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All Journal Jurnal Ilmu Dasar Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Al-Kimia JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline Jurnal Ilmu Kefarmasian Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Fifteen Aprila Fajrin
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Uji Antifertilitas Kombinasi Fraksi Kloroform Biji Pepaya (Carica papaya Linn.) dengan Fraksi Metanol Biji Saga (Abrus precatorius Linn.) terhadap Spermatogenesis Tikus Jantan Galur Wistar (Antifertility Study from Combination of Chloroform Fractions o Zainah Rajab; Siti Muslichah; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Chloroform fraction of Carica papaya seed (FKCP) and methanol fraction of Abrus precatorius seed (FMAB) have antifertility activity. This study aims to determine the antifertility activity combination of FKCP and FMAB in spermatogenesis and its reversibility on wistar male rats. This research used 40 wistar male rats that were divided into 5 groups, eight animals each group. Grup P0 (control) was administered by CMC Na 1%, group P1 was administered by combination of FKCP dose of 100 mg/kg BW and FMAB dose of 75 mg/kg BW, group P2 was administered by combination of FKCP dose of 100 mg/kg BW and FMAB dose of 50 mg/kg BW, group P3 was administered by combination of FKCP dose of 50 mg/kg BW and FMAB dose of 75 mg/kg BW, grup P4 was administered by combination of FKCP dose of 50 mg/kg BW and FMAB dose of 50 mg/kg BW for 28 days. Reversibility of spermatogenesis was observed in all group after 28 days of withdrawal of treatment. The results showed degenerative changes in the seminiferous tubules of rats given FKCP and FMAB. Conclusion of this research is the combination of these fractions reduced spermatogenesis, but it was reversible. Keywords: antifertility, saga seed, papaya seed, spermatogenesis, reversibility.
Penetapan Kadar Fenol Total dan Pengujian Aktivitas Antioksidan Minyak Jahe Gajah (Zingiber officinale var. officinale) (Determination of Total Phenolic Content and Antioxidant Activity of Jahe Gajah (Zingiber officinale var. officinale) Oil) Tsabit Barki; Nia Kristiningrum; Endah Puspitasari; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5897

Abstract

Jahe gajah (Zingiber officinale var. officinale) is one of export commodity plant in Indonesia. Part of jahe gajah often to be used is the rhizome, that content lots of essentials oil. One of the essential oil content is a phenolic compound. Phenolic compound is a natural product function as antioxidant reducing oxidative damage in the body that cause inflammation. The aim of this study was to determine the total phenolic content and antioxidant activity of jahe gajah oil. The total phenol content was determined using Folin-Ciocalteu method and the antioxidant activity assay was done using DPPH method. The total phenol content for jahe gajah oil was 0.626 ± 0.022 mg GAE/g . The IC50 of jahe gajah oil was 5,766 ± 0,087 µl/ml. Antioxidant activity from jahe gajah oil was suggested to be contributed by the phenolic compound and result from synergistic action of all constituents. Keywords: essential oil, aktivitas antioxidant, phenolic content
Ekstrak n-Heksana Daun Maja (Aegle marmelos) Menurunkan Kadar LDL Mencit Diabetes yang Diinduksi Aloksan (n-Hexane Extract of Maja Leaves (Aegle marmelos) Decreases LDL Levels on Diabetic Mice Induced by Alloxan) Lesti Eko Pangestuti; Fifteen Aprila Fajrin; Diana Holidah
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes mellitus is a metabolic disorder which characterized by hyperglicaemia due to abnormalities of carbohydrate, fat an protein metabolism resulting from defects in insulin secretion, insulin action or both. Metabolic disorders are caused by diabetes induce lipolysis, resulting in changes in the levels of LDL in the blood. This research aims to know the effect of n-hexane extract of maja leaves in LDL levels in diabetic mice. Test animals were induced by alloxan 210 mg/kg BW intraperitoneally. Twenty five mice were divided into 5 groups, control negative group (CMC Na 1%), control positive group (glibenclamide suspension 0.65 mg/kg BW), and the treatment group was given 3 suspension of of n-hexane extract of maja leaves (dose of 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW) for 14 days. The result showed that the decrease of LDL level due to N-hexane extracts of maja leaves dose 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW was -10,54%; 9,07%; 31,69%; respectively. N-hexane extracts of maja leaves decreases LDL levels on diabetic mice induced by alloxan with the best activity indicated by doses 800 mg/kg BW. Keywords: Aegle marmelos, n-hexane, diabetes melitus, LDL, alloxan
Uji Toksisitas Subkronik Jamu Asam Urat pada Hati Mencit Galur Balb-C (Subchronic Toxicity Study of Jamu Asam Urat in Liver of Balb-C Mice) M Nuril Huda; Diana Holidah; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3952

Abstract

Jamu asam urat is one of the most-consumed herbal medicine product to threat gout arthritis. This study aimed to determine of jamu asam urat effect for long-term consumption on mice's liver. Mice were divided into 4 groups of 10 each group. A control group was administered with aquadest and 3 treatment groups were administered with jamu sample per oral in dose of 1,800 (D1); 3,600 (D2); and 7,200 mg/kg BW (D3) in 28 days. The examination included GPT and GOT serum level measurement and liver histopathology. The result showed that GPT serum level was 34.33 ± 2.48 U/L (D1), 41.20 ± 1.94 U/L (D2), and 46.32 ± 2.84 U/L (D3), while GOT serum was 44.60 ± 2.94 U/L (D1), 55.53 ± 3.22 U/L (D2), and 63.31 ± 2.63 U/L (D3), respectively. Parenchymatous degeneration and necrosis in liver were found in histopathology examination. Increase of GPT, GOT level, and parenchymatous degeneration liver changes at D1 and D2 counted as mild degeneration, meanwhile necrosis change at D3 counted as moderate degeneration but it did'nt greatly affect liver function. Thus jamu asam urat is still save to be consumed. Keywords: subchronic toxicity, jamu asam urat, GPT, GOT, liver histopathology
Efektivitas Penggunaan Insulin pada Penderita Diabetes Melitus dengan Kehamilan di Rawat Inap RSD dr. Soebandi Jember Tahun 2012-2013 (Effectivity of Insulin Usage on Diabetic Mellitus Gestational Hospitalized Patient at RSD dr. Soebandi Jember in 2012-20 Riza Rastri Wihardiyanti; Prihwanto Budi Subagio; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Gestational diabetes melitus is a diseases that are frequently happen to pregnant women, and is happen to be one of the causes of mortality on mother and fetus. The use of drugs during pregnancy should be prudentially considered for pregnant women, since they are not allowed to consume anti-diabetic drug (OAD) and just allowed to use insulin as therapy. The purpose of this study was to describe the use of insulin, as well as assessing the effectiveness of insulin therapy in patients with gestational diabetes mellitus in RSD dr. Soebandi Jember. The sample in this study was taken from 23 patients. We found that the disease affect 7.69% patients of 20-24 years of age, 11.54% patients of 25-29 years of age, 26.92% patients of 30-34 years of age, 30.77% patients of 35-39 years of age, 7.69% patients of 40-44 years of age and 15.38% patients of above 45 years of age. The insulin used in the sampling is Actrapid for 10 patients and Novorapid for 4 patients. It is known that the effectiveness of insulin based on blood glucose random levels with insulin Actrapid and Novorapid in sub-cutaneous do not have significant differences. Keywords: diabetic mellitus gestational, insulin, antidiabetic drugs
KETERKAITAN CYCLOOXYGENASE (COX)-2 TERHADAP PERKEMBANGAN TERAPI KANKER Fifteen Aprila Fajrin
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

The growth of tumors is caused by imbalances between the rates at which cells are produced through cell division and the rate at which they die through a natural cell death process known as programmed cell death (also referred to as apoptosis). Problems in apoptosis mechanisms also contribute to therapy resistance, making tumors more difficult to kill with radiation or chemotherapy. It is important therefore to understand why tumors become refractory to apoptosis and to devise strategies for restoring proper function to cell death pathways in tumor cells. Recently it has been discovered that cyclooxygenase-2 (COX-2) have a relationship with apoptosis pathway. Higher levels of COX-2 have been reported in some kinds of cancer. One of the roles of COX-2 in tumor development is its positive effect on the survival of tumor cells. The goal of this project is to provide review insights into the role of COX-2 in cancer. We will explore whether COX-2 inhibitors can shut off survival genes in cancer cells, and we will study how COX-2 affects the programmed cell death machinery of cancer cells. Understanding the mechanisms by which COX-2 contributes to cancer development will reveal to what extent this enzyme is an important target in the chemoprevention and treatment of cancer.
The Effectiveness of GABA Agonist in Decreasing Expression of NR2B Subunit of N-Methyl-D-Aspartate (NMDA) Receptor in Neuropathic Mice by Partial Sciatic Nerve Ligation (PSNL) Method FIFTEEN APRILA FAJRIN; JUNAIDI KHOTIB; IMAM SUSILO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Neuropathy pain is a pain that caused by nerves injury. Nowadays, treatment for neuropathic pain change to drugs that works as GABA agonist and cause reimbalance between excitatory and inhibitory neurotransmitter in central nervous system (CNS). The present study was designed to investigate the effectiveness of gabapentin and baclofen in decreasing N-Methyl-D-Aspartate (NMDA) receptor NR2B subunit activity in neuropathic pain. Fourty mice were divided into 8 groups i.e sham, negative control, gabapentin (10, 30, 100 nmol) and baclofen (1, 10, 30 nmol). Neuropathic pain was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method). Treatments were administrated intrathecally once a day for seven consecutive days, at a week after induction. On day 15th, mice were sacrified and the spinal cord were removed quickly. The expression of NMDA receptor NR2B subunit were examined with imunohistochemistry and data were analyzed by one way anova. The result from this research was gabapentin and baclofen administration significantly decrease expression of NMDA receptor NR2B subunit in mice compared to sham group. The higher the dose, the more effective to decrease the number of neuron that express NR2B. The conclusion of this research was gabapentin and baclofen treat neuropatic pain by decreased the number of NMDA receptor NR2B subunit.
Gerakan Perilaku Hidup Bersih dan Sehat (PHBS) di Masa Pandemi COVID-19 pada Anak di Yayasan USK “Untukmu Si Kecil” Kabupaten Jember Fifteen Aprila Fajrin; Ika Puspita Dewi
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 12, No 2 (2022): Desember 2022
Publisher : LPPM UNINUS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30999/jpkm.v12i2.2129

Abstract

Corona Virus Disease 2019 (COVID-19) merupakan penyakit yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Di Indonesia sendiri, kasus ini pertama kali diumumkan secara resmi pada 2 Maret 2020. Hingga saat ini, COVID-19 belum juga mereda sehingga salah satu cara untuk meminimalkan resiko keparahan akibat COVID-19 adalah melalui edukasi. Salah satu bentuk edukasi untuk pencegahan dari COVID-19 yang dapat dilakukan oleh masyarakat dengan mudah adalah peningkatan perilaku hidup bersih dan sehat (PHBS). PHBS ini seyogyanya dimulai dari usia dini. Pada kenyataannya, banyak anak usia sekolah yang kurang memahami pentingnya hidup sehat, contoh yang paling sederhana adalah membiasakan menggunakan hand sanitizer, serta penggunaan masker saat ke luar rumah. Oleh sebab itu sosialisasi ini dilakukan dengan bertarget apad anak-anak sekolah di salah satu Yayasan pendidikan di Kabupaten Jember yaitu  USK “Untukmu Si Kecil” Rumah Belajar dan Rumah Bermain yang terletak di Jl. Sumatra VI/35C Kelurahan Sumbersari, Kecamatan Sumbersari, Kabupaten Jember. Tujuan dari kegiatan ini adalah adanya peningkatan pengetahuan anak-anak SD terhadap bahaya COVID-19 serta bagaimana cara pencegahan yang dapat di lakukan dalam kegiatan sehari-hari. Untuk mempermudah pemahaman mengenai bahaya COVID-19 dan pencegahannya, maka dilakukan edukasi. Kegiatan pengabdian ini akan dilakukan dalam 3 metode, yaitu: (1) Edukasi dan praktek PHBS pada anak-anak USK Untukmu Si Kecil melalui buku bergambar, serta (2) Pengenalan tanaman obat keluarga (TOGA). Setelah sosialisasi ini anak-anak di Yayasan USK telah menunjukkan peningkatan pengetahuan mengenai PHBS.
Penggunaan Bronkodilator Tunggal atau Bersama Kortikosteroid dapat Memperbaiki Parameter Sesak, w/h, dan r/h pada Pasien Rawat Inap dengan PPOK Eksaserbasi Akut di RS.X di Jember Tahun 2018 Fifteen Aprila Fajrin; Ika Puspita Dewi; Lelyta - Septiandini; Ajeng Merdeka Putri
Jurnal Farmasi Klinik Indonesia Vol 11, No 3 (2022)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2022.11.3.198

Abstract

Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyebab utama kematian ke-empat di dunia yang ditandai dengan adanya hambatan aliran udara yang bersifat progresif dan berkaitan dengan respon inflamasi kronis pada saluran napas dan atau paru-paru akibat adanya partikel atau gas yang berbahaya. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, pola pengobatan serta efek penggunaan bronkodilator dengan atau tanpa kortikosteroid terhadap perubahan nilai sesak, ronki (r/h), wheezing (w/h) dan SaO2 pasien rawat inap dengan PPOK eksaserbasi akut di RS.X di Jember. Penelitian ini bersifat deskriptif non eksperimental dengan pengumpulan data secara retrospektif dari data rekam medik elektronik pasien selama tahun 2018 dan pengambilan sampel menggunakan total sampling dengan jumlah pasien sebanyak 105 pasien. Analisis data yang digunakan yaitu analisis deskriptif dan analisis statistik berupa uji T berpasangan dan uji Wilcoxon dengan derajat kepercayaan sebesar 95%. Pasien PPOK eksaserbasi akut didominasi oleh laki-laki (64,8%), berdasarkan usia yang tertinggi adalah kelompok umur 45-64 tahun (50,5%), status pendidikan terbanyak pada kelompok tamat SD/sederajat (64,8%), dan berdasarkan pekerjaan pasien didominasi oleh petani (32,4%). Bronkodilator yang paling banyak digunakan adalah aminofilin (87,6%) dan kortikosteroid yang paling banyak digunakan yaitu metil prednisolone (63,8%). Hasil analisis berdasarkan parameter sesak, r/h dan w/h pada pasien yang menggunakan bronkodilator dengan atau tanpa kortikosteroid menunjukkan adanya perbedaan bermakna antara sebelum dan sesudah pengobatan (p<0,05). Parameter SaO2 menunjukkan hasil tidak ada perbedaan bermakna antara sebelum dan sesudah pengobatan bronkodilator dan ada perbedaan yang bermakna setelah pengobatan kortikosteroid. Kesimpulan dari penelitian ini adalah penggunaan bronkodilator dengan atau tanpa kortikosteroid dapat memperbaiki parameter sesak, r/h, dan w/h sesudah pengobatan. Kata kunci: bronkodilator, kortikosteroid, PPOK eksaserbasi akut, ronki, sesak, wheezing The Use of a Bronchodilator Alone or Combination with Corticosteroids Can Improve Shortness of Breath, w/h, and r/h Parameters in Patients with Acute Abstract Exacerbations of COPD at RS.X Jember in 2018 Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the world, characterized by progressive airflow obstruction and is associated with a chronic inflammatory response to the airways and or lungs due to the presence of harmful particles or gases. The purpose of this study was to determine the characteristics of the patient, treatment patterns, and the effect of using bronchodilators with or without corticosteroid on changes in the value of spasms, rhonchi (r/h), wheezing (w/h), and SaO2 of inpatients with acute exacerbation of COPD in RS.X in Jember. This research was descriptive and non-experimental with retrospective data collection from the patient’s electronic medical records during 2018 and using a total sampling of 105 patients. The data analysis used descriptive analysis and statistical analysis with paired T-test and Wilcoxon test with a confidence degree of 95%. Acute exacerbation of COPD patients was dominated by males (64.8%), based on the highest age in the age group of 45-64 years old (50.5%), the most education status in the group graduated from elementary school/equivalent (64.8%), and based on the patient’s job is dominated by farmers (32.4%). The most widely used bronchodilator is aminophylline (87.6%) and the most widely used corticosteroid is methylprednisolone (63.8%). The results of the analysis based on the parameters of spasms, r/h, and w/h in patients using bronchodilators with or without corticosteroids showed a significant difference before and after treatment (p<0,05). However, based on the SaO2 parameter, there was no significant difference between before and after bronchodilator treatment and there were differences that play a role after corticosteroid treatment. The use of bronchodilators with or without corticosteroids could improve the parameters of spasms, r/h, and w/h after treatment. Keywords: acute COPD exacerbation, a bronchodilator, corticosteroid, rhonchi, wheezing
The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy Rahmayanti, Finas; Pratoko, Dwi Koko; Fajrin, Fifteen Aprila
Jurnal ILMU DASAR Vol 23 No 2 (2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v23i2.23030

Abstract

Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 (TRPV1), a key receptor in PDN). Paradol, which obtained from gingerol and shogaol metabolism, also had potent activities in several diseases, compared to the other derivatives of gingerol and shogaol. However, shogaol and paradol is very similar in chemical structure with only different in one double bond in 4-5 position. Until now there is no explanation about paradol mechanism in TRPV1. Based on this, our study was designed to predict the activity of 6-paradol and its derivatives to TRPV1 as target receptor in PDN using in-silico model. 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol were used as ligands. Capsaisin, the agonist of TRPV1, was used as a native ligand in this study. TRPV1 was obtained from protein data bank (PDB). Ligand bond prediction and affinity was performed using Molegro Virtual Docker. The results showed 2-paradol, 4-paradol, 6-paradol, 8-paradol and 10-paradol had good affinity against TRPV1. These result indicated that 6-paradol and the derivatives had potential as a drug compound for PDN therapy.
Co-Authors A Nurrochmad AE Nugroho Ajeng Merdeka Putri Annisa Shalihah Atmawati, Siti Dwiana Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Chusna Mufida Diana Holidah Dianasari, Dewi Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Hasana, Ani Riani Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Junaidi Khotib Kartika Senjarini Lelyta - Septiandini Lesti Eko Pangestuti M Nuril Huda Muhammadiy, Noer Sidqi My, Truong Nhat Nia Kristiningrum Prihwanto Budi Subagio R Susilowati Rahmayanti, Fina Rahmayanti, Finas Riza Rastri Wihardiyanti Song, Le Huu Tsabit Barki Velavan, Thirumalaisamy P. Wardhani, Firdha Aprillia Zainah Rajab