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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Jurnal Kesehatan Medula Majalah Anestesia dan Critical Care Jurnal Anestesi Obstetri Indonesia Jurnal Neuroanestesi Indonesia Majalah Anestesia & Critical Care (MACC)
Syafruddin Gaus
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal Kesehatan

 1 
COMPARISON OF TWO DIFFERENT DOSAGES OF COMBINATION OF INTRAVENOUS GRANISETRON WITH INTRAVENOUS DEXAMETHASONE AS A PROPHYLAXIS FOR NAUSEA AND VOMITING IN CAESAREAN SECTION WITH SUBARACHNOID BLOCK Irfan Faisal Sjattar; Syafruddin Gaus; Andi Salahuddin; Arifin Seweng
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.25811

Abstract

Granisetron can be used to treat and prevent nausea and vomiting in patients receiving chemotherapy or radiotherapy, as well as during or after surgery. To compare the effects of two doses of intravenous granisetron on nausea and vomiting in Caesarean section with subarachnoid block. This study was a randomized double-blind clinical trial. Subjects were randomized into two groups: Granisetron 10 mcg/kg (GD10) and granisetron 25 mcg/kg (GD25). Dexamethasone 0.1 mg/kg was also administered to all subjects. A total of 21 subjects were included for each group. Data was analyzed using Mann Whitney U test. The results When comparing the incidence of nausea and vomiting in the GD10 and GD25 groups, there was a significant difference in the incidence of nausea (p = 0.001). In the GD10 group, there were nine participants who experienced nausea, whereas the GD25 group had none. Neither of the groups experienced vomiting, hence no additional therapy given to both groups. Granisetron is a selective 5-HT3 receptor antagonist and an effective antiemetic during and after neuraxial anesthesia for Caesarean section. The combination of granisetron and dexamethasone has been reported to be more potent than granisetron alone. Administration of granisetron 25 mcg/kg had a positive impact on patients, with no incidence of nausea and vomiting compared to administration of granisetron 10 mcg/kg.
COMPARISON OF MULTIMODAL ANALGESIA FOR PAIN CONTROL AND MEASURING INFLAMMATION LEVELS USING PARACETAMOL WITH VARIOUS DOSAGE OF IBUPROPHENE IN CAESARIAN SURGICAL PATIENTS Yudhitya Afif; Syafruddin Gaus; Alamsyah Ambo
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27753

Abstract

The concept of multimodal analgesia in the treatment of postoperative pain has been around for a long time. Various drugs have been used to control pain after cesarean section (SC). The purpose of this study was to compare the combination of paracetamol with ibuprofen at various doses as multimodal analgesia and to measure levels of Interleukin-6 (IL-6) as a marker of inflammation in CS surgical patients. Methods this study was a single-blind experimental study. A total of 40 patients who underwent SC surgery under spinal anesthesia using hyperbaric Bupivacaine 0.5% 8 mg were divided into 2 groups, namely IBU4 group (paracetamol 750 mg and ibuprofen 400 mg), and IBU8 (paracetamol 750 mg and ibuprofen 800 mg) given intravenously 1 hour preoperatively, and every 6 hours for 24 hours. Then the degree of pain was assessed at rest and moving using a Numeric Rating Score (NRS) at 2, 4, 6, 12, and 24 hours postoperatively, and IL-6 levels were measured 1 hour preoperatively, 6 and 12 hours postoperatively. Calculate the amount of fentanyl given for rescue. Then repeated ANOVA, paired t-test, and chi-square analysis were performed using SPSS 21 for Windows. The results are declared meaningful if the p-value < 0.05. The results the IBU8 group showed lower values of the silent NRS, motion NRS, and IL-6 levels than the IBU4 group; this difference was significant with a value (p<0.05). All patients in the IBU8 group also did not require rescue fentanyl (p<0.05). The combination of paracetamol 750 mg and ibuprofen 800 mg showed the best results on NRS values, IL-6, and CRP levels for postoperative pain management SC without the need for rescue fentanyl and side effects.
EFFECT OF CRYSTALLOID FLUID LOADING AND VASOPRESSOR PRE-TREATMENT ON THE TIME OF BLOOD PRESSURE DROP IN CESAREAN SECTION WITH SUBARACHNOID BLOCK Muhammad Irfan Djafar; Andi Salahuddin; Syafruddin Gaus
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27761

Abstract

Caesarean section (SC) is the most frequently performed surgery in obstetrics. Subarachnoid block (SAB) and epidural block are the most widely used anesthetic techniques in CS surgery. Objectives To analyze the effect of loading crystalloid fluid and administration of vasopressors on the time of occurrence of a decrease in blood pressure in SC with SAB anesthesia. Method single-blind randomized controlled clinical trial consisting of 2 treatment groups, namely crystalloid fluid loading and vasopressor pre-treatment. The Results There was a significant difference in mean blood pressure between the crystalloid group and the vasopressor group at 2 to 8 minutes (p<0.05). The average systolic blood pressure for 46 minutes in the three groups showed that the decrease in blood pressure occurred first in the crystalloid group compared to the vasopressor group, and hypotension occurred at 5 minutes in the crystalloid group. After the first 10 minutes, average blood pressure tends to be relatively stable. There was a significant difference in the incidence of hypotension, which occurred more in the crystalloid group, which was 9 or 45%, the vasopressor group with hypotension was 2 or 10% (p<0.05). The incidence of decreased blood pressure was found to be more common with crystalloid loading than with vasopressor pretreatment, in accordance with the findings of previous studies. The incidence of decreased blood pressure in SC with SAB anesthesia was faster and more common with loading crystalloids than pretreatment with vasopressors. Administration of vasopressor pretreatment has been shown to prevent the incidence of a decreased blood pressure in SAB anesthesia.
COMPARISON OF THE EFFECTS OF PRE-EMPTIF ANALGESIA PREGABALINE 75 WITH 150 MG ON THE GRADE OF PAIN AND CAESARIAN SECTION SEDATION SCORE WITH SUBARAKHNOID BLOCK Ardiansyah Siradjuddin; Muhammad Ramli Achmad; Syafruddin Gaus
Jurnal Kesehatan Vol 15 No 1 (2022): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v15i1.27762

Abstract

In recent years, many studies have been carried out on the pre-emptive analgesia of pregabalin for various types of surgery with varying results. Preemptive analgesia in caesarean section (SC) usually uses pregabalin at a dose of 150 mg, and there have been no studies using low doses (75 mg) Objective This study aimed to determine the effects of pregabalin 75 mg vs 150 mg doses for controlled pain, their sedation score in patients after C-section under spinal anesthesia. Methods This study was a double-blind randomized trial study examining 20 samples of patients who underwent elective C-sections under spinal anesthesia and divided into 2 equal groups, P75 (who received oral pregabalin 75 mg) and P150 (who received pregabalin 150 mg). The Results There were no significant differences in NRS between the 75 vs 150 mg group (p>0.05), and there were significant differences in Ramsay sedation score between the 75 vs 150 mg group on 2 and 6 hours after surgery(p<0.05) and there were no significant differences about the need for fentanyl rescue between 75 vs 150 mg group (p>0.05). Pregabalin has an opioid-sparing effect and larger doses of pregabalin may increase its efficacy. The sedative effect that arises is due to the mechanism of action of pregabalin which binds potently to the 2δ subunit calcium channel and modulates calcium influx at nerve endings, thereby reducing the release of several excitatory neurotransmitters (glutamate), such as the mechanism of action of various intravenous and inhaled anesthetic agents. Preemptive administration of pregabalin 75 mg is recommended for C-section surgery because it might reduce NRS and the need for fentanyl rescue with minimal sedation side effects.
Co-Authors , Masrianil A.A. Ketut Agung Cahyawan W A.M. Takdir Musba Abdul Wahab Adil, Andi Agussalim Ali Ahmad, Muh. Ramli Alamsyah Ambo Alamsyah Ambo Ala Husain Andi Adil Andi Muhammad Takdir Musba Andi Salahuddin Andi Salahuddin Ardiansyah Siradjuddin Arifin Seweng Arifin Seweng Aulyan Syah, Bau Indah Aulyan Syah, Bau Indah Bambang J Oetoro Bangun, Chrismas Gideon Bangun, Chrismas Gideon Budianto, Jeffri Charles Wijaya Tan Datu, Madonna Damayanthie Dewi Yulianti Bisri Faisal Muchtar Firdaus, Riyadh Harahap, M Sofyan Harsakti Rasyid Hisbullah Husain, Alamsyah Ambo Ala Husni Tanra Ida Bagus Krisna Jaya Sutawan Ilham Jaya Patellongi Ilhamjaya Patellongi Irfan Faisal Sjattar Irina, Sinta Isbul Isbul Jeffri Budianto Krisna J. Sutawan, Ida Bagus Kristiono, Evan Kulsum Kulsum, Kulsum Mohamad Sofyan Harahap Muh. Ramli Ahmad Muh. Ramli Ahmad Muhammad Irfan Djafar Muhammad Ramli Achmad Muhammad Ramli Ahmad Muhammad Ramli Ahmad Musba, A. M. Takdir Nur Surya Wirawan Nurdin, Haizah Oetoro, Bambang J Oetoro, Bambang J. Oetoro, Bambang J. Patellongi, Ilham Jaya Permatasari, Endah Permatasari, Endah Prawira, Lienardy Rakhmat Ilhamsyah RATNAWATI Ratnawati Ratnawati Rose Mafiana Rr Sinta Irina Rum, Muhammad Salahuddin, Andi Saleh, Siti Chasnak Saleh, Siti Chasnak Santosa, Dhania Anindita Santosa, Dhania Anindita Satya Nugraha, Eva Soedibjo, Dennis Prakas Sri Rahardjo Syafri Kamsul Arif Tatang Bisri Tatang Bisri Widiastuti, Monika Winanda, Haris Yudhitya Afif