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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Jurnal Kimia Mulawarman Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Jurnal Farmasi Sains dan Komunitas Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Jurnal Ners Jurnal Abdi Insani Sriwijaya Journal of Ophthalmology Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Proceedings National Conference Sisi Indonesia Global Medical and Health Communication
Fatmawati
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PENYULUHAN DAN PELATIHAN PEMBUATAN SALEP MENGKUDU UNTUK PENCEGAHAN INFEKSI JAMUR KULIT PADA MASYARAKAT DESA TEBEDAK 2 Susilawati; Dalilah; Gita Dwi Prasasty; Dwi Handayani; Fatmawati; Hafid Syahputra
Jurnal Abdi Insani Vol 13 No 2 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i2.3639

Abstract

Infeksi jamur kulit seperti panu dan kurap masih sering terjadi pada masyarakat Desa Tebedak 2 akibat iklim lembap, kebiasaan higienitas yang kurang optimal, serta minimnya pemanfaatan bahan alam sebagai alternatif penanganan awal. Kegiatan pengabdian ini dilaksanakan untuk meningkatkan pengetahuan masyarakat tentang penyakit jamur kulit dan melatih keterampilan pembuatan salep anti jamur berbasis ekstrak mengkudu sebagai produk herbal sederhana yang aman dan ekonomis. Metode kegiatan meliputi penyuluhan interaktif mengenai etiologi, faktor risiko, penularan, dan pencegahan infeksi jamur, pelatihan pembuatan salep ekstrak mengkudu melalui demonstrasi dan praktik langsung, serta evaluasi pengetahuan dan keterampilan menggunakan pre-test, post-test, observasi praktik, dan kuesioner. Hasil kegiatan menunjukkan peningkatan pengetahuan yang signifikan, di mana 98% peserta menjawab benar seluruh soal pada post-test, meningkat dari pengetahuan awal yang masih terbatas terutama pada aspek faktor risiko dan PHBS. Peserta juga mampu mengikuti seluruh tahapan pembuatan salep dan menghasilkan 50 pot salep. Respons masyarakat sangat baik, ditandai tingginya antusiasme dan keinginan melanjutkan praktik pembuatan produk herbal secara mandiri. Kegiatan ini menyimpulkan bahwa penyuluhan dan pelatihan pembuatan salep ekstrak mengkudu efektif meningkatkan pemahaman dan keterampilan masyarakat dalam pencegahan serta penanganan awal infeksi jamur kulit.
The role of interleukin-17 in vulvovaginal candidiasis (VVC): literature review Rizka Amelia; Susilawati Susilawati; Fatmawati Fatmawati
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.57356

Abstract

Vulvovaginal candidiasis (VVC) is one of the most prevalent infections of the female genital tract. According to epidemiological data, almost 75% of women will at some point in their lives contract VVC. The main causative agent is Candida albicans. One of the main mediators is IL-17, a pro-inflammatory cytokine that is essential to the immunopathogenesis of VVC. Although IL-17 is essential for antifungal immunity, excessive or prolonged activation may lead to pathogenic inflammation and recurrence. This intricacy highlights the necessity of more research into the IL-17 regulation mechanisms in VVC and its possible use as a therapeutic target. Research published between 2020 and 2025 was included in a literature search that was done using databases including Scopus, PubMed, and Google Scholar. Eight of the 64 examined papers satisfied the requirements for inclusion. IL-17 is a key mediator in the immunopathogenesis of vulvovaginal candidiasis (VVC), according to preclinical, mechanistic, and clinical research. Treatments for VVC either increase or decrease IL-17 responses, and genetic variations in the IL-17/IL-23 axis are associated with a higher risk of developing the disease. In conclusion, IL-17 plays a key role in the pathophysiology of VVC. It is a promising biomarker and therapeutic target since it influences both immunological modulation and vulnerability through therapeutic treatments and genetic differences in the IL-17/IL-23 axis.
Arcangelisia flava L. Merr. Aqueous Extract Potential as a Xanthine Oxidase Inhibitor Fatmawati; Subandrate; Rini Yana; Maharani Puspita Sari HS; Nadia Permata Sari
Global Medical & Health Communication (GMHC) Vol. 13 No. 3 (2025): Accredited Sinta 2
Publisher : UPT Publikasi Ilmiah Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i3.7968

Abstract

Arcangelisia flava L. Merr. contains several secondary metabolites, including berberine and palmatine, which are known to have potential as inhibitors of xanthine oxidase (XO). XO is an enzyme involved in purine metabolism, catalyzing the oxidation of hypoxanthine to xanthine and then xanthine to uric acid. The community uses the stems and leaves of A. flava to maintain health by brewing them in hot water. The potential of this plant to inhibit XO using an aqueous solvent has never been studied. This study aims to assess the xanthine oxidase inhibitory activity of water extracts derived from the stems and leaves of A. flava. The study design was an in vitro experimental study conducted in the Basic Medical Chemistry Laboratory of Universitas Sriwijaya from September to December 2023. The aqueous extract of stems and leaves from A. flava was tested using an in vitro xanthine oxidase inhibitory assay, as observed through a decrease in uric acid levels via UV absorption. The stem extract exhibited stronger XO inhibition (IC50=21.15 μg/ml, 95% CI=19.87–22.51) compared with the leaf extract (IC50=68.42 μg/ml, 95% CI=61.35–76.28). The inhibitory activity of the stem extract approached that of allopurinol (IC50=16.78 μg/ml, 95% CI=15.62–18.02). In conclusion, the aqueous stem extract of A. flava demonstrates significantly XO inhibitory activity than the aqueous leaf extract.
Inhibitory Effect of Ethanol Extract of Cherry Mistletoe Leaves (Dendrophthoe pentandra (L.) Miq) on Xanthine Oxidase Enzyme Hana Daini Sabathania; Subandrate Subandrate; Sadakata Sinulingga; Safyudin Safyudin; Liniyanti D Oswari; Fatmawati Fatmawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008252

Abstract

One plant that can be used as an alternative treatment for hyperuricemia is the cherry plant. The usefulness of these plants is due to the secondary metabolite compounds that can inhibit the enzyme xanthine oxidase. Cherry mistletoe is thought to have the same flavonoids, saponins, alkaloids, terpenoids, and tannins as the cherry plant, which can act as inhibitors. The aim of the study was to determine the inhibitory effect of an ethanol extract of cherry mistletoe leaves on the xanthine oxidase enzyme. This study was conducted as  an in vitro experimental study. Cherry mistletoe leaves were extracted with 96% ethanol. The extract was done with phytochemical screening, followed by an inhibition test on the xanthine oxidase enzyme using a spectrophotometer at a wavelength of 400 nm. Allopurinol was a positive control. The ethanol extract of cherry mistletoe leaves contains flavonoids, saponins, alkaloids, terpenoids, and tannins. The IC50 value of the ethanol extract of cherry mistletoe leaves was 23.44 mg/L. The ethanol extract of cherry mistletoe leaves has an inhibitory effect on the xanthine oxidase enzyme with moderate activity. Accordingly, the cherry mistletoe leaf extract can be considered as an alternative inhibitor of the xanthine oxidase enzyme in the control of hyperuricemia.
Co-Authors Alderiantama Akhmad Aliah Ramadhani Puteri Anwar, Chairil Ardesy Melizah Kurniati Athiah, Medina Aulia Firdha Tariza Dalilah Dazakiah Dwi Handayani Dwi Handayani Dzakiyah Dzakiyah Dzakiyah Ella Amalia Ella Amalia, Ella Erizka Rivani Ester G Pansserga Ester Gonzales Panserga Fadiya Fadiya Fadiya Fahira Anindita Fahira Anindita Fahira Aninditia Fidalia Firmansyah Basir Firmansyah Seta Basyir Gita Dwi Prasasty Gita Dwi Prasasty Hafid Syahputra Hana Daini Sabathania Hartati Humairah Binti Huda HUSNUL KHOTIMAH Irfannudin Irfannudin Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Kusumo Hariyadi Kusumo Hariyadi L.O Oswari Liniyanti D Oswari Liniyanti D Oswari Liniyanti D. Oswari Liniyati D Oswari Liniyati D Oswari M Athiah M Fakhri Altiyan M Fitra Romadhon M. Ivan Pratama Maharani Natasya Maharani Puspita Sari HS Mgs Irsan Saleh Mohammad Fazel Iftikhar Syahdafy Muhammad Irsan Saleh Muhammad Rusdi Muhammad Usman Salim Nadia Permata Sari Nadya Nadya Nadya Naomi W Tioline Nita Parisa Nurlutfiyyah Aini Prima Maya Sari Putra Ramadhan Algiffary Irianto Dunda Qherine Bhelqis Qherine Bhelqis RACHMAT HIDAYAT Radiyati Umi Partan Rara Inggarsih Rara Inggarsih Rifka Purnama Sari Rini Yana Rini Yana Rini Yana Rizka Amelia Rona Hawa Kamilah Rona Hawa Kamilah S Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safira Azahra Safyudin Safyudin Safyudin Safyudin Salni Salni Siti Devita Utami Siti Rusdiana Puspa Dewi Sri Hartati Sri Wahyuni Subandrate Subandrate Susilawati Susilawati Susilawati Susilawati Susilawati Syarif Husin Theodorus Theodorus Venny Larasati Yundari, Yundari Ziske Maritska