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The Effect of Various Concentrations of Liquid Smoke with Time Differences on the Viability of Candida albicans Nahla Nahla; Endang Sri Lestari; Nadia Hardini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.30112

Background: Dentures that are rarely cleaned will trigger the growth of Candida albicans, which is a fungus known to be a major cause of opportunistic infections of the oral cavity. Liquid smoke is a chemical produced by distillation of smoke from combustion, containing phenol, carbonyl and carboxylic acids that are effective in killing fungi.Objective: To determine the effect of various concentrations of liquid smoke with different periods of time on the viability of Candida albicans.Methods: This was an experimental laboratory research with post-test only control group design. This study used Candida albicans colonies as samples with 6 different treatment concentrations of liquid smoke (100%, 50%, 25%, 12.5%, and 6.25%) and different periods of time (5 and 15 minutes), with 5 duplications.Results: The Kruskal-Wallis test on the MIC (Minimum Inhibitory Concentration) showed that there are significant differences (p <0.001) in the experimental groups, while the test on the MBC (Minimum Bactericidal Concentration) also showed the same result (p <0.001). The Mann-Whitney test stated that there was a significant difference between liquid smoke concentrations of 12.5% with positive control. The lowest concentration that could inhibit the growth of Candida albicans is 12.5%. At 24 hours incubation with 5 and 15 minute soaking time, the MBC of Candida albicans was 100% with 15 minute soaking time.Conclusions: Liquid smoke affected the growth of Candida albicans, characterized by MIC at a concentration of 12.5% and MBC at a concentration of 100% with a 15-minute soaking time.

KUALITAS DAN KUANTITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DI RUMAH SAKIT NASIONAL DIPONEGORO SEBELUM DAN SETELAH PENYULUHAN PPRA Eka Susanti; Endang Sri Lestari; Helmia Farida; V. Rizke Ciptaningtyas
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 8, No 4 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Penggunaan antibiotik yang tidak bijak dapat menyebabkan resistensi antibiotik. Peresepan antibiotik yang tidak bijak dapat diturunkan dengan melakukan penyuluhan kepada dokter. Salah satunya adalah penyuluhan oleh tim Program Pengendalian Resistensi Antimikroba (PPRA) yang diadakan di Rumah Sakit Nasional Diponegoro (RSND) yang merupakan rumah sakit tipe C. Tujuan : Menganalisis kualitas dan kuantitas penggunaan antibiotik pada pasien anak di RSND sebelum dan setelah penyuluhan PPRA. Metode : Penelitian dengan desain studi intervensi dengan melakukan pengambilan data dari rekam medis pasien anak yang rawat inap di RSND. Perbandingan kualitas penggunaan antibiotik dianalisis menggunakan uji Chi-square dan kuantitas penggunaan antibiotik menggunakan uji independent t test atau Mann-Whitney. Hasil : Kualitas penggunaan antibiotik yang bijak sebelum penyuluhan 42,9% dan setelah penyuluhan 30,5%, kualitas penggunaan antibiotik yang tidak bijak sebelum penyuluhan 30,6% dan setelah penyuluhan 11,9%, kualitas penggunaan antibiotik yang tidak ada indikasi sebelum penyuluhan 26,5% dan setelah penyuluhan 57,6% (p = 0,003). Kuantitas penggunaan antibiotik sebelum penyuluhan 51,65 Defined Daily Dose (DDD/100 pasien-hari) dan setelah penyuluhan 53,45 DDD/100 pasien-hari (p = 0,151). Simpulan : Penyuluhan saja tidak cukup untuk memperbaiki kualitas dan kuantitas penggunaan antibiotik. Rumah sakit memerlukan intervensi tambahan, seperti pembuatan kebijakan rumah sakit mengenai penggunaan antibiotik dan pemberian umpan balik kepada dokter.Kata Kunci : Kualitas, kuantitas, penggunaan antibiotik, anak, PPRA

FAKTOR RISIKO KOLONISASI Staphylococcus aureus PADA PETUGAS KESEHATAN DI RUMAH SAKIT NASIONAL DIPONEGORO SEMARANG Anggi Danupratama; Winarto Winarto; Endang Sri Lestari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 6, No 1 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Kolonisasi S. aureus banyak ditemukan di hidung bagian depan (nares anterior). Kolonisasi memegang peranan penting dalam terjadinya infeksi dan dapat dipengaruhi berbagai hal salah satunya faktor risiko yang ada. Faktor risiko yang dapat mempengaruhi terjadinya kolonisasi S. aureus dapat berasal dari faktor usia, jenis kelamin, tingkat pendidikan, pekerjaan, lama kerja, kebiasaan mencuci tangan, alat pelindung diri dan hand hygiene agent.Tujuan : Mengetahui faktor risiko yang mempengaruhi kolonisasi S. aureus pada petugas kesehatan di Rumah Sakit Nasional Diponegoro (RSND) Semarang.Metode : Penelitian menggunakan studi cross sectional. Subyek penelitian 76 responden dari petugas kesehatan baik medis dan non medis di RSND Semarang. Prosedur penelitian meliputi pengambilan nasal swab dan wawancara dengan alat bantu kuisioner. Identifikasi kolonisasi dilakukan pemeriksaan laboratorium sesuai standar mikrobiologi. Analisis data menggunakan analisa bivariat (uji chi-square / fischer exact) dan analisa multivariat (regresi logistik).Hasil : Dari 78 responden terdapat 28,2% (22/78) dengan kolonisasi S. aureus positif. Analisa bivariat diperoleh jenis kelamin laki-laki (p = 0,037), tingkat pendidikan non perguruan tinggi (p = 0,001), pekerjaan tenaga non medis (p = 0,001), lama kerja kurang dari 1 tahun (p = 0,006), dan alat pelindung diri ≥ 2 jenis (p = 0,10) mempunyai pengaruh yang bermakna terhadap kolonisasi S. aureus. Analisa multivariat diperoleh lama kerja kurang dari 1 tahun paling berpengaruh terhadap kolonisasi S. aureus pada petugas kesehatan di RSND ( p = 0,043 ; RP = 3,611 ; IK 95% = 1,041-12,522).Kesimpulan : Prevalensi kolonisasi S. aureus sebesar 28,2 % dan lama kerja kurang dari 1 tahun merupakan faktor risiko terjadinya kolonisasi S. aureus pada petugas kesehatan di RSND.

Hubungan Antara Pengetahuan Perawat Tentang Rekam Medis Dengan Kelengkapan Pengisian Catatan Asuhan Keperawatan Bedah di Rumah Sakit PKU Muhammadiyah Gombong Endang Sri Lestari; sri wariyanti, astri; Kusumawati, Erna Adita
Indonesian Journal of Health Information Management Vol. 3 No. 2 (2023)
Publisher : Sekolah Tinggi Ilmu Kesehatan Mitra Husada Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54877/ijhim.v3i2.109

Hospital as a health-care facilities are oblged to make medical records. One of the important things in the medical record document is the completeness of the medical record. According to Permenkes No.24 of 2022 recording and documentation must be complete, clear, and carried out after the patient receives health services by including the name, time and signature of the health woeker providing the service. Nurses as health workers are required to make nursing care records. The purpose of this study was to analyze the nurse relationship knowledge of medical records with surgical nursing care filling records. This study used observasional with a cross sectional approach. The subjects in this study were all nurse who served in the central surgical installation of PKU Muhammadiyah Gombong Hospital. The Object of research is the medical record files of inpatient who are analyzed with saturated samples technique. The research was conducted from september to november 2022 with a questionnaire. The research instrument to assess the level of knowledge abaut medical record. Statistical test using chi squared with SPSS The nurse’ knowledge of medical records with the completeness of filling in surgical nursing care records obtained a significance value of p= 0.024. However, this value did not meet the requirements because there were 3 cell that I got less than 5. The fisher extract test was carried out with a value of p= 0.016. In conclusion, there is a relationship between nurses’ knowledge of medical record s and the completeness of filling out surgical care records.

Modulation of Inflammatory and Regenerative Pathways by Channa striata Extract in End-to-End Anastomotic Wound Repair: A Systematic Review Faizurrahman Andi Kusuma; Sigit Adi Prasetyo; Endang Sri Lestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1264

Background: Intestinal anastomotic healing is a complex process, often complicated by inflammation and impaired regeneration, leading to leakage and stricture. Channa striata (snakehead fish) extract, traditionally used for wound healing, possesses bioactive compounds with potential anti-inflammatory and regenerative properties. This systematic review aimed to critically appraise the in vivo evidence for the effects of Channa striata extract on inflammatory and regenerative pathways in end-to-end anastomotic wound repair. Methods: A comprehensive search of PubMed/MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library databases was conducted for studies published between 2013 and 2024. Inclusion criteria comprised in vivo studies using animal models with end-to-end intestinal anastomosis, evaluating Channa striata extract versus a control, and reporting on relevant inflammatory and regenerative markers. Data extraction and risk of bias assessment (using SYRCLE's tool) were performed. Results: Seven studies met the inclusion criteria. These studies, primarily using rat models, demonstrated that Channa striata extract significantly modulated key inflammatory and regenerative pathways. Specifically, the extract reduced pro-inflammatory cytokines, increased anti-inflammatory cytokines, enhanced growth factor expression, and promoted collagen deposition at the anastomotic site. These effects were associated with improved anastomotic bursting pressure and reduced leakage rates. Risk of bias varied across studies, with some limitations in blinding and allocation concealment. Conclusion: Channa striata extract shows promise as a therapeutic agent for promoting anastomotic healing by modulating key inflammatory and regenerative pathways. However, further high-quality, standardized studies are needed to confirm these findings, elucidate precise mechanisms, and optimize extract formulation and dosage before clinical translation.

The Role of Channa striata in Attenuating Inflammatory Markers (PCT, TNF-α, CRP) Following Intestinal Anastomosis in Hyperglycemic Rats: A Systematic Review and Dose-Response Meta-Analysis Anangga Haryanto; Endang Sri Lestari; Sigit Adi Prasetyo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1270

Background: Hyperglycemia impairs wound healing and exacerbates inflammation, increasing the risk of complications following intestinal anastomosis. Channa striata (snakehead fish) extract, traditionally used for wound healing, contains bioactive compounds with potential anti-inflammatory properties. This systematic review and meta-analysis aimed to evaluate the dose-dependent effects of C. striata extract on procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) levels in hyperglycemic rats undergoing end-to-end intestinal anastomosis. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases for studies published between 2013 and 2024. Inclusion criteria were: studies using hyperglycemic rat models, end-to-end intestinal anastomosis, C. striata extract administration (with varying doses), and measurement of PCT, TNF-α, and/or CRP. Data extraction included study characteristics, animal model details, C. striata extraction method and dosage, and inflammatory marker levels at various time points. Risk of bias was assessed using the SYRCLE's RoB tool. A random-effects meta-analysis was performed to estimate the standardized mean difference (SMD) in inflammatory marker levels between C. striata-treated and control groups. Dose-response relationships were explored using meta-regression. Results: Seven studies met the inclusion criteria. C. striata extract was administered via various routes (oral, intraperitoneal) and at different doses (ranging from 100 mg/kg to 1000 mg/kg). Meta-analysis revealed a significant reduction in PCT levels (SMD = -1.25, 95% CI: -1.80, -0.70; p < 0.001), TNF-α levels (SMD = -1.55, 95% CI: -2.15, -0.95; p < 0.001), and CRP levels (SMD = -1.38, 95% CI: -1.98, -0.78; p < 0.001) in C. striata-treated groups compared to controls. Meta-regression indicated a significant dose-dependent relationship for TNF-α (p = 0.02) and CRP (p = 0.04), with higher doses showing greater reductions. Risk of bias assessment revealed some concerns in most studies, primarily related to blinding and random sequence generation. Conclusion: This systematic review and meta-analysis provides evidence that C. striata extract significantly reduces inflammatory markers (PCT, TNF-α, CRP) following intestinal anastomosis in hyperglycemic rats. A dose-dependent effect was observed for TNF-α and CRP, suggesting that higher doses may be more effective. Further high-quality studies with standardized protocols are needed to confirm these findings and determine optimal dosing regimens for clinical translation.

Short Chain Fatty Acid Concentrations in the Cecum of Obese Rats after Giving Dangke (Fermented Milk) from Enrekang Magfirah, Ariel; Diana Nur Afifah; Endang Sri Lestari; Pramono, Adriyan; Rustanti, Ninik
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 4 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i4.3774

Obesity is one of the main causes of metabolic syndrome. This incident is triggered by an imbalance in the intestinal microbiota, resulting in inflammation, impaired tissue function and insulin resistance. Lactic acid bacteria, which are probiotics capable of balancing the gut microbiota, are present in fermented milk. The purpose of this study is to evaluate the variations in SCFA concentrations following dangke administration. The method in this research was a true experimental design, specifically a completely randomized, post test only design with a control group. This study used thirty male Sprague Dawley rats were split up into five equal groups, obesity intervention (X1, X2 and X3), obese control (P1), and health control (P0). A high fat sucrose diet (HFSD) was used to promote obesity in P1, X1, X2 and X3, whereas (P0) served as a healthy control group. Additionally, the X1, X2, and X3 groups received doses of L-Bio at 0,018 g/200 g body weight, dangke at 1,8 g/200 g bodyweight, and dangke at 3,6 g/200 g bodyweight, respectively for 28 days. Data were analyzed statistically with One Way Anova test and significant data (<0.05) were further tested using Bonferroni Post Hoc test. The result of this study showed the highest SCFA Acetate, Propionat, Butirat, and Total of SCFA (P0> X3> X2> X1, P1) (p=0.000). The conclusion of this study found that giving a dose of 3.6 g/ 200 g body weight of dangke could elevate SCFA levels thereby, dangke can enhance obesity management by boosting the synthesis of SCFA.

Pengaruh pemberian actinomycetes terhadap penurunan jumlah leukosit pada mencit diare Ivena Claresta; Endang Sri Lestari; Gemala Anjani
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 2 (2024): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i2.1445

Background: Diarrhea cases are mostly caused by enteropathogenic escherichia coli (EPEC). Elevated white blood cells or leucocytes are closely associated with the incidence of diarrhea due to bacterial infection. Actinomycetes are known to have antibacterial properties that can fight pathogenic microorganisms.Objectives: To analyze of the effectiveness of Actinomycetes from the right wing of Musca domestica on leucocyte counts in EPEC-induced mice.Methods: Experimental study with randomized post-test only with control group design. This study was conducted from June to July 2023 at the Pharmacology Laboratory of Muhammadiyah Surakarta University, using 30 mice divided into 5 groups. Actinomycetes intervention was given equivalent to 0,5 McFarland standard with dose variations: 0,26ml/20gBW (group P1), 0,65ml/20gBW (group P2), and 1,3ml/20gBW (group P3). EPEC induction was 0,5ml orally in the treatment group and negative control group (KN). The healthy control group (KS) was given 0,5ml of mineral water. The variable measured was the number of leucocytes of Mus musculus mice taken on the third day after the intervention. Data processing was performed using the Kruskall-Wallis Test to determine differences between groups with level significantly p<0,05.Results: There was a decrease in the leucocytes counts in the treatment group compared to the KN group (p=0,027). The highest mean leukocyte count was seen in the KN group (8.786,7 mm3) while, the lowest mean leukocyte count was in the P2 group (6.48,3 mm3).Conclusion: Actinomycetes intervention in EPEC-induced diarrhea mice effectively reduces leucocyte counts.KeywordActinomycetes, Leukocyte, Diarrhea

The Role of Channa striata in Attenuating Inflammatory Markers (PCT, TNF-α, CRP) Following Intestinal Anastomosis in Hyperglycemic Rats: A Systematic Review and Dose-Response Meta-Analysis Anangga Haryanto; Endang Sri Lestari; Sigit Adi Prasetyo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1270

Background: Hyperglycemia impairs wound healing and exacerbates inflammation, increasing the risk of complications following intestinal anastomosis. Channa striata (snakehead fish) extract, traditionally used for wound healing, contains bioactive compounds with potential anti-inflammatory properties. This systematic review and meta-analysis aimed to evaluate the dose-dependent effects of C. striata extract on procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) levels in hyperglycemic rats undergoing end-to-end intestinal anastomosis. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Cochrane Library databases for studies published between 2013 and 2024. Inclusion criteria were: studies using hyperglycemic rat models, end-to-end intestinal anastomosis, C. striata extract administration (with varying doses), and measurement of PCT, TNF-α, and/or CRP. Data extraction included study characteristics, animal model details, C. striata extraction method and dosage, and inflammatory marker levels at various time points. Risk of bias was assessed using the SYRCLE's RoB tool. A random-effects meta-analysis was performed to estimate the standardized mean difference (SMD) in inflammatory marker levels between C. striata-treated and control groups. Dose-response relationships were explored using meta-regression. Results: Seven studies met the inclusion criteria. C. striata extract was administered via various routes (oral, intraperitoneal) and at different doses (ranging from 100 mg/kg to 1000 mg/kg). Meta-analysis revealed a significant reduction in PCT levels (SMD = -1.25, 95% CI: -1.80, -0.70; p < 0.001), TNF-α levels (SMD = -1.55, 95% CI: -2.15, -0.95; p < 0.001), and CRP levels (SMD = -1.38, 95% CI: -1.98, -0.78; p < 0.001) in C. striata-treated groups compared to controls. Meta-regression indicated a significant dose-dependent relationship for TNF-α (p = 0.02) and CRP (p = 0.04), with higher doses showing greater reductions. Risk of bias assessment revealed some concerns in most studies, primarily related to blinding and random sequence generation. Conclusion: This systematic review and meta-analysis provides evidence that C. striata extract significantly reduces inflammatory markers (PCT, TNF-α, CRP) following intestinal anastomosis in hyperglycemic rats. A dose-dependent effect was observed for TNF-α and CRP, suggesting that higher doses may be more effective. Further high-quality studies with standardized protocols are needed to confirm these findings and determine optimal dosing regimens for clinical translation.

Hubungan Antara Pengetahuan Perawat Tentang Rekam Medis Dengan Kelengkapan Pengisian Catatan Asuhan Keperawatan Bedah di Rumah Sakit PKU Muhammadiyah Gombong Endang Sri Lestari; sri wariyanti, astri; Kusumawati, Erna Adita
Indonesian Journal of Health Information Management Vol. 3 No. 2 (2023)
Publisher : Sekolah Tinggi Ilmu Kesehatan Mitra Husada Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54877/ijhim.v3i2.109

Hospital as a health-care facilities are oblged to make medical records. One of the important things in the medical record document is the completeness of the medical record. According to Permenkes No.24 of 2022 recording and documentation must be complete, clear, and carried out after the patient receives health services by including the name, time and signature of the health woeker providing the service. Nurses as health workers are required to make nursing care records. The purpose of this study was to analyze the nurse relationship knowledge of medical records with surgical nursing care filling records. This study used observasional with a cross sectional approach. The subjects in this study were all nurse who served in the central surgical installation of PKU Muhammadiyah Gombong Hospital. The Object of research is the medical record files of inpatient who are analyzed with saturated samples technique. The research was conducted from september to november 2022 with a questionnaire. The research instrument to assess the level of knowledge abaut medical record. Statistical test using chi squared with SPSS The nurse’ knowledge of medical records with the completeness of filling in surgical nursing care records obtained a significance value of p= 0.024. However, this value did not meet the requirements because there were 3 cell that I got less than 5. The fisher extract test was carried out with a value of p= 0.016. In conclusion, there is a relationship between nurses’ knowledge of medical record s and the completeness of filling out surgical care records.

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