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All Journal Jurnal Anestesiologi Indonesia Medical Journal of Indonesia Indonesian Journal of Electrical Engineering and Informatics (IJEEI) The Indonesian Biomedical Journal Biomedical Journal of Indonesia Universa Medicina Global Conference Index Eksakta : Berkala Ilmiah Bidang MIPA Majalah Kedokteran Neurosains Biomolecular and Health Science Journal JURNAL KESEHATAN BHAKTI HUSADA Indonesian Journal of Multidisciplinary Science Neurona Jurnal Kedokteran Meditek Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Nurhadi Ibrahim
Departemen Fisiologi Kedokteran FK Universitas Indonesia
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Journal : The Indonesian Biomedical Journal

 1 
Combination of Aerobic Exercise and Continuous Environmental Enrichment Improves Adult Male Rats’ Spatial Memory: Study on Hippocampal Insulin Like Growth Factor 1 (IGF-1) and Fibroblast Growth Factor 2 (FGF-2) Expression Sophie Yolanda; Sri Redjeki; Trinovita Andraini; Dewi Irawati Soeria Santoso; Nurhadi Ibrahim; Rena Mailani
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.731

Abstract

BACKGROUND: Memory declines with the progression of age through the neurodegeneration process. Aerobic exercise and environmental enrichment can delay neurodegeneration by improving neuroplasticity via expression of insulin like growth factor 1 (IGF-1), fibroblast growth factor 2 (FGF-2) and other proteins. Combination treatment of aerobic exercise and continuous environmental enrichment and their effect on the expression of IGF-1 and FGF-2 which were expected to improve memory function has not been studied previously. Thus, this study aimed to observe it.METHODS: This is an experimental research using 24 male Wistar rats (Rattus norvegicus, 300-400 g, age 7-8 months) divided randomly into 4 groups: control (C), aerobic exercise (A), continuous (EE), and combination of aerobic exercise and continuous environmental enrichment (A-EE). At the end of an 8-week treatment, rats were sacrificed, and an enzyme-linked immunosorbent assay (ELISA) examination was performed to assess hippocampal IGF-1 and FGF-2 levels.RESULTS: In the 8th week, A-EE group showed the best improvement in rats’ spatial memory (47.84±10.6 %) followed by EE group (45.03±4.1 %), A group (38.61±3.8 %), and C group (22.76±7.12 %). However, A-EE group’s hippocampal IGF-1 (16.21±7.56 ng/mg protein) and FGF-2 (1.29±0.57 ng/mg protein) expression were not higher than other groups.CONCLUSION: Improvement in memory function in the combination group is a result of induction of various growth factors’ expression in the hippocampus, including IGF-1 and FGF-2, but the primary pathway of memory function improvement may be from other growth factors.KEYWORDS: spatial memory, aerobic exercise, environmental enrichment, hippocampus, IGF-1, FGF-2
Effect of the High-Intensity Interval Training on BDNF Level in Ischemic Stroke Rat Model on the Recovery of Motor Function Yani, Sri; Harris, Salim; Jusuf, Ahmad Aulia; Goenarjo, Roman; Makkiyah, Feda Anisah; Sabita, Rifqi; Ibrahim, Nurhadi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2911

Abstract

BACKGROUND: Stroke is one of the major causes of disability in the world. High-intensity interval training (HIIT) is known as a novel treatment to promote stroke recovery. However, the results differ in their effects on irisin, which is a regulator of brain-delivered neurotrophic factor (BDNF). Therefore, this study was conducted to investigate the effect of HIIT on BDNF and irisin levels in a rat model of ischemic stroke with middle cerebral artery occlusion (MCAO) induction on recovery motor function.METHODS: Rats were categorized into 4 groups: sham, MCAO, MCAO+moderate-intensity interval training (MIIT), and MCAO+HIIT. MCAO induction was performed to create the ischemic stroke rats model. The motor function was assessed through rotarod and footprint tests. Blood samples were obtained 6 days before MCAO and 14 days after MCAO to examine BDNF and irisin levels with enzyme-linked immunosorbent assay (ELISA). Brain tissue samples were collected 14 days after MCAO for histopathological examination of cortical tissue with hematoxylin-eosin (HE) staining.RESULTS: Rats in the MCAO+HIIT group exhibited an enhanced ability to walk on the rotarod (p=0.016). The stride-length hind paw right in the MCAO+HIIT group demonstrated a noteworthy increase in comparison to baseline value (p=0.036), and the stride-length fore paw right showed a significant increase in both the MCAO+HIIT (p=0.036) and MCAO groups (p=0.034). BDNF significantly improved in the MCAO+MIIT (p=0.043) and MCAO+HIIT groups (p=0.018). The irisin level only showed a significant enhancement in the MCAO+HIIT group (p=0.018).CONCLUSION: HIIT increased motor function, while BDNF level increased with HIIT and MIIT intervention. This preclinical research is useful for supporting the recovery of stroke patients by HIIT intervention.KEYWORDS: BDNF, HIIT, MIIT, irisin, ischemic stroke, MCAO
Co-Authors A.A. Ketut Agung Cahyawan W Ahmad Aulia Amir S. Madjid, Amir S. Amirah Yusnidar Andon Hestiantoro Arjo Tedjo Astuti, Brilliant Putri Kusuma Brown, Paul T. Budi Iman Santoso Citra Ariani, Citra Dewi F. Suniarti Endang W. Bachtiar Erni Hernawati Purwaningsih, Erni Hernawati Ernie H. Purwaningsih Erwinanto Goenarjo, Roman Hakim, Manfaluthy Hamdani Zain Hamdani Zain Harrina Erlianti Rahardjo, Harrina Erlianti Imelda Rosalyn Sianipar Ina S. Timan, Ina S. Irfannuddin Irfannuddin Jasirwan, Shanty Olivia Jaslindo, Lieka Nugrahi Joedo Prihartono Julia Rahadian Jusman, Sri Widia Azraki Khamelia Malik La Febry Andira Rose Cynthia Legiran Legiran Lina Marlina Lyra Puspa Mahyuddin, Hilman Mailani, Rena Makkiyah, Feda Anisah Martina Wiwie Setiawan Nasrun Martina Wiwie Setiawan Nasrun Minarma Siagian Minarma Siagian Mohamad Sadikin Mohamad Saekhu Muhammad Ramli Ahmad Neng Tine Kartinah Almuktabar Ninik Mudjihartini Paul T. Brown Puspa, Lyra Putu Indah Paramita Adi Putri Rickie Rizal Zainal Ronokusumo, Teguh A.S. Sabita, Rifqi Sadikin, Abdul Halim Salim Harris, Salim Santoso, Dewi Irawati Soeria Shadrina, Amalia Siti Setiati Sophie Yolanda Sophie Yolanda Sri Redjeki Suci Anggraini Sudigdo Sastroasmoro Surahman Hakim Trinovita Andraini Trinovita Andraini Wanarani Alwin Wawan Mulyawan Widjajalaksmi Kusumaningsih, Widjajalaksmi Wijaya, Ade Wiwoho, Yudi Yuwono Wresti Indriatmi B. Makes Yani, Sri Zenik Kusrini