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All Journal Indonesian Journal of Applied Sciences International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Sari Pediatri Paediatrica Indonesiana Jurnal Maternitas Aisyah (JAMAN AISYAH) Jurnal Ilmu Keperawatan dan Kebidanan

Eddy Fadlyana

Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran Rumah Sakit Dr. Hasan Sadikin, Bandung

Author-ID : 2500748

Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Short term memory, physical fitness, and serum brain-derived neurotrophic factor in obese adolescents Rini Rossanti; Dida Akhmad Gurnida; Eddy Fadlyana
Paediatrica Indonesiana Vol 55 No 5 (2015): September 2015
Publisher : Indonesian Pediatric Society

Background Obesity in adolescents is a major health problem and has been associated with low academic achievement. Brainderived neurotrophic factor (BDNF), a neurotrophin, plays a role in appetite suppression and memory, and its secretion is enhanced by physical activity. This neurotrophin may be associated with academic achievement in obese. Objective To compare physical fitness and serum BDNF levels to short term memory levels in obese adolescents aged 10â€“14 years. Methods This comparative, cross-sectional, analytic study was carried out on 40 elementary and high school students in Bandung, West Java, who were recruited by stratified random sampling. Short term memory was assessed by a psychologist using the Wechsler Intelligence Scale for Children-III Digit Span test (WISC-III Digit Span). Physical fitness was assessed by a clinical exercise physiologist using the Asian Committee on the Standardization of Physical Fitness Test (ACSPFT). Serum BDNF levels were measured by ELISA test in a certified laboratory. ANOVA test was used to assess for a correlation between serum BDNF concentration and short term memory, as well as between physical fitness level and short term memory. Pearsonâ€™s correlation test was used to analyze for a correlation between serum BDNF and physical fitness levels. Results The majority of subjects were in the physical fitness categories of moderate or poor. Subjects had a mean BDNF level of 44,227.8 (SD 10,359) pg/mL. There was no statistically significant difference in physical fitness with either serum BDNF or with short term memory levels (P=0.139 and P=0.383, respectively). Also, no correlation was determined between serum BDNF and physical fitness levels (r=0.222; P=0.169). Conclusion In obese adolescents, short term memory levels are not significantly different between physical fitness levels nor between serum BDNF levels.

Risk factors for obesity in 6 to 12-year-old children Andy Japutra; Eddy Fadlyana; Anggraini Alam
Paediatrica Indonesiana Vol 55 No 1 (2015): January 2015
Publisher : Indonesian Pediatric Society

Background The causes of obesity in children are multifactorial, including genetics, physiology, metabolism, psychology, socioeconomic status, lifestyle, and culture. Objective To assess for relationships between obesity in 6 to 12-year-old children and maternal nutritional status, maternal education, eating breakfast, eating fast food, physical activity, TV watching, and playing video games. Methods This case-control study included students of Sejahtera Public School aged 6 to 12 years. Questionnaires were distributed to their parents for data on maternal education, eating breakfast, eating fast food, physical activity, TV watching and playing video games. Maternal nutritional status was assessed by one of the researchers. Univariate analysis with Chiâ€“square test was used to assess every risk factor. Those with a P value of <0.25 were subjected to multivariate analysis, performed using multiple logistic regression analysis. Results From June to July 2013, 60 obese children and 60 wellnourished children, as a control group, were enrolled in the study. Obese mothers tended to have obese children [odds ratio/OR 252.48; 95%CI 33.4 to 1908.4]. Children who ate fast food 6â€“8 times/week, had low physical activity, and watched TV more than 8 hours/week had significantly higher risk for obesity [OR 12.94, 95%CI 1.7 to 100.7; and OR 266.94, 95% CI 7.8 to 9137.7; OR 21.44, 95%CI 2.68 to 171.61; respectively]. Maternal education, eating breakfast, and playing video games were not significant risk factors for childhood obesity. Conclusion Maternal obesity, eating fast food 6-8 times per week, low physical activity and watching TV more than 8 hours/ week are risk factors for childhood obesity.

Agreement between the Denver II and Parentsâ€™ Evaluation of Developmental Status tests, with and without the assistance of a table of categorical responses Arief Priambodo; Meita Dhamayanti; Eddy Fadlyana
Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

Background Among standardized developmental screening tools, the Denver II is commonly used by Indonesian pediatricians, but the Parentâ€™s Evaluation of Developmental Status (PEDS) test has gained in popularity. The Denver II test is filled by physicians, while the PEDS test is meant to be filled by parents. From a practical standpoint, however, parents often require assistance from doctors when filling out the PEDS forms. Hence, the advantage of the PEDS test over the Denver II test is not fully realized.Objective To compare the agreement between Denver II and PEDS tests, with and without parental use of a table of categorical responses taken from the PEDS manual.Methods We conducted a cross-sectional study in children aged 6 months to 5 years in Bandung from November 2015 to March 2016. Subjects were divided into two groups using block randomization. One group of subjectsâ€™ parents filled the PEDS questionnaires with the assistance of a table of categorical responses taken from the PEDS manual, while the other group of subjectsâ€™ parents filled PEDS forms without this table. All subjects underwent Denver II screening by pediatricans. The agreement between the PEDS and Denver II results were assessed by Kappa score.Results Of 254 children, 239 were analyzed. Kappa scores between the Denver II and PEDS tests were 0.05 (95%CI: -0.10 to 0.20) without the table of categorical responses, and -0.06 (-0.23 to 0.10) with the table of categorical responses.Conclusion Agreement between the Denver II and PEDS tests is poor. The table of categorical responses does not increase the agreement between Denver II and PEDS.

Safety and immunogenicity of the DTP/HB /Hib combination vaccine: phase I study Kusnandi Rusmil; Eddy Fadlyana; Novilia Sjafri Bachtiar; Hadyana Hadyana
Paediatrica Indonesiana Vol 53 No 6 (2013): November 2013
Publisher : Indonesian Pediatric Society

Background The World Health Organization (WHO) hasrecommended the introduction ofhepatitis B (HB) and Haemophilusinfluenza type b (Hib) vaccines into routine childhood vaccinationprograms. A new diptheria/tetanus/pertussis (DTP) /hepatitis B/Hibpentavalent combination vaccine has been developed.Objective To evaluate the safety and immunogenicity of a newcombination DTP/HB/Hib liquid vaccin e in infants.Met hods An open-label, uncontrolled, prospective interventionphase I study was con ducted on 30 healthy infants aged 6- 11weeks. Each subject received 3 doses of DTP/HB/Hib vaccine,formulated by Bio Fanna, 0.5 mL intramuscularly at the leftanterolateral thigh region using a 25-gauge n eedle of 25 mmlength . Subjects were followed for 1 month after administration ofeach vaccine dose to evaluate its safety, while serum anti-diphteria,tetanus, HB, Hib, and per tussis antibodies were measured priorto the l '' dose and 1 month after the Jtd dose.Results Among 30 vaccinated subjects, 18 infants had fever within24 hours after the first vaccination. Most cases of fever were mildin intensity and resolved within 24 hours. No other systemic orlocal reactions, or serious adverse events were observed in oursubjects during the study. The immunogenicity results after Jtdvaccine dose showed that the geometric mean titer of the antipolyribosylribitolphosphate (PRP) antibody levels increasedsignificantly from 0.0041Î¼,g/mL to 4.3 7 Î¼,g/mL after vaccination,and most infants h ad a fourfo ld or greater rise in antibody levelsover their pre-injection levels . All subjects who received DTP/HB/Hib liquid vaccine had seropro tective antibodies againsttetanus, diphtheria,a and hepatitis B, while 29/30 infants hadseroprotective antibodies against pertussis.Conclusion This new diphtheria/tetanus/pertusis/hepatitis B/Hibcombination vaccine has excellent safety profile and antibodyresponses in infants. These results encourage further clinicalevaluation in phase II.

Comparison of language and visual-motor developments between exclusively and non-exclusively breastfed infants through cognitive adaptive test/clinical linguistic and auditory milestone scale Lesmana Syahrir; Eddy Fadlyana; Sjarif Hidajat Effendi
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Background Provision of adequate nutrients is needed in theearly year oflife to support the most rapid growth and development period in infant's life. Moreover, warm and responsive parent-child interaction associated with breastfeeding is beneficial for optimal child development.Objective The objective of this study was to compare the language and visual-motor developments between exclusively breast-fed and non-exclusively breast-fed infants.Methods This historical cohort study was performed from Mayto June 2009. Study subjects consisted of 6-month-old infantslived in Puskesmas Garuda operational area. Language and visual-motor development were measured by cognitive adaptive test/clinical linguistic &auditory milestone scale (CAT/CLAMS). The differences of CAT /CLAMS scores between groups were analyzed with Mann-Whitney test.Results There were 39 exclusively breastfed and 39 non-exclusively breastfed infants enrolled in this study. No significant differences were found between the two groups concerning the subject or their parents characteristics. Mean CAT/CLAMS score of the exclusively breastfed infants was 8.34 points higher than that of the non-exclusively breastfed infants (P=0.002). Similar outcomes were found in language and visual-motor scales which were higher in the exclusively breastfed infants with the differences of9.82 points (P=O.OOl) and 6.85 points (P=0.039), respectively.Conclusion Exclusively breastfed infants has higher language andvisual-motor developmental quotient score than non-exclusivelybreastfed infants.

The occurrence of pulmonary hypertension in patients with thalassemia major Hasan Basri; Armijn Firman; Kusnandi Rusmil; Eddy Fadlyana
Paediatrica Indonesiana Vol 43 No 5 (2003): September 2003
Publisher : Indonesian Pediatric Society

Background The life of patients with thalassemia major dependson blood transfusions, while repeated blood transfusions may causeadverse effects such as iron deposition in various organs, includ-ing heart and lungs, which eventually increases the pulmonaryarterial pressure.Objective This study was proposed to know the occurrence ofpulmonary hypertension in patients with thalassemia major, mea-sured by echocardiography in the Thalassemia Clinic, Departmentof Child Health, Medical School, Padjadjaran University/HasanSadikin Hospital, Bandung.Methods A descriptive cross-sectional study was carried outon 30 patients with thalassemia major, aged 10-14 year-old whoreceived repeated blood transfusions. The study was conductedfrom April to May 2002. Subjects were examined right after ablood transfusion completed and the pulmonary arterial pres-sure was assessed using Dopplerâ€“echocardiography and 2-Dechocardiography.Results Twenty two out of 30 subjects showed pulmonary hyper-tension, with pulmonary arterial pressure ranged between 32.3 to46.2 mmHg. According to the age group, pulmonary hypertensionwas found in 12 out of 17 subjects aged 10-12 years old and 10out of 13 subjects aged 13-14 years old.Conclusion The occurrence of pulmonary hypertension in patientswith thalassemia major at Hasan Sadikin Hospital was 22/30 andseemed to increase with the age of the patients

Immunogenicity and safety of a trivalent inactivated influenza vaccine Eddy Fadlyana; Kusnandi Rusmil; Novilia Sjafri Bachtiar; Rachmat Gunadi; Hadyana Sukandar
Paediatrica Indonesiana Vol 51 No 1 (2011): January 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.1.2011.22-8

Background Trivalent inactivated influenza vaccines (TIV) containing antigens of two influenza A strains, A(H1N1) and A(H3N2), and one influenza B strain, are the standard {onnulation for influenza prevention. The vaccines must be updated annually to provide optimal protection against the predicted prevalent strains for the next influenza season.Objective To assess the immunogenidty and safety of the inactivated influenza vaccine (FlubioÂ®) in adolescents and adults, 28 days after a single dose.Methods In this experimental, randomized, single-blind, bridging study, we included 60 healthy adolescents and adults. A single, 0.5 mL dose was administered intramuscularly in the deltoid muscle of the left ann. Blood samples were obtained before and 28 days after immunization. Standardized hemagglutination inhibition (HI) test was used to assess antibody response to influenza antigens.Results From January to February 2010, a total of 60 adolescents and adults enrolled in the study, but two participants did not provide the required blood samples. One hundred percent of the subjects had an anti-influenza titer â‰¥ 1:40 HI units to all three strains, A/Brisbane/59/2007 (H1N1), A/Uruguay/716/2007 (H3N2), and B/Brisbane/60/2008 (P=1.000) after immunization. The Geometric Mean Titers (GMT) after immunization increasedfor all strains: A/Brisbane, 76.4 to 992.7, A/Uruguay, 27.6 to 432.1, and B/Brisbane, 19.9 to 312.7. Twenty eight days after immunization, we found a 4 times increase in antibody titers in 75.8% of the subjects for A/Brisbane, 84.5% for A/Uruguay, and 77.6% for B/Brisbane. We also observed that 100% of seronegative subjects converted to seropositive for all 3 strains. All vaccines were well-tolerated. There were no serious adverse events reported during the study.Conclusion In adolescents and adults, the FlubioÂ® vaccine was immunogenic and safe.

Serum IGF-1 and short stature in adolescents with Î²-thalassemia major Monalisa Elizabeth; Eddy Fadlyana; Lelani Reniarti; Faisal Faisal; Hadyana Sukandar; Kusnandi Rusmil
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Background The prevalence of short stature in thalassemia patients ranges from 39.3 to 65%. The cause of short stature is complex and still up for debate. In Indonesia, data on the prevalence and risk factors of short stature in adolescents with thalassemia have been limited. Objective To assess for the prevalence and risk factors of short stature in adolescents with beta-thalassemia major. Methods This cross-sectional study was done from February to March 2017 at the Thalassemia Clinic at Dr. Hasan Sadikin General Hospital, Bandung. The baseline characteristics data of 80 adolescents with thalassemia aged 10-14 years were recorded. Short stature was assessed by height-for-age, (Z-score <-2SD) based on the 2007 WHO Reference Growth Chart. Mid-upper arm circumference was scored according to age and sex and serum IGF-1 was measured by ELISA method. Data analyses used were Chi-square, Fisherâ€™s, and Mann-Whitney tests. Logistic regression model was used to further analyze for risk factors of short stature. Results Subjects were 40 males and 40 females, 81.2% of whom had short stature. The mean serum IGF-1 level was 32.2 (SD 26.38) ng/mL. The IGF-1 cut-off point by ROC curve was â‰¤38.51 ng/mL, with sensitivity of 64.4% and specificity of 86.7%. The risk factors of short stature were IGF-1 level â‰¤38.51 ng/mL (PR 40.66; 95%CI 4.37 to 377.58; P<0.001) and low family income (PR 19.76; 95%CI: 1.152 to 256.08; P=0.022). Conclusion IGF-1 level may be useful as a predictor of short stature in adolescent beta-thalassemia major patients.

Neutrophil-lymphocyte count ratio correlation to procalcitonin and PELOD-2 score in pediatric sepsis Desak Gede Arie Yudhantari; Dadang Hudaya Somasetia; Eddy Fadlyana; Djatnika Setiabudi
Paediatrica Indonesiana Vol 61 No 4 (2021): July 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.4.2021.211-6

Background Sepsis is a leading cause of children’s mortality worldwide. Procalcitonin (PCT) is a widely used infection marker, but has limitations in terms of cost and availability. The neutrophil-lymphocyte count ratio (NLCR) is easy to perform, low-cost, and widely used as a diagnostic and prognostic marker of various inflammatory processes. Objective To investigate possible correlations of NLCR to PCT and Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score among pediatric sepsis patients. Method A retrospective study was conducted by reviewing the Pediatric Sepsis Registry at Dr. Hasan Sadikin General Hospital, Bandung, West Java, from January 2019–June 2020. We recorded patients’ characteristics, PELOD-2 score, NLCR, and PCT results. Correlation analysis was conducted using Spearman’s Rank test with significance value of P<0.05. Results Ninety patients were included in the study. Most patients were male (56.7%), under 2 years of age (57.8%), and had lower respiratory tract infection (67.8%) as the most common source of infection. The NLCR value had significant, positive correlations to PCT (r=0.642; P<0.001) and PELOD-2 score (r=0.233; P=0.027) in pediatric sepsis patients. Conclusion The NLCR is directly proportional to PCT in pediatric sepsis patients. This result suggents that NLCR may have a potential role as an alternative marker for sepsis in emergency setting.

Co-Authors Adhitya Agung Pratama Alex Chairulfatah Alex Chairulfatah Andy Japutra Anggraini Alam Anna Alisjahbana Anne Susanty Arief Priambodo Arifah Nur Istiqomah Armijn Firman Cissy Kartasasmita Dadang Hudaya Somasetia Dadang Hudaya Somasetia Dany Hilmanto Desak Gede Arie Yudhantari Dewi Marhaeni Diah Herawati Dida Akhmad Gurnida Djatnika Setiabudi Dwi Putra, Muhammad Gilang Elda Khalida Elizabeth, Monalisa Elsa Pudji Setiawati Endah Pujiastuti Erwina Sumartini Faisal Faisal Faisal Faisal Fathiyah Maâ€™ani Firman Fuad Wirakusumah Fitriah, Iin Prima Fiva A Kadi Fiva A Kadi Ghaniyyatul Khudri Gladys Gunawan Gustomo Panantro Hadyana Hadyana Hadyana Hadyana Hadyana Sukandar Hadyana Sukandar Hasan Basri Heda Melinda Nataprawira Herman Susanto Herry Garna Herry Herman Ilsa Nelwan Istiqomah, Arifah Nur Ita Susanti Iwin Sumarman Iwin Suwarman Jusuf Sulaeman Effendi Kartasmita, Cissy B Krisnadi, Sofie Kusnandi Rusmil Kusnandi Rusmil Kusnandi Rusmil Lelani Reniarti Lesmana Syahrir Lina H Soemara Mardiah, Behesti Zahra Marietta Shanti Prananta Meita Dhamayanti Meita Dhamayanti Meita Dhamayanti Muchlisah Noor Nanan Sekarwana Nita Arisanti Nita Arisanti Nova Sylviana Novila Sjafri Bachtiar Novilia S Bachtiar Novilia Sjafri Bachtiar Novilia Sjafri Bachtiar Novilia Sjafri Bachtiar Novilia Sjafri Bachtiar Novillia S Bachtiar Novina Novina Panantro, Gustomo Prananta, Marietta Shanti Primadevi, Inggit Puspasari Sinaga R Dharmayanti Rachmat Gunadi Rachmat Gunadi Rafa Fathia Suhud Rini Mulia Sari Rini Rossanti Rodman Tarigan Selly Selly Setyorini Irianti Sheilla Selvina Sheilla Selvina, Sheilla Shinta Larasaty Sinaga, Puspasari Sinthura Vimalan Subramaniam Siti Aminah Sjarif Hidajat Effendi Soenarjati Soedigo Adi Soenarjati Soedigo Adi Sofia, Norlaila Sri Endah Rahayuningsih Sri Utami Suwarto Subramaniam, Sinthura Vimalan Suganda Tanuwidjaja Susiarno, Hadi Tommy Nugrahadi Whisnubrata Yenny Purnama Yulia Sofiatin Yundari, Yundari

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