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All Journal Indonesian Journal of Biotechnology Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya International Journal of Nursing and Health Services (IJNHS) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Conservative Dentistry Journal Indian Journal of Forensic Medicine & Toxicology The Hip and Knee Journal Physical Therapy Journal of Indonesia Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana
Dwikora Novembri Utomo
Orthopaedic And Traumatology Department, Faculty Of Medicine, Universitas Airlangga/Dr Soetomo General Hospital
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Intraarticular Allogenic Mesenchymal Stem Cells and Vascular Endothelial Growth Factor Injection in Anterior Cruciate Ligament Reconstruction Utomo, Dwikora Novembri; Mahyudin, Ferdiansyah; Zulkarnain, Arif; Purwati, Purwati; Setyawati, Rossy
Folia Medica Indonesiana Vol. 56, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Graft tunnel healing is important for the successful reconstruction of the anterior cruciate ligament by using the hamstring tendon autograft. There are studies that intra graft tunnel Bone Marrow Mesenchymal stem cells (BMSCs) or intra graft tunnel Vascular endothelial growth factor (VEGF) accelerated graft tunnel healing. This study aimed to investigate the effect of using BMSCs+VEGF injected intra-articular on graft tunnel healing. We reconstructed the anterior cruciate ligament (ACL) of 12 rabbits using an autograft hamstring tendon with and without intra-articular BMSCs+VEGF. Histological evaluation was done at 3 and 6 weeks after ACL reconstruction. On the surface between the graft and the bone tunnel obtained collagen fiber thickness or Sharpey fiber is significantly more than the control group (p< 0.05) in the evaluation of 3 weeks and 6 weeks either side of the tibia and the femur. To evaluate the progression of the treatment, treatment group and control group gained progression had significantly when compared to 3 weeks and 6 weeks. It can be concluded that intra-articular injection of VEGF+BMSCs can accelerate the integration of the graft tunnel from histology evaluation on 3 and 6 weeks.
Pengaruh Latihan Lari Sprint 50m terhadap Peningkatan Speed dan Power Tendangan Dollyo Chagi pada Atlet Taekwondo Tamara Tsania; Dwikora Novembri Utomo; Abdurrachman Abdurrachman; Damayanti Tinduh
Majalah Kedokteran Indonesia Vol 72 No 1 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.1-2022-560

Abstract

Introduction: Several training techniques are used to improve the performance of taekwondo athletes, one of which is sprint running. Sprinting is one of the branches of athletic sports which requires strength, muscle power, agility and speed. Dollyo chagi kicks is most often used both in attack and defense in taekwondo competition. To be a profesional athlete, they must have sport components such as muscle strengh, muscle power, speed, flexibility, agility, and endurance. The winner of the taekwondo competition is determined by the number of points earned. The author choose the speed an power of dollyo chagi because it is reliable to get points taekwondo matches.Methods: This is a quasi-experimental study with one-group pre-test and post-test design. Using purposive sampling techniques, seventeen junior taekwondo athletes (9 males and 8 female) were recruited. The athletes were trained with 50-meter sprint run for 4 weeks with intensity of 3 sets and 4 times a week. Result: Speed of dollyo chagi kicks increase significantly 17.74% (p less than 0.05) and power of dollyo chagi kicks increase significantly 23.06% (p less than 0.05). Conclusion: 50m sprint training can increase the speed and power of dollyo chagi kicks in taekwondo athletes.
Novel Rabbit Model for Femoral Head Osteonecrosis Characterized by Osteoclast Activity and Number of Empty Lacunae Sihombing, Masri; Dewi, Fitriya Nur Anisa; Siregar, Nurjati Chairani; Utomo, Dwikora Novembri; Pawitan, Jeanne Adiwinata; Dilogo, Ismail Hadisoebroto; Kekalih, Aria
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 15 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v15i1.2026.35-47

Abstract

Background: Osteonecrosis, or avascular necrosis (AVN) of the femoral head, is a progressive and irreversible bone pathological condition with an increasing amount of morbidity each year in Indonesia. Testing therapeutic strategies requires an ethical and reliable protocol for inducing femoral head AVN in animal models. This study evaluates a rabbit protocol's feasibility to support a larger investigation into secretome-based treatments.Methods: In this in vivo study, New Zealand white rabbits were divided into three test groups and one control group (n = 3 per group). Methylprednisolone was injected three times at 24-hour intervals, with lipopolysaccharide administered to the third test group on day four. Following a four-week observation period, effects were evaluated using histology, immunohistochemistry, lipid profiles, and radiology.Results: The results showed that both a dose of 20 mg/kgBW methylprednisolone plus 10 μg/kgBW lipopolysaccharide and 20 mg/kgBW methylprednisolone alone resulted in statistically significant femoral head AVN induction, characterized by an increase number of osteoclasts on caspase-3 staining and empty lacunae on hematoxylin–eosin staining. Conversely, the test group with a lower concentration did not show significant differences.Conclusion: These findings support the recommendation of a credible and promising animal model of femoral head osteonecrosis as a basis for the study of osteocytes, osteoblasts, and osteoclast regeneration, along with secretome therapy, which acts as a potential non-surgical treatment option. The absence of radiological confirmation limits a more established analysis, and further studies on this matter are needed.
Long-term functional mobility and gait-related outcomes after single-event multilevel surgery in ambulatory children with cerebral palsy: A systematic review Sufandi Fahmi; Tri Wahyu Martanto; Dwikora Novembri Utomo; Arif Zulkarnain; Hizbillah Yazid
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.443

Abstract

Background: Single-event multilevel surgery (SEMLS) is widely used to manage multilevel lower-limb deformities and gait impairment in ambulatory children with cerebral palsy. However, the long-term relationship between gait correction, functional mobility, biomechanical outcomes, and the need for additional surgery remains incompletely defined. This systematic review evaluated long-term functional mobility and gait-related outcomes after SEMLS or related multilevel surgical procedures in ambulatory children and adolescents with cerebral palsy. Methods: A systematic literature search was conducted in PubMed and Scopus. Long-term follow-up was defined as postoperative follow-up exceeding 12 months. Eligible studies included original clinical studies evaluating SEMLS, multilevel gait improvement surgery, or procedure-specific interventions performed as part of a multilevel surgical approach in ambulatory individuals with cerebral palsy. Functional mobility outcomes included Functional Mobility Scale (FMS), Gillette Functional Assessment Questionnaire Walking Scale (FAQWS), Gross Motor Function Classification System (GMFCS), assistive device use, and wheelchair use. Gait-related outcomes included global gait indices, three-dimensional gait analysis, spatiotemporal parameters, kinematic and kinetic variables, and biomechanical measures. Methodological quality was assessed using MINORS, and findings were synthesized narratively. Results: Of 480 identified records, 10 studies met the inclusion criteria. Functional mobility outcomes showed maintenance or improvement of ambulatory ability after SEMLS, although outcomes varied according to baseline GMFCS level and walking distance. Patients with GMFCS levels I–II generally demonstrated more favorable household and community mobility than those with GMFCS level III. Global gait indices, including GPS, GDI, EVGS, and GGI, generally improved after SEMLS. However, residual abnormalities such as pelvic tilt, swing-phase knee motion, postoperative back-kneeing, and recurrent crouch gait were also reported. Several long-term cohorts reported additional orthopedic surgery because of recurrence, residual deformity, or newly developed biomechanical problems. Conclusion: SEMLS was associated with favorable long-term functional mobility and gait-related outcomes in ambulatory cerebral palsy. However, postoperative outcomes remained heterogeneous across functional level, gait domain, surgical composition, and follow-up duration.
Co-Authors Abdurrachman Abdurrachman Adrianto Prasetyo Perbowo Agung Dwi Wahyu Widodo Ahmad Hannan Amrullah Airlangga, Primadenny Ariesa Andi Syahrimayani Andre Yanuar Andriati Andriati Angga Fiandana Anthoni Yusbida Aria Kekalih Arif Rahman Nurdianto Arif Zulkarnain Arif Zulkarnain Arif Zulkarnain Cakra Waritsu Cita Rosita Sigit Prakoeswa Damayanti Tinduh Dewi, Fitriya Nur Annisa Dian Agustin Wahjuningrum Farah Yusrania Farhan Nur Ahmad Dzakiya Fedik Abdul Rantam Ferdiansyah Ferdiansyah Mahyudin Fery Setiawan Firman Oswari Hamzah Hamzah Hari Basuki Notobroto Heppy Chandra Waskita HERAWATI, LILIK Heri Suroto Hizbillah Yazid I Gde Adi Widiastana I Ketut Martiana I Putu Dharma Kresna Ika Benny Kartika Sari Ismail Hadisoebroto Dilogo Jeanne Adiwinata Pawitan Kukuh Dwiputra Hernugrahanto Kurniawati, Ninuk Dian Lukas Widhiyanto Lumban Gaol, Imelda Martanto, Tri Wahyu Mohammad Zaim Chilmi Mouli Edward muslim, Jeffry andrianus Nurjati Chairani Siregar Patricia Maria Kurniawati Pratama, Arlingga Primadita Esther Rosita Purwati Purwati Reyner Valiant Tumbelaka Ria Chusnita Rio yudistira christanto Romaniyanto Romaniyanto Romaniyanto Sari, Gadis Meinar Setyabudi Setyabudi Setyawati, Rossy Sihombing, Masri Siswahyudianto Soetjahjo, Bintang Steesy Benedicta Subiantoro, Januar Ari Sufandi Fahmi Suyenci Limbong Tamara Tsania Wardhana, Teddy Heri Wardhani, Indrayuni Lukitra Wibisono, Raden Taufan Mulyo