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All Journal JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Ilmiah Medicamento Jurnal Impresi Indonesia Riset Informasi Kesehatan Journal of Pharmaceutical and Sciences. Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Info Kesehatan
Hartyana Sutarna, Titta
Fakultas Farmasi Universitas Jenderal Achmad Yani
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Formulasi dan Karakterisasi Nanokristal Meloksikam Menggunakan Kombinasi Penstabil Polimer dan Surfaktan untuk Meningkatkan Kelarutan Al-Hakim, Nur Achsan; Sutarna, Titta Hartyana; Ratih, Hestiary; Azzara, Karina Putriani
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12523

Abstract

Background: Low solubility in water is a major obstacle for Meloxicam (MLX) and has implications for its limited bioavailability. Nanocrystallization techniques show potential for improving drug solubility, but nanoparticles tend to aggregate, suggesting the use of a combination of Hydroxypropyl Methylcellulose (HPMC) and Decyl Glucoside (DG) as stabilizers to overcome this problem.Objective: This study aims to develop and characterize meloxicam nanocrystals (MLX-NC) with a combination of HPMC and DG in an effort to improve solubility. MLX-NC was synthesized using ultrasonication and dried by lyophilization.Methods: The resulting formulation exhibited excellent physical stability over 28 days, as evidenced by consistent particle size (~11 nm) and polydispersity index (<0.3). Physical evaluation and characterization were performed, including particle size analysis (DLS), zeta potential, particle morphology (SEM), thermal analysis (DSC), X-ray diffraction (XRD), and saturated solubility testing.Results: The MLX-NC formulation showed a more than 200-fold increase in solubility compared to pure MLX, from 0.005 mg/mL to 1.064 mg/mL. XRD and DSC analyses confirmed that the nanocrystallization process converted the crystalline phase of MLX into an amorphous phase. These results indicate that induced amorphization can significantly improve solubility.Conclusion: The solubility of MLX can be significantly improved using ultrasonication combined with HPMC and DG. This approach has the potential to overcome the solubility limitations of BCS Class II drugs.
Formulation Strategy to Prevent Sticking in Calcium Carbonate–Cholecalciferol Chewable Tablets: The Role of Citric Acid Ratih, Hestiary; Gosepa, Oke Setiawan; Alatas, Fikri; Sutarna, Titta Hartyana
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2325

Abstract

The sticking phenomenon is a critical issue in the production of calcium carbonate–cholecalciferol (vitamin D3) chewable tablets, primarily driven by the hygroscopicity and reactivity of citric acid, which is used as a flavor-masking agent. This study aims to evaluate and determine the optimal method for mitigating sticking by modifying citric acid excipients using two approaches: granulation with mannitol (F1: 0.5%, F2: 1%) and coating with HPMC (F3: 0.5%, F4: 1%). The evaluation was conducted on the properties of the granule mass and quantitatively measured the percentage of sticking in industrial-scale modifications for 24 hours. The results showed that the control formula (F0), without modification, had the lowest sticking percentage (10.88%) and the highest moisture content (3.36%), as indicated by a "passable" flow property with a compressibility index of 21.47%. The 1% HPMC coating modification method (F4) was successful in eliminating stickiness to 0%, supported by moisture-control data (2.25%) and a significant improvement in powder-flow properties to “fair,” with a compressibility index of 17.06%. Although the 1% mannitol granulation method (F2) is relatively effective in reducing stickiness (0.85%), the 1% HPMC coating (F4) is more effective at physically isolating citric acid. This study concludes that the HPMC coating method is superior to the granulation method for physically isolating citric acid, yielding stable, non-sticking calcium carbonate–cholecalciferol chewable tablets.      
Evaluation of The Rationality of Hypertension Medication Use in Puskesmas Central Cimahi Faizal Hermanto; Anna Choirunissa; Titta Hartyana Sutarna; Riza Amelia; Akmal Rizwan
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8673

Abstract

A persistent and abnormal increase in blood pressure in the arteries is known as hypertension (HT. This research aims to assess the consumption of antihypertension at the Puskesmas Central Cimahi. Non-analytical descriptive methods were used in this investigation. Retrospective data was collected by accessing patient prescriptions and medical record data. Fifty-six patient samples in this study met the inclusion requirements. Quantitative and qualitative methods are used to evaluate rationality. Quantitative data analysis is processed to determine the number of patients, gender, age, and type of drug classification. Qualitative data analysis is processed to evaluate the appropiate of the indication, drug, patient and dose. Based on the research results, 52 people suffered from stage 1 hypertension, and four patients suffered from stage 2 hypertension. Amlodipine monotherapy was the most frequently prescribed drug, namely 92%. While the combination of amlodipine, captropil, amlodipine, and hydrochlorothiazide amounted to 4%. The rationality of treating hypertensive patients who meet the right indications, the right drug, the right patient and the right dose is 100%. It can be concluded that the evaluation and use of hypertension medication at the Puskesmas Central Cimahi as a whole meets the criteria for rational treatment.
Co-Authors Abdul Azizsidiq, Fahmi Afifah Bambang Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Ahmad Ngadeni Akmal Rizwan Alya Nur Asilla Amalia Hasna Ambarsundari Ambarsundari Ambarsundari, Ambarsundari Angraeni, Wulan Anna Choirunissa Azzara, Karina Putriani Bintary, Dyan Dini Tereslina Dwijayanti, Anisa Elivas Simatupang Elivas Simatupang Erina Sifa Mutmainah Euis Reni Yuslianti, Euis Faizal Hermanto Fathia, Syafa Giana Febrianti, Mia Fikri Alatas Frita Ferlita Shafri Djohan Gayatri Simanullang Gosepa, Oke Setiawan Haq, Fahmy Ahsanul Hestiary Ratih Karin, Amada Lucky Rachmawan Lucky Rachmawan Meilina, Tika Moch. Reza Pratama Ngadeni, Achmad Nira Purnamasari, Nira Nur Achsan Al-Hakim Oskar Skarayadi, Oskar Pratama, Moch. Reza Pratiwi, Gladdis Kamilah Prianto, Ulla L. F. Purwoko, Agus Qotrunnada, Daffa Rachmah, Mutia Alifah Rachmawan, Lucky Ratih, Hestyari Regita Ayu Lestari Ririn Puspadewi Ririn Puspadewi, Ririn Riza Amelia Sari, Suci Wulan Simatupang, Elivas Sintia Resni Pratiwi Sri Mulyani Suci Nar Vikasari, Suci Nar Sundani Nurono Soewandhi Tresna Lestari, Tresna Wulan Anggraeni Yoga Windu Wardhana