Article Per Year (5 Year)
p-Index From 2020 - 2025
3.942
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Biologi Tropis Jurnal Pengabdian Magister Pendidikan IPA Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Abdi Insani Indonesian Journal of Pharmaceutical Education INDRA: Jurnal Pengabdian kepada Masyarakat Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Pengabdian Masyarakat: BAKTI KITA Jurnal Pepadu Lombok Medical Journal
Eva Triani
Universitas Mataram
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

Published : 38 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Indonesian Journal of Pharmaceutical Education

 1 
The Effect of Patikan Kebo (Euphorbia hirta) Herbal Extract on Collagen Levels in the Kidney and Heart of Fibrotic Rats Pahmi, Khairil; Rahim, Adelia Riezka; Musanip, Musanip; Sahrul Hudha, Lalu; Triani, Eva; Halim, Amran
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.28940

Abstract

Noncommunicable diseases (NCDs) are the leading cause of death worldwide. There are around 36 million deaths every year. An example of NCD, a non-communicable disease, is hypertension. Excessive consumption of sodium chloride (NaCl) is the main factor that can cause hypertension and organ fibrosis. A natural ingredient that has the potential to act as an antifibrosis agent against fibrosis is quercetin by increasing PPAR-γ expression. Based on research, one of the plants that contains quercetin is the herb of Patikan Kebo (Euphorbia hirta Linn). Collagen is a protein biomarker of fibrosis synthesized via the PPAR-γ signaling pathway. The aim of this research was to determine the organ protective effect of administration of Patikan Kebo herbal extract against renal fibrosis and heart in Wistar rats (Rattus norvegicus) induced with 1.5% NaCl. The method involved 15 male Wistar rats aged 2.5 months with a body weight of 100-150 grams, which were divided into three groups (KI: control; KII: induced by 1.5% NaCl; KIII: induced by 1.5% NaCl + Patikan Kebo extract 200 mg/kg body weight. The induction was carried out for 8 consecutive weeks. On day 56, the kidneys and heart were removed in groups I and II, while in group III the treatment with the Patikan-Kebo extract from Patikan-Kebo at a dose of 200 mg/kg body weight was continued for 28 days in Group III. Specifically, for group III, kidneys and heart were collected on day 84 after treatment with Patikan kebo extract on day 84. Collagen was stained with Giemsa stain. Data were analyzed using a Kruskal-Wallis test. The difference is considered significant if the probability value is p0.05. The result showed that there were significant differences between the control and treatment groups. Patikan Kebo extract can reduce collagen in rats with induced fibrosis with 1.5% NaCl.
Co-Authors Adelya Rahma Putri Afifi, Farhani Afifi, Farhani Agung Difa Annisa, Athiyatun Arfi Syamsun Arista, Rida Dwi Artiani Tresna Imut Exhasna Ayda Fitri Madani Dede Taruna Kreisnna Murti Dedianto Hidajat Dewa Agung Istri Sintha Prajnyaswari Dhea Asty Ramadhani Didit Yudhanto Dini Suryani Dita Supriantarini Dody Handito Dody Handito Dwi Astuti Wulandari Eka Arie Yuliyani Eka Arie Yuliyani Eka Arie Yuliyani Eka Arie Yuliyani Eustachius Hagni Wardoyo Fadila Olivia Faisal Libryan Fathul Djannah Fatikha Rudia Ahda Gina Aulia Azizaturrahmah Gunawan, Artika Indriani Gusti Anom Christyandi Ramarantika Halim, Amran Hasbi, Nurmi - I Gede Aditya Satrya Bhuwana Cakra Ida Lestari Harahap Ika Primayanti Indana Eva Ajmala Indana Eva Ajmala Indana Eva Ajmala Januarman, Januarman Jurnal Abdi Insani Universitas Mataram Jurnal Pepadu Khaula Karima Kusumadewi, Rima Cahyati Lestary, Ayundha Rizky M. Arya Rifqi Ilham M. Fardi Anugrah Madani, Ayda Fitri Mawaddah, Alfia Mochamad Fauzi Aulia Akbar Mochamad Fauzi Aulia Akbar Muhammad Afif Rabbani Muhammad Ghifari Rifansha Musanip, Musanip Muthia Cenderadewi, Muthia Ni Komang, Sanca Dara Dahnitha Ni Made Meta Satya Buda Duarsa Ni Made Sri Padma Puspita Ni Nyoman Geriputri Nurma'rifatullah Nurul Imaniaty A Nurul Imaniaty As-syarifiah Pahmi, Khairil Paradini Sukma Candra Puji Widyastuti Putri, Lendi Leskia Putu Cicilia Rarasati Kuta Putu Suwita Sari Putu Suwita Sari Putu Suwitasari PW, Ni Putu Ayu Dewanthi Qurrata'yuni Pratiwi Rahim, Adelia Riezka Ranti Filarma Negara Purnama Resistayani, Luh Gede Janny Rifana Cholidah Rika Hastuti S Rika Hastuti Setyorini Rika Hastuti Setyorini Rika Hastuti Setyorini Rika Hastuti Setyorini Rika Hastuti Setyorini Rika Hastuti Setyorini, Rika Hastuti Rizka Vidya Lestari Rosita Wenilia Rukmanggana Satya Pratiwi Saesal, Fulqy Fatmala Sahrul Hudha, Lalu Salim, Baiq Henny Sari Putu Suwita Sastrawan, I Gede Pande Devin Agastya Suryantini, Ni Kadek Mega Syari, Mayuarsih Kartika Syihabul Muttaqin Utari, Desak Made Dinda Kartika Wahyu Sulistiya Affarah Walid Rivaldi Fatahillah Wibowo, Ruth Christina Yudhi Kurniawan Yumna Iftinan Khalda