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All Journal International Journal of Public Health Science (IJPHS) Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kesehatan Masyarakat Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kesehatan Lingkungan indonesia e-Journal Pustaka Kesehatan Jurnal Anestesi Perioperatif Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Universa Medicina Paediatrica Indonesiana Medical Laboratory Technology Journal Smart Medical Journal Jurnal Kesehatan Prima Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Journal of Health Sciences JHECDs: Journal of Health Epidemiology and Communicable Diseases Jurnal Respirasi (JR) Medical and Health Science Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Scientific Journal of Pediatrics Cermin Dunia Kedokteran
M. Ali Shodikin
Departemen Mikrobiologi Fakultas Kedokteran Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Prostaglandin E1 Dose and Duration as Determinants of Adverse Outcomes in Neonates with Duct-Dependent Congenital Heart Disease: A Systematic Review and Meta-Analysis Dina Luthfiyah; Muhammad Ali Shodikin; Sri Lilijanti Widjaja
Scientific Journal of Pediatrics Vol. 3 No. 2 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v3i2.261

Abstract

Introduction: Prostaglandin E1 (PGE1) infusion remains the cornerstone of medical stabilisation in neonates with duct-dependent critical congenital heart disease (DD-CCHD), yet contemporary guidance on optimal dose and duration is not informed by quantitative synthesis of recent evidence. Methods: A systematic review and meta-analysis were conducted in accordance with the PRISMA 2020 and MOOSE statements. PubMed/MEDLINE, ScienceDirect, OpenAlex and Europe PMC were searched (1st January 2014 – 30th April 2026) for original observational studies reporting PGE1 dose and/or duration with at least one adverse outcome in neonates (≤28 days) with DD-CCHD. The Newcastle–Ottawa Scale (NOS) and GRADE were applied. The primary outcome was the pooled prevalence of any PGE1-related adverse event using the Freeman–Tukey arcsine transformation under a DerSimonian–Laird random-effects model with the Hartung–Knapp–Sidik–Jonkman variance adjustment. The secondary, hypothesis-generating outcome was the pooled standardised mean difference (Hedges g) between higher- and lower-dose strata via the Chinn conversion. Heterogeneity, leave-one-out sensitivity, prespecified subgroup analyses, meta-regression and Egger regression were performed. Results: Ten observational studies enrolling 1,060 neonates were included. The pooled prevalence of any PGE1-related adverse event was 0.617 (95% confidence interval [CI] 0.509–0.724; I² = 87.6%). The secondary pooled Hedges g was 0.085 (95% CI −1.93 to 2.10), reflecting directional heterogeneity. Apnoea ranged from 9% to 52%, with a clear dose-related signal in two studies (relative risk approximately 1.97, p = 0.037; relative risk approximately 0.44, p = 0.015). Egger's intercept was 0.58 (p = 0.81), indicating no asymmetry. Meta-regression on median initial dose suggested dose-related apnoea risk. Conclusion: In neonates with DD-CCHD, approximately 62% experienced at least one PGE1-related adverse event. Initiation at 0.005–0.010 µg/kg/min should be regarded as the contemporary clinical default, with structured surveillance for apnoea and fever within 48 hours, gastrointestinal intolerance after 7–10 days and skeletal toxicity after 28 days.
Hubungan antara Obesitas, Pola Makan, dan Nyeri Saat Buang Air Besar pada Anak dengan Konstipasi Fungsional: Tinjauan Literatur: Tinjauan Pustaka Nuridah, Ayu Lilyana; Putri, Awalya Rahma; Anggraeni, Yunita Dewi; Shodikin, Muhammad Ali
Cermin Dunia Kedokteran Vol 53 No 05 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i05.1949

Abstract

Latar Belakang: Konstipasi fungsional didefinisikan sebagai keterlambatan atau kesulitan buang air besar yang berlangsung selama ≥2 minggu dan menimbulkan distres. Penelitian ini bertujuan untuk melihat hubungan antara obesitas, pola makan, dan nyeri defekasi terhadap kejadian konstipasi fungsional pada anak. Metode: Tinjauan literatur dari sumber data Google Scholar, PubMed, dan ScienceDirect menggunakan kata kunci yang sudah ditentukan. Kriteria inklusi mencakup artikel akses terbuka yang terbit pada tahun 2014–2024. Sebanyak 9 artikel yang memenuhi kriteria dianalisis lebih lanjut. Hasil: Konstipasi fungsional berhubungan dengan beberapa faktor risiko, termasuk obesitas, pola makan yang tidak sehat, dan nyeri defekasi. Beberapa studi menunjukkan korelasi positif antara obesitas dan konstipasi fungsional, meskipun masih bervariasi dan tidak selalu signifikan. Konsumsi makanan rendah serat dan tinggi lemak dilaporkan berkontribusi terhadap gangguan motilitas usus. Nyeri saat defekasi dapat memperkuat perilaku menahan feses, yang pada akhirnya memperburuk gejala konstipasi. Simpulan: Tinjauan ini menegaskan pentingnya mempertimbangkan faktor obesitas, pola makan, dan nyeri defekasi untuk pencegahan dan tatalaksana konstipasi fungsional pada anak.
Clinical Profile of Children Hospitalized with COVID-19 in Indonesia’s District Hospital : A First Year Pandemic Wave Single Centre Study Luthfiyah, Dina; Shodikin, Muhammad Ali
Smart Medical Journal Vol 5, No 2 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i2.57406

Abstract

Background: Children are known to be less infected by Coronavirus disease 2019 (COVID-19) rather than adults. However, children are still a vulnerable group and the incidence of patients admitted to hospital continues to increase. As Indonesia’s district has limited resources during pandemic wave, the data on pandemic cases was still underreported especially cases of children.Methods: This retrospective observational study collected data on pediatric case aged 0 – 18 years old, who were hospitalized at dr. Soebandi Hospital, Jember, Indonesia and confirmed to have COVID-19, from March 2020 to the end of March 2021.Results: 40 children were hospitalized and confirmed COVID-19 during the study period, the majority aged 15 – 18 years (40%), male (65%), and had a history of contact (67.5%). The most common symptoms were cough (85%), fever (67.5%), and shortness of breath (40%). Laboratory results showed that the majority had decreased neutrophils and increased lymphocytes, while most of the patient had normal chest X-rays (52.5%). From 5 pediatric patients who had multimorbidity, 4 patients died. All four had common underweight clinical morbidity, while acute respiratory distress syndrome was dominated the cause of death. The mortality rate in this study reached 10%.Conclusion: The majority of pediatric patients were found to have mild to moderate symptoms with good outcomes. Case mortality rate in this study was lower than national data. Meanwhile, the underweight comorbid in children with COVID-19 was worsening the outcome in this study.
Co-Authors Achmad Ma'ruf Fauzi Adelia Handoko Adilah Julinar Irianti Agustin, Aisyiyah Alviana Ainindya Pasca Rachmadiani Aisyiyah Alviana Agustin Anaditya Wahyu Kumudhaningsih Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anggraeni, Yunita Dewi Annisa Nadhifa Witanto Bagus Hermansyah Bellynda, Wynne Billy Jusup Kurniawan Cholis Abrori, Cholis Cicih Komariah Desi Dwi Wisudanti Desie Dwi Wisudanti Diana Chusna Mufida Dina Luthfiyah Dini Agustina Dissa Yulianita Suryani Dita Diana Parti Dwita Aryadina Dwita Aryadina Rachmawati Ekvan Danang Setya Pramudito Ellen Ocktavironita Elvia Rahmi Marga Putri ENNY SUSWATI Erfan Efendi Eva Deswinta Maharani Firman Pratama Andraputra Gianevan, Nicholas Jirezra Hadi Khoiruddin, Mukhammad Arif Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Inke Kusumastuti Irawan Fajar Kusuma Kristianningrum Dian Sofiana Kurnia Elka Vidyarni Laila Rizqi Kurniawati Lailatis Shofia Luthfiyah, Dina Marchianti, Ancah C N Muhammad Alif Taryafi Nexia Nevarachell Onny Amirsyah Nisrina Salsabila Firmansyah Nuridah, Ayu Lilyana Nurlaila Ayu Purwaningsih Oessi Salsabila Pradewi, Ranny Tandria Pramono, Anang Putra Uta, Diego Rafi Putri Prameswari Nastiti Ayu Putri, Awalya Rahma Qintar Layallia Faza Rahami, Nahla Ahmad Ramadhanty, Mira Haninda Renny Suwarniaty Rini Riyanti Rosita Dewi Rumastika, Nindya Shinta Safitri, Athiyah Naura Saputra, Antonius Dwi Semita, I Nyoman Sheilla Rachmania, Sheilla Shofia, Lailatis Sri Lilijanti Widjaja Sudarmanto, Yohanes Susanto Nugroho Tohari, Achmad Ilham Tsintani Nur Aristiana Wahidah Nur Indasyah Widhiasari Normaningtyas Wiwien Sugih Utami Wiwin Sugih Utami Yasmin Auralia Putri Yudha Nurdian Yuli Hermansyah Yuli Hermansyah Yuli Hermansyah, Yuli Yuli Lusiana Sari Yunita Armiyanti