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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Sistem Kesehatan JPPPF (Jurnal Penelitian dan Pengembangan Pendidikan Fisika) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ilmu Terapan Universitas Jambi

Budi Handono

Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin Bandung

Author-ID : 274448

Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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LAPORAN KASUS: Eksensefali sebagai Salah Satu Komplikasi Amniotic Band Syndrome Dewi Maharsita Sri Prajanta Putri; Hadi Susiarno; Budi Handono
Indonesian Journal of Obstetrics & Gynecology Science Volume 1 Nomor 1 Maret 2018
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakAmniotic band syndrome(ABS) merupakan kelainan non genetik dengan spektrum luas dari konstriksi dan amputasi sederhana pada jari ekstremitas hingga kelainan kraniofasial mayor hingga defek visera bahkan kematian. Beberapa laporan kasus menyebut anensefali merupakan contoh defek kraniofasial yang dihubungkan dengan ABS. Sonografi membantu diagnosis eksensefali sebagai kondisi peralihan menuju kondisi terminal anensefali sebagai kondisi yang lebih sering ditemukan yaitu kondisi otak janin sudah habis teresorbsi oleh cairan serebrospinal. Fetus dengan eksensefali tidak dapat bertahan hidup, sebagian besar berakhir dengan abortus, intrauterine fetal death dan stillbirth sehingga jika terdeteksi perlu dipertimbangkan untuk dilakukan terminasi kehamilan. Berdasar laporan kasus persalinan spontan Bracht di kamar bersalin RS Hasan Sadikin pada 1 Desember 2016, Ny RA 33 tahun, G3P1A1 gravida 30-31 minggu, letak sungsang, eksensefali, anemia. Pada laporan kasus ini ditemukan membran amniotik berfusi dengan kranium bayi dan absennya tulang tengkorak pada tempat perlekatan membran amnion. Eksensefali pada kasus ini diperkirakan diawali oleh residu selaput korion berupa jaringan fibrosa yang membentang cavum korionik dan menekan kranium sehingga migrasi membran neurokranium tergganggu dan berakhir dengan akalvaria. Ekstremitas yang berkembang sempurna namun cacat pada beberapa segmen terutama tempat perlekatan membran amnion dan kranium sesuai letak kejadian cincin konstriksi mendukung teori Torpin. Kata kunci: amniotic band syndrome; acrania Exencephaly as One of Amniotic Band Syndrome ComplicationAbstractAmniotic Band Syndrome includes a spectrum of non-genetic anomalies, varying from simple digital band constriction to major craniofacial and visceral defects, and even fetal death. Anencephaly represents the most common neural tube defect. Sonographic as well as pathologic evidence points to a close link between exencephaly (also frequently referred to as “acrania”) and anencephaly. It has been proposed that the brain tissue of exencephalics may gradually degenerate due to the exposure to amniotic fluid in combination with mechanical trauma. ABS is an aetiological factor in exencephaly. Appropriate counselling for affected families needs to be given after prenatal diagnosis. Based on medical report Mrs RA 33 years old , G3P1A1 30-31 weeks of pregnancy, breech presentation, exencephaly, anemia that delivered her baby on Delivery Room Hasan Sadikin General Hospital at December 1,2016.Amniotic membrane found fused with fetal cranium and on its attachment found that the cranium was absent (acrania) In the case reported here, the amniotic membrane was well fused to the scalp, and skull bones were absent on the site of attachment of the amniotic membrane. This case supports Torpin’s hypothesis of early amnion rupture, with failure of the cranial bones to develop at the site of attachment of the amniotic band as “early amnion disruption sequence.”. The fibrous strands would entangle and entrapped the fetal head, resulting in faulty migration of the membranous neurocranium which leads to exencephaly on this case. Keywords: Amniotic band syndrome; exencephaly

Perbandingan Faktor Determinan dan Luaran Preeklamsi Periode Sebelum dan Saat Program Jaminan Kesehatan Nasional Dilaksanakan Irene Leha; Johanes C Mose; Budi Handono; Anita Deborah Anwar; Zulvayanti Zulvayanti; Hanom Husni Syam
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Mencari perbedaan faktor determinan (karakteristik dan faktor risiko), morbiditas dan mortalitas ibu dan bayi dalam kasus preeklamsi pada periode sebelum dan saat program Jaminan Kesehatan Nasional dilaksanakan.Metode: Rancangan penelitian ini adalah studi cross-sectional terhadap data sekunder untuk menganalisis karakteristik faktor risiko, morbiditas dan mortalitas pada kejadian preeklamsi di RSUP Dr. Hasan Sadikin antara periode Maret−September 2012−1 Januari 2016−31 Desember 2017. Penelitian ini dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Februari−Mei 2018.Hasil: Didapatkan perbedaan yang bermakna (p<0,05) pada(usia, pasien, indikator, antenatal care, dan penyakit-penyakit) subjek penelitian. Didapatkan peningkatan angka seksio sesarea pada kasus preeklamsi (p<0,001). Tidak ditemukan perbedaan yang bermakna pada angka kematian ibu dengan kasus preeklamsi (p=0,366). Tidak terdapat perbedaan yang bermakna pada hasil luaran perinatal pada subjek penelitian dari segi skor APGAR, kejadian stillbirth dan kematian neonatal dini.Simpulan: Pada periode saat program JKN dilaksanakan terdapat perbedaan karakteristik dan faktor risiko ibu preeklamsi, serta terdapat peningkatan angka seksio sesarea. Tidak didapatkan perbedaan angka mortalitas ibu dan luaran (morbiditas dan mortalitas) bayi.Comparison of Determinant Factors and Outcome of Preeclampsia in Periods Before and When the National Health Insurance Program was ImplementedAbstractObjective: To distinguish determinant factors (characteristics and risk factors), maternal and neonatal morbidity and mortality in preeclampsia cases in periods before and when the National Health Insurance program was implemented. Method: The study design is cross sectional analyticstudy by taking the data from medical record to analyze the determinant factor (characteristics and risk factors), morbidity and mortality of preeclampsia at Dr. Hasan Sadikin General Hospital Bandung on March−September 2012 and January 2016−December 2017. This study was conducted in Dr. Hasan Sadikin General Hospital Bandung during February-May 2018.Results: There is a significant difference (P<0.05) in characteristics and risk factor subject of research in terms of age, gestational age, parity, educational degree, ANC, a history of hypertension and cardiovascular disorder. There is an incrising of cesarean section rate on preeclampsia cases (p<0.001).There is no significant difference in maternal mortality and perinatal outcomes (APGAR score, stillbirth and early neonatal death). Conclusion: There are differences in determinant factor (characteristics and risk factors) preeclampsia when the National Health Insurance program was implemented. There was no difference in maternal mortality and perinatal outcomes.Key words: preeclampsia, National Health Insurance, maternal and perinatal outcome

Luaran Kehamilan pada Pasien dengan Infertilitas Berkaitan dengan Endometriosis, Infertilitas karena Faktor Tuba, dan Unexplained Infertility, setelah Menjalani Prosedur IVF / ICSI di Klinik Aster RSUP Dr. Hasan Sadikin Bandung Dewi Retno Wulandari; Budi Handono; Anita Rachmawati; Dini Hidayat
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 2 September 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v3n2.206

Tujuan: Penelitian ini bertujuan untuk mengetahui dan membandingkan luaran kehamilan dari setiap penyebab infertilitas pada pasien yang dilakukan teknologi reproduksi berbantu.Metode: Penelitian ini merupakan penelitian analisis komparatif yang dilakukan secara longitudinal retrospektif. Data didapatkan dari rekam medik pasien dengan infertilitas terkait endometriosis, faktor tuba, dan unexplained infertility, setelah menjalani prosedur in vitro fertilization dan intra cytoplasmic sperm injection pada Januari 2013− Desember 2018. Luaran yang dinilai pada penelitian ini adalah kehamilan, abortus, dan kehamilan ektopik. Hasil: Sebanyak 94 pasien menjadi subjek penelitian ini. Infertilitas karena faktor tuba menjadi penyebab infertilitas terbanyak (74,5%) dan unexplained infertility menjadi penyebab terjarang (8,5%). Intra cytoplasmic sperm injection merupakan metode reproduksi berbantu yang paling sering dilakukan (78,7%). Luaran kehamilan dengan persalinan terjadi pada 65 subjek (69,1%) sementara sisanya abortus. Tidak terdapat kejadian kehamilan ektopik. Tidak terdapat perbedaan bermakna dalam luaran kehamilan berdasarkan penyebab infertilitasnya (p=0,21).Kesimpulan: Tidak terdapat perbedaan luaran kehamilan baik partus ataupun abortus pada pasien yang dilakukan teknologi reproduksi berbantu berdasarkan penyebab infertilitasnya.Pregnancy Outcomes in Patients with Infertility Related to Endometriosis, Infertility due to Tubal Factors, and Unexplained Infertility, After Undergoing IVF/ICSI Procedures in Aster Clinic General Hospital Dr. Hasan Sadikin BandungAbstractObjective: This study was aimed to describe and compare the pregnancy outcomes in each cause of infertility on patients who get assisted-reproduction technology procedure.Method: This was an analytic comparative study, that conducted longitudinal-retrospectively. The data were obtained from medical records of patients with endometriosis associated infertility, tubal factors associated infertility, and unexplained infertility after got either in vitro fertilization or intra cytoplasmic sperm injection procedure from January 2013–December 2018. The pregnancy outcomes consisted of delivery, abortion, or ectopic pregnancy. Result: A total of 94 patients were enrolled in this study. Tubal factors was the commonest cause of infertility (74.5%) and unexplained infertility was the most rarely cause of infertility (8.5%). Intra cytoplasmic sperm injection was the most frequent procedures (78.7%). Labor were occurred in 65 subjects (69.1%) and the remains aborted. Ectopic pregnancy was not occurred. There was no significant difference in pregnancy outcomes according the causes of infertility. (p=0,21).Conclusion: Pregnancy outcomes, both labor and abortion, were not different based on the cause of infertility among patients who get assisted-reproduction technology procedure.Key words: assisted-reproduction technology, in vitro fertilization, infertility, intra cytoplasmic sperm

Hubungan Kadar Asam Urat, Laktat Dehidrogenase, Aspartat Aminotransferase Serum Penderita Preeklamsi Berat Disertai Komplikasi dan tanpa Komplikasi Galih Apriadi; Budi Handono; Akhmad Yogi Pramatirta; Jusuf S. Effendi; Tita Husnitawati Madjid; Adhi Pribadi
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 1 Maret 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Tujuan: penelitian ini untuk mencari perbedaan kadar asam urat, laktat dehydrogenase (LDH) dan aspartat aminotransferase (AST) pada serum penderita preeklamsi berat disertai komplikasi dan tanpa komplikasi dan mengukur kuatnya hubungan peningkatan kadar asam urat, LDH dan AST dengan peningkatan risiko terjadinya komplikasi pada pasien preeklamsi berat. Metode: Rancangan penelitian ini adalah penelitian comparative cross sectional dengan metode consecutive sampling. Subjek penelitian adalah penderita preeklamsi berat disertai komplikasi dan tanpa komplikasi (n=68). Hasil: Hasil penelitian didapatkan perbedaan kadar asam urat, LDH dan AST pada kedua kelompok secara bermakna dengan nilai p ≤ 0,05. Peningkatan kadar asam urat, LDH dan AST berhubungan dengan peningkatan risiko terjadinya komplikasi dengan nilai cut off kadar asam urat > 6,5 mg/dL sebesar 33 kali, LDH > 573 U/L sebesar 8,95 kali dan AST > 30 U/L sebesar 5,19 kali. Jika terjadi peningkatan seluruh kadar asam urat, LDH dan AST diatas nilai cut off maka risiko terjadinya komplikasi sebesar 98,1%.Kesimpulan: Penelitian ini menyimpulkan kadar asam urat, LDH, AST pada preeklamsi berat disertai komplikasi lebih tinggi dibandingkan preeklamsi berat tanpa komplikasi dan peningkatan kadar asam urat, LDH, AST berhubungan dengan peningkatan risiko terjadinya komplikasi pada preeklamsi berat. Relations of Uric Acid, Lactat Dehydrogenase, and Aspartat Aminotransferase Serum LevelIn Severe Preeclampsia with and Without ComplicationsAbstractObjective: This study compared level of uric acid, LDH, and AST level between severe preeclampsia patients with complication and without complication, and measured correlation between the rise level of uric acid, LDH and AST towards the increased risk of complication in patient with severe preeclampsia.Method: The study design was comparative cross sectional study with consecutive sampling method that compare the results of laboratorium uric acid, LDH, AST between complications and without complications group. Subjects of this study were severe preeclampsia patients with and without complication that fulfilled study criteria (n=68). Result: It is revealed that the differences level of uric acid, LDH, and AST in both groups were significant with p value ≤ 0.05. Increase level of uric acid, LDH, and AST were related to inreased risk of complication in severe preeclampsia occurence with cut off point of uric acid level of > 6.5 mg/dL by 33 times, LDH level of > 573 U/L by 8.95 times, and AST level of > 30 U/L by 5.19 times. If all uric acid, LDH, and AST level rise above the cut off value so the risk of complication of severe preeclampsia will rise by 98.1%. Conclusion: It is concluded that level of uric acid, LDH, and AST in severe preeclampsia with complication were higher than severe preeclampsia without complication and the rise of uric acid, LDH, and AST were related with the rise of complication risk on severe preeclampsia. Key word: Severe preeclampsia, complication, uric acid, LDH, AST

Hubungan antara Kadar Hemoglobin dan Jumlah Leukosit dengan Kejadian Prematuritas di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Idham Rizali Saleh; Johanes C. Mose; Budi Handono
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 2 September 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2.282

Tujuan: Untuk mengetahui adanya hubungan antara kadar hemoglobin dan kadar leukosit maternal dengan kejadian prematuritas di Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung. Metode: Rancangan penelitian ini adalah observasional analitik dengan desain studi potong-lintang. Subjek penelitian adalah pasien dengan persalinan pada kehamilan usia 24–42 minggu di Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung periode Januari – Desember 2019 yang berjumlah 82 pasien. Dilakukan pengumpulan data dari rekam medis pasien berupa usia kehamilan, kadar hemoglobin, kadar leukosit, dan faktor perancu berupa usia, tingkat pendidikan, dan tingkat paritas. Hubungan antara kadar hemoglobin dan jumlah leukosit dengan persalinan prematur dianalisis statistik dengan uji Chi-square. Variabel-variabel perancu akan dikendalikan melalui analisis multivariat dengan regresi logistik. Hasil: Terdapat hubungan yang signifikan antara kadar hemoglobin dan kadar leukosit dengan terjadinya persalinan prematur (p<0,05). Hasil analisis dengan uji regresi logstik menunjukkan bahwa tetap terdapat hubungan bermakna antara kadar hemoglobin (OR 0,27; p<0,05) dan kadar leukosit (OR 3,60; p<0,05) dengan persalinan prematur setelah dilakukan pengendalian faktor perancu. Kesimpulan: Kadar hemoglobin dan kadar leukosit memiliki hubungan yang signifikan dengan kejadian persalinan prematur tanpa dipengaruhi oleh usia, tingkat pendidikan, dan tingkat paritas. Associated Between Hemoglobin and Leukocytes Levels with the Incidence of Prematurity in Dr. Hasan Sadikin General Hospital BandungAbstract Objective: To examine whether an association exists between maternal hemoglobin and leukocyte level and the risk of preterm delivery in Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung. Method: An analytical cross-sectional study involving 82 pregnant women who delivered at 24 – 42 weeks gestation at Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung in January – December 2019 was conducted. Gestational age, maternal hemoglobin level, maternal leukocyte level, and confounding factors including age, education level, and parity data were collected from patients’ medical records. The association between maternal hemoglobin and leukocyte level with the risk of preterm delivery was analyzed using Chi-Square test. Multiple logistic regression models were used to control for confounding variables. Result: Maternal hemoglobin and leukocyte level were significantly associated with the risk of preterm delivery (p<0.05). Multiple logistic regression models showed that the associations between maternal hemoglobin level (OR 0.27; p<0.05) and maternal leukocyte level (OR 3.60; p<0.05) with the risk of preterm delivery were still significant after adjusting for confounding variables. Conclusion: Maternal hemoglobin and leukocyte level were significantly associated with the risk of preterm delivery after adjusting for age, education level, and parity. Key word: Hemoglobin, Prematuritas, Leukocyte.

Faktor-faktor yang Mempengaruhi Perempuan Usia Reproduksi dalam Mencari Bantuan Penanganan Inkontinensia Urin di Rumah Sakit Hasan Sadikin Bandung Indra Gazali; Benny Hasan Purwara; Edwin Armawan; Jusuf Sulaeman Effendi; Budi Handono; Hadi Susiarno
Indonesian Journal of Obstetrics & Gynecology Science Volume 2 Nomor 1 Maret 2019
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

AbstrakTujuan: Inkontinensia urin merupakan kondisi yang sering dialami wanita. Meskipun demikian, hanya kurang dari setengah wanita dengan gejala tersebut yang berkonsultasi ke dokter mengenai inkontinensia, dan faktor penentu dalam pengobatan tidak dipahami dengan baik. Penelitian ini bertujuan untuk mengetahui dan menganalisis apakah faktor pengetahuan, budaya, pendidikan, dan penghasilan memengaruhi pasien inkontinensia urin tidak berobat ke rumah sakit, serta mengetahui faktor yang paling dominan dan alasan-alasan pasien inkontinensia urin tidak berobat ke rumah sakit. Metode: Jenis penelitian ini adalah metode kombinasi (mixed methods) dengan desain penelitian cross sectional atau potong lintang. Sampel pada penelitian ini berjumlah sebanyak 70 pasien menderita inkontinensia urin. Adapun pasien yang diwawancarai adalah sebanyak 10 orang pasien atau informan. Hasil: Penelitian kuantitatif pada variabel faktor pendidikan dan faktor penghasilan, hasil analisis Kolmogorov test terlihat nilai P>0.05. Pada variabel faktor pengetahuan dan faktor budaya, hasil analisis Kolmogorov test terlihat nilai P<0.05 Kesimpulan: Penelitian kuantitatif dari empat faktor yang berpengaruh adalah variabel faktor pengetahuan dan budaya, sedangkan yang paling berpengaruh adalah variabel faktor budaya, Pada hasil penelitian kualitatif diketahui bahwa faktor pengetahuan dan budaya paling banyak berpengaruh, hal ini dikarenakan pengetahuan responden tentang inkontinensia urin sangat kurang serta rasa malu pada diri responden apabila ada orang lain yang mengetahui mengenai inkontinensia urin yang dideritanya. Factors Associated with Women’s Treatment for Urinary Incontinence in Dr. Hasan Sadikin HospitalAbstractObjective: Urinary incontinence is a highly prevalent and burdensome condition among women. However, fewer than half of women with symptoms talk to a physician about incontinence. The factors, including knowledge, culture, education, and income, the most dominant factor influence anf the reason patient of urinary incontinence not to go to hospital.Method: The method used in this research is mixed methods with cross sectional research design. The sample amounted to 70 patients suffering from urinary incontinence. The patients interviewed were 10 patients / informants.Result: The quantitative research with Kolmogorov test is known that on variable of educational and income factors, with P >0,05. The knowledge and cultural factors result with P <0,05. Conclusion: There is correlation between knowledge and eastern culture with urinary incontinence patient not treatment at polyclinic RS Hasan Sadikin Bandung, the most dominant factor influencing is the culture factor, as well as the reasons patients with urinary incontinence do not go to the hospital is due to not knowing that urinary incontinence is a disease and a shame.Key words: Urinary incontinence, knowledge factor, cultural factor, educational factor, income factor

Motivation is the Strongest Influence in Choosing Delivery Place: Motivasi adalah Faktor yang Paling Kuat Memengaruhi Pemilihan Tempat Persalinan Indria Astuti; Dany Hilmanto; Budi Handono
Indonesian Journal of Obstetrics and Gynecology Volume. 1, No. 4, October 2013
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To analyze the factors that correlated with decision to choose the most appropriate delivery place of mothersâ€™ delivery attended by health personnel, in West Bandung District. Method: This was a case-control study with consecutive sampling method on the mothers who gave birth at two health centers: Cikalong Wetan and Cipongkor, West Bandung District. There were two groups of mothers. First, the case group consisted of 52 mothers at non-healthcare facilities. Second, control group consisted of 52 mothers at healthcare facilities. There were sociodemographic (culture, educational), contextual (income, transportation, distance, availability health facilities) and characteristics of needs (counseling, prenatal care, motivation) factors and dependent variable was decision in choosing the place of delivery. The data was analyzed using chi square test to determine the correlation factors, whereas multiple logistic regression was used to determine the strongest correlating factors. Result: The results showed that there were correlation between various factors with the decision selection of delivery place of the mothers by health care in: cultural factor (OR = 23; p < 0.001; CI 95% : 7.99-66.20), educational factor (OR = 4.86; p < 0.001; CI 95% : 1.35- 19.09), income factor (OR = 2.36; p = 0.031; CI 95%: 6.51-57.49), transportation factor (OR = 19.35; p < 0.001; CI 95%: 6.51 to 57.49), distance factor (OR = 3.19, p = 0.007; 95% CI: 1.67-37.69), availability health facilities factor (OR = 7.94, p = 0.007; CI 95% 1.67-37.69 and OR = 3.97; CI 95% : 0.40-39.75), counseling factor (OR = 23, p < 0.001; CI 95%: 7.99-66.20), prenatal care factor (OR = 5.21, p < 0.001; 95%: 2.24-12.12), motivational factor (OR = 196, p < 0.001; CI 95 % : 41.64-922.48). The strongest factor was the motivational factor (OR = 103.33; p < 0.001; CI 95%: 10.00-1065.72). Conclusion: This study concluded that there was correlation between sociodemographic, contextual, and characteristics of needs with the decision in choosing place of delivery that attended by health personnel. Motivation was the strongest factor correlated to the mothersâ€™ decision to deliver at public health center. Keywords: characteristics of demand, contextual, delivery place, socio-demographic

Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM.

The Analysis of Premature Rupture of Membrane Outcomes: Comparison Between 34-36 Weeks and Term Gestation Yordian, Kendry Savira; Pribadi, Adhi; Syam, Hanom Husni; Nugrahani, Annisa Dewi; Handono, Budi; Susiarno, Hadi; Suardi, Dodi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.710

Introduction: This study analysed the maternal and neonatal outcomes in premature rupture of membrane at 34-36 weeks of gestation compared to term gestation to provide an overview of the current protocol’s efficacy which is currently widely varied. Method: This was a cross-sectional study using a simple random sampling technique. The subject of this study consisted of a total of 450 pregnant women diagnosed with PPROM at 34-36 weeks and term gestation during the period January 2019-December 2021. P<0.05 was considered statistically significant. Results: That women with premature rupture of membrane (PROM) at term gestation had a higher risk of 1.13 times (OR= 1.13, CI 95%) for neonatal asphyxia, 1.34 times for early neonatal death (OR= 1.34, CI 95%), and 4.03 times for developing clinical chorioamnionitis (OR= 4.03, CI 95%) compared to the 34-36 weeks of gestation group. There was no statistically significant difference between gestational age and the incidence of early neonatal death (P= 0.70). There were no maternal deaths in this study. Conclusion: the management protocol applied for both groups had the same efficacy. The incidence of clinical chorioamnionitis was higher in the term gestation group, which may be associated with risk factors such as COVID-19 and hepatitis B.Analisis Hasil Ketuban Pecah Dini: Perbandingan Antara Usia Kehamilan 34-36 Minggu dan Masa Kehamilan Cukup BulanAbstrakPendahuluan: Penelitian ini menganalisis hasil maternal dan neonatal pada ketuban pecah dini pada usia kehamilan 34 - 36 minggu dibandingkan dengan kehamilan jangka panjang untuk memberikan gambaran tentang kemanjuran protokol saat ini yang sangat bervariasi. Metode: Penelitian ini adalah studi cross-sectional menggunakan teknik simple random sampling. Subjek penelitian ini terdiri atas total 450 wanita hamil yang didiagnosis dengan PROM pada 34 - 36 minggu dan kehamilan jangka panjang selama periode Januari 2019 - Desember 2021. P<0,05 dianggap signifikan secara statistik. Hasil: hasil analisis menunjukan bahwa wanita dengan ketuban pecah dini pada usia kehamilan memiliki risiko lebih tinggi 1,13 kali (OR= 1,13, CI 95%) untuk asfiksia neonatal, 1,34 kali untuk kematian neonatal dini (OR= 1,34, CI 95%), dan 4,03 kali untuk mengembangkan chorioamnionitis klinis (OR= 4,03, CI 95%) dibandingkan dengan kelompok kehamilan 34 - 36 minggu. Tidak ada perbedaan yang signifikan secara statistik antara usia kehamilan dan kejadian kematian neonatal dini (P = 0,70). Tidak ada kematian ibu dalam penelitian ini. Kesimpulan: Protokol manajemen yang diterapkan untuk kedua kelompok memiliki kemanjuran yang sama. Insiden chorioamnionitis klinis lebih tinggi pada kelompok kehamilan, yang mungkin terkait dengan faktor risiko seperti COVID-19 dan hepatitis B.Kata kunci: Ketuban pecah dini, asfiksia, kematian neonatal

Maternal Characteristics of Very Low Birth Weight and Extremely Low Birth Weight Incidence Pajajaran, Badar Muhammad; Sumawan, Herman; Judistiani, Raden Tina Dewi; Handono, Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.654

Introduction: Low birth weight (LBW) infants have the potential for cognitive deficits, motor delays, cerebral palsy, and other behavioral and psychological problems. Household expenses and health care system costs can be reduced by alleviating the burden of LBW. Currently, there are no available data on the maternal characteristics of very low birth weight (VLBW) and extremely low birth weight (ELBW) incidence in Indonesia.Method: This was a retrospective analytical observational study with a cross-sectional design. The sample in this study included all infants born with a birth weight of <1500 grams at Margono Purwokerto Hospital during 2018-2022. Univariate and bivariate analyses were performed using a significance level of p≤0.05.Results: A total of 65 patients in the ELBW group and 59 patients in the VLBW group were included in this study. Statistical test results showed no significant differences in the characteristics of age, parity, birth weight of the infant, criteria for hypertension during pregnancy, criteria for anemia, comorbidities, hospital treatment, postpartum care, and type of delivery. The variables that differed significantly were anemia (Hb VLBW vs Hb ELBW; 9.06 vs 8.21) and neonatal outcomes.Conclusion: There was no difference between the maternal characteristics of the incidence of very low birth weight and extremely low birth weight, except for anemia. Checking hemoglobin levels in patients with ELBW is essential for providing appropriate treatment.Karakteristik Ibu dengan Bayi Berat Badan Lahir Sangat Rendah dan Kejadian Berat Badan Lahir Sangat RendahAbstrakPendahuluan: Bayi dengan berat badan lahir rendah (BBLR) berpotensi mengalami defisit kognitif, keterlambatan motorik, Cerebral Palsy, serta permasalahan perilaku dan psikologis lainnya. Pengeluaran rumah tangga dan biaya sistem pelayanan kesehatan dapat dikurangi dengan meringankan beban BBLR. Saat ini belum tersedia data mengenai karakteristik ibu dengan kejadian berat badan lahir sangat rendah (BBLR) dan berat badan lahir sangat rendah (BBLSR) di Indonesia.Metode:Penelitian ini merupakan penelitian observasional analitik retrospektif dengan desain cross-sectional. Sampel dalam penelitian ini meliputi seluruh bayi yang lahir dengan berat badan lahir <1500 gram di RS Margono Purwokerto selama tahun 2018-2022. Analisis univariat dan bivariat dilakukan dengan tingkat signifikansi p≤0,05.Hasil:Sebanyak 65 pasien pada kelompok BBLR dan 59 pasien pada kelompok BBLSR dilibatkan dalam penelitian ini. Hasil uji statistik menunjukkan tidak terdapat perbedaan bermakna pada karakteristik umur, paritas, berat badan lahir bayi, kriteria hipertensi saat hamil, kriteria anemia, penyakit penyerta, perawatan di rumah sakit, perawatan nifas, dan jenis persalinan. Variabel yang berbeda secara signifikan adalah anemia (Hb BBLSR vs Hb BBLR; 9,06 vs 8,21) dan luaran neonatal.Kesimpulan:Tidak terdapat perbedaan karakteristik ibu terhadap kejadian berat badan lahir sangat rendah dan berat badan lahir sangat rendah, kecuali anemia. Pemeriksaan kadar hemoglobin pada pasien BBLR sangat penting untuk memberikan pengobatan yang tepat.Kata kunci: bayi berat lahir sangat rendah, BBLSR, bayi berat lahir sangat rendah, BBLR

Co-Authors Adhi Pribadi Adhi Pribadi Ahmad Farried Akhmad Yogi Pramatirta, Akhmad Yogi Aloysius Suryawan Amran Amrullah Anabela, Lisa Milena Andi Kurniadi, Andi Anita Deborah Anwar Anita Rachmawati Anita Rachmawati Aziz, Muhammad Alamsyah Benny Hasan Purwara Budi Setiabudiawan Dany Hilmanto Dewi Maharsita Sri Prajanta Putri Dewi Marhaeni Diah Herawati Dewi Retno Wulandari Dini Hidayat Dodi Suardi Dyaz, Iqbal Edwin Armawan Erfiandi, Febia Faried, Leri S Farried, Ahmad Firman Fuad Wirakusumah Galih Apriadi Gita Indah Triyanti Gita Indah Triyanti, Gita Indah Hadi Susiarno Hanindya, Yovita Hanom Husni Syam Herlambang Herlambang Herlambang Herman Susanto Herry Aktyar Matondang Hiroyuki Kuwanto Idham Rizali Saleh Indra Gazali Indria Astuti Intan Renata Silitonga, Intan Renata Irene Leha Johanes C. Mose Johanes Cornelius Mose Johannes Cornelius Mose Jusuf S. Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Kuwanto, Hiroyuki Lani Gumilang Lasma R. Pohan, Lasma R. Leri S Faried Lestari, Indiyah Linasari, Desy Lulu Eva Rakhmilla, Lulu Eva M. Rizkar Arev Sukarsa Magnadi Yogi Rahma Nazila Maghfiratul Abrar Nazila Maghfiratul Abrar, Nazila Maghfiratul Nugrahani, Annisa Dewi Pajajaran, Badar Muhammad Prihatni, Delita Raden Tina Dewi Judistiani Ramdhan, Muhammad Raihan Ritonga, Mulyanusa Amrullah Sefty Mariany Samosir Setyorini Irianti Sofie R. Krisnadi Sumawan, Herman Sunjaya, Deni i Kurniad Supahar, Supahar Suryawan, Alfonsus Zeus Susiarno, Hadi Tan, Zaki Miftah Nalalindra Teuku Kyan Nuryasin Tita Husnitawati Madjid Tono Djuwantono Wiryawan Permadi Yordian, Kendry Savira Zaenudin, Aditya Rifandi Zukhruf, Naura Zulvayanti Zulvayanti

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