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All Journal HAYATI Journal of Biosciences CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Jurnal Veteriner Jurnal Ilmu Dasar Journal of Applied Chemical Science Alchemy Jurnal Penelitian Kimia Indonesian Journal of Cancer Agrica: Journal of Sustainable Dryland Agriculture Journal of Health Sciences and Medicine Indonesian Journal of Cancer Journal of Veterinary and Animal Sciences

I Made Dira Swantara

Program Studi Kimia FMIPA Universitas Udayana, Jimbaran, Bali, Indonesia

Author-ID : 254411

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Earth & Planetary Sciences Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Veterinary

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IDENTIFIKASI SENYAWA ANTIRADIKAL BEBAS PADA RUMPUT LAUT Sargassum ringgoldianum I M. Dira Swantara; A. A. Bawa Putra; I P. Surya Udayana
Jurnal Kimia (Journal of Chemistry) Vol. 6, No. 1 Januari 2012
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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The identification of antiradical compounds from Sargassum ringgoldianum seaweed has been conducted. Its metabolite extraction was carried out by maceration using ethanol and acetit acid mixture with ratio 9:1. It produced 7,02 gram crude extract from 230 grams of sample pollen. This crude extract has free-radical reduction activity of 66,50% at the fifth minute and 78,77% at the sixtieth minute. Separation and purification were carried out by partition, thin layer chromatography, and column chromatography. Partition was accomplished using petroleum ether, chloroform, ethyl acetate, and also water. Petroleum ether ectract had the highest free-radical reduction percentage, of 76,21%, which was obtained on the fifth minute, and 91,16% on the sixtieth minute. The petroleum ether extract was further separated with column chromatography, using stationary phase of silica gel 60 and mobile phase of a mixture of petroleum ether : acetone (7:3) and produced five fractions (FA, FB, FC, FD, dan FE). The most active fraction with antiradical activity was fraction B with percentage of free-radical reduction of 62,77% on the fifth minute and 92,19% on the sixtieth minute. This activity equals 93,06% of the antiradical activity of vitamin E. Fraction B was identified to consist of six compounds : ethyl myristate; dibutyl phthalate; ethyl palmitate; methyl isostearate; dioctyl phthalate; and 3?-bromo cholest-5-ene.

ANTIBACTERIAL ACTIVITY OF Samanea saman LEAF ETHANOL EXTRACT AGAINST Escherichia coli AND Staphylococcus aureus AND ITS TOTAL FLAVONOID AND PHENOLIC CONTENTS W. S. Rita; I M. D. Swantara; I. A. R. Astiti Asih; N.K. Sinarsih
Jurnal Kimia (Journal of Chemistry) Vol.12 No.2 Juli 2018
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Antibacterial activity of Samanea saman usually shows a positif correlation to the flavonoid and phenolic contents. The aim of this study was to evaluate the antibacterial activity of the ethanol extract of Samanea saman against Escherechia coli and Staphylococcus aureus and determine the total flavonoid and phenolic contents of the extract. The extraction was done by ethanol 96% at room temperature. The antibacterial assay was conducted by agar disc diffusion method. The total flavonoid and phenolic contents were determined by UV-Vis Spectrofotometer with the standard of quersetin and galic acid, respectively. The extraction of 250 g of Samanea saman leaves resulted in 24.5 g of ethanol extracts. The ethanol extract showed a moderate inhibition of 8.33 mm towards E. coli and a strong inhibition of 13.6 mm towards S. aureus at the concentration of 4%. The Minimum Inhibitory Concentration (MIC) of the extract against E. coli and S.aureus were of 3% and 0.3%”, respectively. The total flavonoid and phenolic contents were successively 1233.2991 mg QE/100g and 2544.6154 mg GAE/100g. Keywords: Escherechia coli, flavonoid and phenolic content, Samanea saman, Staphylococcus aureus

UJI AKTIVITAS ANTIBAKTERI FRAKSI KULIT BATANG NANGKA I Made Dira Swantara; Ida Bagus Gede Darmayasa; Ni Komang Ayu Kumala Dewi
Jurnal Kimia (Journal of Chemistry) Vol. 5, No. 1 Januari 2011
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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This research aims to isolate and identify antibacterial compounds in jackfruit bar husk (Artocarpus heterophyllus, Lam.). 735.55 gramc of jackfruit bar husk yielded 500,25 grams of crude methanol.extract. The methanol extract was fractionated using petroleum ether, ethyl acetate and of n-butanol and then evaporated to yield crude extract of ethyl acetate 4.11 grams of petroleum ether (yellowish), 2.11 grams of ethyl acetate extract (brownish), and 1.17 grams of n-butanol (dark green).Bioactivitigs tests to Staphylococcus aureus and Eschericia coli showed that ethyl acetate extract had the largest inhibition zone. The purification of ethyl acetate extract with column chromatography resulted a faction which was antibacterial active (faction C).Identification of faction C using Gas Chromatography Mass Spectroscopy showed 3 compounds namely methyl hexadecanoate, dioctyl hexadioate, and dioctyl-1,2-benzene dicarboxylate.

IDENTIFIKASI SERTA UJI AKTIVITAS ANTIBAKTERI SENYAWA FLAVONOID EKSTRAK DAUN SRIKAYA (Annona squamosa Linn) I M. D. Swantara; P. A. Damayanti; I W. Suirta
Jurnal Kimia (Journal of Chemistry) Vol. 16, No.1, Januari 2022
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2022.v16.i01.p06

Salah satu tanaman yang memiliki kandungan senyawa flavonoid yang sering dimanfaatkan sebagai obat tradisional di Indonesia adalah tanaman srikaya (Annona squamosa Linn). Isolasi, identifikasi serta uji aktivitas antibakteri senyawa flavonoid dari ekstrak daun srikaya terhadap bakteri Staphylococcus aureus dan Escherichia coli dengan metode sumur difusi telah dilakukan pada penelitian ini. Serbuk daun srikaya dengan kadar air 8% dimaserasi menggunakan metanol lalu dievaporasi hingga diperoleh ekstrak kental 113,85 g. Ekstrak tersebut dipartisi dengan pelarut n-heksana, etil asetat dan n-butanol yang menghasilkan 3,43 gram ekstrak n-heksana, 2,30 g ekstrak etil asetat dan 3,85 g ekstrak n-butanol. Uji fitokimia menunjukkan bahwa ekstrak etil asetat positif mengandung flavonoid dengan kadar total flavonoid terbanyak 26.117,4 mg QE/100 g. Isolat F5 hasil pemisahan serta pemurnian dari ekstrak etil asetat, positif mengandung flavonoid dan relatif murni secara kromatografi lapis tipis. Identifikasi isolat F5 dengan spektrofotometer UV-Visible dan Fourier-Transform Infrared (FTIR) menunjukkan dua pita serapan yaitu pada ? maks 376,40 nm (pita I) dan 256,40 nm (pita II) serta mengandung dugaan gugus fungsi yang terdapat dalam senyawa flavonoid yaitu OH, C=C aromatik, C-H alifatik, C-H aromatik, C-O eter dan C-O alkohol. Isolat tersebut mampu menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli pada konsentrasi 15% (b/v) dengan diameter hambat secara berturut-turut sebesar 7,75 mm dan 7,25 mm. Hasil ini menunjukkan bahwa senyawa flavonoid hasil isolasi dari ekstrak daun srikaya diduga adalah 5,3’,4’-trihidroksiflavonol dan mempunyai aktivitas antibakteri dengan daya hambat sedang. Kata kunci: antibakteri, daun srikaya (Annona squamosa Linn), isolasi flavonoid, 5,3’,4’-trihidroksiflavonol. One of the plants containing flavonoid compounds, commonly used as traditional medicine in Indonesia, is srikaya (Annona squamosa Linn). Isolation, identification and antibacterial activity test of flavonoid compounds from srikaya leaf extract against Staphylococcus aureus and Escherichia coli by using diffusion well method have been done in this research. Srikaya leaf powder with 8% moisture content was macerated with methanol then evaporated until concentrated extract of 113.85 grams was obtained. The extract was partitioned with n-hexane, ethyl acetate and n-butanol solvents and produced 3.43 grams of n-hexane extract, 2.30 grams of ethyl acetate extract and 3.85 grams of n-butanol extract. The phytochemical test showed that the ethyl acetate extract positively contained flavonoids with the highest total flavonoid levels of 26,117.4 mg QE/100 grams. Isolate F5, as the result of separation and purification of ethyl acetate extract, was positive containing flavonoids and resulting relatively pure isolate, analyzed by thin layer chromatography. Identification of isolate F5 using spectrophotometer UV-Visible and Fourier-Transform Infrared (FTIR) showed two absorption bands at ? max of 376.40 nm (band I) and 256.40 nm (band II) as well as contained functional groups of flavonoid which was OH, C=C aromatic, C-H aliphatic, C-H aromatic, C-O ether and C-O alcohol. These isolates were able to inhibit the growth of Staphylococcus aureus and Escherichia coli at the concentration of 15% (w/v) with inhibitory diameter of 7.75 and 7.25 mm, respectively. These results indicated that flavonoids isolated from srikaya leaf extract were suspected 5,3’,4’-trihydroxyflavonol and had antibacterial activity with moderate inhibitory ability. Keywords: antibacterial, flavonoid isolation, srikaya leaf (Annona squamosa Linn),5,3’,4'-trihydroxyflavonol.

SKRINING ANTIKANKER MELALUI PENDEKATAN UJI TOKSISITAS TERHADAP LARVA UDANG (Artemia salina Leach) SERTA IDENTIFIKASI GOLONGAN SENYAWA AKTIF PADA BUAH PLUM (Prunus domestica L.) Ni Made Susita Pratiwi; I Made Dira Swantara; Ni Luh Rustini
Jurnal Kimia (Journal of Chemistry) Vol. 9, no. 1 Januari 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Isolation and identification of toxic compounds from ethanol extract of Prunus domestica L. have been conducted. Extraction of 1000 gr of plum fruit produced 128,75 g concentrated ethanol extract. The results of toxitcity tests of the extract using Artemia salina L. larvae showed the LC50 value of 100 ppm. Partition of ethanol extract yielded chloroform (10,52 g), n-hexane (26,58 g), and water (52,57 g) extracts. The toxicity test showed the chloroform extract to be the most toxic with LC50 of 31,97 ppm. Chloroform extract was separated by column chromatography using silica gel as stationary phase and chloroform : ethanol : water (5:4:1) as mobile phase giving three fractions. The toxicity test showed that fraction II was the most toxic with LC50 of 364,74 ppm. The phytochemical test result showed that fraction II (the active isolate) belonged to terpene groups. Analysis using UV-Vis spectrophotometer showed three peaks at 241, 409, and 668 nm, showing the possibility of the presence of funtional groups of C-H aliphatic, C-O alkoholic and C=O, respectively

IDENTIFIKASI SENYAWA ANTIBAKTERI PADA DAUN KECAPI (Sandoricum koetjape (Burm.f.) I M. Dira Swantara; Yenni Ciawi
Jurnal Kimia (Journal of Chemistry) Vol. 3, No. 2 Juli 2009
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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Identification of antibacterial compound for Micrococcus luteus dan Eschericia coli bacteri have beenconducted to kecapi leaf extract (Sandoricum koetjape (Burm.f.)). Extraction of that compounds was carried out bymaseration methods using 70% etanol. Separation of the fraction by liquid-liquid partition (n-hexane, ethyl acetateand chloroform) and two step column chromatographic method using silicagel as stationary phase and ethyl acetate –chloroform (3:7;2,5:7,5; dan 2:8) as first eluent and ethyl acetate – chloroform (2:8; 1,5:8,5; dan 1:9) as secondeluent. The active fraction (2.1 and 2.3 fraction) were identified by gas chromatography-mass spectroscopy (GCMS).The 2.1 fraction contain 3 compound which are heksil n-valerate (C11H22O2); 2,3-dihidrobenzofurane (C8H8O);and 2,6-dimetoxy fenol (C8H10O3). The 2.3 fraction contain 2 compound which are ester dioctilehexadioat(C22H42O4) with M+ = 370 and basic peak equal to 129 and 3,5-di-tert-buthyl-4-hydroxy-toluene (C15H24O).

ISOLASI DAN IDENTIFIKASI SENYAWA TOKSIK PADA SPONS DARI PERAIRAN GILI SULAT-LOMBOK I M. Dira Swantara; Agus Supriyono; Mila Trinoviani
Jurnal Kimia (Journal of Chemistry) Vol. 1, No. 2 Juli 2007
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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The isolation and identification of toxic compound on sponge from BPPT collection sub P3-TFM derivedfrom Gili Sulat, Lombok waters has been conducted. The extraction applied was maceration method, which wastotally conducted using three kinds of solvents namely, methanol, dichloromethane, and n-hexane. The total extractobtained was then partitioned into liquid using ethyl acetate and n-butane respectively. The most toxic extraction wasseparated by chromatography column with sephadex LH-20 as the stationary phase and methanol as the mobilephase. Identification of the active isolate was conducted by gas chromatography - mass spectroscopy with the aim ofWiley 275.L. database.Toxin test to sponge of BPPT collection sub P3-TFM showed that SL2 sponge was proved to be the mosttoxic one. The most toxic fraction of SL2 sponge at LC50 at 100 ppm was assumed to be the combination of 7compounds, namely benzene acetatic acid (8.9%), dioktil hexadioate (4.5%), bis (2etilheksil) 1.2-benzeneboksilat(53.1%), 2, 6, 10, 15, 19, 23 hexamethyl 2, 6, 10, 14, 18, 22-tetracosahexene, (17.1%), nonacosane (7.8%),cholesterol (3.8%) and eicosane (4.8%).

Ekstrak Etanol dan Fraksi Heksan Buah Pare (Momordica charantia) Sebagai Penurun Kadar Glukosa Darah Tikus Diabetes (ETHANOL EXTRACT AND HEXANE FRACTION OF MOMORDICA CHARANTIA DECREASE BLOOD GLUCOSE LEVEL OF DIABETIC RAT) I Nyoman Suartha; I Made Dira Swantara; Wiwik Susanah Rita
Jurnal Veteriner Vol 17 No 1 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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The research on the potency of Momordica charantia as lowering blood glucose has been carried out.The fruit was extracted by 70 % ethanol at room temperature. The extract was then partition with NHexane.The filtrate of partition was purified with thin layer chromatography. Three months old of whitemale rats (Rattus novergicus) with approximately 200-250 grams in weight were used as Bio-indicators.This study used a randomized block design (CRD) consisting of eight treatment groups (each treatmentconsisted of five rats). Rats were injected with streptozotocin to get hyperglycemic condition. The M.charantia fruit fraction (fraction 1-5) with dose 100 mg/kg bw was treated to each group when the ratt wason hyperglycemic condition. Rat blood glucose levels were observed on days 0, 4, 11, and 18 respectively .The results showed that blood glucose levels of M. charantia fraction 1and 5 with dose of 100 mg/kg bwhave the same effect with a negative control from day 4th, fraction 2 on day 18 whereas The others fractionare 3, and 4 were effect on days 18th. Based on the result it can be concluded that the M. charantia fraction1 with dose of 100 mg/kg bw effectively in decreasing the blood glucose levels of diabetic rat.

Identification of The Bactericide Active Fraction on Zingiber gramineum Blume Bark I Made Dira Swantara
Jurnal ILMU DASAR Vol 10 No 2 (2009)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

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Bactericide fraction as been isolated and identified from Zingiber gramineum Blume bark. The isolation carried out using partition by n-hexane, chloroform, and ethyl acetate eluent. The extract bactericide active (ethyl acetate extract) as been isolated using column chromatograpic method by benzene-chloroform (3:2) eluen system. The activity test of that isolate using Micrococcus luteus and Eschericia coli. The chemical structure of the compound was identified using gas chromatography-spectroscopy massa with Wiley 275.L library. The active fraction for E. coli contain hexadecanoic acid, ethyl ester; linoleic acid, ethyl ester; oleic acid, ethyl ester; and octadecanoic acid, ethyl ester. The active fraction for M. luteus contain octadecnoic acid; 9,12-octadecadienoic acid; octadec-9-enoic acid; and hexadioic acid, dioctyl ester.

ISOLASI DAN IDENTIFIKASI SENYAWA YANG BERSIFAT ANTIBAKTERI DAN TOKSIK DALAM TUMBUHAN ILER {Coleiis scutellarioides [L.] Benth) Dionisius Tungga; I Made Dira Swantara; Yenni Ciawi
AGRICA Vol. 1 No. 2 (2008): December
Publisher : Agriculture Faculty of Flores University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/agr.v1i2.484

The isolation and identification of antibacterial and toxic compound on Coleiis scutellarioides [L.] Benth. has been conducted. The extraction applied was maceration method using ethanol 85 %. The ethanol extract then partitioned using three kinds of solvents namely n-hexane, chloroform, ethyl acetate respectively. The most toxic and active antibacterial extraction was separated by chromatography column with n-hexane: chloroform as the mobile phase. Identification of the active isolate was conducted by gas chromatography-mass spectroscopy with the aim of'Wiley 229.L database. Toxic test and antibacterial activity test showed that FB2 was proved to be the most toxic and active antibacterial one. The most toxic and active antibacterial fraction of FB2 showed a retardation area of 66,98 mm2 to Micrococcus luteus and 54,43 mm2 to Escherichia coli, and LC50 at 90,72 ppm. Gas chromatography-mass spectroscopy data show that the FB2 fraction contains 4 compounds namely palmitate acid (24,41%); stearate acid (19,53%); 9-oktadekenamida (22,95%); and Esther dioctyl hexadioat (33,11 %»)•

Co-Authors A. A. Bawa Putra A. A. Indah Purna Dewi Adi Djona Silaen Agung Ari Chandra Wibawa Agus Supriyono C. T. Theodora Dionisius Tungga HERNINDYA, ANISA I Gede Mahardika I GustiKetut Suarjana I M, Sukadana I Made Adi Suardhyana I Made Merdana I Nyoman Suartha I P. Surya Udayana I Putu Sudiarta I Wayan Gede Gunawan I Wayan Suirta I. A. R. Astiti Asih Ida Bagus Gede Darmayasa James Sibarani Jamhari Jamhari Kadek Dewi Wirmandiyanthi Ketut Sepdyana Kartini Luh Made Sudimartini Made Rai Rahayu Manuntun Manurung Melisa Anggraini Mila Trinoviani N.K. Sinarsih Ni Komang Ariati Ni Komang Ayu Kumala Dewi Ni Luh Indra Dewi Senisk Ni Luh Rustini Ni Luh Yuli Damayanti Ni Made Diani Ni Made Dwi Desiyanti Ni Made Puspawati Ni Made Suaniti Ni Made Sukma Sanjiwani Ni Made Susita Pratiwi Ni Wayan Oktarini A.C.Dewi Ni Wayan Sri Sukmarianti Osamu Iitsuka P. A. Damayanti Putu Lakustini Cahyaningrum Retno Kawuri Riski Fatur Rachman Rr Anisa Hernindy Rr. Anisa Hernindya Sagun Chandra Yowani SRI LESTARI Sry Agustina Tungga , Dionisius W. S. Rita Wiwik Susana Rita WIWIK SUSANAH RITA Yenni Ciawi

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