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All Journal JURNAL GIZI INDONESIA International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Indonesian Journal of Cancer Jurnal Sistem Kesehatan Universa Medicina JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Indonesian Journal of Obstetrics & Gynecology Science JURNAL KESEHATAN PERINTIS Jurnal Kesehatan Jurnal Medikes (Media Informasi Kesehatan) Indonesian Trust Health Journal Indonesian Journal of Cancer Media Dermato-Venereologica Indonesiana Indonesian Trust Health Journal
Yudi Mulyana Hidayat
Department Of Obstetrics And Gynecology, Division Of Oncology, Faculty Of Medicine, Universitas Padjadjaran/ Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Althea Medical Journal

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Response to Chemotherapy in Patients with Gestational Trophoblastic Neoplasia in A Tertiary Hospital in Indonesia Farisa Raudina; Yudi Mulyana Hidayat; Sylvia Rachmayati
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1894

Abstract

Background: The incidence of gestational trophoblastic neoplasia (GTN) is high in Indonesia. Based on the FIGO prognostic score, GTN is classified into low-risk and high-risk categories. The high-risk group requires multidrug chemotherapy whereas the low-risk group requires single-drug chemotherapy. Response to chemotherapy would reflect the remission rate. The aim of this study was to describe the response to chemotherapy in GTN patientsMethods: This was a cross-sectional descriptive retrospective study on medical records of patients with GTN treated in Dr. Hasan Sadikin General Hospital during the period of 2016 to 2018. The inclusion criteria were GTN patients who received > 3 cycles of chemotherapy while the exclusion criteria were incomplete, inaccessible, or missing data. Data were collected on patient’s age, parity, history of previous pregnancy, pregnancy-therapy interval, tumor size, number and location of metastases, and history of failed chemotherapy.Results: Of the189 medical records of the GTN patient collected, only 88 met the inclusion criteria, (63.6% low risk and 36.4% high risk). Most patients were responsive to chemotherapy (61.4%), aged<40 years old, multiparity, tumor size >5 cm, had 4 month interval from previous pregnancy <4 months, had a history of molar pregnancy, had no metastases, and no previous failed chemotherapy.Conclusion: The chemotherapy response in gestational trophoblastic neoplasm patients is fairly good with most patients are in the low-risk groups. Specific tumor markers used in early diagnosis of GTN may play a major role.
Co-Authors A.W., Gatot Nyarumenteng Ahmad Faried Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Amillia Siddiq Andi Kurniadi, Andi Anwar , Ruswana Aprilina Aprilina Arieff Kustiandi Arifa Rakhmana Abdullah Astri Novianti Benny Hasan Purwara Berland Budiman Deni K. Sunjaya Dimas Erlangga Luftimas Dodi Suardi Edhyana Sahiratmadja Edwin Armawan Elsa Pudji Setyawati Eunike Febe Febriani Farid Husin Farid Husin Farid Husin Farisa Raudina Firman Fuad Wirakusumah Gaga Irawan Nugraha Gatot N. A. Winarno Gatot N. A. Winarno Hadyana Sukandar Halimatussa'adiah , Melly Hanom Husni Syam Harjito, Vanessa Natasha Harsono, Ali Budi Hendra Gunawan Herman Susanto Herry Herman Hiroshi Koyama Huda Toriq Husin, Farid Indah Amelia Indah Amelia Jasmi ati Johanes C Mose Johanes C. Mose Johanes Cornelius Mose Kemala Isnainiasih Mantilidewi Kevin Dominique Tjandraprawira LAURENS DAVID PAULUS LAURENS DAVID PAULUS, LAURENS DAVID Leri Septiani M. Rizkar Arev Sukarsa MARINGAN DIAPARI LUMBAN TOBING Martasari, Bellia Loranthifolia Megantari, Salsa Bila Mieke Hemiawati Satari Mieke Hemiawati Satari Muhammad Nasir Shafiee Mutakin Mutakin Nanan Sekarwana Niken Bayu Argaheni Oki Suwarsa Pati Aji Achdiat Putu Giri Saputro R. M. Sonny Sasotya Radiastomo Samekta Budi Ramdan Panigoro Rasmia Rowawi Reiva Farah Dwiyana Reyshiani Johan Rezah Andriani Rizky Abdulah Rohmawati, Enny Rotinggo, Rico Salima, Siti Siti Salima Sofie R. Krisnadi Steven Ridwan, Steven Supriadi Gandamihardja SUPRIADI GANDAMIHARJA Supriadi Gandamiharja Susiarno, Hadi Syahrul Rauf Sylvia Rachmayati Tono Djuwantono Unggul Yudatmo Vanessa Natasha Harjito Wiryawan Permadi Yopi Wulandhari Yuli Astuti Yusuf Sulaeman Effendi