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All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia The Indonesian Biomedical Journal Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Journal of Community Empowerment for Health JK Unila (Jurnal Kedokteran Universitas Lampung) Berita Kedokteran Masyarakat Advances In Social Humanities Research Indonesian Journal of Biomedicine and Clinical Sciences Indonesian Journal of Pharmacology and Therapy
Anggoro Budi Hartopo
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Working Group On Pulmonary Hypertension, Indonesian Heart Association
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Association between serum endothelin-1 level and major adverse cardiovascular events following percutaneous coronary intervention in stable coronary artery disease Rahayu, Dian Herlusiatri; Anggrahini, Dyah Wulan; Hartopo, Anggoro Budi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.20513

Abstract

Coronary artery disease (CAD) affects greatly the global population, exhibits high mortality and morbidity rates. Major adverse cardiovascular events (MACE), such as stroke, myocardial infarction, heart failure, and death, are the focus of research due to their significant contribution to morbidity and mortality in patients with CAD. Endothelin-1 is identified as a CAD prognostic indicator, especially for heart failure outcome. This study aimed to investigate the association between serum endothelin-1 level and MACE within 1 yr observation in patients with CAD underwent percutaneous coronary intervention (PCI). It was a retrospective cohort study where conducted at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Subjects were patients with stable CAD who underwent elective PCI. Baseline serum endothelin-1 level was measured by ELISA at the time of elective PCI procedure. The outcome was MACE, which consisted of heart failure, acute coronary syndrome, stroke, and cardiac death, occurred within 1 yr after elective PCI. The ROC curve was designed to determine serum endothelin-1 cut-off value to predict MACE. Sixty-three subjects were enrolled and the endothelin-1 level in serum samples was analyzed. Out of these, 11 (17.5%) experienced MACE within 1 yr post elective PCI. Serum endothelin-1 cut-off value was 1.932 pg/mL, which determined based on ROC curve. There was no significant association between serum endothelin-1 and MACE. There was a trend of higher incidence of MACE, in subjects with above-cut-off endothelin-1 level (≥1.932 pg/mL) (MACE incidence: 23.1% vs. 8.3%; p=0.181). Above-cut-off endothelin-1 level significantly associated with incidence of heart failure (100% vs. 0%; p=0.039) for 1 yr follow-up after elective PCI. Higher serum endothelin-1 level had a trend of higher incidence of 1-yr MACE in patients with stable CAD undergone elective PCI. Among 1-yr MACE, higher serum endothelin-1 associated with increased incidence of heart failure.
Co-Authors Abdul Majid Halim Wiradhika Abdul Majid Halim Wiradhika Abdul S Wahab, Abdul S Abdus Samik Wahab Ade Meidian Ambari Ahmad Hamim Sadewa Alifia Salsabila Ambari, Ade Meidian Anandini, Hesti Andreasta Meliala Anggraeni, Vita Yanti Anggrahini, Dyah Wulan Annis Rakhmawati Anwar Santoso Anwar Santoso Arityanti, Dean Armalya Pritazahra Armalya Pritazahra Azhafid Nashar Badai Bhatara Tiksnadi Baiq Gerisa Rahmi Faharani Baiq Gerisa Rahmi Faharani Bambang Budi Siswanto Bambang Dwiputra Bambang Irawan Bambang Irawan Basuni Radi Budi Yuli Setianto Cholid Tri Tjahjono Citra Dewi Wahyu Fitria Desandri, Dwita Rian Detty Siti Nurdiati Deva Bachtiar Deva Bachtiar Dwiputra, Bambang Dyah Samti Mayasari Dyah Wulan Anggrahini Eko Budiono Erna Ashlihah Rochmat Erwan, Nabila Erina Evita Devi Noor Rahmawati Fajarwati, Prahesti Febrianora, Mega Fika Humaeda Assilmi Firandi Saputra Fitra, Maha Gharini, Putrika Prastuti Ratna Gumilang, Rizki Amalia Hariadi Hariawan Hariadi Hariawan Hasan, Harris Hasanah Mumpuni Hendry Purnasidha Bagaswoto Hergaf, Indah Widyasari I Dewa Putu Pramantara Ika Trisnawati Indah Sukmasari Indra Widya Nugraha Ira Puspitawati Iri Kuswadi Irsad Andi Arso Irsad Andi Arso Irsad Andi Arso Irsad Andi Arso, Irsad Andi Iswandi Darwis Jarir At Thobari Jarir At Thobari Jati, Lintang Daru Julia Sari Kathrine, Anita Septiana Maria Kelvin Supriami Krevani, Citra Kiki Krisdinarti, Lucia Likke Prawidya Putri Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Krisdinarti Lucida Kris Dinarti, Lucida Kris Luhur Pribadi Luhur Pribadi Lukman Ade Chandra M. Taufik Ismail M. Yogi Riyantama Isjoni Makes, Indira Kalyana Mardiah Suci Hardianti Megawati Abubakar Megawati Abubakar Metalia Puspitasari Muhammad Gahan Sarwiko Muhammad Gahan Satwiko Muhammad Gahan Satwiko Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Ridwan Nahar Taufiq Nahar Taufiq Nahar Taufiq, Nahar Noriaki Emoto Nu Pravitasari Pamrayogi Hutomo Pompini Agustina Sitompul Pompini Agustina Sitompul Prasetia, Arif Eka Putri Ayudhia Trisnasari Putrika Prastuti Ra Gharini Putrika Prastuti Ra Gharini Qhabibi, Faqrizal Ria Raden Heru Prasanto Rahadiyani, IDA Swasty Rahayu, Dian Herlusiatri Raynaldo, Abdul Halim Real Kusumanjaya Marsam Rita Hamdani Rizki Amalia Gumilang Rochmat, Muflihatul Baroroh Royhan Rozqie setiaji, dimas Shiddiq, Achmad Sjughiarto, M.Afies Susanti, Vina Yanti Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Togi Junice Hutadjulu Togi Junice Hutadjulu Tri Asti Isnariani Tri Asti Isnariani Umi Sa'adatun Nikmah Umi Sa'adatun Nikmah Vera Dewanto Vera Dewanto Vienna Rosalinda Vina Yanti Susanti Vita Yanti Anggraeni Vita Yanti Anggraeni Winardi Emmanuel Setiawan Wiradhika, Abdul Majid Halim Yasmine Fitrina Siregar Yulia Wardhani