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I Dewa Gede Ugrasena
Department Of Child Health, Faculty Of Medicine, Airlangga University/Dr. Soetomo Hospital, Surabaya, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : The Indonesian Biomedical Journal

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MTHFR C677T and TS 5’-UTR 3R/3R Gene Polymorphism in Methotrexate-Resistant Childhood Acute Lymphoblastic Leukemia I Dewa Gede Ugrasena; Harianto Notopuro; Subijanto Marto Sudarmo; Ketut Sudiana; Djajadiman Gatot; Ponpon Idjradinata
The Indonesian Biomedical Journal Vol 12, No 2 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i2.1109

Abstract

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy in Indonesia and often treated by methotrexate (MTX). Though it can be cured in 30-60% of patients, MTX resistance remains the major cause of treatment failure in childhood ALL. Previous sudies showed that its anti-leukemic property was moderated by MTX ability to inhibitmethylene tetra hydrofolate reductase (MTHFR) and thymidylate synthase (TS) in folate metabolism. This study investigates the correlation between MTHFR and TS polymorphism and MTX resistance in ALL children.METHODS: A total of 155 subjects obtained from all subjects prior to chemotherapy. DNA from blood samples were extracted and underwent polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) to evaluate MTHFR C677T and TS 5’-UTR 3R/3R polymorphism.RESULTS: There was significant correlation between MTHFR C677T and TS 5’-UTR 3R/3R gene polymorphism with MTX resistance. Subjectswith MTHFR C677T and TS 5’-UTR 3R/3R gene polymorphism were 4 times (p=0.007) and 6.4 times (p=0.001) more likely to be MTX resistant than those without gene polymorphisms, respectively.CONCLUSION: MTHFR C677T andTS 5’-UTR 3R/3R represent dominant gene polymorphism related to MTX resistance in childhood ALL.KEYWORDS: gene polymorphism, folate metabolism, acute lymphoblastic leukemia
Co-Authors Ahmad Suryawan Anang Endaryanto Andi Cahyadi Andi Cahyadi Andi Cahyadi Aras, Jusli Arief, Yuni Sufyanti Aryati Aryati Bambang Permono Budi Utomo Diah Kusuma Arumsari Dimarzsiana Dara Sjahruddin Djajadiman Gatot Djajadiman Gatot Dominicus Husada Dominicus Husada Eileen Savage Endang Retnowati Endang Retnowati Erawati Armayani Erfina Lim Esthy Poespitaningtyas Evisina Hanafiati Frans Fauzi, Intani Dewi Syahti Hapsari Widya Ningtiar Harianto Notopuro I Gusti Ayu Putu Eka Pratiwi I Wayan Bikin Suryawan I. G.A.A Putri Sri Rejeki IGAA Putri Sri Rejeki IM Widiaskara Intani Dewi Syahti Fauzi Irene Ratridewi Irwanto Irwanto Irwanto, Irwanto Ismoedijanto Kaoru Nishiyama Kardani, Astrid Kristina Kezia Warokka Putri Larasati, Maria C Shanty Mahrus A Rahman, Mahrus A Mangihut Rumiris Maria C Shanty Larasati Maria Christina Shanty Larasati Maria Christina Shanty Larasati Maria Christina Shanty Larasati Masafumi Matsuo Maulidia, Rahmawati Mia Ratwita Mia Ratwita Andarsini Mohammad Sjaifullah Noer Muchtaruddin Mansyur Muhammad Faizi Murti Andriastuti, Murti Mutiani, Faradillah Nathalya Dwi Kartikasari Ningtiar, Hapsari Widya Ninik Asmaningsih Soemyarso Noer Saudah Noer Saudah, Noer Nunki, Nastasya Nursalam Nursalam Nursalam, Nursalam Parwati Setiono Basuki Ponpon Idjradinata Priscilla Putri Harmany PT Pramitha Puspa Wardhani R Fatchul Wahabe Retno Asih Retno Asih Setyoningrum Riadi Wirawan Rianto Setiabudy Risky Vitria Prasetyo Roedi Irawan S.Pd. M Kes I Ketut Sudiana . Savitri Laksmi Winaputri Shanty, Maria Christina Sherly Yuniarchan, Sherly Shrimarti Rukmini Devy Soedewo, Fery Hudowo Soeprapto Ma’at Sudarmo, Subijanto Marto Suprapto Ma'at Ma'at Susanto Nugroho Syntia TJ Taku Shirakawa Tanzilia, May Fanny Teddy Ontoseno Tigor Pandapotan Sianturi Widiaskara IM Yetti Hermaningsih Yetti Hernaningsih