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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Sistem Kesehatan Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth
Anggun Rafisa
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin Deficiencies among Adult Patients with Recurrent Aphthous Stomatitis: A Systematic Review Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of the oral mucosa characterized by recurrent, painful ulcerations that significantly impair quality of life. Although its etiology is multifactorial, nutritional factors, particularly vitamin deficiencies, have been proposed as potential contributors through their roles in immune regulation, epithelial integrity, and wound healing. Evidence regarding vitamin status in adults with RAS, however, remains inconsistent. This systematic review aimed to synthesize and critically evaluate available evidence on vitamin levels in adult patients with recurrent aphthous stomatitis. A comprehensive literature search was conducted in PubMed and Scopus for studies published between January 2015 and December 2025, following PRISMA 2020 guidelines. Eligible studies included adult participants (≥18 years) diagnosed with RAS and reported serum or salivary vitamin levels. Observational and interventional studies were considered. Data were extracted on study characteristics, vitamin assessment methods, and key findings, and were analyzed descriptively. Seven studies met the inclusion criteria. Vitamin D was the most frequently investigated micronutrient, followed by vitamin B12 and other hematinic parameters. Several studies reported lower vitamin D levels in patients with RAS compared with controls, while others found similarly high rates of deficiency in both groups. Associations between vitamin levels and clinical severity of RAS were generally weak, although vitamin D deficiency was linked to increased ulcer multiplicity in one study. Vitamin B12 deficiency was primarily observed in populations with concomitant iron deficiency anemia rather than in otherwise healthy adults with RAS. Current evidence suggests that vitamin deficiencies, particularly vitamin D, may function as modifying or aggravating factors in adult RAS rather than direct causal agents. Further high-quality studies are required to clarify their clinical relevance and therapeutic implications.
Malnutrition and oral Health in Elderly: a Narrative Review Anggraini, Jamas Ari; Najmi, Nuroh; Rafisa, Anggun; Febriane Balafif, Felisa; Sari, Kartika Indah
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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The aging process is generally defined as the accumulation of various changes that occur in cells and tissues as we age. According to the World Health Organization (WHO), an elderly individual is defined as a person who has reached or surpassed 60 years of age. Changes in conditions experienced by the elderly are not only physical changes, but also social and psychological changes. These changes influence each other and interact with other factors, which have an impact on the health conditions of the elderly, including appetite regulation which indirectly also has an impact on nutritional status in elderly. As we already know, nutrition is an important component for the elderly that affects the entire aging process and the general health condition of the elderly, including their oral health. Oral health and nutrition themselves have a multidirectional relationship. This relationship is manifested in the oral cavity, including plaque formation, dental caries, periodontal disease and other oral conditions. It is imperative for clinicians to comprehend the interplay between oral health and nutrition, as this knowledge is crucial for the effective management of elderly patients. This article focuses on the relationship between nutrition an oral health and its impact on older adults.
Soy Isoflavone Mediated Modulation of IL-1β Related Inflammatory Pathways in Oral Mucosal Cells: A Scoping Review of Experimental Studies Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Balafif, Felisha Febriane
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Background: Soy isoflavones, particularly genistein, have been widely studied for their anti-inflammatory properties. However, evidence regarding their modulatory effects on interleukin-1β (IL-1β)–related inflammatory pathways in oral mucosal tissues remains limited. Objective: This scoping review aimed to map the available experimental evidence on the effects of genistein on inflammatory responses associated with IL-1β in the oral cavity. Methods: A scoping review was conducted following a comprehensive literature search of PubMed and ScienceDirect databases. Articles published in English between 2016 and 2026 were screened using predefined keywords related to soy isoflavones, genistein, IL-1β, inflammation, and oral or periodontal tissues. Original experimental studies focusing on inflammatory modulation in oral or periodontal contexts were included. Results: From the literature search, only one experimental study met the inclusion criteria. The included study investigated a genistein-loaded folic acid–modified liposome-hydrogel composite for periodontitis treatment. The findings demonstrated that genistein exerted anti-inflammatory effects by modulating inflammatory cytokines, including IL-1β, and inhibiting the TLR4/MyD88/NF-κB signaling pathway. The study also reported improved inflammatory regulation through macrophage phenotype modulation and interaction with periodontal ligament stem cells. Conclusion: Current experimental evidence on the role of genistein in modulating IL-1β–related inflammation in the oral cavity is scarce. The limited findings suggest that genistein has potential anti-inflammatory effects in periodontal inflammation; however, further well-designed experimental studies focusing specifically on oral mucosal cells and inflammatory pathways are needed to support its therapeutic application.
Co-Authors Ahmad Yani ahmad yani Anggraini, Jamas Ari Asty Samiaty Setiawan, Asty Samiaty Balafif, Felisa Febriane Balafif, Felisha Balafif, Felisha Febriane Chandra, Angievel Cucu Zubaedah Cucu Zubaedah Dewi Marhaeni Diah Herawati Fairuz, Anargya Alfa Faisal Kuswandani Faisal Kuswandani Falisha Febriane Balafif Farhani, Dahlia Salsa Febriane Balafif, Felisa Febriane Balafif, Felisha Felisha Febriane Balafif Gilang Yubiliana, Gilang Gita Dwi Jiwanda Sovira Kuswandani , Faisal Mochammad Rodian Nabila Anisha Nani Murniati Nuroh Najmi Nuroh Najmi Nuroh Najmi Rasmi Rikmasari Rosita Aisyah Sari, Kartika Indah Sarilita, Erli Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati, Sri