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All Journal Jurnal Kimia Mulawarman Al-Kimia JISIP: Jurnal Ilmu Sosial dan Pendidikan JUPE : Jurnal Pendidikan Mandala Fullerene Journal of Chemistry Jurnal Ilmiah Wahana Pendidikan Jurnal Ilmiah Sangkareang Mataram JURNAL ILMIAH GLOBAL EDUCATION DEVOTE: Jurnal Pengabdian Masyarakat Global Jurnal Sains, Teknologi dan Kesehatan UNITY: Journal of Community Service Journal of Science and Technology: Alpha SELAYAR: Jurnal Pengabdian Masyarakat Pure Chemistry Research
Muhsinun
Universitas Nahdlatul Ulama Nusa Tenggara Barat
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Journal : Journal of Science and Technology: Alpha

 1 
Asam Lemak Hidroksamat: Sifat Kimia dan Aplikasinya dalam Bidang Bioteknologi Muhsinun, Muhsinun
Journal of Science and Technology: Alpha Vol. 1 No. 1 (2025): Journal of Science and Technology: Alpha, January 2025
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/alpha.v1i1.93

Abstract

Fatty hydroxamic acids are chemical derivatives formed through the modification of the carboxyl group of fatty acids into a hydroxamate group, imparting unique and functional properties. The key chemical properties of these compounds include the ability to form strong complexes with metal ions, act as antioxidants, and possess high thermal and chemical stability. These combined properties make hydroxamate fatty acids relevant for various applications in the field of biotechnology. In waste treatment, these compounds serve as chelating agents to selectively bind heavy metals. In the pharmaceutical and food industries, hydroxamate fatty acids show potential as antimicrobial agents and natural preservatives. Furthermore, these compounds are used in enzymatic engineering to enhance the efficiency of biocatalytic reactions. Recent research also explores their use in microbial metabolic engineering to produce bioactive compounds with high added value. This article provides an in-depth review of the chemical properties, mechanisms of action, and diverse innovative applications of hydroxamate fatty acids, as well as discusses the technical challenges and opportunities for further development in the modern biotechnology era.
Penerapan Asam Lemak Hidroksamat dalam Industri Farmasi dan Kosmetik Muhsinun, Muhsinun; Yanuar, Emsal
Journal of Science and Technology: Alpha Vol. 1 No. 2 (2025): Journal of Science and Technology: Alpha, April 2025
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/alpha.v1i2.146

Abstract

This study aims to explore the application of hydroxamic fatty acids in the pharmaceutical and cosmetic industries, with a focus on their biological activities, product formulations, and compound stability in practical applications. Biological activity assays demonstrated that hydroxamic fatty acids exhibit significant antimicrobial effects against Escherichia coli and Staphylococcus aureus, as well as effective anti-inflammatory activity by reducing the production of pro-inflammatory cytokines in RAW 264.7 cells. Furthermore, anticancer tests on human breast cancer cells (MCF-7) showed that these compounds can inhibit cancer cell proliferation. In terms of product formulation, hydroxamic fatty acids were found to be stable in cosmetic products (facial serums and hair masks) and pharmaceutical products (topical ointments), with results indicating improvements in skin elasticity and hair quality, along with a reduction in inflammation symptoms in patients. However, a major challenge in the application of hydroxamic fatty acids lies in their complex synthesis process, which requires hazardous chemicals, thereby increasing production costs and impacting environmental sustainability. Therefore, further research is needed to develop more efficient and environmentally friendly synthesis methods. Overall, the findings of this study suggest that hydroxamic fatty acids hold significant potential for development as effective and safe active ingredients in the pharmaceutical and cosmetic industries.
Co-Authors Ahmad Zuhri Rosyidi Alpi Zaidah Alpi Zaidah, Alpi Alpiana Hidayatulloh Amrullah, Lalu Arianti, Dina Asrorul Azizi ATIKA SALMAN PARIS Desimal, Iwan Emsal Yanuar Fena Prayunisa Fitriani, Esi Hendra Suryadi Hidayatulloh, Alpiana Indah Arry Pratama Irwansah Iwan Desimal Lalu Amrullah Littaqwa, Lalu Auliya Akraboe Mahariyanti, Ermila Muh. Zaini Hasanul Muttaqin MULIA RASYIDI Pratama, Indah Arry Sry Anita Rachman Sukarto Sukarto Sumardiana, Sumardiana Syamsul Hidayat Yanuar, Emsal