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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Ilmu Dasar Jurnal Pendidikan IPA Indonesia Jurnal Penelitian Pendidikan Matematika dan Sains Matematika dan Sains Vidya Karya E-Dimas: Jurnal Pengabdian kepada Masyarakat JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya Resona : Jurnal Ilmiah Pengabdian Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Al-Kimia PENDIPA Journal of Science Education Jurnal PTK dan Pendidikan Molekul: Jurnal Ilmiah Kimia Jurnal Pemberdayaan Masyarakat Universitas Al Azhar Indonesia JPPS (Jurnal Penelitian Pendidikan Sains) Jurnal Abdi: Media Pengabdian Kepada Masyarakat Sains dan Matematika Jurnal Penelitian Pendidikan Matematika dan Sains Studies in Philosophy of Science and Education Indonesian Journal of Chemical Science and Technology IJORER : International Journal of Recent Educational Research Jurnal Pijar MIPA Jurnal Akademika Kimia Unesa Journal of Chemistry Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Jurnal Akademika Kimia KOPEMAS
I GUST MADE SANJAYA
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Negeri Surabaya, Jawa Timur, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Earth & Planetary Sciences Education Energy Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Journal : Jurnal Kimia (Journal of Chemistry)

 1 
THE INFLUENCE OF KCL CONCENTRATION ON ENCAPSULATION EFFICIENCY OF YACON-TUBERS EXTRACT’S CHLOROGENIC ACID S. Oktaviyanti; I G. M. Sanjaya
Jurnal Kimia (Journal of Chemistry) Vol. 15, No.2, Juli 2021
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2021.v15.i02.p10

Abstract

Enkapsulasi asam klorogenat ekstrak umbi yakon merupakan salah satu cara untuk melindungi senyawa-senyawa aktif menggunakan paduan polimer alam kappa karagenan-locust bean gum dengan penggunaan ion K+ sebagai pengikat matriks melalui metode gelasi ionik. Pada penelitian ini dilakukan pembentukan gel dari kappa karagenan dan locust bean gum dengan bantuan larutan KCl. Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi larutan KCl pada pembentukan gel serta efektifitas enkapsulasinya. Bertambahnya konsentrasi larutan KCl juga membuat gel menjadi lebih kaku. Hasil uji menunjukkan bahwa penggunaan larutan KCl 0,3M dapat menghasilkan nilai efisiensi enkapsulasi sebesar 79,44%. Kemiripan spektra IR antara gel kappa karagenan-locust bean gum, asam klorogenat murni dan asam klorogenat terenkapsulasi menunjukkan bahwa asam klorogenat hanya terperangkap secara fisik dalam matriks kappa karagenan-locust bean gum dan perubahan spektra karakteristik dari kappa karagenan dari 1018 cm-1 menjadi 1023,62 cm-1 pada sampel hasil enkapsulasi menunjukkan adanya interaksi antara gugus OH dari locust bean gum dan kappa karagenan. Kata kunci: asam klorogenat; enkapsulasi; kappa karagenan, locust bean gum, Yakon The encapsulation of chlorogenic acid of yacon tuber extract is one way to protect the active compounds using naturals polymers kappa carrageenan-locust bean gum with K+ ions as a matrix binder through the ionic gelation method. This process was carried out by forming a gel from kappa carrageenan and locust bean gum with the help of KCl solution. This encapsulation process has purposes to determine the effect of the concentration of KCl solution on gel formation and the effectiveness of its encapsulation. The test results indicated that the use of 0.3M KCl solution resulted in an encapsulation efficiency value of 79.44%. The bonding between the two polymers and the K+ cation was thought to result in a higher encapsulation effectiveness. The similarity of IR spectra among kappa carrageenan-locust bean gum gel, pure chlorogenic acid and encapsulated chlorogenic acid showed that chlorogenic acid was only trapped physically in the kappa carrageenan-locust bean gum matrix and the shift of kappa carrageenan peak from 1018 cm-1 to 1023,62 cm-1 of the encapsulated sample had shown an interaction between OH groups from locust bean gum and kappa carrageenan. Keywords: chlorogenic acid; encapsulation; kappa carrageenan, locust bean gum, Yacon
STUDI PENGEMBANGAN OBAT KANKER KOLON DARI TURUNAN ASAM ELAGAT L. R. Jannah; I G. M. Sanjaya
Jurnal Kimia (Journal of Chemistry) Vol. 15, No.2, Juli 2021
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2021.v15.i02.p13

Abstract

Penelitian ini bertujuan untuk mengembangkan obat kanker kolon dengan bahan baku senyawa asam Elagat dan turunannya menggunakan metode Hubungan Kuantitatif Struktur-aktivasi (HKSA) dan penambatan molekular. Deskriptor yang dipakai HKSA meliputi deskriptor elektronik, sterik, dan hidrofobik. Karakter dari masing-masing deskriptor dikomputasikan menggunakan software NWchem dan MarvinSketch dengan teori HF (Hartree-Fock). Penambatan molekul dilakukan dengan menggunakan software Autodock Tools dan Biovia. Hasilnya menunjukkan bahwa model persamaan terbaik HKSA senyawa bahan obat dari asam elagat dan turunanya adalah Log P = -7.103 + (-0.005*PSA) + (-0.729*MR) + (0.003*Volume) + (0.002*SA) + (-99.912*Homo) + (-38.893*Lumo)+ (-0.072*MD)+ (0.006*Eh) + (1.409*P) yang diperoleh untuk senyawa 2,3,7-trichloro-8-methoxychromeno[5,4,3-cde]chromene-5,10-dione. Hasil penambatan molekular tersebut memiliki energi ikat sebesar -9.94 kkal/mol dan konstanta inhibisinya 51,54 nM. Kata kunci: asam elagat, HKSA, kanker kolon, penambatan molekular This study aimed to develop a colon cancer drug with a raw material of ellagic acid and its derivatives using the Quantitative Structure-Activity Relationship (QSAR) method and molecular docking. The descriptors used in QSAR were electronic, steric, and hydrophobic descriptors. The characters of each descriptor were computed using NWchem and MarvinSketch software with the HF (Hartree-Fock ) theory. Molecular docking was performed using Autodock Tools and Biovia software. The results show that the best equation of QSAR model for medicinal compounds from ellagic acid and derivatives was Log P = -7.103 + (-0.005 * PSA) + (-0.729 * MR) + (0.003 * Volume) + (0.002 * SA) + (- 99,912 * Homo) + (-38,893 * Lumo) + (-0.072 * MD) + (0.006 * Eh) + (1.409 * P) obtained for 2,3,7-trichloro-8-methoxychromeno [5,4, 3-cde] chromene-5,10-dione compound. The result of molecular docking had a binding energy of -9.94 kcal/mol and an inhibition constant of 51.54 nM. Keywords: colon cncer, ellagic acid, molecular docking, QSAR.
Co-Authors Abdul Kodir Achmad Lutfi AFAF BAKTIR Agustin, Zulfani Nurdiana Ananta Adita Eka Putra Aprido Bernando Simamora Asfiyah, Sofi Nur Astutik, Julia B. Jatmiko Bagus Rahmat Basuki Beni Setiawan Bertha Yonata Budi Jatmiko Damayanti, Ni Noman Triyani Dian Novita Dina Kartika Maharani ENDANG SUSANTINI Endang Susantini Firlia Nur Fadila Firman Adji Nur Hidayat Gatot Suparno1 Hakimah, Nurul Lathifatul Hanifa Rachmah Kamila Hariyono, Eko Ika Ambarwati Indarwati, Rosi Ishma, Ervina Fadhilatul ISMONO ISMONO Isnawati1 Julian Sagus Bramasta Kardi, Soeparman Karimah, Iffah Koestiari, Toeti Koestiari Kurdaningsih, Kurdaningsih Kurniawati, Laili Kusumawati Dwiningsih L. R. Jannah Lukas S. Budipramana1 Madlazim Madlazim Madlazim Madlazim Mardiyanti, Nur Eka Agusti Maria Monica Sianita Muchlis Muchlis Mufid, Mohammad Fakhrul Muhammad Nasir Murniati, Diani Rachmanita Nafisa Cahyani Ngandoh, Satwika Trianti Nita Kusumawati Nita Kusumawati Nur Hayati Pirim Setiarso Rosyidah*, Kholifatur Rosyiidah, Nur Anisa S. Oktaviyanti S. R. Yunus Samik Samik Samik Samik Samik Samik Sari Edi Cahyaningrum Satwika Trianti Ngandoh Selvi Marcellia Soeparman Kardi Solly Aryza Sophia Allamin Sri Poedjiastoeti Sri Poedjiastoeti Sutrisno Sutrisno Sutrisno, Sutrisno Suyatno Sutoyo SUYONO Syahdiani Syahdiani Syahdiani, Syahdiani Syahrani, Achmad Titik Taufikurohmah Toeti Koestiari Koestiari Trisanti, Diah Candra Tukiran Tukiran Tukiran Tukiran Tukiran Tukiran Viyana Choyrunisa, Ratrie Wahono Widodo Wanita, Defitiana WIELIYANI, ARI YUNI SRI RAHAYU ZAINUL ARIFIN IMAM SUPARDI Zeinur Rochma Fandis Romadhon