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All Journal Jurnal Anestesiologi Indonesia Medical Journal of Indonesia Indonesian Journal of Electrical Engineering and Informatics (IJEEI) The Indonesian Biomedical Journal Biomedical Journal of Indonesia Universa Medicina Global Conference Index Eksakta : Berkala Ilmiah Bidang MIPA Majalah Kedokteran Neurosains Biomolecular and Health Science Journal JURNAL KESEHATAN BHAKTI HUSADA Indonesian Journal of Multidisciplinary Science Neurona Jurnal Kedokteran Meditek
Nurhadi Ibrahim
Departemen Fisiologi Kedokteran FK Universitas Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Eksakta : Berkala Ilmiah Bidang MIPA

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Learning and Memory Impairment in High Fat Diet Induced Obesity Ariani, Citra; Ibrahim, Nurhadi; Yolanda, Sophie
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 26 No. 01 (2025): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol26-iss01/483

Abstract

Obesity is a manifestation of abnormal fat accumulation which can lead to impairment in several organs, including the brain. Neuroinflammation is considered the cause of cell death as well as reactive oxygen species in hippocampal neuron cells. It results in disturbance of memory forming process. Impaired learning and memory function affects a person's ability to carry out daily tasks and lower quality of life over time, so they should be circumvented with preventive, curative, and rehabilitative measures. The understanding of the pathological mechanisms of obesity-induced memory impairment based on the changes at molecular levels is imperative for an effective management. We collected and reviewed research articles to summarize the pathological mechanisms. Twenty studies were included in this review in terms of signaling pathway, molecular markers in brain and changes in memory and behavior pattern. It is showed that memory changes in obesity could be resulted from inflammation, impaired neurogenesis and cell senescence via various mechanisms and pathways. In conclusion, the understanding of the pathomechanisms in obesity-induced memory impairment aids to its the prevention and treatment.
Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Aulia Amir S. Madjid, Amir S. Amirah Yusnidar Andon Hestiantoro Arjo Tedjo Astuti, Brilliant Putri Kusuma Brown, Paul T. Budi Iman Santoso Citra Ariani, Citra Dewi F. Suniarti Dewi Sukmawati Endang W. Bachtiar Erni Hernawati Purwaningsih, Erni Hernawati Ernie H. Purwaningsih Erwinanto Frans Ferdinal Goenarjo, Roman Hakim, Manfaluthy Hamdani Zain Hamdani Zain Harrina Erlianti Rahardjo, Harrina Erlianti Imelda Rosalyn Sianipar Ina S. Timan, Ina S. Irfannuddin Irfannuddin Jasirwan, Shanty Olivia Jaslindo, Lieka Nugrahi Joedo Prihartono Julia Rahadian Jusman, Sri Widia Azraki Khamelia Malik La Febry Andira Rose Cynthia Legiran Legiran Lina Marlina Lyra Puspa Mahyuddin, Hilman Mailani, Rena Makkiyah, Feda Anisah Martina Wiwie Setiawan Nasrun Martina Wiwie Setiawan Nasrun Minarma Siagian Minarma Siagian Mohamad Sadikin Mohamad Saekhu Muhammad Ramli Ahmad Neng Tine Kartinah Almuktabar Ninik Mudjihartini Paul T. Brown Puspa, Lyra Putu Indah Paramita Adi Putri Rickie Rizal Zainal Ronokusumo, Teguh A.S. Sabita, Rifqi Salim Harris, Salim Santoso, Dewi Irawati Soeria Satriotomo, Irawan Shadrina, Amalia Siti Setiati Sophie Yolanda Sophie Yolanda Sri Redjeki Suci Anggraini Sudigdo Sastroasmoro Surahman Hakim Trinovita Andraini Trinovita Andraini Wanarani Alwin Wardaya Wardaya Wawan Mulyawan Widjajalaksmi Kusumaningsih, Widjajalaksmi Wijaya, Ade Wresti Indriatmi B. Makes Yani, Sri Zenik Kusrini