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All Journal Jurnal Teknologi Dan Industri Pangan Agroland : Jurnal Ilmu-Ilmu Pertanian AGRISAINS REKAYASA agriTECH Biocelebes AGRARIS: Journal of Agribusiness and Rural Development Research AGROLAND: The Agricultural Sciences Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pengolahan Pangan Conference on Innovation and Application of Science and Technology (CIASTECH) Samakia: Jurnal Ilmu Perikanan Jurnal Kelautan Nasional Jurnal Ilmiah AgriSains JOMPA ABDI: Jurnal Pengabdian Masyarakat Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Jurnal Pengabdian Masyarakat AGROLAND: The Agricultural Sciences Journal Mitra Sains
Asriani Hasanuddin
Animal Husbandry Study Program, Faculty Of Animal Husbandry And Fisheries, Tadulako University
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The Effect of Seaweed Soy Tempe Extract on the Reduction of Blood Sugar Levels in Alloxan Induced Rats (Mus musculus) Laenggeng, Abdul Hakim; Hasanuddin, Asriani; Nuryanti, Sitti; Trianto, Manap
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.11307

Abstract

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia due to impaired insulin secretion or action. This study aimed to examine the antihyperglycemic effect of seaweed soybean tempeh extract in alloxan-induced diabetic mice. A Completely Randomized Design (CRD) was used with 20 healthy male mice (2–3 months old, 25–30 g), divided into five groups: negative control, positive control (metformin), and three treatment groups receiving extract doses of 25, 75, and 125 mg/kg BW. Prior to treatment, mice underwent acclimatization to ensure uniform baseline conditions. Blood glucose levels were measured to assess the effects of the extract. Data were analyzed using ANOVA followed by the Least Significant Difference (LSD) test. The results showed that alloxan effectively induced hyperglycemia by damaging pancreatic beta cells. Administration of seaweed soybean tempeh extract significantly reduced blood glucose levels (p < 0.05). The highest dose (125 mg/kg BW) produced the most notable effect, comparable to metformin, while the 75 mg/kg BW dose also demonstrated significant efficacy. Both were significantly more effective than the lowest dose. In conclusion, seaweed soybean tempeh extract has potential as an alternative antihyperglycemic agent, especially at higher doses.
Co-Authors . Mappiratu Abdul Hakim Laenggeng Abdul Rahim Adetya Maryani Adrianton A. Ahmad Rizal ahmad rizal Aidah, Nur Alimudin Laapo Alismi M Salanggon Amalia Noviyanty Andi Darmawati Tombolotutu Andi Eni Firdani Arsal Arsal Arsal, Arsal Bau Toknok Chairil Anwar Chairil Anwar Dedi Fardiaz Didit Kustantio Dewanto Eny Yuniati Fachry L. Fadly Y Tantu Fajriani Fajriani Fajrul Amin Finarti Finarti Finarti, Finarti Gatot Siswo Hutomo Gina N. Putri Hafsah Hafsah Hafsah Hafsah Hasmida Hasmida, Hasmida Hi. Fatmawati If'all, If'all Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jusri Nilawati Lien Damayanti Manap Trianto Marhawati Mappatoba Marhawati Mappatoba Marwah Marwah Marwah Max Nuralam Minarny Gobel Muhammad F. Haq Mulkiah Amal Basri Nasmia Nasmia Nova Rugayah Nova Susanti Novalina Serdiati Nur Aidah Nurfadilah Nurul Awwaliyah P. Firman Nuryanti, Sitti Pitriani Pitriani Pitriani, Pitriani Putri A. Arta Putut Har Riyadi Roni Hermawan Roni Hermawan Rosedi Rosedi Rosedi Rosedi Rosmiaty Arief Rusdi Rusdi Rusdi Rusdi Rustam Abd. Rauf S. Malasugi Sari Aswani Sinta Amelia Siti B. Al-Amri Sugiarto Sugiarto Sukisman Abdul Halid Syahna Shaldan Syahraeni Kadir Syahrir Syahrir Syahrir Syamsul Lakahoro Trismansyah Trismansyah Umrah Umrah Wa Ode S. Musnina Wendy Alexander Tanod Yonelian Yuyun Yuliet Yuliet