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All Journal HAYATI Journal of Biosciences CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Jurnal Veteriner Jurnal Ilmu Dasar Journal of Applied Chemical Science Alchemy Jurnal Penelitian Kimia Indonesian Journal of Cancer Agrica: Journal of Sustainable Dryland Agriculture Journal of Health Sciences and Medicine Indonesian Journal of Cancer Journal of Veterinary and Animal Sciences

I Made Dira Swantara

Program Studi Kimia FMIPA Universitas Udayana, Jimbaran, Bali, Indonesia

Author-ID : 254411

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Earth & Planetary Sciences Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Veterinary

Published : 47 Documents Claim Missing Document

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The Extraction and Phytochemical Test of Toxic Extract of Xestospongia testudinaria Sponge I Made Diraswantara; Wiwik Susanah Rita
Journal of Health Sciences and Medicine Vol 2 No 1 (2018): JHSM (February 2018)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (172.559 KB)

This research aims toextraction and phytochemical test of the toxic extract of the Xestospongia testudinaria sponge collected from Sanur beach, Bali, Indonesia. Extraction of the sponges was carried out by methanol at room temperature. Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). The compounds of the toxic extract were performed by phytochemical test. Based on the results, it was found that the methanol extract of X. testudinaria sponges has toxic activity with LC50 of 31.62 ppm. The toxic extract contained alkaloid, steroid, polyphenol, and saponin compounds.

THE ESSENTIAL OIL CONTENTS OF JERINGAU (Acorus calamus L.) RHIZOMES AND THEIR ANTIFUNGAL ACTIVITY AGAINST Candida albicans Wiwik Susanah Rita; Retno Kawuri; I Made Dira Swantara
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Acorus calamus L. rhizome was trusted having antibacterial activity. This study aimed to identify the compounds in the Acorus Calamus L. rhizomes essential oils and to recognize the antifungal activity of the oils against Candida albicans. The extraction of essential oils from rhizome was carried out by steam distillation technique. Identification of compounds in the oils was conducted by Gas Chromatography- Mass Spectroscopy (GCMS), while the antifungal test against Candida albicans was done by well diffusion method. Extraction of 10 kg of rhizomes produced 16.53 mL essential oil with a yield of 0.1653% (? = 1.066), the oil was brownish yellow and very flavorful. GC-MS analysis showed that the essential oil contained 11 compounds, they are (E)-3,7 dimethyl-1,3,6-Octatriene (trans-?-Ocimene) (3,73%), linalool (1,07%), ?-elemene (1,15%), trans methyl isoeugenol (7,68%), shyobunon (15,74%), bicyclogermakren (0,93%), dehidroxy-isocalamendiol (2,61%), ?-calacorene (3,34%), euasarone (26,84), cis-asarone (18,62%); dan trans- asarone (18,29%). Antifungal activity test showed that the growth and biomass inhibition of C. albicans increased with the increase of the oil concentration. Minimum Inhibitory Concentration (MIC) of essential oil toward C. albicans was 1% with the inhibition of 7.83 mm.

ISOLATION AND PHYTOCHEMICAL TEST OF ANTICANCER ISOLATE OF SPONGE Hyrtios erecta I Made Dira Swantara; Wiwik Susanah Rita; Rr Anisa Hernindy
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

AbstractThis research aims to isolate and phytochemically test of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from the waters of Pari Island beach, Thousand Islands (Jakarta). Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). The compounds of the active isolate were performed by phytochemical test. Based on the results, it was found that the toxic isolate of Hyrtios erecta sponges has anticancer activity with IC50 of 30,497 ppm. The anticancer isolate contained alkaloid, steroid, and polyphenol compounds

Identifikasi Fraksi Toksik Ekstrak Rumput Laut Eucheuma cottonii Lin I MADE DIRA SWANTARA
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i2.85

Based on previous research, seaweed extract of Eucheuma sp was reported having antitumour activities. Eucheuma cottonii collected from Pari Island (Seribu archipelago) showed toxicity towards Artemia salina. Toxicity test using Artemia salina as bioindicator was a prescreening testing for anticancer agent. The aims of this research were to isolate and identify any potentially anticancer agent from the most toxic fraction of E. cottonii extract. Sample was extracted with 85 % ethanol using maceration method. The crude ethanol exract was then partitioned into n-hexane, chloroform, and ethyl acetate. The most active fraction towards artemia salina toxicity test was then purified using silica gel column chromatography with n-hexane:chloroform (2:3) as eluent. The pure active fraction having LC50 14.80 ppm was contitued of five compounds which identified using Gas Chromatography-Mass Spectrometry as Cyclododecana (3.23%), Tetradecanoic acid (7.10%), Hexadecanoic acid (54.74%), Cholesta-4,6-dien-3?-ol (6.67%), and Cholest-5-en-dien-3?-ol (Cholesterol) (28.26%).

Potensi Antikanker Isolat Toksik Tiga Spons Indonesia MADE DIRA SWANTARA; WIWIK SUSANAH RITA; JAMES SIBARANI
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v7i4.311

Telah dilakukan uji antikanker isolat toksik 3 (tiga) jenis spons yang berasal dari perairan Indonesia. Ketiga spons tersebut adalah Callyspongia aerizusa, Haliclona fascigera, dan Lanthella basta. Isolasi metabolit dalam spons dilakukan dengan cara maserasi, kemudian dilanjutkan dengan tahap pemisahan dan pemurnian menggunakan cara partisi serta kromatografi kolom. Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat yang paling toksik menggunakan sel HeLa. Berdasarkan hasil penelitian ini diperoleh bahwa spons Callyspongia aerizusa bersifat sebagai antikanker dengan LC50 sebesar 5,50 ppm. Spons Haliclona fascigera tidak bersifat antikanker terhadap sl HeLa, karena harga LC50 sebesar 44,67 ppm. Sedangkan spons Lanthella basta bersifat antikanker dengan harga LC50 sebesar 18,62 ppm.Kata Kunci: aktivitas antikanker; Callyspongia aerizusa; Haliclona fascigera; Lanthella basta

UJI TOKSISITAS EKSTRAK DAN ISOLAT DAUN SRIKAYA (Annona squamosa Linn) DAN IDENTIFIKASI SENYAWANYA Ni Luh Indra Dewi Senisk; I Made Dira Swantara; Ida Ayu Raka Astiti Asih
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 10 No 2 (2022): Cakra Kimia (Indonesian E-Journal of Applied Chemistry)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK: Srikaya (Annona squamosa Linn) merupakan tanaman yang mengandung banyak manfaat yaitu pencegahan penyakit jantung, mencegah penyakit asma, mengatasi penyakit diabetes, mengobati masalah hipertensi mencegah dan mengobati penyakit kanker. Penelitian ini dilakukan untuk mengetahui aktivitas toksik ekstrak dan isolat daun srikaya serta identifikasi kandungan senyawanya. Metode Brine Shrimp Mortality Test (BSLT) digunakan untuk uji toksisitas dan identifikasi senyawa dengan menggunakan instrumen LC MS/MS. Maserasi 750 g serbuk daun srikaya kering menggunakan pelarut metanol menghasilkan 64,45 g ekstrak kental. Uji toksisitas ekstrak kental metanol menunjukkan nilai LC50 sebesar 26,30 ppm. Partisi 45,0 g ekstrak kental metanol menghasilkan 14,3 g ekstrak n-heksana, 2,57 g kloroform dan 9,05 g n-butanol dengan nilai LC50 berturut-turut 104,71; 52,48; dan 323,59 ppm. Pemisahan senyawa pada ekstrak kloroform dilakukan dengan kromatografi kolom menghasilkan empat fraksi dengan fraksi A menunjukkan aktivitas paling toksik dengan nilai LC50 sebesar 100,00 ppm. Analisis LC MS/MS fraksi A menunjukkan adanya senyawa (6S,7?R)-6-hydroxy-4,4,7?-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (Loliolide); Cocamidopropyl betaine; Linolenic Acid; dan 1-Dodecyl-2-azepanon (Laurocapram). ABSTRACT: Sugar apple (Annona squamosa Linn) has many benefits, i.e. preventing heart disease, preventing asthma, overcoming diabetes, treating hypertension problems, preventing and treating cancer. This research aims to find out the toxicity of sugar apple leaf extract and isolate and to identify their compounds. Brine Shrimp Mortality Test (BSLT) method was used for toxicity test and identification compounds carried out using the LC MS/MS instrument. Maceration of 750 g of dry sugar apple leaf powder using methanol as solvent yielded 64.45 g of thick extract. Toxicity test of methanol viscous extract showed an LC50 value of 26.30 ppm. Partition of 45.0 g of methanol thick extract produced 14.3 g of n-hexane extract, 2.57 g of chloroform and 9.05 g of n-butanol with LC50 values ??of 104.71; 52.48; and 323.59 ppm respectively. The separation of compounds in the chloroform extract was carried out by column chromatography resulting in four fractions with fraction A showing the highest toxicity with an LC50 value of 100.00 ppm. LC MS/MS analysis of fraction A showed the presence of compound (6S,7?R)-6-hydroxy-4,4,7?-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (Loliolide) ; Cocamidopropyl betaine; Linolenic Acid and 1-Dodecyl-2-azepanone (Laurocapram).

Herbal Extract as An Antibacterial Against Gram Positive Bacteria Causing Dermatitis Complex I Nyoman Suartha; I GustiKetut Suarjana; Luh Made Sudimartini; I Made Merdana; I Made Dira Swantara
Journal of Veterinary and Animal Sciences Vol 1 No 1 (2017)
Publisher : Institute for Research and Community Service, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JVAS.2017.v01.i01.p07

Study in order to evaluate the antibacterial effect of herbal extract from leaves of three different species of plant namely neem(Azadirachtaindica A. Juss), gotu-kola (Centellaasiatica), andsoursop (Annona muricata L) against bacteria causing dermatitis complex in dogs have been undertaken. The antibacterial activities of the herbal extract were evaluated using the agar diffusion test with extract at three different concentrations 5%, 10%, and 25%, respectively.Staphylococcus aureus was isolated from the dermatitis complex cases in dogs. The results showed various antibacterial activities of all the herbal extract at all concentration as indicated by the diameter of inhibition haloes produced around the orifice. The average inhibition haloes for each herbal extract concentration was 2.19± 0.53 mm; 4.32± 0.84 mm; 5.86± 0.79 mm, respectively. It can be concluded that herbal extract from the three plants is a potential antimicrobial against agents causing dermatitis complex.

Co-Authors A. A. Bawa Putra A. A. Indah Purna Dewi Adi Djona Silaen Agung Ari Chandra Wibawa Agus Supriyono C. T. Theodora Dionisius Tungga HERNINDYA, ANISA I Gede Mahardika I GustiKetut Suarjana I M, Sukadana I Made Adi Suardhyana I Made Merdana I Nyoman Suartha I P. Surya Udayana I Putu Sudiarta I Wayan Gede Gunawan I Wayan Suirta I. A. R. Astiti Asih Ida Bagus Gede Darmayasa James Sibarani Jamhari Jamhari Kadek Dewi Wirmandiyanthi Ketut Sepdyana Kartini Luh Made Sudimartini Made Rai Rahayu Manuntun Manurung Melisa Anggraini Mila Trinoviani N.K. Sinarsih Ni Komang Ariati Ni Komang Ayu Kumala Dewi Ni Luh Indra Dewi Senisk Ni Luh Rustini Ni Luh Yuli Damayanti Ni Made Diani Ni Made Dwi Desiyanti Ni Made Puspawati Ni Made Suaniti Ni Made Sukma Sanjiwani Ni Made Susita Pratiwi Ni Wayan Oktarini A.C.Dewi Ni Wayan Sri Sukmarianti Osamu Iitsuka P. A. Damayanti Putu Lakustini Cahyaningrum Retno Kawuri Riski Fatur Rachman Rr Anisa Hernindy Rr. Anisa Hernindya Sagun Chandra Yowani SRI LESTARI Sry Agustina Tungga , Dionisius W. S. Rita Wiwik Susana Rita WIWIK SUSANAH RITA Yenni Ciawi

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