Article Per Year (5 Year)
p-Index From 2021 - 2026
1.152
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Dasar Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Al-Kimia JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline Jurnal Ilmu Kefarmasian Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Fifteen Aprila Fajrin
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy Fajrin, Fifteen Aprila; Rahmayanti, Fina; Pratoko, Dwi Koko
Jurnal ILMU DASAR Vol 21 No 2 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v21i2.15501

Abstract

Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN). Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and paradol is very similar in chemical structure with only different in one double bond in 4-5 position. Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10- paradol had good affinity against TRPV1. These result indicated that 6-paradol and the derivatives had potential as a drug compound for PDN therapy.Keywords: ginger, 6-paradol, painful diabetic neuropathy, trpv1.
Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan Dianasari, Dewi; Fajrin, Fifteen Aprila
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.812

Abstract

Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).
Predisposing Factors in Preventing The Transmission of Drug-Resistant TBC: A Qualitative Study in Jember Atmawati, Siti Dwiana; Fajrin, Fifteen Aprila; Mufida, Diana Chusna
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.3173

Abstract

Drug-Resistant Tuberculosis (DR TB) is a form of tuberculosis caused by Mtb bacteria resistant to anti-tuberculosis drugs (OAT). The prevalence of DR TB in Jember has significantly increased over the years, and many still refuse treatment. These individuals actively spread the bacteria to people at home or in the workplace. This research aims to identify predisposing factors in preventing the transmission of DR TB based on knowledge, attitudes, and beliefs. It is a qualitative case study involving primary subjects, DR TB patients, additional information from patient support organizations, and health department officials in Kab. Jember. The criteria for research subjects are residing in Kab. Jember, undergoing treatment, and willing to participate. The subject selection technique uses purposive sampling, resulting in 10 individuals. Data collection techniques involve in-depth interviews and observations. Data presentation follows the guidelines of Milles and Huberman, employing Thematic Content Analysis (TCA) for analysis. Data validity checks use credibility and dependability tests with source and technique triangulation. The research results indicate varying knowledge among subjects regarding DR TB prevention, with most obtaining information from healthcare professionals and patient support. In terms of attitude perspectives, all subjects show a positive response, expressing willingness to prevent DR TB transmission. Belief perspectives reveal diverse actions in DR TB transmission prevention. Most trust advice from healthcare professionals and patient support, while a minority still believe in herbal treatments and the culture of "tirah" to support TB treatment. In conclusion, knowledge, attitude, and belief perspectives are positive, but there is room for improvement in the behavior of implementing DR TB transmission prevention measures.
Occult Hepatitis B infection (OBI) in Indonesia: A Systematic Review Muhammadiy, Noer Sidqi; Senjarini, Kartika; Fajrin, Fifteen Aprila; Velavan, Thirumalaisamy P.; My, Truong Nhat; Song, Le Huu
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53733

Abstract

Hepatitis B Virus (HBV) infection remains a significant global health concern, with various genotypes exhibiting distinct clinical characteristics. Occult hepatitis B infection (OBI) is a latent form of HBV infection that is difficult to detect and poses a risk of transmission, particularly among high-risk populations such as blood donors, hemodialysis patients, and kidney transplant recipients. In Indonesia, studies on HBV genotype diversity and OBI prevalence remain limited, highlighting the need for a systematic analysis better to understand genotype distribution and its implications for public health. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed on Google Scholar, Springer, ResearchGate, ScienceDirect, and PubMed using keywords related to OBI, HBV genotypes, and the Indonesian population. Studies that met the inclusion criteria were analyzed to assess genotype distribution and OBI prevalence. Among 352 screened articles, 35 studies met inclusion criteria. Genotypes B and C were identified as predominant HBV strains, with regional distribution variations. The highest OBI prevalence was recorded in eastern Indonesia (13.03%), followed by central (4.31%) and western (3.36%) regions. Nested PCR was the primary detection method for OBI. The predominance of genotype C in eastern Indonesia may contribute to higher OBI prevalence, emphasizing the need for region-specific diagnostic and management strategies. Further research is necessary to elucidate the association between HBV genotypes and clinical outcomes in OBI patients.
Co-Authors A Nurrochmad AE Nugroho Ajeng Merdeka Putri Annisa Shalihah Atmawati, Siti Dwiana Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Chusna Mufida Diana Holidah Dianasari, Dewi Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Hasana, Ani Riani Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Junaidi Khotib Kartika Senjarini Lelyta - Septiandini Lesti Eko Pangestuti M Nuril Huda Muhammadiy, Noer Sidqi My, Truong Nhat Nia Kristiningrum Prihwanto Budi Subagio R Susilowati Rahmayanti, Fina Rahmayanti, Finas Riza Rastri Wihardiyanti Song, Le Huu Tsabit Barki Velavan, Thirumalaisamy P. Wardhani, Firdha Aprillia Zainah Rajab