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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Pengolahan Hasil Perikanan Indonesia ILMU KELAUTAN: Indonesian Journal of Marine Sciences Indonesian Journal of Chemistry Narra J Makara Journal of Science Borneo Journal of Pharmacy Biodiversitas Journal of Biological Diversity
Novriyandi Hanif
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, IPB University, Kampus IPB Darmaga, Bogor 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Harnessing the metabolites from the marine sponge Melophlus sarasinorum for the discovery of eco-friendly antifoulants WALTER BALANSA; RIYANTI RIYANTI; MARIA A. PATRAS; KIRSTEN H. BALANSA; NOVRIYANDI HANIF; FRETS J. RIEUWPASSA; MARGARET HILL; TILL F. SCHÄBERLE
Biodiversitas Journal of Biological Diversity Vol. 26 No. 4 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260411

Abstract

Abstract. Balansa W, Riyanti, Patras MA, Balansa KH, Hanif N, Rieuwpassa FJ, Hill M, Schäberle TF. 2025. Harnessing the metabolites from the marine sponge Melophlus sarasinorum for the discovery of eco-friendly antifoulants. Biodiversitas 26: 1590-1606. Marine biofouling remains an unresolved issue in both the maritime industry and the marine environment, demanding the discovery of new eco-friendly antifoulants. This study aimed to evaluate the antifouling potential of the marine sponge, Melophlus sarasinorum (Thiele, 1899), through metabolomic, computational, and field studies. Seven compounds were dereplicated as sarasinosides A1-A3, D, L, M, and M2 (1-7) from extracts of M. sarasinorum from Kawaluso and Mahumu Islands. Molecular docking showed robust binding affinities for 1-7 (-8.2 to -9.6 kcal/mol), rivaling acetylcholinesterase (AChE) inhibitors, synoxazolidinones A (8) and C (9), commercial antifoulants medetomidine/selektope® (12) and econea® (13) (-9.2, -9.3, -9.5, -9.3 kcal/mol, respectively) as well as the antifouling agents, seanin_211 (10) (-8.9 kcal/mol) and irgarol_1505 (11) (-5.5, -6.5 kcal/mol, respectively). The strong binding affinities of 1-7 suggest possible new allosteric interactions with AChE. The ANOVA test revealed a significant difference in biofouling growth (p<0.05) between nets pre-treated with 1:1, 1:2, or 1:3 sponge powder/epoxy mixture compared to other treatments, as confirmed by a post-hoc Duncan test. Notably, toxicity studies with EPI SuiteTM indicated that 1-7 had more eco-friendly toxicological parameters (i.e., low Log Kow, Log Koc, Biotransformation Half-life, and water solubility) compared to AChE inhibitors and commercial antifouling agents (p<0.05). Our results demonstrate the antifouling activity of sarasinosides (1-7), providing insight into the design of novel, eco-friendly antifoulants that warrant further investigation into their mode of action and optimization.
Short Communication: Phytochemistry and chemical fingerprint of katuk (Sauropus androgynus) leaves extract from four varieties FACHRUDDIN FACHRUDDIN; AGIK SUPRAYOGI; NOVRIYANDI HANIF
Biodiversitas Journal of Biological Diversity Vol. 26 No. 2 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260230

Abstract

Abstract. Fachruddin, Suprayogi A, Hanif N. 2025. Short Communication: Phytochemistry and chemical fingerprint of katuk (Sauropus androgynus) leaves extract from four varieties. Biodiversitas 26: 824-830. Katuk (Sauropus androgynus) is a medicinal plant known to consist of four varieties based on the presence and distribution of white spots on the leaf surface. These characteristic differences affect the content of active compounds and their biological activities. This study aimed to determine the phytochemical content of crude ethanol extracts and to analyze the chemical fingerprints of the n-hexane fractions from the leaves of four S. androgynus varieties. The extraction process was conducted using ethanol to obtain the crude extract, followed by partitioning with n-hexane to separate the non-polar fractions. Qualitative phytochemical tests were performed on the crude ethanol extract, while chemical fingerprint analysis was carried out on the n-hexane fraction using LC-MS instruments. The results showed that the crude ethanol extract contained flavonoids, saponins, tannins, and steroids. LC-MS analysis revealed that all S. androgynus varieties shared similarities in their chemical fingerprint patterns, particularly the Zanzibar-Bastar varieties (six peaks on the chromatogram had the same retention times). The major compound groups found in the n-hexane fractions included triterpenoid glycosides (Zanzibar), diterpenoids (Bastar and Paris), and steroids (Kebo). These similar fingerprints and slight variations in chemical composition provide insights that are likely to produce subtly different pharmacological effects, thereby sparking further intrigue and eagerness for future research in the field of medicinal plant studies.
Indonesian honey bioactivity profile linking composition to antioxidant and antibacterial potency ACHMAD GUS FAHMI; AKHMAD ENDANG ZAINAL HASAN; NOVRIYANDI HANIF; YAYA RUKAYADI; KHOZIRAH SHAARI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 10 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d261015

Abstract

Abstract. Fahmi AG, Hasan AEZ, Hanif N, Rukayadi Y, Shaari K. 2025. Indonesian honey bioactivity profile linking composition to antioxidant and antibacterial potency. Biodiversitas 26: 4991-5002. Indonesian honey, sourced from diverse tropical flora, is valued for its antimicrobial and antioxidant properties, yet comparative multi-parameter studies are limited. This study evaluates five Indonesian honey types (Akasia/Acacia carpa honey, Rambutan/Nephelium lappaceum honey, Randu/Ceiba pentandra honey, Flores honey, and Kelulut honey) for physicochemical traits, bioactive compounds, antioxidant capacity, and antibacterial activity against Escherichia coli and Salmonella Typhi. Physicochemical analysis determined pH, moisture, ash, and color. Total phenolic content (TPC) and total flavonoid content (TFC) were measured spectrophotometrically. Bioactives were identified via LC-MS. Antioxidant activity was assessed by DPPH radical scavenging and antibacterial efficacy was tested using disk diffusion. Data were analyzed using ANOVA and principal component analysis (PCA). All samples adhered Codex and SNI (RSNI3 8664:2024) quality standards. Flores honey had the highest TPC (4526.12 mg GAE/100 g) and TFC (3810.96 QE/100 g), yielding superior antioxidant activity (IC??: 2.11±0.03 mg/mL). Kelulut honey showed the strongest antibacterial effect (inhibition zone: 13.50 mm against E. coli and 9.42 mm against Salmonella Typhi), linked to amino acids (L-proline, leucine) and phenolic acids (caffeic, quercetin). PCA revealed distinct clustering by bioactive profile: phenolic/flavonoid-rich honeys (e.g., Flores honey) aligned with antioxidant potency, while amino acid-rich honeys (e.g., Kelulut honey) correlated with antibacterial activity. Indonesian honey exhibits diverse and potent bioactivities, surpassing or matching Southeast Asian and Manuka honeys in key metrics. Flores honey represents a promising dietary antioxidant source, while Kelulut honey shows potential for antimicrobial applications such as topical formulations. Future work should isolate and characterize specific bioactives to support functional food and therapeutic development.
Co-Authors ACHMAD GUS FAHMI AGIK SUPRAYOGI Agik Suprayogi Aisyah, Siti Zanuba AKHMAD ENDANG ZAINAL HASAN Anggia Murni Aprilyana, Lia Aris Tjahjoleksono Atabany, Afton Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan Dondy Arafat Dyah Iswantini Elfahmi Elfahmi, Elfahmi Fachruddin Fachruddin FACHRUDDIN FACHRUDDIN Fadillah, Wendi Nurul Fadjar Satrija Franco, Christopher MM FRETS J. RIEUWPASSA Hidayaturrahmah Hidayaturrahmah Huda Shalahudin Darusman Junichi Tanaka Karuwal, Ritha Lusian Katrin Roosita KHOZIRAH SHAARI KIRSTEN H. BALANSA Kustiariyah Tarman Mada Triandala Sibero MARGARET HILL MARIA A. PATRAS Mashuri Waite Muladno - Nampiah Sukarno Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Rahminiwati, Min RITHA LUSIAN KARUWAL Ritha Lusian Karuwal RIYANTI RIYANTI Ronald Tarigan Sani, Lalu M. Iqbal SUHARSONO SUHARSONO Suharsono Suharsono Suharsono Suharsono Syafrizayanti, Syafrizayanti TILL F. SCHÄBERLE Waite, Mashuri WALTER BALANSA Wei Zhang Welly Sugiono Wendi Nurul Fadillah YAYA RUKAYADI Yosie Andriani Yuliantoni Yuliantoni