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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Dasar Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Al-Kimia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Poltekita : Jurnal Ilmu Kesehatan Pharmacon: Jurnal Farmasi Indonesia

Fifteen Aprila Fajrin

Fakultas Farmasi Universitas Jember

Author-ID : 263347

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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KAJIAN TENTANG PENTINGNYA METODE PBL (PROBLEM-BASED LEARNING) DALAM SISTEMPEMBELAJARAN DI PERGURUAN TINGGI Fajrin, Fifteen Aprila
Jurnal Pengembangan Pendidikan Vol 3, No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

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Abstrak. PBL (Problem-Based Learning)merupakan salah satu metode pembelajaran dimana mahasiswa berperan sebagaiâactive learnerâ bukan sebagai âpassive learnerâ. Dengan adanya PBL diharapkanmahasiswa dapat berperan serta dalam menyelesaikan permasalahan-permasalahanyang terjadi di sekitarnya berdasarkan bidang ilmu yang menjadi kehliannya.Dengan adanya PBL, mahasiswa juga diharapkan dapat memotivasi dirinya untukterus dan selalu belajar, sehingga tujuan dari sistem pendidikan nasional dapattercapai dengan baik.Â Kata kunci : Sistem pendidikan nasional, belajar, PBL(Problem-Based Learning).

KETERKAITAN CYCLOOXYGENASE (COX)-2 TERHADAP PERKEMBANGAN TERAPI KANKER Fajrin, Fifteen Aprila
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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The growth of tumors is caused by imbalances between the rates at which cells are produced through cell division and the rate at which they die through a natural cell death process known as programmed cell death (also referred to as apoptosis). Problems in apoptosis mechanisms also contribute to therapy resistance, making tumors more difficult to kill with radiation or chemotherapy. It is important therefore to understand why tumors become refractory to apoptosis and to devise strategies for restoring proper function to cell death pathways in tumor cells. Recently it has been discovered that cyclooxygenase-2 (COX-2) have a relationship with apoptosis pathway. Higher levels of COX-2 have been reported in some kinds of cancer. One of the roles of COX-2 in tumor development is its positive effect on the survival of tumor cells. The goal of this project is to provide review insights into the role of COX-2 in cancer. We will explore whether COX-2 inhibitors can shut off survival genes in cancer cells, and we will study how COX-2 affects the programmed cell death machinery of cancer cells. Understanding the mechanisms by which COX-2 contributes to cancer development will reveal to what extent this enzyme is an important target in the chemoprevention and treatment of cancer.

Aktivitas Antikanker Pektin Kulit Buah Kakao Terhadap Jumlah Sel Goblet Kolon Rizki, Kinanthi P; Rochmah, Wahyu W; Cempaka, Nandan G; Hartono, Sugi; Fajrin, Fifteen A
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 3 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Jumlah penderita kanker kolon yang tinggi mendorong penelitian akan pengobatan yang lebih efektif dan mengurangi efek samping dari pengobatan masa kini, salah satunya adalah dengan pengobatan secara herbal. Kulit buah kakao (Theobroma cacao) memiliki kandungan pektin yang diketahui dapat menekan pertumbuhan sel kanker. Penelitian ini bertujuan untuk mengetahui potensi aktivitas antikanker kolon dari pektin kulit buah kakao (Theobroma cacao) pada tikus yang diinduksi dengan 7,12-dimethylbenzen(Î±)anthrasena (DMBA) dengan dosis 20 mg/kgBB. Tikus dikelompokkan menjadi empat kelompok yaitu kelompok I kontrol negatif, kelompok II pektin dosis 8 mg/kgBB, kelompok III pektin dosis12 mg/kgBB, dan kelompok IV pektin dosis 16 mg/kgBB. Hasil penelitian menunjukkan dosis uji tertinggi, yaitu 16 mg/kgBB memberikan aktivitas terbaik dalam memulihkan kembali sel goblet yang rusak akibat induksi dari senyawa karsinogen. Dengan demikian dapat disimpulkan bahwa pektin kulit buah kakao (Theobroma cacao) memiliki potensi aktivitas antikanker kolon pada dosis uji.Kata kunci: DMBA, kulit buah kakao, pektin, sel goblet.Kata kunci: DMBA, kulit buah kakao, pektin, sel goblet

Effect of Gabapentin and Baclofen on Histology Study in Neuropathic Pain Fajrin, Fifteen A.; Khotib, Junaidi; Susilo, Imam
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Neuropathic pain resulted from injury to nerves is often resistant to current treatments and can seriously cause chronic pain if no appropriate treatment is given. This study was designed to prove the effectiveness of gabapentin and baclofen in increasing latency time toward thermal stimulus and recovering the morphology of dorsal horn of spinal cord in neuropathic-induced chronic pain. Forty mice were divided into 8 groups i.e sham, negative control, gabapentin at three different doses (10, 30, 100 nmol) and baclofen at three different doses (1, 10, 30 nmol). Neuropathic condition was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method. Gabapentin and baclofen were administrated intrathecally once a day for seven days, a week after neuropathic induction. Latency time toward thermal stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after induction. Histology of the dorsal horn of spinal cord tissue was examined by haematoxylline-eosin staining. The results showed that intrathecal injection of gabapentin and baclofen significantly increased latency time of mice toward thermal stimulus compared with negative control. Gabapentin and baclofen are effective as treatment for neuropathic pain. They can also help the recovery process of the histology in dorsal horn in neuropathic pain.Keywords: Baclofen, dorsal horn, gabapentin, neuropathic pain, PSNLEfek Gabapentin dan Baclofen terhadap Studi Histologi pada Nyeri NeuropatiNyeri neuropati berasal dari luka pada saraf yang umumnya sulit diterapi sehingga menyebabkan nyeri kronik bila tanpa managemen terapi yang tepat. Tujuan penelitian ini adalah membuktikan efektivitas gabapentin dan baclofen dalam meningkatkan waktu ketahanan terhadap panas dan memperbaiki morfologi dorsal horn dari spinal cord pada keadaan nyeri kronik yang disebabkan neuropati. Empat puluh mencit terbagi ke dalam delapan kelompok, yaitu sham, kontrol negatif, gabapentin (dosis 10, 30 dan 100 nmol) serta baclofen (dosis 1, 10 dan 30 nmol). Nyeri neuropati diinduksi menggunakan metode Partial Sciatic Nerve Ligation (PSNL). Gabapentin dan baclofen diberikan secara intratekal satu kali sehari selama tujuh hari pada satu minggu setelah induksi nyeri neuropati. Waktu ketahanan terhadap stimulus panas diamati pada hari ke-0, 1, 3, 5, 7, 8, 10, 12, dan 14 setelah induksi. Histologi dorsal horn dari spinal cord mencit diamati menggunakan pewarnaan haematoxylline-eosin. Injeksi intratekalgabapentin dan baclofen meningkatkan waktu ketahanan terhadap stimulus panas secara signifikan dibandingkan kontrol negatif. Gabapentin dan baclofen efektif sebagai terapi nyeri neuropati. Keduanya juga dapat memperbaiki histologi dorsal horn pada kondisi nyeri neuropati.Kata kunci: Baclofen, dorsal horn, gabapentin, nyeri neuropati, PSNL

Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan Dianasari, Dewi; Fajrin, Fifteen Aprila
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).

AKTIVITAS EKSTRAK ETANOL KETAN HITAM UNTUK MENURUNKAN KADAR KOLESTEROL Fajrin, Fifteen Aprila
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

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Cardiovascular disease has become a number one causing of death in Asia Pasific. From Sudarmanto research (2006), frying oil consumption that was used for 27 times can affect to serum total cholesterol levels. Black glutinous rice have chemical compound such as anthocyanin that have hipolipidemic activity. This research was an experimental study, using the post test only group design. The samples are 28 male wistar rats, were divided into 7 groups, 4 rats for each group. The control group, given by CMC-Na 1%. The negative control group, given by frying oil used and CMC-Na 1%. The treatment group, given by frying oil used and ethanol extract dose 150,300,600 and 1200 mg/kgBW. The positive control group, given by frying oil used and simvastatin 0,5 mg/kgBW. The results :show ethanol extract of black glutinous rice dose 1200 mg/kgBW have the greatest anticholesterol effect. ethanol extract of black glutinous rice can decrease cholesterol serum 54,40 mg/dL±3,98 and haven’t significant differences with simvastatin.Conclusion of this research show: ethanol extract of black glutinous rice have an anticholesterol effect on male wistar rats. ABSTRAK Penyakit kardiovaskular merupakan penyebab kematian nomor satu di kawasan Asia Pasifik. Berdasarkan penelitian Sudarmanto (2006) menyatakan bahwa konsumsi minyak goreng bekas pakai 27 kali dapat mempengaruhi kadar kolesterol total. Ketan hitam memiliki kandungan senyawa kimia yaitu antosianin yang diduga mempunyai kemampuan sebagai agen hipolipidemik. Penelitian eksperimental ini berdesain post test only control group, menggunakan 28 tikus Wistar jantan yang dibagi 7 kelompok, masing-masing kelompok 4 tikus. Kelompok kontrol, diberi CMC-Na 1%. Kelompok kontrol negatif diberi diet minyak goreng bekas pakai dan CMC-Na 1%. Kelompok perlakuan, diberi diet minyak goreng bekas pakai dan ekstrak etanol ketan hitam dosis 150,300,600 dan 1200 mg/kgBB. Kelompok kontrol positif diberi diet minyak goreng bekas pakai dan simvastatin. Perlakuan diberikan selama 14 hari. Hasil penelitian berupa kadar kolesterol serum total diuji dengan menggunakan one way anova (p<0,05).Hasil penelitian menunjukkan ekstrak etanol ketan hitam dengan dosis 1200 mg/kgBB memberikan efek antikolesterol dengan penurunan kadar kolesterol total serum paling besar yaitu sebesar 54,40±3,98 dan tidak berbeda signifikan dengan simvastatin. Kesimpulan dari penelitian ini Pemberian ekstrak etanol ketan hitam menurunkan kadar kolesterol total serum pada tikus putih jantan yang diberi perlakuan minyak goreng bekas pakai.

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN SELEDRI (Apium graveolens L) PADA MENCIT JANTAN Fifteen Aprila Fajrin
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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ABSTRACTCelery (Apium graveolens L.) is one of plants that initially only used for cooking. Based onthe research by Wolski, et al., 2002, celery contains chemical compound such as tannins andpolyphenols. Tannins may be useful as an anti-diarrheal because of the adstringent effect. Thisstudy aims to determine the antidiarrheals activity of celery leaf in male mice strain Balb-C that wasinduced by castor oil. The ethanolic extract of celery leaves divided into three dose group (5,10 and20 mg/kgBW). This research was done by two methods, protection of castor oil induced diarrheaand intestinal transit. After five hours treatment, frequency of defecation, number of soft/liquidfeses and weight of stools were calculated. The gastrointestinal transit rate was expressed as thepercentage of longest distance traversed by the charcoal divided by the total length of the smallintestine.From the protection of castor oil induced diarrhea method, ethanol extract of celery 20mg/20gBW doses decrease frequency of defecation, quantity of the soft / liquid stool and weight ofstool after 5 hours treatment in male mice that had been induced by castor oil. The effectiveness ofethanol extract 20mg/20gBW dose equivalent to loperamid 0.06mg/20gBW (one way anova test atthe α = 95%). Besides, the ethanol extract of celery can prolong intestinal transit of mice, but lowerthan loperamid 0.06mg/20g (one-way anova test at the α = 95%).Keywords: antidiarrheal, castor oil, celery, intestinal transit, taninns

Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.

Anti inflammatory Activity of the Ethanol Extract of Cinnamon (Cinnamomum burmannii) Bark using Membrane Stabilization Method and Protein Denaturation Annisa Shalihah; Fransiska M. Christianty; Fifteen Aprila Fajrin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36323

Inflammation is the body's reaction to infection, irritation, or foreign substances, as an effort to defend the body's defenses. Inflammatory mediators such as bradykinin, prostaglandins, fluid extravasation, and tissue damage are essential to protect our body as an inflammatory response. One of the plants in Indonesia which is the potential to develop is Cinnamomum burmanii. These plants are identified to contain some substances such as flavonoid, tannin, and saponin. This study was aimed to determine the anti-inflammatory effect of the Cinnamomum burmanii extract using in vitro method compared with diclofenac sodium. Cinnamon bark was extracted using 96% of ethanol, and phytochemical screening was determined. Anti-inflammatory test in vitro using two methods, membrane stabilization using red blood cell suspension and protein denaturation inhibition using bovine serum albumin. After an anti-inflammatory test using the membrane stabilization method, the IC50 of the extract was 84.45 ± 3.55 g/mL, while in the protein denaturation method, the IC50 of the extract was 57.412 ± 0.718µg/mL. Even though the IC50 of the extract was lower, it is still higher than diclofenac sodium as drug control. Our result showed that cinnamon has potential as an antiinflammation and needs to develop further

The Influence of Long-term Diabetes Mellitus on Pain Response in Mice: In Vivo Models of Painful Diabetic Neuropathy (PDN) Fifteen Aprila Fajrin; R Susilowati; A Nurrochmad; AE Nugroho
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 3 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACTPainful diabetic neuropathy (PDN) is a complication of long-term Diabetes Mellitus (DM) characterized by hyperalgesia and allodynia. In streptozotocin (STZ)-induced diabetic mice, higher dose of STZ and lengthen hiperglycemic condition results in better model of PDN. However, higher dose of STZ tend to induce mortality. Evaluate the doses of STZ that caused PDN with less mortality rate and the timing of pain behavior development in mice model of PDN. Balb/c mice were divided into non-diabetic and STZ-induced diabetic group. The doses of STZ were started from 180 mg/kg i.p. Serum glucose levels were measured 7 days after induction. Mice with glucose levels ≥ 200 mg/dl were considered as diabetic. Pain behaviour was determined by four method i.e. hot plate, tail flick test, von Frey fillament and Randall Selitto,measured on week-0 (baseline), 1, 2, 3, 4 and 5. Data were presented as mean±SEM. The mean differences between weeks were evaluated by One-Way ANOVA and the mean differences between two groups by independent t-test. STZ doses 180 mg/kg, 150 mg/kg and 120 mg/kg caused 100% death and STZ 90 mg/kg failed to induce diabetic condition. STZ 110 mg/kg resulted in 0% mortality while it induced diabetes in 100% mice. Latency time toward thermal stimulus decreased to 5.8 s at 1st week after the mice become diabetes (p<0.05) and it was continued decrease until 4th week. The same result was also showed in tail flick test and Randal Selitto. The pain sensitivity determined by von Frey filament decreased to 1.37 g at week 1 (p<0.05) and continued decrease until 5th week. Optimum dose of STZ to induce PDN was 110 mg/kg. Pain behaviour of diabetic group was observed at 1st week after diabetic and continued until 4th week.Keywords: PDN, hot plate, tail flick test, von Frey fillament, Randall Selitto

Co-Authors A Nurrochmad AE Nugroho Afifah Machlaurin Ainur Rokhmah Ajeng Merdeka Putri Alfarisy, Fariz Kustiawan Andrean Roni Angga Mardro Rahardjo Annisa Shalihah Atmawati, Siti Dwiana Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Chusna Mufida Diana Holidah Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Fransiska Maria Christianty Hadi Paramu Hasana, Ani Riani Herdian Pradana Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Irma Prasetyowati Junaidi Khotib Kartika Senjarini Kinanthi P Rizki, Kinanthi P Laily Ilman Widuri, Laily Ilman Lelyta - Septiandini Lesti Eko Pangestuti Lutvi Anggraeni M Nuril Huda Mohammad Rofik Usman Monica Cinuradha Aura Salsabina Muhammadiy, Noer Sidqi My, Truong Nhat Nandan G Cempaka, Nandan G Nia Kristiningrum Nur Jazilah Prihwanto Budi Subagio R Susilowati Rahmayanti, Finas Restanto, Didik Pudji Riza Rastri Wihardiyanti Sholihatil Hidayati Song, Le Huu Sugi Hartono, Sugi Tsabit Barki Velavan, Thirumalaisamy P. Wahyu W Rochmah, Wahyu W Wardhani, Firdha Aprillia Yuli Witono Zainah Rajab

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