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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran The Indonesian Biomedical Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Berkala Kesehatan JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Manuju : Malahayati Nursing Journal Indonesian Journal of Perinatology Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Gema Lingkungan Kesehatan Jurnal Abdimas Mahakam
Iskandar Iskandar
Public Health Study Program, Undergraduate Program, Faculty Of Medicine And Health Sciences, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PHYTOCHEMICAL PROFILING AND ANTIBACTERIAL ACTIVITY OF SUNGKAI (PERONEMA CANESCENS) LEAF EXTRACT AGAINST STAPHYLOCOCCUS AUREUS Noor Muthmainah; Eko Suhartono; Gusti Muhammad Perdana Putera; Dona Marisa; Mashuri Mashuri; Lisda Hayatie; Iskandar Iskandar; Syaifullah Akbar Pradito
Dentino: Jurnal Kedokteran Gigi Vol 11, No 1 (2026)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v11i1.26090

Abstract

Background: Staphylococcus aureus is an opportunistic Gram-positive bacterium that can colonize the oral cavity and cause various infections such as oral abscesses, stomatitis, and post-dental procedure infections. The increasing problem of antibiotic resistance has encouraged the exploration of medicinal plants as alternative antibacterial agents. Sungkai (Peronema canescens) leaves are traditionally used by the Dayak Meratus community as herbal medicine and are known to contain bioactive compounds with potential antibacterial activity. Purpose: This study aimed to analyse the phytochemical content and antibacterial activity of sungkai leaf extract against Staphylococcus aureus. Methods: This research used a true experimental design with a post-test-only control group design. Methanol extract of sungkai leaves was prepared using the maceration method. Phytochemical analysis included determination of flavonoid, alkaloid, and steroid contents using spectrophotometric and gravimetric methods. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar against S. aureus at concentrations of 25%, 50%, 75%, and 100%. Clindamycin was used as a positive control and sterile distilled water as a negative control. Results: Phytochemical analysis showed that sungkai leaf extract contained flavonoids (85.47 mg/mL QE), steroids (26.797%), and alkaloids (18.436%). The antibacterial test showed inhibition zones that increased with extract concentration, namely 10.19 ± 0.23 mm (25%), 12.89 ± 0.43 mm (50%), 14.80 ± 0.41 mm (75%), and 17.72 ± 0.57 mm (100%). Conclusion Sungkai leaf extract contains several bioactive compounds and demonstrates antibacterial activity against Staphylococcus aureus, indicating its potential as a natural antibacterial agent.Keywords: Antibacterial Activity, Phytochemical Analysis, Staphylococcus aureus, Sungkai Leaf Extract.
Co-Authors Adelia Anggraini Utama Adelia Anggraini Utama Ahla Syauqia Aisya Amelia Alin, Dhemes Amelia, Aisya Angga Praditya Anggun Oktovia Pratiwi Ari Yunanto Ari Yunanto Azwari, Ayu Riana Sari Beny Acah Yakwan Cynthia Maharani Puspita Sari Destisa Denti Seiza Pratiwi Dona Marisa Dona Marisa, Dona Edi Hartoyo Edi Hartoyo Efrilia Tanjung Eko Suhartono Eko Suhartono Erlena, Erlena Ermina Istiqomah Essy Dwi Damayanthi Fajar Setyo Wardoyo Ghina Raihana Gusti M Perdana Putera Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Gusti Muhammad Perdana Putera Hafifah, Ifa Hapsari Lintang Sekartaji Hapsari Lintang Sekartaji Hapsari Lintang Sekartaji Haryati Haryati Heni Yeni Irham Taufiqurrahman Isna Syauqiah Iwan Aflanie Lisda Hayatie Marlina Vionora Mashuri Mashuri Mashuri Mashuri Mashuri Monalisa Muhammad Hafidz MS Muhammad Luthfi Alfizar Muthaminah, Noor Muthmainah, Noor Naila Mutiara Nabilla Nasution, Annio Indah Lestari Nia Kania Niarsari Anugrahing Putri Niarsari Anugrahing Putri Nila Nirmalasari Nisa Nur Agistni Eriana Noor Muthaminah Noor Muthmainah Nurul Hidayah Prastricia, Meily Andini Pratiwi, Destisa Denti Seiza Pricilia Gunawan Halim Purwakaning Agung Purwanto Budi Santosa Putera, Gusti Muhammad Perdana Ratih Kumala Sari Salmon Siahaan Sanyoto, Didik Dwi Sekartaji, Hapsari Lintang Sheila Nur Salsabilla Silvia Kristanti Tri Febriana Silvia Novitasari Susantu Susantu Syaifullah Akbar Pradito Syauqia, Ahla Trang, Ha Thi Thu Windy Budianto Windy Yuliana Budianto, Windy Yuliana Yakwan, Beny Acah Yaliza, Nella Yosef Dwi Cahyadi Salan Yosef Dwi Cahyadi Salan Yulietrie Yusanto Nugroho Zainal Abidin Zainal Abidin Zairin Noor Zuhrufa Wanna Yolanda