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All Journal Indonesian Journal of Biotechnology Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya International Journal of Nursing and Health Services (IJNHS) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Conservative Dentistry Journal Indian Journal of Forensic Medicine & Toxicology The Hip and Knee Journal Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana

Dwikora Novembri Utomo

Orthopaedic And Traumatology Department, Faculty Of Medicine, Universitas Airlangga/Dr Soetomo General Hospital

Author-ID : 2650822

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Comparison of functional outcome after early and delayed anterior cruciate ligament reconstruction: A systematic review I Putu Dharma Kresna; Kukuh Dwiputra Hernugrahanto; Rr. Indrayuni Lukitra Wardhani; Dwikora Novembri Utomo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 2 (2022): Journal Qanun Medika Vol 6 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i2.11315

This study aims to find the optimal timing for Anterior Cruciate Ligament (ACL) reconstruction by comparing the outcome of early versus delayed ACL reconstruction, meniscus, and chondral damage. A systematic literature search was performed from February to March 2021 from 4 databases. Inclusion criteria were English language Randomized Control Trial (RCT) and observational studies published in 2000-2020, 20-50 years old patients with an isolated ACL tear with/without meniscal injury underwent ACL reconstruction. Early ACL reconstruction was estimated at less than six weeks post-injury, and delayed ACL reconstruction was estimated at more than six weeks. Tegner and Lysholm were the functional outcomes to compare early and delayed ACL reconstruction with a meniscus tear and chondral damage. The search yielded 3094 studies. After removing duplicates, titles and abstracts were screened, leaving 154 potential studies. The studies were selected, and eight studies were eligible. No statistically significant difference between early and delayed ACL reconstruction in Lysholm and Tegner score (p>0,05) was found. Both scores were similar regarding whether the patient performs early/delayed ACL reconstruction. Therefore, early ACL reconstruction could be an optimal timing for the patient who will undergo ACL reconstruction.

Sun Bathing Affects Overweight-Obese Subjects Vitamin D Deficiency Rio yudistira christanto; Andriati; Dwikora Novembri Utomo; Indrayuni Lukitra Wardhani
Surabaya Physical Medicine and Rehabilitation Journal Vol. 4 No. 2 (2022): SPMRJ, AUGUST 2022
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v4i2.23815

Background: There are increasing number of studies that discuss the effect of sun exposure to overweight and obese individuals with vitamin D deficiency (which is UVB exposure can increase serum 25-Hydroxyvitamin D levels). However, until now there is no a literature review about these studies. This shows a weak correlation between sun bathing and serum 25-Hydroxyvitamin D elevation in overweight and obese people. Aim: Describe the effect of the sun bathing for overweight-obese patient with vitamin D deficiency. Material and Methods: Electronic searching tools (ScienceDirect, Pubmed, and Google Scholar) were conducted from the 1990s until the recent literature. A sensitive search strategy uses specific terms. Studies were included if the population with BMI > 25 Kg/m2; Sun Exposure intervention, the studies provided the comparison of implementation method, the studies provided 25-Hydroxyvitamin D status as the outcome. For the exclusion criteria: studies that included subjects metabolics syndrome. MMAT was used for eliminating biased research. Results: Two studies were fulfilled our inclusion criteria. The studies, were excluded, mainly because they lacked data, biased reseach, and failure to answer any authors questions. Conclusion: The sun exposure method has a positive corellation for increasing serum 25-Hydroxyvitamin D level in overweight and obese subjects with vitamin D deficiency, but internal factors (age and skin color) and external factors (season, temperature, dose, and duration) need to be considered to get effective result. Keywords: Obese, Overweight, Sun bathing, Vitamin D deficiency, 25-Hydroxyvitamin D.

A Mixture of Ceramic Biomaterials (Hydroxyapatite and β-Tricalcium Phosphate) and Chitosan as a Scaffold For Critical Sized Defect Bone Dian Agustin Wahjuningrum; S. Setyabudi; Fery Setiawan; Dwikora Novembri Utomo; Ria Chusnita; Andi Syahrimayani; Arif Rahman Nurdianto
Conservative Dentistry Journal Vol. 11 No. 2 (2021): July - December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i2.2021.93-97

Background: Bone is a living tissue that undergoes a continuous regeneration-remodeling process and the second largest organ implanted after the blood transfusion process. Bones can heal completely, but Critical Size Defects (CSD) require graft materials to support the healing process. There are several graft materials, namely: autologous, allogenous, xenograft, and alloplastic material with their respective advantages and disadvantages through the properties: osteogenesis, osteoconduction, osteoinduction, and others. One of the alloplastic materials is Hydroxypatite/HA and β-Tricalcium Phosphate/β-TCP widely used in the grafting process. HA has the disadvantage of having a low degree of solubility, while β-TCP has a high solubility level when exposed to body fluids. Purpose: To explain the mixture of ceramic biomaterials (Hydroxyapatite and β-Tricalcium Phosphate) and Chitosan as a Scaffold for Critical Sized Defect Bone. Methods: This study used article based review from some journals that contain of the review about HA and -TCP. Results: The CSDs are condition where the bone can not heal by itself. It needs bone graft to bridge the heal of CSDs. One of the transplant materials is ceramic biomaterials contains of HA and β-TCP. Each of material has its strengths and weaknesses so that mixture of these ingredients will increase the positive effects and reduce the negative effects of each ingredient. Conclusion: CSD healing requires a scaffold that mimics cancellous bone in the healing process of bone defects played by the mixture of BCP as a bioceramic material and chitosan as a natural biopolymer with low toxicity and high biocompatibility.

Knee Preservation Techniques for Severe Synovial Osteochondromatosis in End-Stage Osteoarthritic Knee Using High Tibia Osteotomies, Cartilage Restoration Procedure, and Biologics; A Case Report in Bilateral Knees Andre Yanuar; Dwikora Novembri Utomo
The Hip and Knee Journal Vol 1, No 1 (2020): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Synovial osteochondromatosis can occur idiopathic or secondary to osteoarthritis. While joint replacement surgery has shown promising results for end-stage osteoarthritis, it isn’t always the answer for certain individual. In young athletic individual, the treatment should be patient specific, with consideration for return to sports activities. We present a 48-year-old ex-national professional football player with significant osteoarthritis and severe synovial osteochondromatosis. After discussion with the patient, we decide that knee preservation is suitable for him. Surgical treatments that are considered the best option are High Tibial Ostetomies, extraction of the loose bodies, partial synovectomy, and microfracture. Those procedures were performed in 8 months interval for each knee. The patient received intra-articular injection of cultured Mesenchymal Stem Cells (MSCs) with hyaluronic acid for 4 weeks after surgery. In a 34-month follow-up for right knee and 26-month follow-up for left knee, the patient regained significantly higher Knee injury and Osteoarthritis Outcome Score (KOOS) compare to before surgery (94 vs. 47). Radiologic examination also reveals the improvement of both knees joint space.

Clinical Outcome Evaluation in Anterior Cruciate Ligament Reconstruction using Transportal Technique Augmented with Platelet Rich Plasma (PRP) Injection Steesy Benedicta; Mouli Edward; Lukas Widhiyanto; Dwikora Novembri Utomo; Kukuh Dwiputra Hernugrahanto
The Hip and Knee Journal Vol 1, No 1 (2020): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Background: Anterior cruciate ligament (ACL) injury is a common injury in the athlete with an incidence of 30-78 cases per year. PRP injection can be applied to enhance graft healing and help patient return to sports faster. Transportal placement is a newer technique and believed can handle this problem. No perspective surveillance system has been made to monitoring the outcome of ACL surgery using the transportal technique and PRP injection in our hospital.Materials and Methods: A total data of 157 patients using medical records in our hospital between 1 January 2014 and 31 December 2018 were evaluated. All patients underwent ACL reconstruction surgery using the transportal technique and additional platelet rich plasma (PRP) intraarticular, with the exclusion of multiple ligament and meniscal injuries. The values evaluated in this study were clinical examination, SF-12 Daily Living Score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford knee Score (OKS), Tegner Lysholm score and Cincinnati score. Patients were followed up from a minimum of 6 months to 4 years after surgery.Results: We found male-dominant (82.8%) patients with the mean age is 25.59 ± 7.61 years old. MOI mostly sports-related activity (78,9%). Anterior drawer and Lachman test post-surgery showed significant improvement. SF-12 showed increasing post-op with mean 80.94. Mean Tegner Lysholm and Cincinnati post-operative was 87.30 and 378.57. OKS pre and post-op mean was 23.56 and 43.82. No significant difference in KOOS score with p0.0001.Conclusions: The ACL reconstruction augmentation with PRP injection with the transportal technique showed significant satisfaction and function restored to normal.

All-epiphyseal All-Inside Technique for Anterior Cruciate Ligament Reconstruction in Prepubescent Patient: A Case Report Lumban Gaol, Imelda; Hernugrahanto, Kukuh Dwiputra; muslim, Jeffry andrianus; utomo, Dwikora novembri
The Hip and Knee Journal Vol 4, No 2 (2023): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46355/hipknee.v4i2.139

Anterior cruciate ligament injuries are common seen in active and young patients. The ACL reconstruction technique in skeletally immature patients tries to minimize the growth disturbance. All physeal sparing technique is technically demanding. In this paper, we described physeal sparing technique of ACL reconstruction in skeletally immature patient. This is an all-epiphyseal all-inside ACL reconstruction with retrodrill of the femoral and the tibial sockets. Both sockets are within epiphysis. This technique used free loop system. This free loop system allows us to make a socket with length 15 mm, that is safe from the physis. This socket also allows us to tension the graft adequately with minimum sockets length. We present a case of 16 years old male who underwent all-epiphyseal all inside reconstruction with our rehabilitation protocol.

Mesenchymal Stem Cells Secretome and Osteoarthritis: A State of The Art Soetjahjo, Bintang; Utomo, Dwikora Novembri
The Hip and Knee Journal Vol 3, No 2 (2022): August
Publisher : Indonesian Hip and Knee Society (IHKS)

No agreed cure or procedure can prevent the damage caused by OA. Current treatments such as physiotherapy, anti-inflammatory drugs, and viscous supplements are symptomatic and are aimed solely at pain relief. Mesenchymal stem cells, on the other hand, refer to a population of cells with immunomodulatory and homing properties. Recent studies have shown that stem cells produce secretomes with tissue regeneration, immunomodulation, anti-inflammatory, and anti-apoptotic capacities.Secretomes in conditioned media produced by mesenchymal stem cells can stimulate the repair of cartilage defects. There are many evidence from many studies both in vitro and in vivo which provide potential results. The improvement can be seen from the morphology, in the form of thickening of the cartilage, an increase in the number of chondrocyte cells, regular joint surfaces, and histologically it can be seen that there is an improvement in the joint cartilage matrix. Likewise, histological studies using immunohistochemistry also showed an increase in the expression of TGF-β, SOX-9, aggrecan, and type II collagen which is a pathway for the formation of hyaline cartilage repair. Not only improvement, other studies have also shown that the secretome can provide a protective effect on joint cartilage by increasing the expression of the COL2A1 gene which functions to form collagen matrix components and reduces apoptosis in chondrocyte cells.Secretomes produced by mesenchymal stem cells can stimulate the repair of cartilage damage, anti-inflammatory, immunomodulator, angiogenesis, and anti-apoptotic abilities from their cytokines and extra vesicles contains miRNA. MSCs secretomes are more stable and provide simpler manufacturing than MSCs themselves.

Profile of Patients with Decreased Bone Density Aged Over 50 Years Old with Cases of Femoral Neck Fracture, Thoracic Vertebral Compression Fracture, Lumbar Vertebral Compression Fracture, and Distal Radius Fracture in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2019-2020 Pratama, Arlingga; Sari, Gadis Meinar; Utomo, Dwikora Novembri
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.1-6

Highlights: Decreased bone density often progresses to osteoporosis, where osteoporosis is a degenerative disease characterized by low bone mass, bone tissue damage, and bone microarchitecture disorders that can lead to an increased risk of bone fracture. Fractures often found in low bone density consist of fractures of the femoral neck, the thoracic and lumbar vertebrae, and distal radius fractures. Abstract Introduction: Human life expectancy will increase over time, as will various chronic degenerative diseases, one of which is fracture caused by decreased bone mass density. This study described fracture features associated with decreased bone mass density in patients over 50 years old. Methods: This study took place at the Polyclinic of Orthopaedics and Traumatology Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, using a quantitative design with a cross-sectional approach. The sample in this study consisted of 56 medical records collected using a questionnaire processed with Microsoft Excel. Results: This study used 56 samples. Femoral neck fractures had the highest number of decreased bone mass density fractures (69.7%). The most common body mass index (BMI) found with fractures was obese patients (32.2%). Most fractures were experienced by females (64.3%). The location of the highest incidence of fractures was found in domestic accidents (66.1%) with low-energy trauma (67.9%). Conclusion: Most of the fractures caused by decreased bone density in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, were femoral neck fractures, with females being the most common gender. These fractures were also the most common in obese patients, and the highest incidence was found in domestic accidents with low-energy trauma.

Antibiotic Susceptibility of Bacteria Isolated from Open Fracture Grade III Presenting to Dr. Soetomo General Academic Hospital Surabaya Wibisono, Raden Taufan Mulyo; Utomo, Dwikora Novembri; Widodo, Agung Dwi Wahyu
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 10 No. 1 (2021): April 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v10i1.2021.1-10

Background: Open fractures are a typical case in the orthopedics field. Infection in an open fracture can cause osteomyelitis. An antibiotic susceptibility testing of patient specimen bacteria with open fractures aimed to determine suitable antibiotic agents with which to treat the infectious diseases caused by these bacteria.Methods: This research is a descriptive study to assess antibiotic susceptibility in cases of open fracture grade III in Dr. Soetomo General Academic Hospital, Surabaya. Total sampling was performed on the microbiological culture results of patients diagnosed with open fracture grade III after debridement from October 2018 to September 2019. The identification of the microbes was based on Gram-positive and Gram-negative categories, and the classification was based on susceptibility to antibiotics, whether sensitive, intermediate, and resistant.Results: The examination of the data from the microbiological culture results of patients with a diagnosis of open fracture grade III after debridement from October 2018 to September 2019 in Dr. Soetomo General Hospital Surabaya resulted in 56 research subjects who met the criteria. Acinetobacter baumannii was the most common bacterial species found in the microbiological examination of patients with open fractures, at 15.84%. Cefazoline and ceftriaxone showed low susceptibility. Levofloxacin showed a relatively good value of susceptibility against both Gram-positive and negative bacterial groups.Conclusion: The antibiotic susceptibility pattern of bacteria from specimens in open fracture grade III patients in Dr. Soetomo General Academic Hospital Surabaya varies between each species of bacteria isolate.

Effect Of Interval Exercise Versus Continuous Exercise On Increases Energy Expenditure On A Treadmill Cakra Waritsu; Dwikora Novembri Utomo; Gadis Meinar Sari
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 2 (2020): November
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i2.314

This study is a pre-experiment with a posttest-only design research design using 16 obese women aged 19-23 years old, body mass index (BMI) 25-35 kg/m2, percentage body fat (PBF) above 30% and fasting blood glucose (FBG) below 100 mg/dL, normal hemoglobin (Hb), normal systolic and diastolic blood pressure, normal resting heart rate, VO2max25-30 mL/kg/min and randomly divided into two groups, namely IE (n=8, interval exercise) and CE (n=8, continuous exercise). Interval exercise and continuous exercise interventions were carried out at 08.00 a.m. for 40-45 minutes using a treadmill. The measurement of energy expenditure was using OMRON Caloriscan HJA-306-EW. Data analysis techniques used the Independent-Samples T Test with the Statistical Package for Social Science (SPSS). The results obtained mean energy expenditure on IE (251.750±19.775) kcal and CE (278.750±23.334) kcal (p=0.026). Based on the results of the study concluded that continuous exercise increases energy expenditure compared to interval exercise in obese women.

Co-Authors Abdurrachman, Abdurrachman Adrianto Prasetyo Perbowo Agung Dwi Wahyu Widodo Ahmad Hannan Amrullah Airlangga, Primadenny Ariesa Andi Syahrimayani Andre Yanuar Andriati Andriati Angga Fiandana Anthoni Yusbida Arif Rahman Nurdianto Arif Zulkarnain Arif Zulkarnain Cakra Waritsu Cita Rosita Sigit Prakoeswa Damayanti Tinduh Dian Agustin Wahjuningrum Farah Yusrania Farhan Nur Ahmad Dzakiya Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Fery Setiawan Firman Oswari Hamzah Hamzah Hari Basuki Notobroto Heppy Chandra Waskita HERAWATI, LILIK Heri Suroto Hernugrahanto, Kukuh Dwiputra I Gde Adi Widiastana I Ketut Martiana I Putu Dharma Kresna Ika Benny Kartika Sari Kukuh Dwiputra Hernugrahanto Kurniawati, Ninuk Dian Lukas Widhiyanto Lumban Gaol, Imelda Martanto, Tri Wahyu Mohammad Zaim Chilmi Mouli Edward muslim, Jeffry andrianus Patricia Maria Kurniawati Pratama, Arlingga Primadita Esther Rosita Purwati Purwati Reyner Valiant Tumbelaka Ria Chusnita Rio yudistira christanto Romaniyanto Romaniyanto Romaniyanto Sari, Gadis Meinar Setyabudi Setyabudi Setyawati, Rossy Soetjahjo, Bintang Steesy Benedicta Subiantoro, Januar Ari Suyenci Limbong Tsania, Tamara Wardhana, Teddy Heri Wardhani, Indrayuni Lukitra Wibisono, Raden Taufan Mulyo

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