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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Indonesian Journal of Chemical Science Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal SOLMA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Cendekia Eksakta Jurnal Abdi Insani Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Kefarmasian Indonesia
Devi Nisa Hidayati
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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PENINGKATAN PENGETAHUAN DAN KETERAMPILAN PEMBUATAN ROLL ON AROMATERAPI DARI MINYAK SEREH SEBAGAI ANTI REPELLENT Yumni, Gharsina Ghaisani; Hidayati, Devi Nisa; K. M., Dewi Andini
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1839

Abstract

Dengue fever (DF) is a global health problem. The epidemiology of dengue fever in Indonesia varies but continues to increase. Dengue fever itself is caused by the Aedes aegypti (Linn.) mosquito. Indonesia's tropical geographical location provides conditions that support the breeding of disease-carrying mosquitoes. This demonstrates the urgency with which disease-carrying mosquito eradication must be carried out. Currently, mosquito control strategies rely on the use of chemical drugs to control mosquitoes, which often cause side effects. Therefore, many mosquito repellents have been developed based on natural ingredients. Cymbopogon nardus, the plant that yields citronella essential oil, is one of them. The purpose of this PkM project is to increase knowledge regarding the benefits of citronella oil. In addition, it also improves the skills of participants to produce citronella oil as an anti-repellent. This training method is a combination of lectures, demonstrations, and practical actions. Participants will be given counseling regarding the benefits of citronella oil for health. The making of roll-on preparations begins with watching tutorials and live demonstrations by the team which are then followed by the participants. The results of this activity showed an increase in participants' knowledge and skills in making lemongrass aromatherapy roll-on preparations. This can be seen in the PkM product in the form of a roll-on aromatherapy preparation that has a distinctive lemongrass aroma, warm and stable at room temperature. Participants can also plan to make roll-on preparations using other essential oils. The knowledge gained is expected to be developed by participants as entrepreneurial capital. The community service activities were carried out smoothly and according to target. The PkM team succeeded in increasing the knowledge and skills of the participants through PkM activities.
Cytotoxic Activity and Apoptosis by Extract and Ethyl Acetate Fraction of Hibiscus tiliaceus Linn in 4T1 Cell Line Hidayati, Devi Nisa; Safitri, Erika Indah; Surayya, Anis; Alviani, Dwi Lutvi; Putri, Masita Nur Amalia
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Waru leaves are proven to have cytotoxic activity. The activity of waru leaves needs to be developed in a molecular direction to see its apoptotic activity. This study aims to determine the cytotoxic activity of methanol extract (EWL) and ethyl acetate fraction fraction (EAFWL) of Hibiscus tiliaceus Linn as well as the induction of apoptosis in 4T1 cells. The methanol extract of hibiscus leaves was obtained by the maceration method, followed by a fractionation process with n-hexane, ethyl acetate, and water as solvents. Cytotoxic test of EWL was carried out at a concentration of 31.25; 62.5; 125; 250; 500 and 1000 μg/mL while EAFWL was at a concentration of 100; 200; 400; 600 and 100 μg/mL, using MTT assay. Analysis of IC50 values using linear regression. The apoptosis induction test at IC50 and ½ IC50 concentrations using flowcytometry. Data on the percentage of apoptosis were analyzed using One Way Anova statistical analysis. The results were EWL and EAFWL cytotoxic tests against 4T1 had IC50 values of 649 μg/mL and 746 μg/mL. EWL obtained a percentage of total apoptosis at a concentration of 324.5 μg/mL of 48.76%; 649 μg/mL was 67.06% and control cells were 36.16%. EAFWL percentage of total apoptosis at a concentration of 746 μg/mL of 30.8%; 373 μg/mL was 42.13% and control cells were 9.6%. So EWL and EAFWL can induce apoptosis of 4T1 cells.
Pea Seed (Pisum sativum L.) Extract Exhibits Cytotoxic Activity against T47D Cancer Cells Chasani, Failasufia Maulida; Hidayati, Devi Nisa; Hartati, Indah
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.62205

Abstract

Pea (Pisum sativum L.) contain flavonoids with potential anticancer activity against breast cancer cells. Yet, the influence of extraction methods and solvent choice on flavonoid yield and bioactivity remains insufficiently studied. This study evaluated the effect of solvent type and extraction method on the flavonoid content and cytotoxic activity of Pisum sativum L. seed extract on T47D breast cancer cells. Extraction was performed using reflux and infusion methods with 96% ethanol, 70% ethanol, and water solvents. Flavonoid content was determined using the AlCl₃ colorimetric test, while cytotoxic activity was tested using the MTT method. The results showed that the 96% ethanol extract had the highest flavonoid content (9.88 ± 0.05 mg QE/g), followed by 70% ethanol (5.91 ± 0.26 mg QE/g) and water extract (2.63 ± 0.06 mg QE/g). Cytotoxic activity was demonstrated by 96% and 70% ethanol extracts with IC₅₀ values of 147.12 ± 8.81 µg/mL and 90.59 ± 5.75 µg/mL, respectively, while the water extract was inactive. These findings confirm that solvent polarity plays an important role in optimizing flavonoid content and cytotoxic potential. However, high flavonoid content does not always correlate with cytotoxic effects, so a comprehensive approach is needed in the development of natural-based anticancer agents.
Pelatihan Produksi Kombucha sebagai Inovasi Pangan Fungsional untuk Kesehatan dan Kewirausahaan Komunitas di Desa Bocor Kebumen Chasanah, Siti Nur; Hartati, Indah; Maharani, Farikha; Mulangsri, Dewi Andini Kunti; Hidayati, Devi Nisa; Nugroho, Agung; Priangkoso, Tabah
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.20905

Abstract

Pendahuluan: Kombucha merupakan minuman fermentasi berbasis teh yang semakin populer sebagai produk pangan fungsional karena kandungan probiotik dan senyawa bioaktifnya yang bermanfaat bagi kesehatan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan komunitas pemuda di Desa Bocor, Kecamatan Buluspesantren, Kabupaten Kebumen dalam memproduksi kombucha secara higienis dan bernilai ekonomi. Metode: Pelatihan meliputi edukasi mengenai manfaat kesehatan kombucha, teknik produksi yang aman, serta strategi pemasaran berbasis potensi lokal. Hasil: Hasil kegiatan menunjukkan bahwa peserta mampu memahami dan menerapkan proses produksi kombucha dengan baik, serta menunjukkan minat terhadap pengembangan usaha berbasis fermentasi pangan. Kesimpulan: Kombucha dinilai memiliki potensi besar sebagai produk kewirausahaan komunitas yang mendukung gaya hidup sehat, pemberdayaan ekonomi lokal, dan pencapaian Tujuan Pembangunan Berkelanjutan (SDG), khususnya SDGs 3.
Co-Authors Alviani, Dwi Lutvi Amalina Firdaus Amaliyah Ayu Nurfitriani Anita Dwi Puspitasari Aqnes Budiarti Aristya Kurniasih Awal Prichatin Kusumadewi Aysah Safitri Chasani, Failasufia Maulida Cicih Sumiarsih Cicih Sumiarsih Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dwi Lutvi Alviani Edy Meiyanto Erika Indah Safitri Esa Evinda Farikha Maharani Fatimatuz Zahroh Fatimatuz Zahroh Fauzizah, Nisa Ferry Sandra Fikriyyah, Shafa Fini Hartanti Fitriasih Fitriasih Fitriasih Fitriasih Gharsina Ghaisani Yumni Hanik Rohmatul Maghfiroh Hartanti, Fini Ibrahim Arifin Ibrahim Arifin Indah Hartati Jenie, Riris Istighfari K. M., Dewi Andini Komariyatun, Siti Laili Nailul Muna Laili Nailul Muna Lalu Ksatria D.S. Lilis Rejeki Lina Wahyuni Lina Wahyuni Lusyana Setiawati Marwan Masita Nur Amalia Putri Mufrod Mufrod Nenni Pratiwi Nenni Pratiwi Nilam Eka Putri Nugroho, Agung NUR AINI Nur Kussamawari Ardian Nur Rahayu Fitriana Nurul Hidayati Parusiza, Intan Meyta Pasha, Salsabilla Putri Buana Pia Annisa Pramesti Dewi Putri, Masita Nur Amalia Rahayu, Putri Rahmatun, Mutia Ririn Lispita Wulandari Riris Istighfari Jenie risha fillah fithria Rumiyati Rumiyati Salsabiila, Iqna Salsabila, Unik Hanifah Siti Mega Komariah Siti Mega Komariyah Siti Nur Chasanah, Siti Nur Siti Nurikha Siti Wahidatun Nisa Sri Susilowati Sufa , Riisyda Faila Sugiyono - Surayya, Anis Syahrul Iqbal Setiawan Tabah Priangkoso Ulya Felasufah Umroh Mahmudah Umroh Mahmudah Yance Anas Yuni Antika