a more severe anatomical pathology in the joint tissues of rat ankles, including synovial hyperplasia, cartilage damage, and bone erosion.
Flavonoids and Their Role As Anti-Inflammatory Agents Fatmawati; Aliah Ramadhani Puteri; Humairah Binti Huda
Biomedical Journal of Indonesia Vol. 10 No. 2 (2024): Vol 10, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i2.187

Abstract

The human civilizations have been using plants and herbs for their rich sources of phytonutrients and bioactive compounds. Polyphenols are one of the groups of beneficial compounds found naturally, they include a wide variety of molecules and are divided into 4 main categories, which are flavonoids, phenolic acids, lignans, and stilbenes. It is estimated that more than 10,000 flavonoid compounds have been isolated and then identified, with the results finding that the majority of flavonoids are widely accepted as therapeutic agents. It is found in various flowers, fruits, and leaves such as red peppers, celery, parsley, chamomile, mint, and ginkgo biloba. Flavonoids are known for their anti-inflammatory properties using a mechanism that is thought to be different. The mechanism used may include an enzyme inhibition mechanism for enzymes that regulate transcription factors. This has a very important role, one of the roles being the control of mediators involved in an inflammatory process. The study for this systematic review was conducted without a time constraint using scientific databases such as Google Scholar and ScienceDirect, with 5 years’ time limitation. Previous research has validated the pharmacological characteristics of some flavonoids and their potential health advantages.
Determination of Secondary Compounds in Extracts from Catfish (Pangasius sp) Siti Rusdiana Puspa Dewi; Sadakata Sinulingga; Fatmawati Fatmawati; Maharani Natasya; Siti Devita Utami; Putra Ramadhan Algiffary Irianto Dunda
JURNAL KIMIA MULAWARMAN Vol 21 No 1 (2023)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v21i1.1009

Abstract

Ikan patin (Pangasius sp.) umumnya dijumpai pada perairan air tawar di Indonesia, seperti di Sumatera dan Kalimantan. Di Sumatera Selatan, ikan jenis ini digunakan sebagai salah satu kuliner seperti pindang dan brengkes. Tujuan dari penelitian ini adalah untuk mengetahui kandungan fitokimia metabolit sekunder dari ekstrak ikan patin (Pangasius sp.). Metode yang digunakan pada penelitian ini adalah studi deskriptif dengan menggunakan ekstrak yang diperoleh dari kulit, tulang, dan daging ikan patin. Ekstrak yang digunakan adalah ekstrak dari pelarut etanol, etil asetat, dan n-heksana dengan proses maserasi dan akudes dengan proses infusa. Hasil penelitian menunjukkan bahwa pada ekstrak etanol, kulit ikan mengandung alkaloid, saponin, dan steroid; pada tulang mengandung flavonoid dan saponin; pada daging mengandung alkaloid, saponin, dan flavonoid. Pada ekstrak etil asetat, kulit dan tulang ikan mengandung alkaloid; sedangkan pada daging mengandung flavonoid dan steroid. Pada ekstrak n-heksana, kulit ikan mengandung alkaloid dan steroid; tulang ikan mengandung alkaloid; dan daging ikan mengandung saponin dan terpenoid. Pada akuades, kulit ikan mengandung alkaloid, saponin, tanin, dan steroid; tulang ikan mengandung alkaloid; danging ikan mengandung alkaloid, flavoid, dan saponin. Kesimpulan dari penelitian ini bahwa Pangasius sp. memiliki metabolit sekunder alkaloid, flavonoid, saponin, tanin, terpenoid, dan steroid.
Anti-hyperuricemia Potential of Ethyl Acetate Fraction from Ethanolic Stem Extract of Arcangelisia flava Fatmawati, Fatmawati; Saleh, Irsan; Parisa, Nita; Salni, Salni; Izzah, Puspita Nurul; Subandrate, Subandrate; Athiah, Medina
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13510

Abstract

Arcangelisia flava, with its secondary metabolites in flavonoids, has shown promising potential as an alternative treatment for hyperuricemia. The study aimed to determine the effectiveness of the ethyl acetate fraction from the ethanolic stem extract of Arcangelisia flava in inhibiting xanthine oxidase. This research, conducted at the Medical Basic Chemistry Laboratory Universitas Sriwijaya in September–December 2022, used in vitro study methods. The stem of Arcangelisia flava was extracted by maceration using ethanol. The ethanolic stem extract of Arcangelisia flava was then fractionated using n-hexane and ethyl acetate. The ethyl acetate fraction and ethanolic extract of Arcangelisia flava were measured to inhibit the xanthine oxidase using UV-vis spectrophotometry with allopurinol as a comparison. The IC50 was calculated by linear regression. The ethanol extract and ethyl acetate fraction have flavonoids, alkaloids, terpenoids, and quinones. The IC50 value of the ethanol extract was 30.04 ppm, the ethyl acetate fraction was 23.99 ppm, and the allopurinol was 17.16 ppm. The ethyl acetate fraction inhibited xanthine oxidase better than the ethanol extract. The study's significant finding is that the ethyl acetate fraction of the ethanolic stem extract of Arcangelisia flava strongly inhibits xanthine oxidase, offering a potential new avenue for treating hyperuricemia.
The Effectiveness of Cinnamon extract (Cinnamomum burmannii) to reducing ureum level in male Rattus norvegicus Unilateral Ureteral Obstruction (UUO) model Evi Lusiana; Theodorus Theodorus; Nita Parisa; Fatmawati Fatmawati; M. Ivan Pratama
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.112

Abstract

Cinnamon extract's effectiveness as a renoprotective has not been previously investigated due to its widespread use in daily life, either as a cooking ingredient or as a herb. The aim of this study is to determine the effectiveness extract of cinnamon (Cinnamomum burmannii) as a renoprotective in lowering urea levels in the kidneys. An in vivo experimental study with a pre-post test and control group design was conducted at the Faculty of Medicine's Animal House and Biotechnology Laboratories. Male white rats (Rattus norvegicus) were used as the research subjects. Thirty rat were divided into five groups: negative control, positive control, cinnamon extract at 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW. The data were processed using SPSS 22.0. Cinnamon extract doses of 100 mg/kgBW and 200 mg/kgBW were the most effective in reducing urea levels and suspending the progression of the renal fibrosis process in Wistar male white rats with unilateral ureteral obstruction (UUO) model.
Persepsi Ibu Tentang Susu Formula dan Model Pemberian Susu Formula Pada Anak Bawah Dua Tahun Muhammad Rusdi; Ardesy Melizah Kurniati; Ella Amalia; Syarif Husin; Fatmawati Fatmawati
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.122

Abstract

Air susu ibu (ASI) direkomendasikan untuk terus diberikan bersama dengan makanan pendamping ASI hingga anak berusia dua tahun. Terdapat beberapa indikasi medis sehingga anak harus mendapatkan susu formula pada rentang usia tersebut. Namun, banyak ibu yang memberikan susu formula tanpa alasan indikasi medis. Belum diketahui apakah keputusan memberikan susu formula tersebut dipengaruhi persepi ibu tentang susu formula. Penelitian ini bertujuan untuk mengetahui persepsi ibu tentang susu formula, model pemberian susu formula, dan hubungan antara kedua variabel tersebut. Penelitian ini merupakan penelitian observational analitik dengan desain potong lintang, pada populasi ibu yang memiliki anak di rentang usia 6-24 bulan yang terdaftar di Puskesmas wilayah kerja Kecamatan Ilir Timur II Palembang. Sampel penelitian diambil dengan menggunakan metode consecutive sampling hingga mencapai 96 responden. Ibu yang memberikan susu formula tanpa indikasi medis dan bersedia berpartisipasi selanjutnya diwawancarai. Sebanyak 70,8% responden memiliki persepsi negatif terhadap susu formula. Sebagian besar memberikan susu formula secara parsial (75%). Uji Chi-Square menunjukkan tidak adanya hubungan antara persepsi ibu tentang susu formula dan model pemberian susu formula (p>0,05). Tidak terdapat hubungan antara persepsi ibu tentang susu formula dengan pemberian susu formula pada anak bawah dua tahun di Kecamatan Ilir Timur II Palembang.
Pemanfaatan Produk Alam dalam Mengatasi Resistensi Antimikroba: Tinjauan Naratif Sistematis Menuju Inovasi Kesehatan Berkelanjutan Rona Hawa Kamilah; Fatmawati
Proceedings National Conference Sinesia Vol. 1 No. 2 (2025): Accelerating SDGs Implementation in Indonesia towards a Golden Indonesia 2045
Publisher : Yayasan Penelitian dan Pengabdian Masyarakat Sisi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69836/ncrcs-sinesia.v1i2.92

Abstract

Resistensi antimikroba (AMR) telah menjadi ancaman kesehatan global yang serius, mengurangi efektivitas antibiotik konvensional dan menantang sistem kesehatan masyarakat. Produk alam, termasuk senyawa turunan tumbuhan dan jamur endofit, merupakan sumber potensial agen antimikroba baru. Tinjauan naratif sistematis ini bertujuan untuk mengidentifikasi dan merangkum studi-studi terbaru (2020–2025) mengenai potensi antimikroba produk alam dan perannya dalam inovasi kesehatan berkelanjutan. Pencarian literatur dilakukan secara komprehensif di PubMed, ScienceDirect, Google Scholar, dan ResearchGate. Studi disaring berdasarkan relevansi, kualitas metodologi, dan ketersediaan teks lengkap. Sebanyak 38 studi memenuhi kriteria inklusi, menyoroti efektivitas flavonoid, alkaloid, terpenoid, dan fenolik terhadap bakteri resisten obat, seperti Staphylococcus aureus, Pseudomonas aeruginosa, dan Escherichia coli. Mekanisme aksi meliputi gangguan membran sel, inhibisi pembentukan biofilm, dan intervensi pada quorum sensing bakteri. Meskipun bukti in vitro kuat, translasi klinis masih terbatas karena variasi metode ekstraksi, standar dosis, dan data farmakokinetik. Temuan ini menekankan potensi produk alam dalam menangani AMR sekaligus mendukung inovasi kesehatan berkelanjutan, khususnya di Indonesia dan Asia Tenggara. Upaya kolaboratif diperlukan untuk menstandarisasi metodologi, memvalidasi efektivitas in vivo, dan mengintegrasikan produk alam ke strategi kesehatan yang sejalan dengan Sustainable Development Goals.
PENYULUHAN DAN PELATIHAN PEMBUATAN SALEP MENGKUDU UNTUK PENCEGAHAN INFEKSI JAMUR KULIT PADA MASYARAKAT DESA TEBEDAK 2 Susilawati; Dalilah; Gita Dwi Prasasty; Dwi Handayani; Fatmawati; Hafid Syahputra
Jurnal Abdi Insani Vol 13 No 2 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i2.3639

Abstract

Infeksi jamur kulit seperti panu dan kurap masih sering terjadi pada masyarakat Desa Tebedak 2 akibat iklim lembap, kebiasaan higienitas yang kurang optimal, serta minimnya pemanfaatan bahan alam sebagai alternatif penanganan awal. Kegiatan pengabdian ini dilaksanakan untuk meningkatkan pengetahuan masyarakat tentang penyakit jamur kulit dan melatih keterampilan pembuatan salep anti jamur berbasis ekstrak mengkudu sebagai produk herbal sederhana yang aman dan ekonomis. Metode kegiatan meliputi penyuluhan interaktif mengenai etiologi, faktor risiko, penularan, dan pencegahan infeksi jamur, pelatihan pembuatan salep ekstrak mengkudu melalui demonstrasi dan praktik langsung, serta evaluasi pengetahuan dan keterampilan menggunakan pre-test, post-test, observasi praktik, dan kuesioner. Hasil kegiatan menunjukkan peningkatan pengetahuan yang signifikan, di mana 98% peserta menjawab benar seluruh soal pada post-test, meningkat dari pengetahuan awal yang masih terbatas terutama pada aspek faktor risiko dan PHBS. Peserta juga mampu mengikuti seluruh tahapan pembuatan salep dan menghasilkan 50 pot salep. Respons masyarakat sangat baik, ditandai tingginya antusiasme dan keinginan melanjutkan praktik pembuatan produk herbal secara mandiri. Kegiatan ini menyimpulkan bahwa penyuluhan dan pelatihan pembuatan salep ekstrak mengkudu efektif meningkatkan pemahaman dan keterampilan masyarakat dalam pencegahan serta penanganan awal infeksi jamur kulit.
The role of interleukin-17 in vulvovaginal candidiasis (VVC): literature review Rizka Amelia; Susilawati Susilawati; Fatmawati Fatmawati
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.57356

Abstract

Vulvovaginal candidiasis (VVC) is one of the most prevalent infections of the female genital tract. According to epidemiological data, almost 75% of women will at some point in their lives contract VVC. The main causative agent is Candida albicans. One of the main mediators is IL-17, a pro-inflammatory cytokine that is essential to the immunopathogenesis of VVC. Although IL-17 is essential for antifungal immunity, excessive or prolonged activation may lead to pathogenic inflammation and recurrence. This intricacy highlights the necessity of more research into the IL-17 regulation mechanisms in VVC and its possible use as a therapeutic target. Research published between 2020 and 2025 was included in a literature search that was done using databases including Scopus, PubMed, and Google Scholar. Eight of the 64 examined papers satisfied the requirements for inclusion. IL-17 is a key mediator in the immunopathogenesis of vulvovaginal candidiasis (VVC), according to preclinical, mechanistic, and clinical research. Treatments for VVC either increase or decrease IL-17 responses, and genetic variations in the IL-17/IL-23 axis are associated with a higher risk of developing the disease. In conclusion, IL-17 plays a key role in the pathophysiology of VVC. It is a promising biomarker and therapeutic target since it influences both immunological modulation and vulnerability through therapeutic treatments and genetic differences in the IL-17/IL-23 axis.
Arcangelisia flava L. Merr. Aqueous Extract Potential as a Xanthine Oxidase Inhibitor Fatmawati; Subandrate; Rini Yana; Maharani Puspita Sari HS; Nadia Permata Sari
Global Medical & Health Communication (GMHC) Vol. 13 No. 3 (2025): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i3.7968

Abstract

Arcangelisia flava L. Merr. contains several secondary metabolites, including berberine and palmatine, which are known to have potential as inhibitors of xanthine oxidase (XO). XO is an enzyme involved in purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine and then xanthine to uric acid. The community uses the stems and leaves of A. flava to maintain health by brewing them in hot water. The potential of this plant to inhibit XO using an aqueous solvent has never been studied. This study aims to assess the xanthine oxidase inhibitory activity of water extracts derived from the stems and leaves of A. flava. The study design was an in vitro experimental study conducted in the Basic Medical Chemistry Laboratory of Universitas Sriwijaya from September to December 2023. The aqueous extract of stems and leaves from A. flava was tested using an in vitro xanthine oxidase inhibitory assay, as observed through a decrease in uric acid levels via UV absorption. The stem extract exhibited stronger XO inhibition (IC50=21.15 μg/ml, 95% CI=19.87–22.51) compared with the leaf extract (IC50=68.42 μg/ml, 95% CI=61.35–76.28). The inhibitory activity of the stem extract approached that of allopurinol (IC50=16.78 μg/ml, 95% CI=15.62–18.02). In conclusion, the aqueous stem extract of A. flava demonstrates significantly XO inhibitory activity than the aqueous leaf extract.
Co-Authors Alderiantama Akhmad Aliah Ramadhani Puteri Ardesy Melizah Kurniati Athiah, Medina Aulia Firdha Tariza Chairil Anwar Dalilah Dazakiah Dita Ardianti Dwi Handayani Dwi Handayani Dzakiyah Dzakiyah Dzakiyah Ella Amalia Ella Amalia, Ella Erizka Rivani Ester G Pansserga Ester Gonzales Panserga Fadiya Fadiya Fadiya Fahira Anindita Fahira Anindita Fahira Aninditia Fidalia Firmansyah Basir Firmansyah Seta Basyir Gita Dwi Prasasty Gita Dwi Prasasty Hafid Syahputra Hana Daini Sabathania Hartati Humairah Binti Huda HUSNUL KHOTIMAH Irfannudin Irfannudin Irfanuddin Irfanuddin Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Kamilah, Rona Hawa Kusumo Hariyadi Kusumo Hariyadi L.O Oswari Liniyanti D Oswari Liniyanti D Oswari Liniyanti D Oswari Liniyanti D. Oswari Liniyati D Oswari Liniyati D Oswari M Athiah M Fakhri Altiyan M Fitra Romadhon M. Ivan Pratama Maharani Natasya Maharani Puspita Sari HS Medina Athiah Mgs Irsan Saleh Mohammad Fazel Iftikhar Syahdafy Muhammad Irsan Saleh Muhammad Rusdi Muhammad Usman Salim Nadia Permata Sari Nadya Nadya Nadya Naomi W Tioline Nita Parisa Nurlutfiyyah Aini Prima Maya Sari Putra Ramadhan Algiffary Irianto Dunda Qherine Bhelqis Qherine Bhelqis RACHMAT HIDAYAT Radiyati Umi Partan Rara Inggarsih Rara Inggarsih Rifka Purnama Sari Rini Yana Rini Yana Rini Yana Rizka Amelia S Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safira Azahra Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Salmi Salmi Salni Salni Siti Devita Utami Siti Rusdiana Puspa Dewi Sri Hartati Sri Wahyuni Subandrate Susilawati Susilawati Susilawati Syarif Husin Theodorus Theodorus Venny Larasati Vera Tanzey Yundari, Yundari Ziske Maritska