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All Journal JURNAL GIZI INDONESIA International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Indonesian Journal of Cancer Jurnal Sistem Kesehatan Universa Medicina JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Indonesian Journal of Obstetrics & Gynecology Science JURNAL KESEHATAN PERINTIS Jurnal Kesehatan Jurnal Medikes (Media Informasi Kesehatan) Indonesian Trust Health Journal Indonesian Journal of Cancer Media Dermato-Venereologica Indonesiana Indonesian Trust Health Journal
Yudi Mulyana Hidayat
Department Of Obstetrics And Gynecology, Division Of Oncology, Faculty Of Medicine, Universitas Padjadjaran/ Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Indonesian Journal of Cancer

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Hubungan antara Ekspresi mRNA Gen Epidermal Growth Factor Receptor (EGFR) dengan Penurunan Kadar β-hCG Serum Pasca-evakuasi Mola Hidatidosa Komplit PAULUS, LAURENS DAVID; HIDAYAT, YUDI MULYANA; GANDAMIHARJA, SUPRIADI
Indonesian Journal of Cancer Vol 9, No 3 (2015): Jul - Sept 2015
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

In 2008, the incidence of hydatidiform mole that occurred in West Java around 1:28. Malignant transformation of Complete Hydatidiform Mole (CHM) is influenced by many factors, among others, is the expression of the epidermal growth factor receptor (EGFR). This study uses Historical Cohort to retrieve CHM patients data and trophoblastic tissue paraffin block in 2007-2012, and perform examination of Polymerase chain reaction.Results of the study: 40 CHM patients, 24 with EGFR (-) and 16 with EGFR (+), at 12 weeks monitoring post evacuation using the Mochizuki regression curve was not obtained persistent mole in the group with EGFR (-), while the group of EGFR (+), all showed an increase in β-hCG levels. Relative risk (RR) of 3.4 in the CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 6th week and RR of 13.0 in CHM group with EGFR (+) into a persistent mole compared with EGFR (-) at 8th week. The conclusion of this study demonstrate the suitability of the hypothesis that the higher mRNA gene expression of EGFR, the slower decrease in serum levels of β-hCG after CHM evacuation and expression EGFR (+) may be a predictor of the occurrence of persistent mole. Pada 2008, insiden mola hidatidosa (MH) yang terjadi di Jawa Barat sekitar 1:28. Transformasi keganasan dari mola hidatidosa komplit (MHK) dipengaruhi oleh banyak faktor, antara lain ekspresi Epidermal Growth Factor Receptor (EGFR). Penelitian ini menggunakan metode historical cohort dengan mengambil data dan parafin block jaringan trofoblas pasien MHK tahun 2007−2012, dan dilakukan pemeriksaan POLYMERASE CHAIN REACTion. Hasil penelitian menunjukkan dari 40 pasien MHK, 24 di antaranya EGFR (-) dan 16 EGFR (+) pada 12 minggu pascaevakuasi menggunakan kurva regresi Mochizuki. Tidak didapatkan mola persisten pada kelompok EGFR (-), sedangkan kelompok EGFR (+) semuanya menunjukkan peningkatan β-hCG (mola persisten). Risiko relatif (RR) sebesar 3,4 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-6 dan RR sebesar 13,0 pada EGFR (+) menjadi mola persisten dibandingkan dengan EGFR (-) pada minggu ke-8. Hasil penelitian ini menunjukkan kesesuaian dengan hipotesis bahwa semakin tinggi ekspresi EGFR maka semakin lambat penurunan kadar β-hCG serum pasca-evakuasi MHK. Ekspresi EGFR dapat menjadi prediktor terjadinya mola persisten.
Co-Authors A.W., Gatot Nyarumenteng Ahmad Faried Ali Budi Harsono Ali Budi Harsono Ali Budi Harsono Amillia Siddiq Andi Kurniadi, Andi Anwar , Ruswana Aprilina Aprilina Arieff Kustiandi Arifa Rakhmana Abdullah Astri Novianti Benny Hasan Purwara Berland Budiman Deni K. Sunjaya Dimas Erlangga Luftimas Dodi Suardi Edhyana Sahiratmadja Edwin Armawan Elsa Pudji Setyawati Eunike Febe Febriani Farid Husin Farid Husin Farid Husin Farisa Raudina Firman Fuad Wirakusumah Gaga Irawan Nugraha Gatot N. A. Winarno Gatot N. A. Winarno Hadyana Sukandar Halimatussa'adiah , Melly Hanom Husni Syam Harjito, Vanessa Natasha Harsono, Ali Budi Hendra Gunawan Herman Susanto Herry Herman Hiroshi Koyama Huda Toriq Husin, Farid Indah Amelia Indah Amelia Jasmi ati Johanes C Mose Johanes C. Mose Johanes Cornelius Mose Kemala Isnainiasih Mantilidewi Kevin Dominique Tjandraprawira LAURENS DAVID PAULUS LAURENS DAVID PAULUS, LAURENS DAVID Leri Septiani M. Rizkar Arev Sukarsa MARINGAN DIAPARI LUMBAN TOBING Martasari, Bellia Loranthifolia Megantari, Salsa Bila Mieke Hemiawati Satari Mieke Hemiawati Satari Muhammad Nasir Shafiee Mutakin Mutakin Nanan Sekarwana Niken Bayu Argaheni Oki Suwarsa Pati Aji Achdiat Putu Giri Saputro R. M. Sonny Sasotya Radiastomo Samekta Budi Ramdan Panigoro Rasmia Rowawi Reiva Farah Dwiyana Reyshiani Johan Rezah Andriani Rizky Abdulah Rohmawati, Enny Rotinggo, Rico Salima, Siti Siti Salima Sofie R. Krisnadi Steven Ridwan, Steven Supriadi Gandamihardja SUPRIADI GANDAMIHARJA Supriadi Gandamiharja Susiarno, Hadi Syahrul Rauf Sylvia Rachmayati Tono Djuwantono Unggul Yudatmo Vanessa Natasha Harjito Wiryawan Permadi Yopi Wulandhari Yuli Astuti Yusuf Sulaeman Effendi