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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Amerta Nutrition Cendekia Journal of Pharmacy JURNAL GIZI DAN KESEHATAN Lumbung Farmasi : Jurnal Ilmu Kefarmasian Community Empowerment Journal of Holistics and Health Sciences (JHHS) Journal of Fundamental and Applied Pharmaceutical Science JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Abdi Masyarakat Indonesia Media Farmasi Indonesia Kreasi: Jurnal Inovasi dan Pengabdian Kepada Masyaraka Mestaka: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacy and Natural Product Indonesian Journal of Community Empowerment (IJCE) Usadha Journal of Pharmacy Journal of Community Empowerment
Dian Oktianti
Universitas Ngudi Waluyo
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Journal : Journal of Fundamental and Applied Pharmaceutical Science

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Yellow Pumpkin (Cucurbita maxima D.) Extract As Anti-Hypercholesterolemia Istianatus Sunnah; Erna Kustiyaningsih; Dian Oktianti
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.10819

Abstract

Hyperlipidemia is a risk factor for various diseases, which is still a big problem in Indonesia. Yellow pumpkin (Cucurbita maxima D.) is a plant containing flavonoids and terpenoids, which can be used as an anti-hypercholesterolemic agent. This study aims to analyze the activity and dosage of yellow pumpkin extract, which can be used as an anti-hypercholesterolemic agent to reduce total cholesterol levels comparable to simvastatin by 1.8mg/kg BW/day. This research is pure experimental research with a pre and post-test group design approach. The number of samples was 25 male Wistar rats induced by high-fat feed, quail egg yolk: pork oil (2:1) by 5 ml/200 gramBW/day for 7 days. The extract dosage range was 200, 400, 600 mg/kg BW/ day  for 7 days. Data were analyzed using One Way ANOVA. The results showed that the administration of yellow pumpkin extract could reduce rats' total blood cholesterol levels with a dose of 600 mg/kg BW/day, comparable to simvastatin 1.8 mg/kg BW/day. The secondary metabolites of the extract were flavonoids and terpenoids. Extract of yellow pumpkin (Cucurbita maxima D.) could reduce total blood cholesterol levels of rats. The dose of 600 mg/kg BW/day could reduce blood cholesterol levels in rats comparable to simvastatin 1.8 mg/kg BW/ day.
Co-Authors Abririn, Martina Lestiana Ade Pratama admin, Yulistiawan Ardita Agitya Resti Erwiyani Al Hajar Fuadatus Zurroh Ambarsari, Utami Angelica, Dita Aprilliana R, Melati Azahra, Intan Cholisoh, Zakky Chotifah, Tila Noer Coreira, Lidya Coreira De Cruz Poety, Cresensia Apolonia Devia, Uci Asna Dewi, Nurul Fitria Dina Sihot Rejeki Gultom Dini Otavianingsih Dita Angelica Djoko Wahyono Djoko Wahyono Elvansi, M. Eningsari, Luh Putu Mahatrianti erika, nurlia Erna Kustiyaningsih Eunike Panjaitan Fajriani, Windha Novia Fiki Wijayanti Galih Y, Yunita Hasani Furdianti, Nova Hati, Anita Kumala Hidayah Karuniawati I Dewa Putu Pramantara I Dewa Putu Pramantara Istianatus Sunnah Jatmiko Rahmat Jatmiko Susilo Jaya Ramadey Bangsa Karina Febrianti Karminingtyas, Sikni Kusuma, Arinda Maya Lidya Coreira Coreira Luh Putu Indah Arviani Luhurningtyas, Fania Putri M. Elvansi Mahyuni, Ni Luh Ayu Mariatun, Mariatun Martina Lestiana Abririn Maulida Hayati Meiji Pujiawati Melati Aprilliana Ramadhani, Melati Aprilliana Muhammad Alim Nabila Ghassani Adani Nabila Hi Daud Nanda Ariyanto Putri Niken Dyah Ariesti Niken Dyaharesti Nova Hasani Furdiyanti Nova Hasani Furdiyanti Nova Hasani Furdiyanti Nova Hasani Furdiyanti, Nova Hasani Novanita Puspa Kencana Nur Hasanah Nurul Fitria Dewi Nurul Huda Setiawan Nurul Maulidya Otavianingsih, Dini Poety, Cresensia Apolonia Da Cruz Pujiawati, Meiji Putu Ayu Danung Ningrat Ragil Setia Dianingati Ragil Setia Dianingati Rahmadi, Romi Rahmadi Richa Yuswantina Rina Suryati Romi Rahmadi Rahmadi Rozalia Sandriana, Mira Sikni Retno Karminingtyas Sismawati Siswati Siswati Siti Haryani Sugeng Maryanto Thalia Dwi Septiyawati Utami Ambarsari Windha Novia Fajriani Windy Harly Yunita Galih Y Zaskia, Annisa Vera