Article Per Year (5 Year)
p-Index From 2021 - 2026
1.945
P-Index
This Author published in this journals
All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) MEDISAINS Biomedika Universa Medicina Jurnal Penelitian Kesehatan Suara Forikes JSFK (Jurnal Sains Farmasi & Klinis) Amerta Nutrition Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Masyarakat Kedokteran Journal of Health and Nutrition Research Indonesian Journal of Medical and Pharmaceutical Science Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Atina Hussaana
Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : MEDISAINS

 1 
Kelakai serum reduces UVB-induced vascular endothelial growth factor and interleukin-6: in vivo study Ulfadhina, Nedya; Hussaana, Atina; Suparmi, Suparmi
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.25906

Abstract

Background: UVB exposure increases reactive oxygen species leading to higher expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6), which accelerate photoaging. Kelakai leaf (Stenochlaena palustris) contains flavonoids and phenolic compounds with antioxidant and anti-inflammatory potential, yet its efficacy in serum formulations has not been evaluated. Purpose: To determine the effect of kelakai leaf extract serum on VEGF and IL-6 expression in BALB/c mice exposed to subchronic UVB radiation. Method: This experimental post-test only control group study used 30 BALB/c mice assigned to five groups: healthy control (K1), UVB-exposed negative control (K2), UVB + 0.025% retinoid serum (K3), UVB + 2% kelakai serum (K4), and UVB + 4% kelakai serum (K5). UVB exposure (160 mJ/cm²) was given for 14 days followed by topical treatment. Skin tissues were examined using immunohistochemistry to assess VEGF and IL-6 expression. Data were analyzed using the Kruskal–Wallis test followed by Mann–Whitney. Results: VEGF and IL-6 expression were highest in K2 and lowest in K1. Both retinoid and kelakai serum significantly reduced expression levels (p<0.05). The 4% kelakai serum (K5) produced greater reductions than the 2% dose, approaching the effect of retinoid serum. Conclusion: Kelakai leaf extract serum at 4% effectively decreases VEGF and IL-6 expression in UVB-exposed mice, supporting its potential as a natural anti-photoaging agent.
Co-Authors ., Chodidjah Arief Adi Saputro Azida, Nining Farrikh Bagas Widiyanto, Bagas Budiarto, Agnes Chodidjah Chodidjah Conita Yuniarifa Danis Pertiwi Dewi, Dwi Arditi Djajadihardja, Andreas Yudi Prasetyo Djam’an, Qathrunnada Edijanti Goenarwo Hadi Sarosa Heni Wijayanti, Heni Ken Wirastuti Marisa, Ana Maryam Mulyaningsih, Ruri Eka Masfiyah Masfiyah, Masfiyah Mediana, Mecha Amalia Mohamad Riza Mohammad Rizal Nur Fauzi Mushidah Mushidah, Mushidah Naila Shulya Ellyana Naniek Widyaningrum Puspitasari, Nesya Ayu Qathrunnada Djam’an Riza, Mohamad Sari, Amalia Nirma Setyaningrum, Widya Ayu Setyo Trisnadi Setyo Trisnadi SHOLIKHAH, ANISATUS Suparmi Suparmi Susilorini Susilorini, Susilorini Taufiqurrachman Nasihun Taufiqurrahman Nasihun, Taufiqurrahman Tsuraya, Ghefira Ulfadhina, Nedya Ulfah Dian Indrayani Wani, Elsayanti Wiwik Handayani Yuniarifa, Conita