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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Pendidikan Matematika dan IPA AL KAUNIYAH Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Human Nutrition Biota Journal of Tropical Biodiversity and Biotechnology BERITA BIOLOGI Jurnal Biodjati Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal JMM (Jurnal Masyarakat Mandiri) Jurnal Mangifera Edu BioEksakta : Jurnal Ilmiah Biologi Unsoed Proceeding Biology Education Conference Berkala Penelitian Hayati Kaunia: Integration and Interconnection of Islam and Science Journal Kenanga : Journal of Biological sciences and Applied Biology Gunung Djati Conference Series Berkala Ilmiah Biologi Jurnal Kefarmasian Indonesia
Laksmindra Fitria
Universitas Gadjah Mada
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Journal : BERITA BIOLOGI

 1 
UJI TOKSISITAS ORAL REPEATED DOSE FILTRAT BUAH LUWINGAN (Ficus hispida L.f.) MENGGUNAKAN MODEL TIKUS (Rattus norvegicus Berkenhout, 1769) GALUR WISTAR Laksmindra Fitria; Rosita Dwi Putri Suranto; Indira Diah Utami; Septy Azizah Puspitasari
BERITA BIOLOGI Vol 19, No 3A (2020)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v19i3A.3936

Abstract

Hairy fig is a tropical medium-sized tree that produces abundant fruits throughout the year. In some Asian countries, the fruits are consumed as traditional medicine and food ingredient. Meanwhile in Indonesia there has not been much use. A series of oral toxicity tests must be conducted to study the possibility of toxic effects and the safety before further exploration. Oral single dose toxicity study of young and ripe hairy fig fruit filtrate has been carried out. Results demonstrated no observed adverse effect level (NOAEL) at a concentration of 100%. This study was aimed to continue the oral toxicity test with repeated dose following standard toxicity procedure by OECD Test Guideline No. 407 with some modifications. Parameters observed were mortality, sublethal effects consisted of physical conditions and behavior, body weight, core temperature, complete blood count, as well as liver, heart, and renal functions by measuring ALT, AST, and creatinine, respectively. Sampling points on day 0, 7, 14, 21, and 28. Results showed no observed adverse effect level (NOAEL) in both young and ripe fruits filtrate at a concentration of 100% however with a tendency to cause anemia and associate with renal dysfunction. Therefore, it is necessary to perform similar method of toxicity test but with lower concentration, also continue with further toxicity tests (subchronic and chronic periods).  
Co-Authors Abdul Razaq Chasani Aditya K. Karim Aditya Krishar Karim Andreas S. Budi, Andreas S. Anggoro Chandra Yulistiyanto Annisa Ridhowati Annisa Ridhowati, Annisa Cannadianti, Nadhira Cut M. Tiraya, Cut M. Diaz Ayu Anjani Dini Anggraini, Dini Eko Agus Suyono Eko Agus Suyono Epa Yohana Toga Torop Erlitaningsih, Ucik Gerald, Jeremia Gunawan, Isma Cahya Putri Handayani, Lisa Hartantyo, Rahadian Yudo Helen Eko Putro Indah Permata Sari Indah Riwantrisna Dewi Indira Diah Utami Intan Woro Prawesti Intan Woro Prawesti, Intan Woro Islami, Putri Dian Isma Cahya Putri Gunawan Kholidatus Silmi Kindi Adam Kindi Adam Kristiawati, Dian Lia Lavi Illiy Lonardo, Albert Lukitowati, Fajar Mahroos, Rifda El Maura Indria Meidianing Mayumi Hersasanti Meidianing, Maura Indria Meliala, Andreanyta Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Mulyati Sarto Mulyati Sarto Mulyati Sarto Mulyati Sarto Narwidina, Paramita Oktavia, Nurfitria Onny Nurrahman Marwayana Paul J. Kawatu Prayogo, Enggal Pricellita Nur’aivy Alvianti Putri Gunawan, Ismi Cahya Putri Nur Nur Aida Rachid, Ayu Aziza Ar Rahadian Yudo Rahadian Yudo Hartantyo Rahadian Yudo Hartantyo Rahadian Yudo Hartantyo Rarafifi, Chalivya Aska Rosita Dwi Putri Suranto Rury Eprilurahman Salsabila, Tantri Ajeng Salma Sanjaya, Wilda Bunga Tina Sari, Annisa Lintang Septy Azizah Puspitasari Siswanto Slamet Widiyanto Slamet Widiyanto Sudesty, Shellya Puti Syifa’ Aulia Rahmah Tika Candra Dewi Wilda Bunga Tina Sanjaya Windah Dwi Nuraini Mappalotteng