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Early-Onset Urticaria Pigmentosa in a 7-Month-Old Infant: A Case Report Nellia Fonna; Mutia Sari; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1218

Background: Urticaria pigmentosa (UP) is the most common form of cutaneous mastocytosis in children, accounting for 70-90% of cases. UP typically presents in infancy or early childhood with characteristic skin lesions that vary in appearance. The hallmark of UP is the presence of reddish-brown macules or papules that urticate or blister upon rubbing, a phenomenon known as Darier's sign. Histopathological examination of a skin biopsy is confirmatory, demonstrating an increased number of mast cells in the dermis. Case presentation: We report a case of early-onset UP in a 7-month-old infant boy who presented with multiple hyperpigmented macules all over his body. The lesions were pruritic and had progressively increased in size and number over the past two weeks. Dermatological examination revealed multiple erythematous macules on the face, hyperpigmented macules on the chest, abdomen, and extremities, hyperpigmented plaques on the legs, and a nodule on the back. The lesions exhibited a positive Darier's sign, characterized by swelling and redness upon rubbing. Systemic examination was unremarkable, with no evidence of hepatomegaly, splenomegaly, or lymphadenopathy. Dermoscopy of the lesions revealed a central pigment network and a light brownish peripheral structure, suggestive of UP. Histopathological examination of a skin biopsy confirmed the diagnosis of UP, demonstrating an increased number of mast cells in the dermis. The patient was treated with oral antihistamines (cetirizine) and topical corticosteroids (hydrocortisone) for four weeks, resulting in significant regression of the lesions. Conclusion: This case highlights the importance of recognizing the clinical features of UP in infants. Early diagnosis and appropriate management can help alleviate symptoms and improve the quality of life for affected children.

Role Essential Oils In Hair Growth Chalik, Cherry; Gustia, Rina
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.40822

The use of essential oils has begus to be in great demand in the community, both for health purposes and in cosmetic ingredients. Essential oils are natural active ingredients containing various growt hcomplex chemical components and unique compounds. Several studies have begun to research the benefits of the bioactive ingredients in essential oils on hair growth. The benefits of essential oils that have begun researched are the stimulating effect of the hair growth. The existence of various components and active ingredients in essential oils requires further studies regarding the mechanism of action and how essential works in growing hair.

The Effect of Alpha Mangostin on The Expression of TGF-β1, SMAD3, Type I Collagen, Proliferation and Migration of Keloid Fibroblasts Asri, Ennesta; Rina Gustia; Indah Indria Sari; Jefrizal Wirman; Yufaz Aidi Mahesa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.41-47

Background: Keloid is a process of abnormal collagen thickening during wound healing in skin tissue accompanied by the formation of new blood vessels. Many keloid therapy modalities have been developed but the recurrence rate of those treatment still ranged 1-70%. Herbal plants have been developed for various types of treatment, one of which is for treating keloids. Purpose: The alpha mangostin content in mangosteen peel is known to have antifibrotic properties, further research is needed regarding the administration of alpha mangostin on the process of keloid occurrence. Methods: The investigation was conducted in vitro on phase III keloid fibroblast cells. There were two groups, which divided into the control groups and the treatment groups. The control groups and treatment groups were given alpha mangostin extract in concentrations of 20 μM; the sample of this study was 16. For each group after 24h of the incubation, fibroblast cell proliferation was measured by Microtetrazolium (MTT) assay, fibroblast cell migration was measured by scratch assay, SMAD3 expression was measured after immunocytochemical staining, and type 1 collagen was measured by Enzyme-Linked Immunosorbent Assay (ELISA). The Ethics Committee at the Research Ethics Commission of Faculty of Medicine Andalas University has reviewed this research. Result: Alpha mangostin can reduce the average expression of TGF-β1, SMAD3 expression, type 1 collagen, proliferation, and migration. . Conclusion: At concentration of 20 μM, alpha mangostin suppressed TGF-β1 expression, SMAD 3, collagen type 1, proliferation, and migration in keloid fibroblast cell.

Karakteristik Pasien Kusta dengan Reaksi dan Tanpa Reaksi Tahun 2018-2021 Di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang Dzakiyyah, Adzristi Zahrah; Rahmatini, Rahmatini; Gustia, Rina
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1204

Abstrak Latar Belakang: Kusta adalah salah satu penyakit menular yang dapat menyerang kulit dan saraf tepi dan disebabkan oleh Mycobacterium leprae. Kusta dapat ditularkan melalui cairan tubuh seperti dari mulut dan hidung serta terdapat kontak erat dan dekat dengan pasien kusta. Kusta dapat menyebabkan seseorang menderita suatu reaksi inflamasi yang disebut dengan reaksi kusta. Reaksi kusta jika tidak diobati secara adekuat dapat menyebabkan kecacatan atau disabilitas. Objektif: untuk mengetahui karakteristik pasien kusta dengan reaksi dan tanpa reaksi pada tahun 2018-2021 di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang Metode: Jenis penelitian ini adalah penelitian deskriptif. populasi penelitian ini adalah seluruh pasien yang terdiagnosis kusta dengan reaksi dan tanpa reaksi oleh klinisi di Poliklinik Kulit dan Kelamin RSUP Dr. M. Djamil Padang dengan jumlah sampel sebanyak 54 orang dari tahun 2018-2021. Hasil: Hasil penelitian didapatkan kasus kusta tanpa reksi terbanyak pada usia lansia, jenis kelamin laki-laki, tipe kusta MB, pemeriksaan BTA positif, dan tidak ada riwayat kontak erat dengan penderita kusta. Selain itu, kasus kusta dengan reaksi kusta terbanyak pada usia remaja, jenis kelamin laki-laki, tipe kusta MB, pemeriksaan BTA positif, tidak ada riwayat kontak erat dengan penderita kusta , tipe reaksi kusta ENL, dan waktu kejadian reaksi setelah MDT. Kesimpulan: Karakteristik pasien kusta dengan reaksi dan tanpa reaksi paling banyak pada kelompok usia remaja dan lansia, jenis kelamin laki-laki, tipe kusta MB, hasil pemeriksaan BTA positif, tidak ada riwayat kontak erat dengan penderita kusta, mengalami reaksi kusta tipe ENL, dan waktu kejadian reaksi setelah MDT. Abstract Background: Leprosy is and infectious disease caused by Mycobacterium leprae which affects the skin and peripheral nerves. Leprosy can caused a person to suffer from an inflammatory reaction called leprosy reaction. If not treated properly, leprosy reaction can lead to deformity or disability. Leprosy still exist in Indonesia and is still an unresolved problem until this day. Objective: This research aimed to determine the characteristics based on age, gender, majority, occupation, place of residence, complications, type of leprosy, AFB test result, history of close contact, type of leprosy reaction, and time of reaction of leprosy patients with and without reactions at the Dermatology and Venereology Polyclinic, RSUP Dr. M. Djamil Padang From 2018-2021. Methods: This study employed descriptive research. the population of this study consists all patients diagnosed leprosy with and without leprosy reaction by doctors with a total sampling methode obtained was 54 people from 2018-2021. Results: Of the 54 people sampled on this study this results showed that the majority of leprosy cases without reaction were found in elderly were 15 people (42,9%), male were 25 people (71,4%), MB type of leprosy were 25 people (71,4%), positive AFB test result were 17 people (48,5%), and patients with no history of close contact with leprosy patients were 31 people (88,6%). Additionally, the majority of leprosy cases with reactions were found in adolscent were 8 people (42,1%), male were 13 people (68,4%), MB type of leprosy, were 18 people (94,7%), positive AFB test result, were 13 people (68,4%), patients with no history of close contact with leprosy patients were 13 people (68,4%), patients with type 2 leprosy reaction (ENL) were 13 people (68,4%), and experiencing the reaction time after MDT were 9 people (47,4%). Conclusion: The majority of leprosy cases without reaction were found in elderly, male, MB type of leprosy, positive AFB test result, and patients with no history of close contact with leprosy patients. Additionally, the majority of leprosy cases with reactions were found in adolscent, male, MB type of leprosy, positive AFB test result, patients with no history of close contact with leprosy patients, patients with type 2 leprosy reaction (ENL), and experiencing the reaction time after MDT. Keyword: Leprosy, Leprosy Reactions, Without Reaction

Gambaran CT Scan Kepala Pasien Trauma Kepala di RSUP Dr. M Djamil Padang Tahun 2021 Hafizah Putri Tasyah; Avit Suchitra; Rina Gustia; Novita Ariani; Dina Arfiani Rusjdi; Aswiyanti Asri
Jurnal Kesehatan Masyarakat Indonesia (JKMI) Vol. 2 No. 4 (2025): Juli
Publisher : Publikasi Inspirasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62017/jkmi.v2i4.4799

Tujuan : mengetahui gambaran CT Scan kepala pasien trauma kepala di RSUP Dr. M. Djamil Padang pada tahun 2021. Metode : Penelitian ini adalah penelitian deskriptif retrospektif. Pengambilan data dilakukan di bagian Radiologi RSUP Dr. M Djamil Padang pada 8 Desember – 22 Desember 2022. Data diambil dalam periode bulan Januari – Desember 2021. Data dianalisis dengan menggunakan analisis univariat. Data dinyatakan dalam bentuk distribusi frekuensi. Hasil: Hasil penelitian ini adalah 357 sampel hasil CT Scan pasien yang memiliki diagnosis trauma kepala. sebanyak 72,5 % adalah laki-laki dan 27,5 % perempuan dari 357 sampel tersebut. Penderita trauma kepala paling banyak berusia 19-59 tahun (51,0 %). Gambaran lesi intrakranial yang terbanyak adalah lesi multipel ( 23,5 %). Kejadian fraktur maksilofasial ditemukan sebanyak 63 kejadian dari 357 pasien trauma kepala. Fraktur mandibular merupakan jenis fraktur yang banyak ditemukan yaitu 26 (7,2 %) kejadian. Fraktur calvaria ditemukan sebanyak 190 kejadian dari 357 pasien. Fraktur os frontal paling banyak ditemukan dengan 52 (14,6 5 %) kejadian Kesimpulan: penderita trauma kepala lebih banyak laki-laki dan lebih banyak pada usia 19-59 tahun. Gambaran lesi multipel paling banyak ditemukan pada gambaran Brain CT Scan. Kejadian fraktur mandibular yang paling banyak untuk fraktur maksilofasial. Fraktur frontal ditemukan paling banyak untuk fraktur calvaria.

The 15-Year Shadow: Borderline Lepromatous Leprosy with Erythema Nodosum Leprosum Following Prolonged Treatment Default Rendra Darmasatria; Tutty Ariani; Yosse Rizal; Rina Gustia; Irdawaty Izrul
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1405

Background: Leprosy, caused by Mycobacterium leprae, persists as a global health issue where the primary challenges are not merely microbial but are deeply rooted in delayed diagnosis and poor treatment adherence. These delays, often driven by profound social stigma, lead to progressive, irreversible disability and sustain community transmission. Erythema Nodosum Leprosum (ENL), an acute immunological complication, further devastates patients' quality of life and complicates management. Case presentation: A 53-year-old Indonesian farmer presented with a 15-year history of untreated leprosy, a journey of neglect initiated by fear of treatment side effects and community ostracism. Clinical examination revealed advanced borderline lepromatous (BL) leprosy with diffuse skin infiltration, multiple anesthetic plaques, and thickened, tender peripheral nerves. He had established WHO Grade 1 disability, characterized by significant sensory loss in his hands and feet and early intrinsic muscle atrophy. A slit-skin smear confirmed a bacteriological index of +3 with a morphological index of 5%, indicating a high load of viable bacilli. Histopathology confirmed BL leprosy with a concurrent mild ENL reaction. A comprehensive, patient-centered management plan was initiated, including a 12-month course of multidrug therapy (MDT-MB), adjunctive care, and intensive counseling. Conclusion: This case powerfully illustrates the "shadow effect" of leprosy—how years of untreated disease, fueled by psychosocial barriers, culminate in a complex nexus of advanced infection, immunological reaction, and permanent neurological impairment. The patient's successful re-engagement with the health system underscores that eradicating the burden of leprosy requires a paradigm shift from a purely pharmacological approach to a deeply humanistic one. Effective control hinges on building compassionate health systems that actively dismantle stigma, empower patients with knowledge, and deliver holistic, multidisciplinary care to prevent the profound human cost of neglect.

The 15-Year Shadow: Borderline Lepromatous Leprosy with Erythema Nodosum Leprosum Following Prolonged Treatment Default Rendra Darmasatria; Tutty Ariani; Yosse Rizal; Rina Gustia; Irdawaty Izrul
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1405

Background: Leprosy, caused by Mycobacterium leprae, persists as a global health issue where the primary challenges are not merely microbial but are deeply rooted in delayed diagnosis and poor treatment adherence. These delays, often driven by profound social stigma, lead to progressive, irreversible disability and sustain community transmission. Erythema Nodosum Leprosum (ENL), an acute immunological complication, further devastates patients' quality of life and complicates management. Case presentation: A 53-year-old Indonesian farmer presented with a 15-year history of untreated leprosy, a journey of neglect initiated by fear of treatment side effects and community ostracism. Clinical examination revealed advanced borderline lepromatous (BL) leprosy with diffuse skin infiltration, multiple anesthetic plaques, and thickened, tender peripheral nerves. He had established WHO Grade 1 disability, characterized by significant sensory loss in his hands and feet and early intrinsic muscle atrophy. A slit-skin smear confirmed a bacteriological index of +3 with a morphological index of 5%, indicating a high load of viable bacilli. Histopathology confirmed BL leprosy with a concurrent mild ENL reaction. A comprehensive, patient-centered management plan was initiated, including a 12-month course of multidrug therapy (MDT-MB), adjunctive care, and intensive counseling. Conclusion: This case powerfully illustrates the "shadow effect" of leprosy—how years of untreated disease, fueled by psychosocial barriers, culminate in a complex nexus of advanced infection, immunological reaction, and permanent neurological impairment. The patient's successful re-engagement with the health system underscores that eradicating the burden of leprosy requires a paradigm shift from a purely pharmacological approach to a deeply humanistic one. Effective control hinges on building compassionate health systems that actively dismantle stigma, empower patients with knowledge, and deliver holistic, multidisciplinary care to prevent the profound human cost of neglect.

Nummular Dermatitis Masquerading as Recalcitrant Tinea Corporis: A Diagnostic Pitfall Resolved by Dermoscopy and Histopathology Rina Gustia; Deasy Archika Alvares; Mutia Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1406

Background: The morphological mimicry between nummular dermatitis (ND) and tinea corporis represents a significant source of diagnostic error in clinical practice. This convergence on a similar clinical phenotype—the annular plaque—often leads to inappropriate antifungal therapy and a protracted, debilitating course for the patient, as powerfully illustrated in this case. Case presentation: We present the case of a 22-year-old female with a five-year history of chronic, recalcitrant, and intensely pruritic annular plaques on her lower legs, with a baseline pruritus score of 8/10 on a Visual Analog Scale (VAS). Previous treatments based on presumptive diagnoses, including potent topical corticosteroids and systemic antifungals, had failed. This report demonstrates a pivot from a morphology-based assessment to a multimodal diagnostic algorithm. The cornerstone of this shift was dermoscopy, which revealed patchy, irregularly distributed red dotted vessels—a classic signature of an eczematous process—and a notable absence of features suggestive of a dermatophyte infection. The diagnosis was confirmed by histopathology. A strong correlation between disease flares and psychosocial stressors was identified, and a holistic management plan targeting the cutaneous inflammation, the compromised skin barrier, and the neurogenic triggers led to a rapid and substantial improvement in her clinical status and quality of life, with the Dermatology Life Quality Index (DLQI) score decreasing from 9 to 3 and the pruritus VAS score dropping to 1/10. Conclusion: This case argues for a revised diagnostic paradigm for chronic annular lesions, one that de-emphasizes ambiguous morphology and prioritizes the integration of a detailed psychodermatological history with in-vivo microscopic analysis via dermoscopy. This approach not only prevents therapeutic futility but also underscores that successful, long-term management of ND is contingent upon a patient-centered strategy that addresses the interconnectedness of the skin barrier, the immune system, and the psycho-neuro-cutaneous axis.

Deciphering Activity in Early Facial Vitiligo: A Case Report Integrating Clinical, Wood's Lamp, and Dermoscopic Findings Rina Gustia; Mutia Sari; Afifah Alfyanita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1408

Background: The management of non-segmental vitiligo hinges on accurately assessing disease activity to guide appropriate therapy. A clinical challenge arises in patients presenting with a low vitiligo area scoring index (VASI), suggesting limited disease, which may be discordant with underlying inflammatory activity, potentially leading to therapeutic inertia. Case presentation: A 34-year-old woman with Fitzpatrick skin type III presented with a two-month history of rapidly progressing facial vitiligo, preceded by an erythematous phase. Despite a low VASI score of 1, the patient-reported vitiligo disease activity (VIDA) score was +4. Dermoscopy was instrumental, revealing definitive in-vivo evidence of inflammation and instability, including a pinkish background, telangiectasias, and a reversed pigment network. Based on this discordance between disease extent and activity, a multi-modal therapeutic regimen was initiated. A six-month follow-up demonstrated disease stabilization and significant perifollicular repigmentation, with resolution of the inflammatory dermoscopic signs. Conclusion: This case report illustrates the critical importance of an integrated diagnostic approach that moves beyond area-based assessment. It highlights how dermoscopy, when used to resolve the clinical paradox of low-extent but high-activity disease, can serve as an objective biomarker to justify timely and robust immunomodulatory intervention. This approach is crucial for altering the disease trajectory and optimizing patient outcomes.

Nummular Dermatitis Masquerading as Recalcitrant Tinea Corporis: A Diagnostic Pitfall Resolved by Dermoscopy and Histopathology Rina Gustia; Deasy Archika Alvares; Mutia Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1406

Background: The morphological mimicry between nummular dermatitis (ND) and tinea corporis represents a significant source of diagnostic error in clinical practice. This convergence on a similar clinical phenotype—the annular plaque—often leads to inappropriate antifungal therapy and a protracted, debilitating course for the patient, as powerfully illustrated in this case. Case presentation: We present the case of a 22-year-old female with a five-year history of chronic, recalcitrant, and intensely pruritic annular plaques on her lower legs, with a baseline pruritus score of 8/10 on a Visual Analog Scale (VAS). Previous treatments based on presumptive diagnoses, including potent topical corticosteroids and systemic antifungals, had failed. This report demonstrates a pivot from a morphology-based assessment to a multimodal diagnostic algorithm. The cornerstone of this shift was dermoscopy, which revealed patchy, irregularly distributed red dotted vessels—a classic signature of an eczematous process—and a notable absence of features suggestive of a dermatophyte infection. The diagnosis was confirmed by histopathology. A strong correlation between disease flares and psychosocial stressors was identified, and a holistic management plan targeting the cutaneous inflammation, the compromised skin barrier, and the neurogenic triggers led to a rapid and substantial improvement in her clinical status and quality of life, with the Dermatology Life Quality Index (DLQI) score decreasing from 9 to 3 and the pruritus VAS score dropping to 1/10. Conclusion: This case argues for a revised diagnostic paradigm for chronic annular lesions, one that de-emphasizes ambiguous morphology and prioritizes the integration of a detailed psychodermatological history with in-vivo microscopic analysis via dermoscopy. This approach not only prevents therapeutic futility but also underscores that successful, long-term management of ND is contingent upon a patient-centered strategy that addresses the interconnectedness of the skin barrier, the immune system, and the psycho-neuro-cutaneous axis.

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