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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Dasar Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Al-Kimia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Poltekita : Jurnal Ilmu Kesehatan Pharmacon: Jurnal Farmasi Indonesia
Fifteen Aprila Fajrin
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy Rahmayanti, Finas; Pratoko, Dwi Koko; Fajrin, Fifteen Aprila
Jurnal ILMU DASAR Vol 23 No 2 (2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v23i2.23030

Abstract

Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN). Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and paradol is very similar in chemical structure with only different in one double bond in 4-5 position. Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol had good affinity against TRPV1. These result indicated that 6-paradol and the derivatives had potential as a drug compound for PDN therapy.
The Effect of Banana Pell (Musa paradisiaca L) Ethanol Extract on The Blood Glucose Level of Diabetic Mice with Alloxan Induction Nur Jazilah; Fifteen Aprila Fajrin; Sholihatil Hidayati; Mohammad Rofik Usman
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6555

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insufficient insulin hormones, or the inability to use insulin effectively. One of the traditional medicine use with DM is to control their blood glucose levels using herbal plants, namely the banana peel plant (Musa paradisiaca L.) which is rich in flavonoids, alkaloids, and tannins. This study aims to determine the effect of ethanol extract banana peel EEBP on glucose levels in mice with alloxan induction. The design of this study was a laboratory experiment, using male white mice (Mus musculus L) Balb/c strain, which were induced with alloxan at a dose of 200 mg/kg.bw. The mice were divided into six groups, namely normal, negative (CMC Na 0.5%), positive (glibenclamide 5 mg/kg.bw), and three groups of EEBP at a dose of 100 mg/kg.bw, 200 mg/kg.bw, and 400 mg/kg.bw. Blood glucose levels were evaluated on day 3 after induction, as well as day 7 and 14 after treatment. Blood glucose level data were analyzed using one-way ANOVA, followed by LSD post hoc test with 95% confidence level. The 400 mg/kg.bw dose of banana peel ethanol extract showed the highest percentage reduction in blood glucose levels, namely 65.83% ± 0.800, compared to other doses. Based on LSD statistical test, doses of 200 mg/kg.bw and 400 mg/kg.bw of EEBP showed no significant difference compared to the positive control (p>0.05). The optimal dose for reducing blood glucose levels in DM mice induced by alloxan is the treatment of EEBP in doses of 200 mg/kg.bw and 400 mg/kg.bw
Predisposing Factors in Preventing The Transmission of Drug-Resistant TBC: A Qualitative Study in Jember Atmawati, Siti Dwiana; Fajrin, Fifteen Aprila; Mufida, Diana Chusna
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.3173

Abstract

Drug-Resistant Tuberculosis (DR TB) is a form of tuberculosis caused by Mtb bacteria resistant to anti-tuberculosis drugs (OAT). The prevalence of DR TB in Jember has significantly increased over the years, and many still refuse treatment. These individuals actively spread the bacteria to people at home or in the workplace. This research aims to identify predisposing factors in preventing the transmission of DR TB based on knowledge, attitudes, and beliefs. It is a qualitative case study involving primary subjects, DR TB patients, additional information from patient support organizations, and health department officials in Kab. Jember. The criteria for research subjects are residing in Kab. Jember, undergoing treatment, and willing to participate. The subject selection technique uses purposive sampling, resulting in 10 individuals. Data collection techniques involve in-depth interviews and observations. Data presentation follows the guidelines of Milles and Huberman, employing Thematic Content Analysis (TCA) for analysis. Data validity checks use credibility and dependability tests with source and technique triangulation. The research results indicate varying knowledge among subjects regarding DR TB prevention, with most obtaining information from healthcare professionals and patient support. In terms of attitude perspectives, all subjects show a positive response, expressing willingness to prevent DR TB transmission. Belief perspectives reveal diverse actions in DR TB transmission prevention. Most trust advice from healthcare professionals and patient support, while a minority still believe in herbal treatments and the culture of "tirah" to support TB treatment. In conclusion, knowledge, attitude, and belief perspectives are positive, but there is room for improvement in the behavior of implementing DR TB transmission prevention measures.
Occult Hepatitis B infection (OBI) in Indonesia: A Systematic Review Muhammadiy, Noer Sidqi; Senjarini, Kartika; Fajrin, Fifteen Aprila; Velavan, Thirumalaisamy P.; My, Truong Nhat; Song, Le Huu
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53733

Abstract

Hepatitis B Virus (HBV) infection remains a significant global health concern, with various genotypes exhibiting distinct clinical characteristics. Occult hepatitis B infection (OBI) is a latent form of HBV infection that is difficult to detect and poses a risk of transmission, particularly among high-risk populations such as blood donors, hemodialysis patients, and kidney transplant recipients. In Indonesia, studies on HBV genotype diversity and OBI prevalence remain limited, highlighting the need for a systematic analysis better to understand genotype distribution and its implications for public health. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed on Google Scholar, Springer, ResearchGate, ScienceDirect, and PubMed using keywords related to OBI, HBV genotypes, and the Indonesian population. Studies that met the inclusion criteria were analyzed to assess genotype distribution and OBI prevalence. Among 352 screened articles, 35 studies met inclusion criteria. Genotypes B and C were identified as predominant HBV strains, with regional distribution variations. The highest OBI prevalence was recorded in eastern Indonesia (13.03%), followed by central (4.31%) and western (3.36%) regions. Nested PCR was the primary detection method for OBI. The predominance of genotype C in eastern Indonesia may contribute to higher OBI prevalence, emphasizing the need for region-specific diagnostic and management strategies. Further research is necessary to elucidate the association between HBV genotypes and clinical outcomes in OBI patients.
Pendampingan masyarakat untuk pembentukan TABOGA Farm guna peningkatan kesejahteraan petani di desa Klangon kabupaten Madiun Alfarisy, Fariz Kustiawan; Restanto, Didik Pudji; Widuri, Laily Ilman; Witono, Yuli; Fajrin, Fifteen Aprila; Paramu, Hadi
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 2 (2024): June
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i2.22740

Abstract

AbstrakDesa Klangon saat ini menjadi desa rujukan tanaman porang Indonesia. Tidak hanya itu Desa Klangon memiliki wisata klangon yang terletak di tengah hutan klangon. Tujuan dari pengabdian masyarakat adalah memberikan pemberdayaan dan pendampingan masyarakat mengenai implementasi Agro Smart Village sebagai solusi pengelolaan wisata dan TABOGA dalam upaya peningkatan kemandirian dan derajat kesehatan masyarakat. Tahapan pelaksanaan kegiatan meliputi koordinasi dengan perangkat desa,  FGD (Focus Group Discussion) dan praktek di beberapa kelompok masyarakat, pendampingan, pembentukan TABOGA farm, dan pendampingan, Pendampingan dalam perencanaan pengembangan usaha hilirisasi produk TABOGA. Kegiatan pengabdian desa Asal melibatkan beberapa perangkat desa, tokoh masyarakat, dan petani yang menjadi sasaran. Hasil yang didapatkan dari kegiatan pengabdian ini diantaranya adalah komoditas TABOGA di desa klangon memiliki potensi yang besar untuk dikembangkan sebagai komoditas unggulan kedua setelah porang. Setidaknya dari hasil FGD tercatat sebanyak 18 jenis tanaman obat tradisional yang banyak tumbuh berdampingan dengan tanaman porang di hutan Desa Klangon. Namun, potensi ini belum banyak dimanfaatkan secara maksimal. Permasalahan utama yang menjadi kendala adalah pemasaran produk TABOGA. Berdasarkan permasalahan tersebut, kontribusi yang diberikan oleh Tim Pengabdi pada kegiatan ini yakni  pendampingan implementasi Agro Smart Village melalui pemetaan komoditas TABOGA untuk meningkatkan minat masyarakat dalam mengembangkan komoditas TABOGA untuk kesejahteraan masyarakat Desa Klangon. Kata kunci: pemasaran; porang; tanaman obat tradisional; wisata. AbstractKlangon Village is currently a reference village for Indonesian porang plants. Klangon Village has a Klangon tourist area which is in the middle of the Klangon forest. The purpose of community service was to provide community empowerment and assistance regarding the implementation of Agro Smart Village as a tourism management solution and TABOGA to increase self-sufficiency and community health status. The method of implementing the assisted village service activities was carried out using two methods, namely FGD (Focus Group Discussion) and practiced in several community groups. The production technology practice method aimed to aid the community regarding the formation of TABOGA Farm. Origin village service activities involved several village officials, community leaders, and targeted farmers. Based on the results of the community service activities, the Klangon people required assistance from universities to make mapping of TABOGA commodities and their marketing. Farmers need institutional support such as BUMDES to become a business unit that accommodates community taboga plant products so that it is hoped that they can increase people's income.Keywords: tourism; traditional medicinal plant; marketing.
Association Between Drug Related Problems and Outcomes of Tuberculosis Patients at Citra Husada Hospital Jember Lutvi Anggraeni; Fifteen Aprila Fajrin; Afifah Machlaurin; Irma Prasetyowati; Angga Mardro Rahardjo
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4h3axm73

Abstract

Background: Tuberculosis (TBC) remains a major global challenge. In Indonesia, the success rate for Drug-Sensitive Pulmonary TB (DS-TBC) treatment is still below target, often linked to Adverse Drug Reaction (ADR) and Drug Related Problem (DRP). The complexity of regimens and polypharmacy increases the risk of DRPs, which are strong predictors of treatment failure. Objective: This study aimed to identify DRPs and analyze their relationship with the clinical outcomes of DS-TBC. Method: A retrospective cohort study was conducted on 281 DS-TBC patients recorded at Citra Husada Hospital Jember from January 2020 to December 2023. Data were collected from medical records and the TBC Information System (SITB). DRPs were identified using the PCNE V9.1 classification, focusing on dose inappropriateness, drug interactions, and ADR. Outcomes were categorized as successful (cured/treatment completed) or unsuccessful. Result: Data analysis included descriptive statistics, bivariate analysis using Chi-Square, and multivariate analysis using Binary Logistic regression with a significance p < 0,05. The result of this study is that patients were predominantly male (55.16%), aged 46-65 years, with a treatment completion rate of 82.21%. DRPs were found in 84.34% of patients, dominated by drug interactions (79%) and ADRs (35.23%), although the accuracy of anti-TB drug dosage was 100%. In multivariate analysis, age ≥65 years was associated with a decreased likelihood of successful treatment (aOR 0.367), while respiratory tract medication administration was associated with an increased likelihood of successful treatment (aOR 2.477). The overall relationship between DRPs and outcome was not statistically significant. Conclusion: Sociodemographic factors (age) and clinical symptom management (respiratory therapy) play the most crucial roles in determining the treatment outcome. Effective pharmaceutical intervention is suggested to mitigate the impact of DRPs on treatment failure. More aggressive clinical management is necessary for elderly patients.
Cost-Effectiveness Analysis (CEA) of Adjunctive Hyperbaric Oxygen Therapy to Standard Wound Care Alone in Diabetic Foot Ulcer (DFU) Herdian Pradana; Afifah Machlaurin; Ayik Rosita Puspaningtyas; Fifteen Aprila Fajrin; Ainur Rokhmah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8z370a41

Abstract

Background: Diabetic foot ulcer (DFU) is a chronic complication of diabetes mellitus that is associated with high treatment costs and an increased risk of amputation. Hyperbaric oxygen therapy (HBOT) has been used as an adjunctive therapy to improve wound healing, yet evidence regarding its cost-effectiveness in Indonesia remains limited. Aim: This study aimed to evaluate the cost-effectiveness of HBOT compared with standard care in patients with DFU. Methods: A retrospective observational analytic study was conducted involving 80 DFU patients treated at RS Paru Jember between January 2024 and September 2025, consisting of 37 patients receiving standard care with HBOT and 43 patients receiving standard care without HBOT. Result: Clinical outcomes assessed included wound status, pain status, duration of healing, and incidence of amputation. Cost analysis was performed from the hospital perspective using direct medical costs, and cost-effectiveness was evaluated using the Incremental Cost-Effectiveness Ratio (ICER). The results showed that the HBOT group had a significantly higher proportion of wound healing compared with the non-HBOT group (21.62% vs 4.63%) and a lower rate of wound deterioration (2.7% vs 20.93%) (p=0.001). Although the mean total treatment cost was lower in the HBOT group than in the non-HBOT group (IDR 11,737,388 vs IDR 14,177,692), the difference was not statistically significant (p=0.118). ICER analysis demonstrated negative values for all evaluated outcomes, including wound healing, pain improvement, healing within six months, and prevention of amputation, indicating cost savings. Conclusion:  HBOT as an adjunctive therapy for DFU provides better clinical outcomes with lower overall treatment costs and may be considered a cost-effective and economically favorable intervention.
Co-Authors A Nurrochmad AE Nugroho Afifah Machlaurin Ainur Rokhmah Ajeng Merdeka Putri Alfarisy, Fariz Kustiawan Andrean Roni Angga Mardro Rahardjo Annisa Shalihah Atmawati, Siti Dwiana Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Chusna Mufida Diana Holidah Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Fransiska Maria Christianty Hadi Paramu Hasana, Ani Riani Herdian Pradana Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Irma Prasetyowati Junaidi Khotib Kartika Senjarini Kinanthi P Rizki, Kinanthi P Laily Ilman Widuri, Laily Ilman Lelyta - Septiandini Lesti Eko Pangestuti Lutvi Anggraeni M Nuril Huda Mohammad Rofik Usman Monica Cinuradha Aura Salsabina Muhammadiy, Noer Sidqi My, Truong Nhat Nandan G Cempaka, Nandan G Nia Kristiningrum Nur Jazilah Prihwanto Budi Subagio R Susilowati Rahmayanti, Finas Restanto, Didik Pudji Riza Rastri Wihardiyanti Sholihatil Hidayati Song, Le Huu Sugi Hartono, Sugi Tsabit Barki Velavan, Thirumalaisamy P. Wahyu W Rochmah, Wahyu W Wardhani, Firdha Aprillia Yuli Witono Zainah Rajab