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All Journal AGRIVITA, Journal of Agricultural Science IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia Jurnal Abdi Insani Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat BIOVALENTIA: Biological Research Journal Jurnal Pepadu Bulletin of Chemical Reaction Engineering & Catalysis
Ferlinahayati Ferlinahayati
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, University Of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir, South Sumatera 30622
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Science and Technology Indonesia

 1 
Secondary Metabolite of Endophytic Fungi Daldinia eschscholtzii from The Leaves of Syzygium polyanthum Mia Tirta Sari; Hary Widjajanti; Ferlinahayati; Hermansyah; Rian Oktiansyah; Elfita
Science and Technology Indonesia Vol. 8 No. 4 (2023): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.4.560-569

Abstract

Salam (Syzygium polyanthum) is a plant that is often used by Indonesian people as traditional medicine. The leaves are consumed to treat various diseases. This study reports the endophytic fungi found from S. polyanthum leaves and its secondary metabolites. Endophytic fungi species were determined through morphological and molecular identification. Potato Dextrose Broth medium was used for the cultivation process and ethyl acetate was used as a solvent for the extraction process. Antioxidant tests was carried out by using the DPPH method. Chromatographic techniques were used for the isolation of secondary metabolite and spectroscopic analysis was carried out to identify their chemical structures. The results of morphological and molecular analysis showed that the sample was Daldinia eschscholtzii. The secondary metabolite obtained from this endophytic fungus was idetified as fonsecinone A with good antioxidant activity. The secondary metabolite have the potential to become a source antioxidants through further research.
Synthesis, In-Vitro Evaluation, and Computational Investigation of Salicylic Hydrazide Derivatives as Potential Tyrosine Kinase–Targeted Anticancer Agents Sulistyowaty, Melanny; Tri Widiandani; Albertus Aditya Setiawan; Seow Lay Jing; Neny Purwitasari; Ferlinahayati; Dwi Setyawan; Galih Satrio Putra; Anastasia Wheni Indrianingsih
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.609-620

Abstract

A series of N2-acyl salicylic hydrazides (S2-S6) and N-(substituted benzylidene) salicylic hydrazides (S7-S9) were synthesized from 2-hydroxybenzohydrazide (S1), using both microwave irradiation and conventional methods, and tested for its in vitro anticancer activity against human lung cancer cell, A549. The salicylic hydrazides were successfully synthesized in good yields (79–98%) and the in-vitro study results indicated that 3,4-dichloro-N'-(2-hydroxybenzoyl)benzohydrazide (S5) was most active among the tested compounds (IC50 value of 68.75 µM). In this work, we applied an integrated approach combining network pharmacology and computational analysis to explore how salicylic hydrazide derivatives affect tyrosine kinase–related pathways. The in-silico findings were in agreement with the in vitro results, indicating that compound S5 produced a docking score of –6.53468 kcal/mol. The findings of this research are expected to support further development toward identifying promising anticancer drug candidates derived from salicylic hydrazide derivatives.
Co-Authors Addy Rachmat Ady Mara, Ady Afreni Hamidah Ahmad Fatoni Albertus Aditya Setiawan Aldes Lesbani Alfarado, Daniel Anastasia Wheni Indrianingsih Bambang Yudono Benyamin Lakitan Budi Untari Cenora, Cindy Cindy Cenora Daniel Alfarado Dasril Basir Desnelli Desnelli Dirli Fahmi Rizal Dwi Setyawan Efita Efita Elfita Elfita Elfita Elfita Elisa Nurnawati Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Emir Fikri Endri Junaidi Endri Junaidi, Endri Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Fatma Fitrya . Fitrya Fitrya Fitrya Fitrya Galih Satrio Putra Hanifa Marisa Hanifa Marisa Hary Widjajanti Heni Yohandini Herlina Herlina Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Julinar Julinar Julinar Julinar Julinar Jurnal Pepadu Juswardi Juswardi Juswardi Juswardi, Juswardi Lenny Anwar Lia Dewi Juliawaty Maryadi Maryadi Merry Hasmeda Mery Hasmeda Mia Tirta Sari Mikha Meilinda Christina MUHAMMAD SAID Muhammad Said Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Mustafa Kamal Mustafa Kamal Nadila Pitriani Nelly Erlina Nisa, Sarifatun Nurlisa Hidayati Nurlisa Hidayati Nurshanti, Dora Fatma Poedji Loekitowati Hariani Purwitasari, Neny Rian Oktiansyah Ricce Fatsiami Rizdha Apriyaty Rizkiani, Delisa Roby Pahala J Gultom Rofiqoh, Purnama Ria Salni Salni Salni Salni Salni Seow Lay Jing Setiawati Yusuf Shaum Shiyan Suheyanto Suheryanto Sulistyowaty, Melanny Susilawati, Susilawati Tarmizi Taher Tri Widiandani Yana Maolana Syah Zaidan, Zaidan