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All Journal Jurnal Keperawatan The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Penelitian Kesehatan Suara Forikes Syntax Literate: Jurnal Ilmiah Indonesia Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Avit Suchitra
Bagian Bedah Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4 Avit Su Suchitra
Majalah Kedokteran Andalas Vol 46, No 12 (2024): Online Oktober 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i12.p1948-1956.2024

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result: The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOT  levels in experimental animals.
Lactococcus lactis D4 Restores Gut Microbiota Balance in Azoxymethane and Dextran Sulfate Sodium-induced Colorectal Cancer Rat Model Rini Suswita; Muhammad Iqbal Rivai; Muhammad Iqbal; Irwan Irwan; Avit Suchitra
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3311

Abstract

BACKGROUND: Gut microbiota plays a crucial role in the initiation and progression of colorectal cancer (CRC), with various bacterial species including Lactococcus lactis implicated in this process. However, there is a lack of studies reporting the specific effects of L. lactis on microbiota balance in the context of CRC, especially strain D4. Therefore, this study was conducted to evaluate the effect of L. lactis D4 administration on gut microbiota balance in a rat model of CRC.METHODS: This experimental study involved Sprague Dawley rats that were separated into untreated control (CO group), CRC-induced (CA group), and L. lactis D4-treated CRC-induced (LLD group). The CRC induction was performed by giving azoxymethane (AOM) and dextran sulfate sodium (DDS). Gut microbiota profile was analyzed using next generation sequencing (NGS), and microbial community dynamics were assessed through alpha and beta diversity metrics.RESULTS: L. lactis D4 restored gut microbiota balance by regulating Firmicutes/Bacteroidota ratio, and changing the microbiota composition by increasing the number of bacteria from the phylum Actinobacteria and decreasing bacteria from the phylum Bacteroidota and Proteobacteria. Alpha diversity was reduced in the LLD group, suggesting a decreased bacterial diversity post-treatment, but more closely aligned with the CO group than the CA group. Beta diversity analysis showed that the microbial composition of the treated group was similar to the CO group, while the CA group exhibited a distinct microbiota profile, characterized by higher abundance of pathogenic bacteria and reducing beneficial microbial species.CONCLUSION: L. lactis D4 administration effectively modulates gut microbiota in CRC model, enhancing the presence of beneficial bacteria from the Firmicutes and Bacteroidota phylum while suppressing pathogenic species from the Proteobacteria phylum.KEYWORDS: colorectal cancer, gut microbiota, next generation sequencing, Lactococcus lactis D4 
Lactococcus lactis D4 Decreases NF-κB and α-SMA in Rat Models of Obstructive Jaundice Avit Suchitra; Alvarino Alvarino; Eryati Darwin; Harnavi Harun; Muhammad Iqbal Rivai; Ade Sukma
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3384

Abstract

BACKGROUND: Obstructive jaundice, often due to choledocholithiasis or malignancies, leads to immune suppression, intestinal damage, and bacterial translocation, worsening outcomes. Some inflammatory mediators like nuclear factor kappa B (NF-κB), alpha-smooth muscle actin (α-SMA), and interleukin-6 (IL-6) are important in this process. Current treatments remain inadequate, highlighting the need for novel approaches. Probiotics, such as Lactococcus lactis D4 (LLD4), may help reduce inflammation and bacterial translocation, thus offering a potential therapeutic option. This study was conducted to evaluate the effects of LLD4 on NF-κB, α-SMA, and IL-6 in obstructive jaundice rat models.METHODS: This post-test randomized controlled study involved 15 male Wistar rats divided into three groups: sham, bile duct ligation (BDL), and BDL+LLD4 groups. The rats were maintained for 7–10 days, with the rats in BDL+LLD4 group received fermented milk containing LLD4 via gavage at a dose of 112 mg/20 gBW per day for 7 days. The expression levels of NF-κB, α-SMA, and IL-6 were analyzed using immunohistochemistry.RESULTS: Administration of LLD4 were able to significantly reduced NF-κB expression compared to the BDL group (40.20±21.276 vs. 53.60 ± 20.403) in obstructive jaundice rat models. Though not significant, BDL+LLD4 group showed lower α-SMA expression compared to BDL group (58.40±14.271 vs. 63.20±9.16). However, administration of LLD4 did not give any significant effect on IL-6 expression.CONCLUSION: LLD4 reduces inflammation in models of obstructive jaundice by lowering the NF-κB and α-SMA expression. This indicates that LLD4 might be potential as an adjunct therapy for reducing morbidity in obstructive jaundice cases.KEYWORDS: obstructive jaundice, bile duct ligation, Lactococcus lactis D4, NF-κB, α-SMA, IL-6
Profil Infeksi Blastocystis sp. pada Penderita Karsinoma Kolorektal Izzati, Ruhilda; Nofita, Eka; Suchitra, Avit; Rusjdi, Selfi Renita; Rustam, Rony; Meinapuri, Malinda
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 3 (2024): Juli-September 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15349

Abstract

Blastocystis sp. is one of the intestinal parasites that are often found in humans that cause digestive system disorders. Blastocystis sp. infection is thought to initiate the development of colorectal carcinoma because it induces inflammation in the gastrointestinal tract. This study aimed to determine the picture of Blastocystis sp. infection in colorectal carcinoma patients at Dr. M. Djamil Padang General Hospital. This study was a descriptive study, which was conducted at Dr. M. Djamil Padang General Hospital and the Parasitology Laboratory of the Faculty of Medicine, Andalas University with a sample size of 47 patients with colorectal carcinoma, who were selected using consecutive sampling techniques. The incidence of Blastocystis sp. infection was determined by microscopic examination of feces. Data were analyzed descriptively in the form of frequency tables and percentages. The results showed the incidence of Blastocystis sp. infection. in patients with colorectal carcinoma was 19.1%, most of whom were male (77.8%), under 50 years of age (44.5%), and generally had loose stool consistency (66.7%). Furthermore, it was concluded that the incidence of Blastocystis sp. infection in patients with colorectal carcinoma was quite high.Keywords: Blastocystis sp. infection; colorectal carcinoma; stool examination ABSTRAK Blastocystis sp. merupakan salah satu parasit usus yang sering ditemukan pada manusia yang menimbulkan gangguan sistem pencernaan. Infeksi Blastocystis sp. diduga dapat menginisiasi berkembangnya karsinoma kolorektal karena menginduksi inflamasi pada traktus gastrointestinal. Penelitian ini bertujuan untuk mengetahui gambaran infeksi Blastocystis sp. pada penderita karsinoma kolorektal di RSUP Dr. M. Djamil Padang. Penelitian ini adalah studi deskriptif, yang dilaksanakan di RSUP Dr. M. Djamil Padang dan Laboratorium Parasitologi Fakultas Kedokteran Universitas Andalas dengan ukuran sampel 47 pasien dengan karsinoma kolorektal, yang diseleksi dengan teknik consecutive sampling. Kejadian infeksi Blastocystis sp. Ditentukan dengan pemeriksaan tinja secara mikroskopis. Data dianalisis secara deskriptif berupa tabel frekuensi dan persentase. Hasil penelitian menunjukkan angka kejadian infeksi Blastocystis sp. pada penderita karsinoma kolorektal adalah 19,1%, yang sebagian besar berjenis kelamin laki-laki (77,8%), berusia di bawah 50 tahun (44,5%), dan konsistensi tinja umumnya encer (66,7%). Selanjutnya disimpulkan bahwa kejadian infeksi Blastocystis sp. pada pasien dengan karsinoma kolorektal cukup tinggi.Kata kunci: infeksi Blastocystis sp.; karsinoma kolorektal; pemeriksaan tinja
The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer Julpa Nurul Aini; Aswiyanti Asri; Noza Hilbertina; Tofrizal; Avit Suchitra; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1182

Abstract

Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC. Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test. Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression. Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.
Co-Authors Ade Sukma Alvarino Aswiyanti Asri Atika Indah Sari Desmawati Desmawati Eka Nofita Eryati Darwin Fira Firdausia Hannan Khairu Anami Harun Harnavi Husna Yetti Ilma Fitri Sakina Irwan Irwan Irwan Irwan Izzati, Ruhilda Julizar Julizar Julpa Nurul Aini Juni Mitra Leni Merdawati M. Iqbal Rivai Malinda Meinapuri Muhammad Adzka Putra Anbiar Muhammad Iqbal Muhammad Iqbal Rivai Muhammad Iqbal Rivai Noza Hilbertina Raditya Arya Dewanda Rizqy Tansa Rustam, Rony Selfi Renita Rusjdi Suswita, Rini Taufik Hidayat Tofrizal Yenita Afriyeni Yudi Ichsan Ramata Zikra Muhammad